Effective treatment of over-the-counter medicines: A Synthesis of Findings from 87 Studies

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Original Abstract of the Article

Major Research Findings

There is no clear consensus regarding systemic treatment of early-stage ovarian cancer (OC). Clinical trials are challenging because of the relatively low incidence and good prognosis. Initial results of the International Collaborative Ovarian Neoplasm (ICON) 1 trial demonstrated benefit in both overall survival (OS) and recurrence-free survival (RFS) with adjuvant chemotherapy. 56

The review highlights that an improved understanding of the molecular basis of ovarian cancer has led to the development of novel agents that work differently from conventional chemotherapy. These include DNA-repair pathway inhibitors, the most common of which are PARP (poly (ADP-ribose) polymerase) inhibitors. 37

This is a short version of a report that presents a comprehensive analysis of clinical trials and publications examining the value of cytotoxic chemotherapy in the treatment of advanced epithelial cancer. The analysis and comments from hundreds of oncologists show that, apart from lung cancer (especially small-cell lung cancer), there is no direct evidence that chemotherapy prolongs survival in patients with advanced carcinoma. Except for ovarian cancer, available indirect evidence rather supports the absence of a positive effect. In the treatment of lung cancer and ovarian cancer, the therapeutic benefit is at best rather small, and a less aggressive treatment seems to be at least as effective as the usual one. It is possible that certain subgroups of patients benefit from the treatment, but the available results do not allow for a sufficiently precise definition of these groups. Many oncologists take it for granted that response to therapy prolongs survival, an opinion based on a fallacy and not supported by clinical studies. To date, it is unclear whether the treated patients, as a whole, benefit from chemotherapy in terms of their quality of life. For most cancer sites, urgently required types of studies such as randomized de-escalations of dose or comparisons of immediate versus deferred chemotherapy are still lacking. With few exceptions, there is no good scientific basis for the application of chemotherapy in symptom-free patients with advanced epithelial malignancy. 4

This systematic literature review investigates the factors that determine surgical success in the treatment of epithelial ovarian cancer. Ovarian cancer is the most lethal gynecological cancer. Progression-free and overall survival are significantly related to surgical success and residual disease volume. It is unclear whether this survival advantage is due to an intrinsic biological element of the tumor cells that enables successful surgery and improved prognosis, or alternatively the number of tumor-sustaining cells remaining irrespective of differences in biology. 48

This is an updated Cochrane review that evaluates the role of adjuvant chemotherapy after surgery for early-stage epithelial ovarian cancer. Epithelial ovarian cancer is diagnosed in over 200,000 women worldwide each year. Ten to 20% of women are diagnosed early, when there is still a good possibility of cure. The treatment of early-stage (stage I and IIa) disease involves surgery to remove the disease, often followed by chemotherapy (adjuvant chemotherapy). The largest clinical trials of adjuvant chemotherapy show an overall survival (OS) advantage with platinum-based chemotherapy; however, the precise role and type of this treatment in subgroups of women with differing prognoses needs to be defined. 62

This review aims to compare the toxicities of different chemotherapy regimens in the treatment of advanced ovarian cancer (AOC) using network meta-analysis. Ovarian cancer (OC) is the 5th leading cause of cancer-related deaths around the world, and several chemotherapy regimens have been applied in the treatment of OC.

Treatment Summary

In the treatment of advanced ovarian cancer, a combination of surgery and chemotherapy is generally considered the most effective approach. Traditionally, surgery is performed first, followed by chemotherapy. However, research suggests that there may be benefits to using chemotherapy before surgery. 75 Additionally, 51 highlights the importance of optimal cytoreductive surgery, which involves removing as much of the tumor as possible during surgery. The less residual tumor left behind, the better the survival rate tends to be.

Treatment for early-stage ovarian cancer (stage I and IIa) often involves surgery to remove the disease, followed by adjuvant chemotherapy. The largest clinical trials of adjuvant chemotherapy have shown an overall survival (OS) advantage with platinum-based chemotherapy. 62 However, more research is needed to determine the precise role and type of adjuvant chemotherapy for subgroups of patients with differing prognoses.

Benefits and Risks

Benefits Summary

In early-stage ovarian cancer, adjuvant chemotherapy can potentially extend overall survival (OS) and recurrence-free survival (RFS). 56 For advanced ovarian cancer, optimal cytoreductive surgery, which aims to remove as much of the tumor as possible, is crucial. 51 Less residual tumor after surgery is associated with a better prognosis.

Risks Summary

Chemotherapy can cause side effects, which vary depending on the drugs used and the dosage. Common side effects include nausea, vomiting, hair loss, fatigue, and bone marrow suppression. 4

Comparison Between Studies

Similarities Between Studies

Many studies agree that a combination of surgery and chemotherapy is effective in treating advanced ovarian cancer. There is also a common understanding that surgery combined with adjuvant chemotherapy is beneficial for treating early-stage ovarian cancer.

Differences Between Studies

There is some variation in findings regarding the optimal chemotherapy regimen for early-stage ovarian cancer. 56 Additionally, research opinions differ on whether surgery first followed by chemotherapy or chemotherapy first followed by surgery is more effective for treating advanced ovarian cancer. 75

Consistency and Contradictions in Results

Current research findings are not entirely consistent when it comes to the optimal chemotherapy regimen for early-stage ovarian cancer. There is also no definitive answer regarding whether surgery first or chemotherapy first is more effective in treating advanced ovarian cancer.

Implications for Real-Life Applications: Important Considerations

Ovarian cancer treatment is individualized and depends on the patient's condition and disease stage. It is essential to consult with your doctor to discuss your situation and choose the most suitable treatment. Chemotherapy can cause side effects, so follow your doctor's instructions and report any side effects promptly.

Limitations of Current Research

Research on ovarian cancer treatment is still ongoing and needs further development. In particular, more research is needed to determine the optimal chemotherapy regimen for early-stage ovarian cancer and whether surgery first or chemotherapy first is more effective in treating advanced ovarian cancer.

Future Research Directions

Future research on ovarian cancer treatment should focus on identifying the optimal chemotherapy regimen for early-stage disease and clarifying the most effective approach for treating advanced disease—surgery first or chemotherapy first. Additionally, research efforts should concentrate on developing new therapies and implementing personalized medicine strategies to further improve ovarian cancer treatment.

Conclusion

While advancements have been made in ovarian cancer treatment, further progress is needed. Surgery combined with adjuvant chemotherapy is generally considered effective for early-stage ovarian cancer, but more research is required to determine the best chemotherapy regimens. A combination of surgery and chemotherapy is generally deemed the most effective approach for treating advanced ovarian cancer, but the optimal sequence—surgery first or chemotherapy first—remains unclear. Research on ovarian cancer treatment is ongoing, and further studies are necessary to develop more effective therapies.

Early detection of ovarian cancer is challenging. Therefore, regular checkups and early detection efforts are crucial. It is also important to be informed about ovarian cancer symptoms and risk factors to increase the chances of early detection. Research on ovarian cancer treatment is continually evolving. Staying informed about the latest treatment advancements and actively engaging in treatment can lead to better outcomes.

