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Results of chemotherapy as an adjunct to surgery in patients with localized ovarian cancer.

Author: DelclosL, RutledgeF N, SmithJ P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 149 patients with early ovarian cancer compared postoperative radiation therapy to chemotherapy with Melphalan. While both treatments resulted in similar outcomes at two years, radiation therapy appeared to improve survival for stage I cancer, chemotherapy improved survival for stage III cancer, and both treatments had similar results for stage II cancer. Chemotherapy was better tolerated, with only one patient experiencing serious side effects. Radiation therapy was associated with bowel injuries requiring surgery in 7 patients. The study suggests that the radiation plan used may be too aggressive for the pelvis and that the cost of treatment varies considerably between the two methods.
Paper Details　
Original Abstract of the Article :
One hundred and forty-nine patients with early cancer of the ovary who were suitable for postoperative radiotherapy were treated in a random study in which whole abdominal irradiation with additional treatment to the pelvis was compared to chemotherapy with Melphalan. The number of patients without ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1234807

データ提供：米国国立医学図書館（NLM）

Chemotherapy: A Powerful Tool in the Desert of Ovarian Cancer

Ovarian cancer, a formidable foe, often presents challenges in treatment. This study investigates the effectiveness of chemotherapy as an adjunct to surgery in patients with localized ovarian cancer. Researchers conducted a randomized study involving 149 patients, comparing whole abdominal irradiation with additional pelvic treatment to chemotherapy with Melphalan. The results showed that both treatments yielded similar outcomes in terms of disease-free survival, with chemotherapy demonstrating a potential advantage for patients with stage III disease. While chemotherapy was well-tolerated, radiation therapy resulted in complications like small bowel injury, highlighting the importance of careful treatment planning and monitoring. This study underscores the importance of individualized approaches and the need for continued research to optimize treatment strategies for ovarian cancer.

A Shifting Landscape: Chemotherapy and Radiation Therapy in Ovarian Cancer

The study reveals a dynamic landscape of treatment options for ovarian cancer, with chemotherapy and radiation therapy offering distinct advantages depending on the stage of disease. The findings emphasize the crucial role of personalized approaches and the need for continued research to refine treatment strategies. Remember, navigating the challenging terrain of ovarian cancer requires a collaborative approach between patients and healthcare professionals.

Navigating the Sands of Ovarian Cancer: A Multifaceted Approach

If you are diagnosed with ovarian cancer, it is essential to seek expert guidance from a qualified oncologist to develop a personalized treatment plan. Early diagnosis, prompt treatment, and ongoing monitoring are critical for optimal outcomes. Remember, the journey through ovarian cancer treatment is best navigated with a skilled guide and a unwavering spirit of hope.

Dr.Camel's Conclusion

This research highlights the evolving landscape of ovarian cancer treatment, with chemotherapy and radiation therapy offering distinct advantages depending on the stage of disease. It underscores the importance of personalized approaches and the ongoing pursuit of effective therapies to combat this formidable foe. Remember, navigating the desert of ovarian cancer treatment requires a collaborative approach, with a strong team and a commitment to ongoing research.

Date :
  1. Date Completed 1977-02-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1234807

DOI: Digital Object Identifier

1234807

SNS
PICO Info
in preparation
Languages

English

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