Effective treatment of schizophrenia: A Synthesis of Findings from 168 Studies

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Original Abstract of the Article

Major Research Findings

Schizophrenia is a serious mental illness that can be chronic and disabling. 141 Antipsychotic medication is the standard treatment for people with schizophrenia. 29 , 31 , 28 , 56 , 22 , 14 , 138 However, a substantial number of patients demonstrate only suboptimal clinical outcome despite adequate treatment with antipsychotics. 110 This is often referred to as treatment-resistant schizophrenia, and clozapine is the only antipsychotic with convincing efficacy for such cases. 120 However, even clozapine does not work for everyone, and 30-40% of patients have an insufficient response to the drug. 120 , 133 Other treatments include cognitive behavioral therapy (CBT), which has been shown to be effective in combination with antipsychotic medication, 120 , 142 , electroconvulsive therapy (ECT), 155 and repetitive transcranial magnetic stimulation (rTMS). 71 , 76

While antipsychotic medications are the mainstay of treatment for schizophrenia, many individuals experience a range of distressing and debilitating symptoms, including positive symptoms, cognitive symptoms, and negative symptoms. 132 Antipsychotic drugs are often only partially effective, particularly in treating negative symptoms, indicating the need for additional treatment. 132

treatmentまとめ

Antipsychotic medication is the standard treatment for people with schizophrenia. 29 , 31 , 28 , 56 , 22 , 14 , 138 For treatment-resistant schizophrenia, clozapine is the only antipsychotic with convincing efficacy. 120 Other treatments that have been studied include cognitive behavioral therapy (CBT), 120 , 142 electroconvulsive therapy (ECT), 155 , repetitive transcranial magnetic stimulation (rTMS). 71 , 76 , and various augmentation strategies. 72 Some evidence suggests that mirtazapine as an antidepressant drug may offer some benefit for negative symptoms when taken in addition to an antipsychotic. 132

Benefits and Risks

Benefit Summary

Schizophrenia treatment can result in improved symptoms, quality of life, and social reintegration. 26 , 62

Risk Summary

Schizophrenia treatment has the risk of side effects. These may include nausea, vomiting, drowsiness, and weight gain. 141 , 155 , 31 , 28 , 22

Research Comparison

Research Similarities

Many studies demonstrate the effectiveness of antipsychotic medication in treating schizophrenia. 29 , 31 , 28 , 56 , 22 , 14 , 138

Research Differences

Various treatments, besides antipsychotic medications, are being researched for schizophrenia, including cognitive behavioral therapy, electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), clozapine, sulpiride, mirtazapine, haloperidol, olanzapine, risperidone, chlorpromazine, sodium nitroprusside, and carbamazepine. 71 , 155 , 120 , 141 , 133 , 72 , 136 , 110 , 93 , 59 , 135 , 70 , 76 , 165 , 132 , 130 , 74 , 142 , 73 , 19 , 87 , 27 , 143 , 151 , 128 , 89 , 33 , 2

Consistency and Contradictions of Results

Research on schizophrenia treatments has produced reports of various treatment methods' effectiveness, but a clear conclusion on which treatment is most effective has not been reached. Each treatment should be evaluated considering the balance between effectiveness and side effects. 107

Considerations for Real-World Application

Schizophrenia treatment should be tailored to each patient's individual circumstances. It is crucial to discuss treatment options with your doctor or psychiatrist to select the best option for you. 26 , 138

Current Research Limitations

Research on schizophrenia treatment faces many challenges. For example, long-term evaluations of treatment efficacy and research assessing patients' quality of life are insufficient. 107 , 163

Future Research Directions

Further research is needed to develop more effective treatments for schizophrenia. In particular, research developing treatments that improve patients' quality of life and long-term evaluations of treatment efficacy are crucial. 107 , 163

Conclusion

Schizophrenia is a treatable illness, and with the right treatment, it is possible for individuals to experience symptom improvement and reintegrate into society. However, treatment can take time and require the patient's active engagement. 165 , 128

It is important to discuss schizophrenia treatment options with your doctor or psychiatrist to find the best fit for your individual symptoms and situation. If you or someone you know is struggling with schizophrenia, please seek help from a medical professional. 165 , 128

Treatment List

Antipsychotic medication, Cognitive Behavioral Therapy (CBT), Electroconvulsive Therapy (ECT), Repetitive Transcranial Magnetic Stimulation (rTMS), Clozapine, Sulpiride, Mirtazapine, Haloperidol, Olanzapine, Risperidone, Chlorpromazine, Sodium Nitroprusside, Carbamazepine