Treatment Keywords

Surgery, Chemotherapy, Platinum-based chemotherapy, Adjuvant chemotherapy, Cytoreductive surgery, DNA repair pathway inhibitors, PARP (poly (ADP-ribose) polymerase) inhibitors, Taxane-based chemotherapy, Gemcitabine, Topotecan, Etoposide, Bevacizumab, Hyperthermic intraperitoneal chemotherapy

Keywords
Benefit Keywords
Ovarian cancer treatment
1
Clinical remission
Five year cure rate
2
Ovarian cancer survival
3
Lung cancer treatment
Ovarian cancer treatment
4
Improved survival
Low-potential malignancy
5
Ovarian cancer treatment
6
Improved survival
7
Effective alternative to standard chemotherapy
Lower gastrointestinal toxicity
Lower nephrotoxicity
8
Ovarian cancer treatment
9
Ovarian cancer treatment
10
Reduced recurrence rates
11
Improved survival for some
No adjuvant therapy needed for some
12
Better results with surgery
13
Improved survival
14
Increased response rate
15
Improved work capacity
16
Effective treatment
17
Improved ovarian cancer treatment
18
Improved ovarian cancer control
19
Improved survival
20
Improved ovarian cancer survival
22
Prolonged survival
23
Ovarian cancer treatment
24
Improved progression-free survival
Improved survival
26
Epithelial ovarian cancer treatment
27
IP chemotherapy
28
Improved survival
29
Neoadjuvant chemo
30
Improved epithelial ovarian cancer treatment
31
Effective treatment
Improved survival
32
Improved epithelial ovarian cancer treatment
33
Epithelial ovarian cancer treatment
34
Improved survival
35
Ovarian cancer treatment
36
Ovarian cancer treatment
37
Ovarian cancer treatment
38
Improved ER utilization
Reduced primary care visits
39
Ovarian germ cell tumor treatment
40
Improved survival
41
Improved ovarian cancer management
42
Improved survival
43
Treatment of ovarian cancer
44
Treatment of early stage ovarian cancer
45
Treatment of epithelial ovarian cancer
46
Effective relapse treatment
Improved survival
47
Improved survival
49
Ovarian cancer treatment
50
Ovarian cancer treatment
51
EOC treatment
52
Relapsed EOC treatment
53
Secondary cytoreductive surgery
54
Gynaecological cancer treatment
55
Chemotherapy for ovarian cancer
56
Ovarian cancer treatment
57
Improved quality of life
Improved survival
Reduced anxiety
58
Ovarian cancer treatment
59
Effective treatment
Safe treatment
60
Ovarian cancer treatment
61
Ovarian cancer treatment
62
Ovarian cancer treatment
63
AOC treatment
66
Early detection
Improved survival
67
Improved ovarian cancer outcomes
68
Immune response
Ovarian cancer treatment
69
Improved ovarian cancer treatment
70
EOC treatment
Novel agents
71
Early detection
Hormone replacement therapy
72
Improved EOC treatment
Reduced EOC mortality
73
Treatment for recurrent ovarian cancer
74
Ovarian cancer treatment
75
Improved EOC treatment
76
Ovarian cancer treatment
77
Epithelial ovarian cancer treatment
78
Improved treatment outcomes
79
Ovarian cancer treatment
Platinum-resistant treatment
Platinum-sensitive treatment
80
Ovarian cancer survival
81
Effective therapy
Ovarian cancer treatment
82
Improved ovarian cancer treatment
83
Treatment for epithelial ovarian cancer
84
Ovarian cancer treatment
85
Improved OS
86
Macroscopic cytoreduction for advanced epithelial ovarian cancer
87
Risk Keywords
Bone marrow depression
Small bowel injury
1
Late diagnosis
3
Chemotherapy side effects
Quality of life decrease
4
Myelosuppression
6
Poor survival for some
12
Increased side effects
15
Increased ovarian cancer mortality in elderly women
19
Leukopenia
Neurologic toxicity
22
Treatment toxicity
25
Inferior survival outcome
30
Epithelial ovarian cancer
31
Thrombocytopenia
32
Epithelial ovarian cancer
33
Controversial outcome
43
Poor prognosis
Toxicity
49
Severe side effects
53
Recurrent ovarian cancer
54
Cost-ineffectiveness
58
Chemotherapy toxicity
66
No systematic CT follow-up
72
Conflicting evidence on optimal paclitaxel dosing
84
Ovarian cancer
86
Literature analysis of 87 papers
Positive Content
83
Neutral Content
3
Negative Content
1
Article Type
29
27
52
47
87
1.

Results of chemotherapy as an adjunct to surgery in patients with localized ovarian cancer.

Author: SmithJ P, RutledgeF N, DelclosL

Ovarian cancer treatment
Bone marrow depression
Small bowel injury

A study of 149 patients with early ovarian cancer compared postoperative radiation therapy to chemotherapy with Melphalan. While both treatments resulted in similar outcomes at two years, radiation therapy appeared to improve survival for stage I cancer, chemotherapy improved survival for stage III cancer, and both treatments had similar results for stage II cancer. Chemotherapy was better tolerated, with only one patient experiencing serious side effects. Radiation therapy was associated with bowel injuries requiring surgery in 7 patients. The study suggests that the radiation plan used may be too aggressive for the pelvis and that the cost of treatment varies considerably between the two methods.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[The problems of prophylactic chemotherapy, the second-look operation and the maintenance of the remission in the treatment of ovarian cancer (author's transl)].

Author: PfleidererA

Clinical remission
Five year cure rate

A review of 1022 ovarian cancer cases found that post-operative prophylactic chemotherapy was beneficial in stages 1 and 2, but only for cases with tumor cells in secretions or ascites, or with known chemotherapy sensitivity. Cyclophosphamide led to remission in about 50% of inoperable stage 3 cases. Radical surgery during remission and continuous chemotherapy for at least 2 years after surgery and radiation are vital for long-term survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

3.

Report on treatment of cancer of the ovary.

Author: KuipersT

Ovarian cancer survival
Late diagnosis

In 254 patients with ovarian carcinoma, irradiation of the pelvis and lumboaortic nodes resulted in a better 3-year survival rate compared to pelvic-only irradiation. Chemotherapy is preferred for stages III and IV due to a high death rate within 8 months, despite whole-abdomen irradiation. The main challenge in ovarian cancer remains late diagnosis, making reliable statistical conclusions difficult.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Chemotherapy of advanced epithelial cancer--a critical review.

Author: AbelU

Lung cancer treatment
Ovarian cancer treatment
Chemotherapy side effects
Quality of life decrease

A review of clinical trials found that chemotherapy does not consistently prolong survival for patients with advanced epithelial cancer, except for lung cancer (especially small-cell lung cancer) and ovarian cancer. Even in these cases, the benefits of chemotherapy are minimal, and less aggressive approaches may be equally effective. There is no clear evidence that responding to chemotherapy improves survival. The impact of chemotherapy on quality of life for patients with advanced cancer is unclear. The study calls for more research to determine the optimal use of chemotherapy in advanced epithelial cancers, including studies comparing different doses and timing of treatment, as well as its value in symptom-free patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Long-term survival with advanced ovarian cancer: an analysis of 5-year survivors in the Australian trial comparing combination versus sequential chlorambucil and cisplatin therapy.

