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Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate.

Author: BakerMatthew J, BremSteven, DanielsStephanie, PhuphanichSurasak, ShermanBeverly

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Sodium phenylbutyrate, a biological-response modifier, showed potential in treating a 44-year-old female with a recurrent, multicentric, malignant glioma. The patient experienced a durable remission lasting more than four years after being treated with sodium phenylbutyrate, despite previous resistance to other therapies. Sodium phenylbutyrate was well tolerated, suggesting its potential for treating malignant gliomas.
Paper Details　
Original Abstract of the Article :
Sodium phenylbutyrate is a biological-response modifier that acts as a dose-dependent inhibitor of glioma cell proliferation, migration, and invasiveness in vitro, possibly by inhibition of urokinase and c-myc pathways. Despite its biological activity in vitro, there have not been any prior reports ...See full text at original site
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引用元：
https://doi.org/10.1023/a:1019905127442

データ提供：米国国立医学図書館（NLM）

A New Oasis of Hope in the Desert of Glioma Treatment: Phenylbutyrate

The battle against malignant gliomas, a type of brain cancer, can feel like a fight against an unforgiving desert. This study, like a beacon in the night, offers a glimmer of hope with the use of phenylbutyrate, a drug that acts like a calming oasis in the desert of cancer cells. The researchers report a case of a patient with a recurrent, multicentric malignant glioma who experienced a durable remission after being treated with phenylbutyrate. The patient's response to the drug was like a sudden blossoming of life in the desert, offering a chance at survival against a daunting foe.

A Hopeful Oasis in the Desert of Glioma: Phenylbutyrate's Promise

This case report, like a lone traveler sharing their story around a campfire, provides a testament to the potential of phenylbutyrate in the treatment of malignant gliomas. The fact that a patient with recurrent, multicentric glioma experienced a durable remission lasting over four years is a remarkable finding, highlighting the potential of this drug as a powerful weapon in the fight against this devastating cancer. While further research is needed to fully understand its efficacy and identify patients who might benefit the most, this study offers a promising path forward, like a newly discovered oasis in a vast desert.

A New Weapon in the Fight Against Glioma: Phenylbutyrate's Potential

This study, like a traveler returning from a successful journey, brings news of a potentially new treatment option for malignant gliomas. While further research is needed, the promising results of this case report offer a glimmer of hope for those facing this challenging diagnosis. It's essential to consult with a healthcare professional to discuss the risks and benefits of this treatment option, like weighing the potential benefits against the challenges of any desert journey.

Dr.Camel's Conclusion

This case report offers a beacon of hope in the desert of glioma treatment, demonstrating the potential of phenylbutyrate as a promising new weapon against this formidable foe. While more research is needed to fully understand its potential, this discovery is a testament to the ongoing search for effective treatments in the fight against cancer.
Date :
  1. Date Completed 2003-04-03
  2. Date Revised 2019-09-10
Further Info :

Pubmed ID

12241121

DOI: Digital Object Identifier

10.1023/a:1019905127442

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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