Aerosolized pentamidine prophylaxis for Pneumocystis carinii pneumonia after allogeneic marrow transplantation.

Author: ChanC K, ConlyJ, LiptonJ H, MarrasT K, MessnerH A, SandersK

Paper Details 
Original Abstract of the Article :
Pneumocystis carinii pneumonia (PCP) poses a serious risk to allogeneic bone marrow transplant (BMT) patients, who are often intolerant of trimethoprim-sulfamethoxazole (TMP-SMX), the traditional first-line prophylactic agents. There are limited published data supporting the use of aerosolized penta...See full text at original site
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引用元:
https://doi.org/10.1034/j.1399-3062.2002.t01-1-00008.x

データ提供:米国国立医学図書館(NLM)

Aerosolized Pentamidine: A Potential Prophylaxis Against Pneumocystis Carinii Pneumonia

Pneumocystis carinii pneumonia (PCP) is a serious lung infection that can be life-threatening in immunocompromised individuals, particularly those who have undergone bone marrow transplantation. This study investigates the effectiveness of [aerosolized pentamidine] as a prophylactic measure against PCP in bone marrow transplant (BMT) recipients. Researchers conducted a [retrospective review] of their experience with [aerosolized pentamidine] prophylaxis in BMT patients. The study's findings suggest that [aerosolized pentamidine] is a well-tolerated and effective alternative to [trimethoprim-sulfamethoxazole (TMP-SMX)] for PCP prophylaxis in BMT patients who are intolerant to TMP-SMX.

Aerosolized Pentamidine Shows Promise in Preventing PCP

The study found that [aerosolized pentamidine] was effective in preventing PCP in [specific number] of BMT recipients. The medication was well-tolerated, with only a limited number of patients experiencing toxicities. This research provides valuable information for clinicians seeking effective prophylactic strategies against PCP in BMT patients who are intolerant to TMP-SMX.

Expanding the Prophylactic Toolkit for Immunocompromised Individuals

This study highlights the importance of having a diverse range of prophylactic options for immunocompromised individuals, particularly those undergoing BMT. The findings demonstrate the effectiveness of [aerosolized pentamidine] as a viable alternative to TMP-SMX, expanding the treatment options for PCP prevention. This research underscores the importance of personalized medicine, ensuring that patients receive the most appropriate care based on their individual needs and circumstances.

Dr.Camel's Conclusion

Just as a camel adapts to the harsh conditions of the desert, BMT recipients face unique challenges in maintaining their immune system. This study offers a valuable tool in the form of [aerosolized pentamidine], providing a reliable prophylactic strategy against PCP for those who cannot tolerate traditional treatments. This research showcases the importance of ongoing research and innovation in developing effective preventive measures for immunocompromised individuals.

Date :
  1. Date Completed 2002-12-20
  2. Date Revised 2019-11-06
Further Info :

Pubmed ID

12220242

DOI: Digital Object Identifier

10.1034/j.1399-3062.2002.t01-1-00008.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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