Author: TattersallM H, SwansonC E, SolomonH J

Improved survival
Low-potential malignancy

A study of 318 patients with invasive ovarian cancer found a 5-year survival rate of 11.4%, while a group of 20 patients with low-potential malignancy had a 5-year survival rate of 85%. There was no significant difference in survival between two chemotherapy regimens: chlorambucil and cisplatin combined versus chlorambucil followed by cisplatin. Patients with less residual tumor after surgery had better 5-year survival rates (15% vs. 8.5%). The study concluded that complete surgical response was a stronger predictor of survival than clinical response. The study also emphasizes the importance of central pathology review for accurate diagnosis and treatment of ovarian cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

High-dose, short-duration cisplatin/doxorubicin combination chemotherapy for advanced ovarian epithelial cancer.

Author: HunterR E, GriffinT W, StevensS, RomanL D, BokhariF, RealeF R, TakW K, FitzgeraldT J, DillonM B, RoseP G

Ovarian cancer treatment
Myelosuppression

A study of 61 patients with ovarian cancer investigated the effectiveness of high-dose chemotherapy followed by second-look laparotomy (SLL) and subsequent treatment with either cyclophosphamide, abdominal radiation, or no additional therapy. 74% of patients achieved complete remission after high-dose chemotherapy, and 64% of patients who underwent SLL had no evidence of disease. The median survival time for all patients was 51.3 months, however, there was no significant difference in survival between the second-line treatment groups. While high-dose chemotherapy was effective in achieving remission, the long-term survival benefit needs further comparison with traditional low-dose regimens. Despite significant myelosuppression, treatment-related complications were manageable.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Chemotherapy in advanced ovarian cancer: an overview of randomised clinical trials. Advanced Ovarian Cancer Trialists Group.

Author:

Improved survival

The use of platinum-based chemotherapy in patients with advanced ovarian cancer may improve survival. There is a possible advantage to using a platinum-based combination chemotherapy regimen over a single agent platinum regimen, and cisplatin and carboplatin appear to be equally effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

8.

[Combined chemo- and hormone-therapy in advanced ovarian carcinoma--theoretical, experimental foundations and clinical results].

Author: SeveldaP

Effective alternative to standard chemotherapy
Lower gastrointestinal toxicity
Lower nephrotoxicity

This study aimed to improve the treatment of advanced ovarian cancer by combining chemotherapy and hormone therapy. A new chemotherapy regimen (AP-VC-MTX) was developed, which used a sequence of different chemotherapy drugs to overcome drug resistance. This regimen was found to be as effective as standard chemotherapy but with fewer side effects (lower kidney and gastrointestinal toxicity). The study also investigated the use of medroxyprogesterone acetate (MPA) as hormone therapy, showing that it had anti-cancer effects and fewer side effects. The combination of AP-VC-MTX chemotherapy and MPA was chosen as the standard treatment for advanced ovarian cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

9.

The role of chemotherapy including ifosfamide for ovarian carcinoma. Austrian Collab. Ovarian Cancer Study Group.

Author: KarrerK, SalzerH, SeveldaP, DittrichC

Ovarian cancer treatment

This study investigated the use of adjuvant chemotherapy for ovarian cancer in Austria. The study found that patients with early-stage, well-differentiated ovarian cancer confined to the ovaries did not benefit from additional chemotherapy after surgery. For patients with more advanced disease (stages III and IV), a new chemotherapy regimen (Adriamycin-cisplatin + vincristine-cyclophosphamide + high-dose methotrexate) was being studied and compared to other chemotherapy combinations. High-dose ifosfamide was also being investigated in pilot studies. This suggests that a multi-drug approach may be more effective in treating advanced ovarian cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Ovarian tumours.

Author: SalzerH

Ovarian cancer treatment

A study of 300 patients with advanced ovarian cancer found that a "changing scheme" chemotherapy regimen (A/P-V/C-HD-MTX) was more effective than standard regimens (adriamycin and cyclophosphamide or adriamycin and cisplatin), resulting in higher remission rates, longer remission durations, and improved survival, particularly for patients with certain tumor characteristics. The changing scheme also caused fewer side effects. These findings suggest that the changing scheme may be a promising treatment option for patients with advanced ovarian cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

The role of adjuvant therapy in Stage I ovarian cancer.

Author: HreshchyshynM M, ParkR C, BlessingJ A, NorrisH J, LevyD, LagasseL D, CreasmanW T

Reduced recurrence rates

A study of women with stage I epithelial carcinoma of the ovary found that adjuvant chemotherapy was more effective than no treatment or radiotherapy in preventing recurrence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

A study of 656 patients with "early" ovarian cancer.

Author: GuthrieD, DavyM L, PhilipsP R

Improved survival for some
No adjuvant therapy needed for some
Poor survival for some

A study of 656 patients with epithelial ovarian cancer found that patients with tumors of borderline malignancy or stage Ia(i) well-differentiated tumors did not require adjuvant therapy. Survival was poor for patients with clear cell carcinoma regardless of stage. No significant difference was found between different adjuvant treatments, but patients who received no further treatment after surgery had significantly better survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

[Comparative study of 2 combined treatment regimens in stage-III to -IV ovarian cancer].

Author: EvdokimovaN I, GrigorovaT M

Better results with surgery

This study compared two treatment approaches for ovarian cancer: surgery followed by combination chemotherapy (including 5-fluorouracil, cyclophosphamide, and hexamethylamine) and a combination of chemotherapy (cytoxan), surgery, and additional combination chemotherapy. Results were better in the group receiving surgery first. Overall, patients with non-ascitic ovarian cancer had better outcomes with the surgery-first approach, while patients with ascitic ovarian cancer showed some improvement with both treatment regimens.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

14.

[The therapy of the early ovarian cancer (T1/T2 M0 N0) (author's transl)].

Author: KrafftW, MorackG, FlachW, BehlingH, SchirmerA, BrückmannD, PreibschW

Improved survival

A study of 60 patients with early-stage ovarian cancer (T1 M0 N0 and T2 M0 N0) compared surgical treatment alone (group A) to surgery followed by chemotherapy (group B). Five-year survival rates were similar in both groups for stage T1 M0 N0 (94% for group A and 90% for group B) and for stage T2 M0 N0 (100% for group A and 76% for group B). However, after 10 years, the survival rate for stage T1 M0 N0 patients in group B decreased to 62%. While there was no statistically significant difference between the two treatment groups, the study highlights the importance of a comprehensive surgical approach. Ruptured secondary ovarian cancers and ascites significantly reduced survival rates. The study concludes that current chemotherapy regimens did not improve long-term survival for patients with early-stage ovarian cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

15.

Low-dose cyclophosphamide versus adriamycin plus cyclophosphamide in advanced ovarian cancer. A randomized clinical study.

Author: BolisG, BortolozziG, CarinelliG, D'IncalciM, GramelliniF, MorascaL, MangioniC

Increased response rate
Increased side effects

This study of 74 patients with ovarian cancer found that the combination of CTX and ADM was associated with a higher response rate (52%) compared to CTX alone (42%). However, the combination treatment was associated with more side effects. There was no significant difference in survival between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

[Chemo-(hormonal)-therapy of advanced ovarian neoplasms in FIGO stages III and IV. Prospective SAKK-study 20/71].

Author: SennH J, LeiD, Castaño-AlmendralA, BrunnerK W, MartzG, ObrechtP, MelchertF, RhombergW

Improved work capacity

Cyclophosphamide (CYT) combined with either medroxyprogesterone acetate (GEST) or 5-fluorouracil (FU) showed a trend towards higher remission rates in patients with advanced ovarian cancer compared to CYT alone. Remission duration and survival were slightly longer in patients receiving combination therapies, but no treatment regimen was superior.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

17.

