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Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms.

Author: AdlardStephen, BlairAlison, BravinJenny, CosgraveElizabeth M, FranceyShona, GermanoDominic, JacksonHenry, McDonaldTony, McGorryPatrick D, PhillipsLisa J, YuenHok Pan, YungAlison R

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Specific preventive intervention, comprising low-dose risperidone therapy and cognitive behavior therapy, effectively reduces the risk of early transition to psychosis in young people at ultra-high risk compared to needs-based intervention alone. While the relative contributions of pharmacotherapy and psychotherapy could not be determined, the intervention resulted in at least a delay in the onset of psychosis, and potentially a reduction in its incidence.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Most disability produced by psychotic illnesses, especially schizophrenia, develops during the prepsychotic period, creating a case for intervention during this period. However, only recently has it been possible to engage people in treatment during this phase. METHODS: A randomized con...See full text at original site
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引用元：
https://doi.org/10.1001/archpsyc.59.10.921

データ提供：米国国立医学図書館（NLM）

First-Episode Psychosis: A Sandstorm of Risk

This research explores interventions designed to prevent the progression to first-episode psychosis in individuals at high risk. The study, utilizing a [randomized controlled trial] design, compared two intervention strategies: needs-based intervention and specific preventive intervention comprising low-dose risperidone therapy and cognitive behavior therapy. The authors found that the specific preventive intervention showed a significant reduction in the risk of progression to first-episode psychosis during the 6-month treatment period. This finding underscores the potential of early intervention in mitigating the risk of psychosis.

Early Intervention: A Path to Prevention

This study demonstrates the effectiveness of early intervention in preventing the progression to first-episode psychosis. The results suggest that a combination of medication and therapy could significantly reduce the risk of developing psychosis in individuals at high risk. These findings offer valuable insights into the potential of early intervention in improving outcomes for individuals at risk of psychosis.

Preventing Psychosis: A Desert of Uncertainty

This research highlights the importance of early intervention in preventing psychosis. The study's findings suggest that a combination of medication and therapy can effectively reduce the risk of developing psychosis. It's crucial to recognize the signs and symptoms of psychosis and seek professional help for early intervention. Just as a camel navigates a desert landscape, early detection and intervention can help individuals avoid the potentially devastating effects of psychosis.

Dr. Camel's Conclusion

This study underscores the crucial role of early intervention in preventing psychosis. Identifying individuals at risk and providing appropriate treatment can significantly reduce the likelihood of developing psychosis. Just as a camel navigates a treacherous desert landscape, early intervention can help individuals find a safe path through the challenging terrain of mental health.

Date :
  1. Date Completed 2002-10-28
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

12365879

DOI: Digital Object Identifier

10.1001/archpsyc.59.10.921

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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