Keywords
Benefit Keywords
Schizophrenia improvement
1
Schizophrenia treatment
2
Shorter hospital stay
3
Improved treatment of resistant schizophrenia
4
Schizophrenia treatment
5
Schizophrenia relapse prevention
8
Improved negative symptoms
Treatment-responsive symptoms
9
Improved schizophrenia treatment
10
Improved compliance
11
Improved symptoms
12
Durable treatment effects
Improved schizophrenia symptoms
13
First-episode psychosis treatment
14
Schizophrenia treatment
15
Improved efficacy
Reduced motor effects
17
Improved symptoms
Reduced relapse
18
Improved schizophrenia treatment
20
Improved schizophrenia treatment
21
Improved schizophrenia treatment
22
Reduced side effects
Schizophrenia treatment
23
Effective recurrence prevention
24
Improved patient acceptance
Lower prolactin levels
Reduced movement disorders
25
Improved compliance with treatment
Reduced relapse rates
26
Effective treatment
27
Antipsychotic efficacy
29
Low relapse rate
30
Improved schizophrenia treatment
33
Improved cognitive function
34
Effective for negative symptoms
Reduced movement disorders
35
Schizophrenia treatment
36
Superior augmentation
37
Psychosis prevention
38
Improves functioning
Improves symptoms
Reduces relapse
39
Schizophrenia treatment
40
Improved treatment response
41
Negative symptoms treatment
42
Improved treatment of TRS
43
Reduced schizophrenia symptoms
44
Quicker onset of action
45
Negative symptoms treatment
46
Schizophrenia treatment
48
Reduced schizophrenia symptoms
49
Better treatment approaches
Improved quality of life
50
Improved negative symptoms
Sustained clinical improvement
51
Improved negative symptoms
53
Reduced PANSS scores
54
Improved schizophrenia treatment
55
Reduced trial discontinuation
Relapse reduction
Symptom improvement
56
Schizophrenia treatment
57
Reduced medication use
58
Global improvement
59
Clinical response
60
Cognitive improvement
Schizophrenia treatment
61
Social outcomes assessment
62
Schizophrenia treatment
63
Improved schizophrenia treatment
64
Quicker onset of action
Reduced aggression
Reduced tardive dyskinesia
66
Improved psychopathology
Increased involvement in treatment
67
Improved schizophrenia treatment
68
Schizophrenia treatment
69
Schizophrenia treatment
70
Potential treatment for schizophrenia
71
Improved clinical response
72
Improved insight
Improved quality of life
Improved social functioning
Increased employment/education
Reduced relapse risk
Reduced treatment discontinuation
73
Negative symptom treatment
74
Schizophrenia prevention
75
Enhanced treatment efficacy
Improved brain function
Reduced symptoms
76
Reduced schizophrenia relapse
77
Improved schizophrenia treatment
78
Improved schizophrenia treatment
79
Improved psychosis treatment
80
Schizophrenia treatment
81
Improved schizophrenia management
82
Schizophrenia treatment
83
Improved schizophrenia treatment
84
Improved schizophrenia treatment
85
Improved outcomes for schizophrenia
86
Decrease anxiety
Improve hopelessness
Reduce psychosis symptoms
87
Improved schizophrenia symptoms
88
Improved negative symptoms
89
Mental illness management
90
Schizophrenia treatment
91
Improved NSS
92
Improved symptoms
93
Symptom decreases
95
Schizophrenia treatment
96
Schizophrenia treatment
97
Schizophrenia treatment
98
schizophrenia treatment
99
Schizophrenia treatment
100
Schizophrenia treatment
101
Schizophrenia treatment
102
Improve global improvement
103
Improved cognition
Safe and effective treatment
104
Schizophrenia treatment
105
Reduced negative symptoms
106
Improved understanding of schizophrenia
107
Cognitive symptoms
Depressive symptoms
Extrapyramidal symptoms
Negative symptoms
Schizophrenia treatment
110
Reduced hallucinations
111
Schizophrenia treatment
112
Schizophrenia treatment
113
Improved response
114
IT for schizophrenia
115
Early diagnosis
Effective treatment
116
Motivational interviewing for schizophrenia
117
Schizophrenia treatment
118
Improved prognosis
119
Schizophrenia treatment
120
Effective for aggression/agitation
Effective for clinical response
121
Schizophrenia treatment
122
Improved mental state
124
Schizophrenia treatment
125
Multidimensional view
126
Psychosocial functioning
127
Improved schizophrenia treatment
128
Amisulpride for negative symptoms
Cariprazine for negative symptoms
129
Negative symptom improvement
130
Improved functioning
131
Improved schizophrenia treatment
132
Improved schizophrenia treatment
133
Schizophrenia remission
Simple treatment algorithm
134
Improved schizophrenia treatment