[Strategy for the ovarian cancer treatment].

Author: OchiaiK

Effective treatment

This study outlines the current treatment approaches for ovarian cancer in Japan, emphasizing the importance of accurate staging for determining treatment plans. For early-stage (stage I) patients, surgery typically includes removal of the uterus, ovaries, appendix, and part of the omentum. Chemotherapy is then administered for 5 cycles. For stage I patients with grade 1 tumors who desire to preserve fertility, a less extensive surgery is performed, and they are enrolled in a trial comparing two chemotherapy regimens. More advanced stages (II and above) involve more extensive surgery, including removal of the omentum and lymph nodes. Chemotherapy is given for 5-10 cycles. Additionally, a study is underway to evaluate the benefit of lymph node removal in patients with optimally debulked tumors (tumor less than 2 cm). These studies aim to improve the treatment and survival outcomes for ovarian cancer patients in Japan.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Japanese

18.

Localized ovarian cancer in the elderly. The Gynecologic Oncology Group experience.

Author: YoungR C, BradyM F, WaltonL A, HomesleyH D, AveretteH E, LongH J

Improved ovarian cancer treatment

This report highlights the need for more research on the best treatment for localized ovarian cancer, particularly for elderly patients, and discusses the ongoing work of the Gynecologic Oncology Group (GOG) in this area.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

Treatment of ovarian cancer in elderly women. Mayo Clinic-North Central Cancer Treatment Group studies.

Author: EdmonsonJ H, SuJ, KrookJ E

Improved ovarian cancer control
Increased ovarian cancer mortality in elderly women

This report explores the therapeutic outcomes of systemic chemotherapy for ovarian cancer in women of different ages, noting an increase in ovarian cancer mortality among American women over 65.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

21.

[Recurrent and 2nd line therapy in ovarian carcinoma: an overview of conventional systemic therapy modalities].

Author: du BoisA, LückH J, MeerpohlH G

Platinum-based chemotherapy is the most effective treatment for platinum-sensitive recurrent ovarian cancer. However, there is limited evidence for effective treatment of platinum-resistant ovarian cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

22.

Three cycles versus six cycles of adjuvant paclitaxel (Taxol)/carboplatin in early stage ovarian cancer.

Author: YoungR C

Improved ovarian cancer survival
Leukopenia
Neurologic toxicity

This study discusses the controversial management of early stage ovarian cancer with poor prognostic features, highlighting the use of paclitaxel and platinum agents in adjuvant chemotherapy trials and the ongoing research to determine the optimal number of chemotherapy cycles.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

A systematic overview of chemotherapy effects in ovarian cancer.

Author: HögbergT, GlimeliusB, NygrenP,

Prolonged survival

This review of 176 studies on chemotherapy for ovarian cancer found that early-stage, low-risk cancer does not require additional treatment after surgery. For high-risk early-stage cancer, the benefit of chemotherapy is unclear and should be investigated further. Paclitaxel and platinum-based combinations have significantly improved survival in advanced-stage ovarian cancer compared to surgery alone, with paclitaxel/cisplatin considered the standard treatment. However, a large study (ICON3) did not show a significant difference between paclitaxel/carboplatin and carboplatin alone, suggesting that carboplatin may be a viable alternative. Intraperitoneal chemotherapy showed some benefits in one study. High-dose chemotherapy with stem cell support can be effective for relapsed patients, but further research is needed before widespread use. Re-treatment with the same platinum-based drugs may be beneficial for patients with long remission periods. For patients resistant to first-line therapy, various single-agent treatments show limited effectiveness and further study is recommended.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

A rapid and systematic review of the clinical effectiveness and cost-effectiveness of topotecan for ovarian cancer.

Author: ForbesC, ShirranL, BagnallA M, DuffyS, ter RietG

Ovarian cancer treatment

Ovarian cancer is a common and often deadly disease, with a 5-year survival rate of only 30% in the UK. While paclitaxel and platinum-based chemotherapy are standard treatments, many patients develop resistance and need alternative therapies. Topotecan is one option for second-line treatment, showing modest effectiveness, but more research is needed as current reviews are based on limited data.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Chemotherapy versus hormonal treatment in platinum- and paclitaxel-refractory ovarian cancer: a randomised trial of the German Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) Study Group Ovarian Cancer.

Author: duBois A, MeierW, LückH J, EmonG, MoebusV, SchroederW, CostaS, BauknechtT, OlbrichtS, JackischC, RichterB, WagnerU

Treatment toxicity

While most ovarian cancer patients don't achieve a cure with initial treatments, current second-line chemotherapy options haven't shown significant benefits and often cause side effects. This study explores whether a less toxic hormonal treatment might be a better option for these patients compared to chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial.

Author: ParmarM K B, LedermannJ A, ColomboN, du BoisA, DelaloyeJ-F, KristensenG B, WheelerS, SwartA M, QianW, TorriV, FlorianiI, JaysonG, LamontA, TropéC,

Improved progression-free survival
Improved survival

Paclitaxel plus platinum chemotherapy improves survival and progression-free survival compared to conventional platinum-based chemotherapy in patients with relapsed platinum-sensitive ovarian cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

[Primary treatment of ovarian cancer].

Author: LyngstadaasAnita, EkangerRoald, HagenBjørn, HimmelmannAnna, IversenOle Erik, IversenTorbjørn, NordalRandi, NorheimOle Frithjof, OnsrudMathias, TretliSteinar, TropéClaes

Epithelial ovarian cancer treatment

Epithelial ovarian cancer is often diagnosed at a late stage, leading to poor survival rates. This study examines the effectiveness of four main treatment approaches for this type of cancer: 1) chemotherapy and/or radiation therapy after surgery, 2) surgery to remove as much cancer as possible, 3) chemotherapy before surgery in advanced cases, and 4) chemotherapy after surgery in advanced cases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Norwegian

28.

Intraperitoneal carboplatin-based chemotherapy for epithelial ovarian cancer.

Author: FujiwaraKeiichi, MarkmanMaurie, MorganMark, ColemanRobert L

IP chemotherapy

This review discusses the current status and future perspectives of intraperitoneal (IP) chemotherapy for ovarian cancer, highlighting its potential benefits in targeting the disease within the peritoneal cavity.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Primary surgery for ovarian cancer.

Author: TropéC, KaernJ

Improved survival

Optimal surgical staging for early-stage ovarian cancer and management for high-risk patients are still debated. Large retrospective studies consistently show residual disease size after cytoreductive surgery as a significant prognostic factor, but the size threshold for survival benefit remains undefined. The effectiveness of neoadjuvant chemotherapy in advanced ovarian cancer is unclear, prompting a large prospective randomized study.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Delaying the primary surgical effort for advanced ovarian cancer: a systematic review of neoadjuvant chemotherapy and interval cytoreduction.

Author: BristowRobert E, EisenhauerEric L, SantillanAntonio, ChiDennis S

Neoadjuvant chemo
Inferior survival outcome

Interval cytoreductive surgery following a concerted but suboptimal attempt at up-front cytoreduction does not appear to have an appreciable impact on survival outcome in patients with advanced-stage ovarian cancer. Neoadjuvant chemotherapy represents a viable alternative management strategy for patients felt to be optimally unresectable; however, currently available data suggest that the survival outcome achievable with initial chemotherapy is inferior to successful up-front cytoreductive surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer.

Author: MorrisonJ, SwantonA, CollinsS, KehoeS

Improved epithelial ovarian cancer treatment
Epithelial ovarian cancer

Epithelial ovarian cancer is often diagnosed at an advanced stage, and treatment typically involves surgery followed by chemotherapy. This study aims to determine if giving chemotherapy before surgery offers any advantages.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Nonplatinum topotecan combinations versus topotecan alone for recurrent ovarian cancer: results of a phase III study of the North-Eastern German Society of Gynecological Oncology Ovarian Cancer Study Group.

Author: SehouliJalid, StengelDirk, Oskay-OezcelikGuelten, ZeimetAlain G, SommerHarald, KlarePeter, StauchMartina, PaulenzAxel, CamaraOumar, KeilElke, LichteneggerWerner

Effective treatment
Improved survival
Thrombocytopenia

A study of 502 women with relapsed ovarian cancer found that combining topotecan with etoposide or gemcitabine did not improve overall survival compared to topotecan alone. The median overall survival was 17.2 months with topotecan, 17.8 months with topotecan plus etoposide, and 15.2 months with topotecan plus gemcitabine. Patients who received combined treatment had a higher risk of severe thrombocytopenia.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer.

Author: Winter-RoachBrett A, KitchenerHenry C, DickinsonHeather O

Improved epithelial ovarian cancer treatment
Epithelial ovarian cancer

Epithelial ovarian cancer causes about 1700 deaths in the UK each year. Only 10-15% of cases are diagnosed early, when there is a good chance of a cure. Treatment for early-stage disease involves surgery, often followed by chemotherapy. Large studies show that chemotherapy after surgery improves survival, but more research is needed to determine the best use of chemotherapy for different groups of patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer.

Author: Winter-RoachBrett A, KitchenerHenry C, DickinsonHeather O

Epithelial ovarian cancer treatment

Epithelial ovarian cancer is diagnosed in 4500 women in the UK each year, with 1700 deaths. Only 10-15% of cases are caught early, when there's a better chance of cure. Early-stage treatment involves surgery to remove the cancer, often followed by chemotherapy. Large studies show that chemotherapy after surgery improves survival rates, but more research is needed to figure out the best way to use chemotherapy for different patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Predicting the outcome of cytoreductive surgery for advanced ovarian cancer: a review.

Author: IbeanuOkechukwu A, BristowRobert E

Improved survival

This article discusses the need for universally applicable clinicopathological and radiological models for predicting optimal resectability in patients with advanced ovarian cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Cytoreductive surgery plus chemotherapy versus chemotherapy alone for recurrent epithelial ovarian cancer.

Author: GalaalKhadra, NaikRaj, BristowRobert E, PatelAmit, BryantAndrew, DickinsonHeather O

Ovarian cancer treatment

Most women with advanced epithelial ovarian cancer experience a return of the disease after initial surgery and chemotherapy. Surgery to remove the cancer again may improve survival for some women, but there are several chemotherapy drugs that are effective for recurrent ovarian cancer. The best approach for treating recurrent ovarian cancer is still not clear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

DNA-repair pathway inhibitors for the treatment of ovarian cancer.

Author: MartinekIgor, HaldarKrishnayan, GaitskellKezia, BryantAndrew, NicumShibani, KehoeSean, MorrisonJo

Ovarian cancer treatment

Ovarian cancer is a major cause of cancer death in women, with most cases diagnosed at a late stage. Treatment typically involves surgery and chemotherapy with platinum-based drugs, sometimes with taxanes. While initial responses are good, most women experience a return of the cancer, requiring further chemotherapy, and eventually developing resistance to treatment. New medications that work differently than traditional chemotherapy are being developed, including those that target DNA repair. These new drugs are being compared to standard treatments to evaluate their effectiveness and side effects, aiming to improve survival and quality of life for women with advanced ovarian cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Overcoming platinum resistance in ovarian carcinoma.

Author: MatsuoKoji, LinYvonne G, RomanLynda D, SoodAnil K

Ovarian cancer treatment

Ovarian cancer is a serious disease because it often returns after initial treatment and becomes resistant to chemotherapy, including platinum-based drugs. There is no standard treatment for ovarian cancer that has become resistant to platinum, as current options have similar, but unfortunately low, success rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Healthcare utilization in women after abdominal surgery for ovarian cancer.

Author: McCorkleRuth, JeonSangchoon, ErcolanoElizabeth, SchwartzPeter

Improved ER utilization
Reduced primary care visits

This study found that an intervention provided by advanced practice nurses and a psychiatric consultation-liaison nurse did not significantly reduce healthcare utilization in women undergoing surgery for a suspected diagnosis of ovarian cancer compared to an attention control intervention. The study found that women in the attention control group went to their primary care providers more often than the intervention group, and this group also reported more depressive symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

40.

Chemotherapy for malignant germ cell ovarian cancer in adult patients with early stage, advanced and recurrent disease.

Author: Abdul RazakAlbiruni Ryan, LiLouise, BryantAndrew, Diaz-PadillaIvan

Ovarian germ cell tumor treatment

Treatment for malignant germ cell tumors of the ovary is often based on data from testicular germ cell cancers due to the rarity of this condition. The effectiveness of chemotherapy for these tumors is not fully understood.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Ultra-radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer.

Author: AngChristine, ChanKaren K L, BryantAndrew, NaikRaj, DickinsonHeather O

Improved survival

Ultra-radical surgery in women with advanced ovarian cancer and carcinomatosis may result in better survival.  It was unclear whether there were any differences in progression-free survival, QoL and morbidity between the two groups. The cost-effectiveness of this intervention has not been investigated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Evaluation of follow-up strategies for patients with epithelial ovarian cancer following completion of primary treatment.

Author: KewFiona, GalaalKhadra, BryantAndrew, NaikRaj

Improved ovarian cancer management

This study explores the effectiveness of routine long-term follow-up for patients treated for ovarian cancer, questioning the need for routine reviews in light of potential limitations on survival, quality of life (QoL), anxiety, and cost-effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Optimal primary surgical treatment for advanced epithelial ovarian cancer.

Author: ElattarAhmed, BryantAndrew, Winter-RoachBrett A, HatemMohamed, NaikRaj

Improved survival
Controversial outcome

This review examines the controversy surrounding the optimal cytoreductive surgery outcome for epithelial ovarian cancer, exploring the impact of residual tumor size on patient survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Epidermal growth factor receptor blockers for the treatment of ovarian cancer.

Author: HaldarKrishnayan, GaitskellKezia, BryantAndrew, NicumShibani, KehoeSean, MorrisonJo

Treatment of ovarian cancer

Ovarian cancer is a significant cause of death in women worldwide. While initial treatment with surgery and platinum-based chemotherapy can be effective, about 55% to 75% of patients experience a relapse within two years. Second-line treatment is palliative, aiming to manage symptoms and prolong life. New drugs targeting the epidermal growth factor receptor (EGFR) are being developed for advanced ovarian cancer, and their effectiveness and safety need to be evaluated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer.

Author: Winter-RoachBrett A, KitchenerHenry C, LawrieTheresa A

Treatment of early stage ovarian cancer

Epithelial ovarian cancer is a serious condition affecting thousands of women in the UK each year. Only 10-15% are diagnosed early when treatment is most effective. While platinum-based chemotherapy after surgery has shown improved survival in large trials, the best approach for different groups of women with varying prognoses is still being determined.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer.

Author: MorrisonJo, HaldarKrishnayan, KehoeSean, LawrieTheresa A

Treatment of epithelial ovarian cancer

Most women are diagnosed with advanced epithelial ovarian cancer. Treatment usually involves surgery followed by chemotherapy. However, whether chemotherapy before surgery offers any benefits is still unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

The impact of second to sixth line therapy on survival of relapsed ovarian cancer after primary taxane/platinum-based therapy.

Author: HankerL C, LoiblS, BurchardiN, PfistererJ, MeierW, Pujade-LauraineE, Ray-CoquardI, SehouliJ, HarterP, du BoisA,

Effective relapse treatment
Improved survival

A maximum of three lines of chemotherapy is beneficial for patients with recurrent ovarian cancer. Optimal primary tumor debulking and platinum sensitivity remain significant prognostic factors even after multiple relapses.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Does tumour biology determine surgical success in the treatment of epithelial ovarian cancer? A systematic literature review.

Author: BorleyJ, Wilhelm-BenartziC, BrownR, Ghaem-MaghamiS

The study investigated whether surgical success and residual disease volume in ovarian cancer are related to intrinsic biological elements of tumor cells or the number of remaining tumor-sustaining cells. The findings suggest that improved prognosis after surgery is likely due to a combination of factors, including both the biological characteristics of the tumor cells and the extent of residual disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma.

Author: ShylasreeT S, BryantAndrew, AthavaleRam

Improved survival
Poor prognosis
Toxicity

Ovarian carcinosarcoma is a rare and aggressive type of ovarian cancer that has a poor prognosis. The standard treatment involves surgery to remove the cancer, followed by radiation and chemotherapy. While there are many different chemotherapy regimens available, their effectiveness is mixed. More research is needed to determine the best treatment for this type of cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Surgical cytoreduction for recurrent epithelial ovarian cancer.

Author: Al RawahiThuria, LopesAlberto D, BristowRobert E, BryantAndrew, ElattarAhmed, ChattopadhyaySupratik, GalaalKhadra

Ovarian cancer treatment

The usual treatment for ovarian cancer is surgery followed by chemotherapy. While many women achieve remission, about 60% of those with advanced disease will experience a return of the cancer. There is no standard treatment for recurrent ovarian cancer, but surgery may be associated with a longer lifespan.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

The role of cytoreductive surgery in advanced-stage ovarian cancer: a systematic review.

Author: VitaleSalvatore Giovanni, MarilliIlaria, LodatoMelissa, TropeaAlessandro, CianciAntonio

Ovarian cancer treatment

Ovarian cancer is a major cause of death from gynecologic cancer in developed countries, often diagnosed at an advanced stage. This review focuses on surgical treatment for advanced ovarian cancer, specifically complete removal of visible tumors (cytoreductive surgery), along with chemotherapy. The review highlights recent advancements like heated chemotherapy and new drugs, emphasizing the importance of referral to specialized centers for optimal outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Interferon after surgery for women with advanced (Stage II-IV) epithelial ovarian cancer.

Author: LawalAramide O, MusekiwaAlfred, GroblerLiesl

EOC treatment

Epithelial ovarian cancer is a serious disease that is often diagnosed at a late stage, making treatment more challenging. While surgery and chemotherapy are effective, the cancer often comes back. New treatments are needed to prevent recurrence, improve survival, and increase quality of life for women with ovarian cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer.

Author: LawrieTheresa A, BryantAndrew, CameronAlison, GrayEmma, MorrisonJo

Relapsed EOC treatment
Severe side effects

Ovarian cancer is a common cancer in women. This study will review the use of pegylated liposomal doxorubicin (PLD) in the treatment of relapsed epithelial ovarian cancer (EOC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Cytoreductive surgery followed by chemotherapy versus chemotherapy alone for recurrent platinum-sensitive epithelial ovarian cancer (SOCceR trial): a multicenter randomised controlled study.

Author: van de LaarRafli, ZusterzeelPetra L M, Van GorpToon, BuistMarrije R, van DrielWillemien J, GaarenstroomKatja N, ArtsHenriette J G, van HuisselingJohannes C M, HermansRalph H M, PijnenborgJohanna M A, SchutterEltjo M J, PelikanHarold M P, VolleberghJos H A, EngelenMirjam J A, InthoutJoanna, KruitwagenRoy F P M, MassugerLeon F A G

Secondary cytoreductive surgery
Recurrent ovarian cancer

This study investigates the role of surgery in the treatment of recurrent ovarian cancer. While platinum-based chemotherapy is standard for platinum-sensitive recurrent ovarian cancer, surgery's role remains unclear. The research examines the potential survival benefits of secondary cytoreductive surgery in specific patient groups.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

55.

Exenterative surgery for recurrent gynaecological malignancies.

Author: AngChristine, BryantAndrew, BartonDesmond P J, PomelChristophe, NaikRaj

Gynaecological cancer treatment

Cancer is a major cause of death globally, and cancers affecting the female reproductive organs (gynecologic cancers) are common. While early-stage cancers are often treated effectively with surgery, advanced or recurrent cancer can be much more challenging and often requires extensive procedures. Pelvic exenteration, which involves removing some or all of the pelvic organs, is a difficult surgery with significant risks, but can offer a chance of cure or symptom relief for carefully selected patients. This review does not include ovarian cancer, which is often treated with chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

Optimal treatment of early-stage ovarian cancer.

Author: CollinsonF, QianW, FossatiR, LissoniA, WilliamsC, ParmarM, LedermannJ, ColomboN, SwartA,

Chemotherapy for ovarian cancer

This report provides 10-year follow-up data on the ICON1 trial, which evaluated the benefits of adjuvant chemotherapy for early-stage ovarian cancer. Results demonstrate long-term benefits in overall survival and recurrence-free survival, supporting the use of adjuvant chemotherapy in this setting.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

Intraperitoneal chemotherapy in advanced epithelial ovarian cancer: a survey.

Author: GrossoGiuseppe, RossettiDiego, CoccoliniFederico, BoganiGiorgio, AnsaloniLuca, FrigerioLuigi

Ovarian cancer treatment

Combining heated chemotherapy with surgery to remove visible tumors is considered the standard of care for advanced ovarian cancer. This approach has shown promising results in research studies, but it's not widely used in practice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

58.

Evaluation of follow-up strategies for patients with epithelial ovarian cancer following completion of primary treatment.

Author: ClarkeTilean, GalaalKhadra, BryantAndrew, NaikRaj

Improved quality of life
Improved survival
Reduced anxiety
Cost-ineffectiveness

Ovarian cancer is a significant health concern for women. Traditional long-term follow-up after treatment may not be effective in improving survival, quality of life (QoL), or reducing anxiety, and its cost-effectiveness is questioned.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for advanced recurrent or refractory ovarian cancer: a systematic review and economic evaluation.

Author: EdwardsSteven J, BartonSamantha, ThurgarElizabeth, TrevorNicola

Ovarian cancer treatment

Ovarian cancer is a common and serious cancer in the UK. While initial chemotherapy is effective, the cancer returns in 55-75% of people within two years. The best chemotherapy regimen for treating recurrent, advanced ovarian cancer is still uncertain.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial.

Author: KehoeSean, HookJane, NankivellMatthew, JaysonGordon C, KitchenerHenry, LopesTito, LuesleyDavid, PerrenTimothy, BannooSelina, MascarenhasMonica, DobbsStephen, EssapenSharadah, TwiggJeremy, HerodJonathan, McCluggageGlenn, ParmarMahesh, SwartAnn-Marie

Effective treatment
Safe treatment

The standard treatment for women with suspected advanced ovarian cancer involves surgery followed by platinum-based chemotherapy. This study examines the effectiveness and safety of using platinum-based chemotherapy as the primary treatment, followed by delayed surgery.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

61.

Cost Effectiveness of Chemotherapeutic Agents and Targeted Biologics in Ovarian Cancer: A Systematic Review.

Author: PoonawallaInsiya B, ParikhRohan C, DuXianglin L, VonVilleHelena M, LairsonDavid R

Ovarian cancer treatment

Chemotherapy is a common treatment for advanced ovarian cancer when surgery alone isn't enough. While the cancer often returns, newer targeted medications can sometimes improve survival and quality of life, but they are very expensive. More research is needed to understand the cost-effectiveness of these new treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer.

Author: LawrieTheresa A, Winter-RoachBrett A, HeusPauline, KitchenerHenry C

Ovarian cancer treatment

Epithelial ovarian cancer is diagnosed in over 200,000 women each year. Early diagnosis is key for successful treatment. Surgery is the primary treatment, and chemotherapy (adjuvant chemotherapy) is often given afterward. While research shows that platinum-based chemotherapy improves overall survival, the best treatment for different groups of women with varying prognoses is still being determined.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

Luteinising hormone releasing hormone (LHRH) agonists for the treatment of relapsed epithelial ovarian cancer.

Author: WuntakalRekha, SeshadriSrividya, MontesAna, LaneGeoff

Ovarian cancer treatment

Ovarian cancer is the seventh most common cancer in women, with about 1.3% of women developing it in their lifetime. Most ovarian cancers are of the epithelial type and often spread widely, requiring surgery and chemotherapy. Unfortunately, three out of four women with advanced epithelial ovarian cancer will experience a recurrence of the disease after treatment. While standard treatments like platinum-based drugs are effective, they can have side effects. LHRH agonists, a type of hormone therapy, have shown some promise in treating recurrent ovarian cancer, with fewer side effects than standard chemotherapy. More research is needed to better understand the role of LHRH agonists in treating this disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

Fertility-sparing surgery in epithelial ovarian cancer: a systematic review of oncological issues.

Author: BentivegnaE, GouyS, MaulardA, PautierP, LearyA, ColomboN, MoriceP

This systematic review examined the feasibility and safety of fertility-sparing surgery (FSS) for early-stage epithelial ovarian cancer (EOC). The study explored the potential of FSS as a treatment option for preserving fertility in women with EOC, but highlights the need for careful patient selection and further research to confirm safety in certain subgroups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Is ovarian cancer a targetable disease? A systematic review and meta-analysis and genomic data investigation.

Author: StaropoliNicoletta, CilibertoDomenico, ChiellinoSilvia, CagliotiFrancesca, GiudiceTeresa Del, GualtieriSimona, SalvinoAngela, StrangioAlessandra, BottaCirino, PignataSandro, TassonePierfrancesco, TagliaferriPierosandro

While a combination of carboplatin, paclitaxel, and bevacizumab is the standard treatment for advanced ovarian cancer, there's still uncertainty about the role of targeted therapies. This study reviewed and analyzed research on targeted treatments for ovarian cancer to better understand their place in treatment plans.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Toxicities of different first-line chemotherapy regimens in the treatment of advanced ovarian cancer: A network meta-analysis.

Author: QuChang-Ping, SunGui-Xia, YangShao-Qin, TianJun, SiJin-Ge, WangYi-Feng

AOC treatment
Chemotherapy toxicity

This network meta-analysis compared the toxicities of different chemotherapy regimens for the treatment of advanced ovarian cancer (AOC).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

67.

Screening program in ovarian cancer: A logical step in clinical management? A meta-analysis.

Author: MarchettiClaudia, De FeliceFrancesca, PerniolaGiorgia, LecceFrancesca, VertechyLaura, MontiMarco, MusioDaniela, MuziiLudovico, TomboliniVincenzo, Benedetti PaniciPierluigi

Early detection
Improved survival

This meta-analysis aimed to evaluate the impact of ovarian cancer (OC) screening programs in asymptomatic women on clinical outcomes, highlighting the challenge of treating OC and the need for early diagnosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

HIPEC in patients with primary advanced ovarian cancer: Is there a role? A systematic review of short- and long-term outcomes.

Author: KireevaG S, GaftonG I, GuseynovK D, SenchikK Y, BelyaevaO A, BespalovV G, PanchenkoA V, MaydinM A, BelyaevA M

Improved ovarian cancer outcomes

Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with cytoreductive surgery shows potential for improving long-term outcomes for patients with primary advanced ovarian cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Antigen-specific active immunotherapy for ovarian cancer.

Author: PaijensSterre T, LeffersNinke, DaemenToos, HelfrichWijnand, BoezenH Marike, CohlenBen J, MeliefCornelis Jm, de BruynMarco, NijmanHans W

Immune response
Ovarian cancer treatment

A Cochrane review of antigen-specific active immunotherapy for ovarian cancer found that despite advances in chemotherapy, the prognosis of ovarian cancer remains poor and antigen-specific active immunotherapy may be an alternative treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

70.

Positron emission tomography (PET) and magnetic resonance imaging (MRI) for assessing tumour resectability in advanced epithelial ovarian/fallopian tube/primary peritoneal cancer.

Author: RozeJoline F, HoogendamJacob P, van de WeteringFleur T, SpijkerRené, VerleyeLeen, VlayenJoan, VeldhuisWouter B, ScholtenRob Jpm, ZweemerRonald P

Improved ovarian cancer treatment

Computed tomography (CT) is currently used to assess tumor resectability in ovarian cancer. However, CT is not perfect, so additional imaging modalities may be considered to optimize treatment selection and improve outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Epidermal growth factor receptor blockers for the treatment of ovarian cancer.

Author: MorrisonJo, ThomaClemens, GoodallRichard J, LyonsThomas J, GaitskellKezia, WiggansAlison J, BryantAndrew

EOC treatment
Novel agents

Epithelial ovarian cancer (EOC) is a common cause of death from cancer in women worldwide. While surgery and chemotherapy are used to treat the disease, many women experience a return of the cancer within two years. New medications that target specific proteins, like those that block epidermal growth factor receptor (EGFR), are being developed to improve treatment outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

[Follow-up of patients treated for an epithelial ovarian cancer, place of hormone replacement therapy and of contraception: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa].

Author: SénéchalC, AkladiosC, BendifallahS, OuldamerL, LecuruF, Rousset-JablonskiC

Early detection
Hormone replacement therapy
No systematic CT follow-up

After treatment for epithelial ovarian, tubal, or primitive peritoneal cancer, symptom evaluation is recommended at 3 months, 6 months, 12 months, 18 months, 24 months, and then yearly.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : French

73.

Primary debulking surgery vs. interval debulking surgery for advanced ovarian cancer: review of the literature and meta-analysis.

Author: ChiofaloBenito, BruniSimone, CertelliCamilla, SperdutiIsabella, BaioccoErmelinda, VizzaEnrico

Improved EOC treatment
Reduced EOC mortality

This systematic review and meta-analysis evaluated the effectiveness of neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS) compared to primary debulking surgery (PDS) followed by chemotherapy in advanced epithelial ovarian cancer (EOC). While the study did not reveal a clear advantage of NACT or IDS over PDS, it underscored the need for further research to determine the optimal approach for individual patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

74.

Gemcitabine for recurrent ovarian cancer - a systematic review and meta-analysis.

Author: BergTobias, NøttrupTrine J, RoedHenrik

Treatment for recurrent ovarian cancer

This study discusses the treatment options for recurrent ovarian cancer, focusing on the use of gemcitabine as a single-agent or combination therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer.

Author: ColeridgeSarah L, BryantAndrew, LyonsThomas J, GoodallRichard J, KehoeSean, MorrisonJo

Ovarian cancer treatment

Most women with epithelial ovarian cancer are diagnosed at a later stage, requiring surgery and chemotherapy. The standard treatment has been surgery followed by chemotherapy, but there may be benefits to giving chemotherapy before surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

76.

Hormone replacement therapy after surgery for epithelial ovarian cancer.

Author: SaeaibNungrutai, PeeyananjarassriKrantarat, LiabsuetrakulTippawan, BuhachatRakchai, MyriokefalitakiEva

Improved EOC treatment

This study examines the use of hormone replacement therapy (HRT) to manage menopausal symptoms in women with epithelial ovarian cancer (EOC) after surgical treatment and chemotherapy, considering the safety concerns associated with HRT in this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

The current status of secondary cytoreduction in ovarian cancer: a systematic review.

Author: MargulDaniel, ColemanRobert L, HerzogThomas J

Ovarian cancer treatment

Ovarian cancer is a deadly disease, with low survival rates especially when it's widespread at diagnosis. While treatment options have improved, recurrent disease remains difficult to manage. Surgery to remove remaining cancer (secondary cytoreduction) is common, but its effectiveness is uncertain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

78.

Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer.

Author: ColeridgeSarah L, BryantAndrew, KehoeSean, MorrisonJo

Epithelial ovarian cancer treatment

Most women with ovarian cancer are diagnosed at an advanced stage, requiring surgery and chemotherapy. The usual approach is surgery first, followed by chemotherapy. However, there may be benefits to giving chemotherapy before surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

79.

Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced ovarian epithelial cancer.

Author: ColeridgeSarah L, BryantAndrew, KehoeSean, MorrisonJo

Improved treatment outcomes

Most women with ovarian cancer are diagnosed at a late stage, needing both surgery and chemotherapy. The usual approach is surgery first, then chemotherapy, but giving chemotherapy before surgery might have benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Randomized Trial of Cytoreductive Surgery for Relapsed Ovarian Cancer.

Author: HarterPhilipp, SehouliJalid, VergoteIgnace, FerronGwenael, ReussAlexander, MeierWerner, GreggiStefano, MosgaardBerit J, SelleFrederic, GuyonFrédéric, PomelChristophe, LécuruFabrice, ZangRongyu, Avall-LundqvistElisabeth, KimJae-Weon, PonceJordi, RaspagliesiFrancesco, KristensenGunnar, ClasseJean-Marc, HillemannsPeter, JensenPernille, HasenburgAnnette, Ghaem-MaghamiSadaf, MirzaMansoor R, LundBente, ReinthallerAlexander, SantaballaAna, OlaitanAdeola, HilpertFelix, du BoisAndreas,

Ovarian cancer survival

Cytoreductive surgery followed by chemotherapy resulted in longer overall survival than chemotherapy alone in women with recurrent ovarian cancer who had a platinum-free interval of 6 months or more. The benefit of surgery was observed across all prognostic subgroups and did not compromise quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

82.

Molecular methods for increasing the effectiveness of ovarian cancer treatment: a systematic review.

Author: ChilimoniukZuzanna, RockaAgata, StefaniakMartyna, TomczykŻaklina, JasielskaFaustyna, MadrasDominika, FilipAgata

Effective therapy
Ovarian cancer treatment

This review examined recent research on ovarian cancer treatments. It analyzed over 200 clinical trials and found that there is ongoing research on various approaches to treat ovarian cancer, aiming to find the most effective and personalized treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer.

Author: TattersallAbigail, RyanNeil, WiggansAlison J, RogozińskaEwelina, MorrisonJo

Improved ovarian cancer treatment

PARP inhibitors (PARPi) are a promising new treatment for ovarian cancer, especially for those with BRCA mutations, offering a different mechanism of action compared to chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Weekly versus tri-weekly paclitaxel with carboplatin for first-line treatment in women with epithelial ovarian cancer.

Author: NgoiNatalie Yl, SynNicholas Lx, GohRobby M, GohBoon Cher, HuangRuby Yun-Ju, SoonYu Yang, JamesElizabeth, CookAdrian, ClampAndrew, TanDavid Sp

Treatment for epithelial ovarian cancer
Conflicting evidence on optimal paclitaxel dosing

This study explores the optimal dosing schedule of paclitaxel when combined with carboplatin as first-line treatment for epithelial ovarian cancer. Intravenous carboplatin and paclitaxel are widely accepted as standard treatment, but there is conflicting evidence regarding the best paclitaxel dosing schedule.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Taxane monotherapy regimens for the treatment of recurrent epithelial ovarian cancer.

Author: PatelAashna, KalachandRoshni, BusschotsSteven, DohertyBen, KaprosEvangelos, LawlorDenise, HallNeville, StordalBritta K

Ovarian cancer treatment

Ovarian cancer is a major health concern, affecting many women worldwide. The most common type is epithelial ovarian cancer. While the standard treatment is surgery followed by chemotherapy, over half of women experience a relapse, needing more chemotherapy. We need clearer guidance on using chemotherapy drugs, including taxanes, for women with recurrent ovarian cancer. Taxanes can be given in different ways, which might have different side effects and effectiveness. Since these cancers are often incurable, it's important to consider the side effects, quality of life, and overall impact of treatment, not just how long it prolongs life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

86.

Ultra-radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer.

Author: HiuShaun, BryantAndrew, GajjarKetankumar, KunongaPatience T, NaikRaj

Improved OS
Ovarian cancer

This review examined the effectiveness and morbidity associated with ultra-radical/extensive surgery in the management of advanced-stage epithelial ovarian cancer. The study found very low-certainty evidence suggesting that ultra-radical surgery may be associated with improved overall survival (OS) compared to standard surgery. However, the evidence was limited to retrospective, non-randomized studies. Further research is needed to confirm these findings.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

87.

Residual Disease After Primary Surgical Treatment for Advanced Epithelial Ovarian Cancer, Part 2: Network Meta-analysis Incorporating Expert Elicitation to Adjust for Publication Bias.

Author: BryantAndrew, GraylingMichael, ElattarAhmed, GajjarKetankumar, CraigDawn, ValeLuke, NaikRaj

Macroscopic cytoreduction for advanced epithelial ovarian cancer

This study examines the association between macroscopic cytoreduction and improved overall survival (OS) in patients with advanced epithelial ovarian cancer. Macroscopic cytoreduction is a surgical technique aimed at removing as much visible tumor as possible.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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