135
Clozapine
TRS treatment
136
Reduce distress
137
Improved schizophrenia treatment
138
Improved psychotic disorder treatment
139
Improved CRS treatment
140
Improved schizophrenia treatment
141
CBT for psychosis
142
Prodopaminergic agents for negative symptoms
143
Schizophrenia treatment
144
Improved schizophrenia treatment
145
Reduced schizophrenia relapses
146
Positive symptoms improvement
147
Antipsychotic efficacy
148
Schizophrenia treatment
149
Rehabilitative approaches for schizophrenia
150
ECT efficacy
151
Schizophrenia treatment
152
tACS for SZ
153
Reduced psychosis
154
Better perfusion
Improved function
Reduced symptoms
155
Schizophrenia treatment
156
Improved schizophrenia treatment
157
Antipsychotics for catatonic schizophrenia
158
CBTp for schizophrenia
159
Schizophrenia treatment
160
Social function improvement
161
Reduced overall mortality
Reduced psychiatric hospitalization
162
SSD treatment
163
Clozapine efficacy
164
Negative symptom reduction
165
Improved clinical insight
166
Improved psychosis
167
Reduced aggression
168
Risk Keywords
Chlorpromazine use
1
Schizophrenia treatment measurement
6
Blood disorders
17
Acute movement disorders
Dizziness
Low blood pressure
Parkinsonism
Sedation
Seizures
Weight gain
18
Side effects
24
Toxicity
27
Insufficient evidence
28
Insufficient evidence
29
Low social functioning
30
Mixed results of psychotherapy
32
Side effects of medication
33
No effect as sole treatment
Not recommended for routine use
37
Dizziness
Fits
Low blood pressure
Movement disorders
Parkinsonism
Sedation
Weight gain
39
Lower acceptability
41
Extrapyramidal symptoms
42
Sedation
45
Insufficient evidence
47
Extrapyramidal symptoms
Sexual dysfunction
Weight gain
49
Schizophrenia
50
Lipid anomalies
More adverse events
Seizures
51
Nausea
54
Schizophrenia
55
Acute movement disorders
Dizziness
Lowered blood pressure
Parkinsonism
Sedation
Weight gain
56
Insufficient evidence
59
Inconclusive evidence
Low acceptability
60
Schizophrenia
64
Sedation
66
Schizophrenia
68
Disability
Relapse
69
Increased prolactin
Movement disorders
72
Hyperprolactinemia
Metabolic side effects
91
Psychotic symptoms
92
Gray matter volume decrease
Lateral ventricular volume increase
94
Nonresponse prediction
95
Negative symptoms
97
low blood pressure
movement disorders
parkinsonism
sedation
weight gain
99
Movement disorders
Parkinsonism
Relapse
103
Mild confusion
104
Psychotic disorders
Schizophrenia
108
Negative symptoms
Schizophrenia
109
Headaches
111
Side effects
114
Relapse rates
115
Debilitating disorder
Reduced life expectancy
Worse functional outcomes
116
Limited evidence
Sedation and dizziness
121
No efficacy
122
Weight gain risk
123
Dyskinesia
124
Public education needed
126
Amisulpride depression risk
Cariprazine manufacturer sponsored
129
Epileptic seizure
Psychotic symptoms
Suicide attempts
134
Antipsychotic side effects
148
Side effects
155
High costs of care
157
Agranulocytosis
Neutropenia
164
Withdrawal symptoms
167
Literature analysis of 168 papers
Positive Content
146
Neutral Content
11
Negative Content
11
Article Type
51
57
97
88
167
1.

Are there schizophrenics for whom drugs may be unnecessary or contraindicated?

Author: RappaportM, HopkinsH K, HallK, BellezaT, SilvermanJ

Schizophrenia improvement
Chlorpromazine use

A study of young men experiencing an acute schizophrenic episode found that those who received placebo while hospitalized showed better long-term outcomes, including improved functioning, fewer rehospitalizations, and better overall community integration compared to those receiving chlorpromazine. Factors associated with better outcomes in the unmedicated group included a good premorbid history and short-lived paranoid symptoms. The study suggests that antipsychotic medications may not be necessary for all schizophrenic patients and that further research is needed to understand how to use these medications more selectively.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

2.

Therapist characteristics and the outcome of treatment in schizophrenia.

Author: TumaA H, MayP R, YaleC, ForsytheA B

Schizophrenia treatment

A study of the treatment of schizophrenia found that therapists play a significant role in treatment outcomes, both with medication and psychotherapy. However, specific therapist characteristics and behaviors that contribute to successful outcomes remain unclear. The study highlights the need to identify cognitive and emotional personality traits in therapists that encourage patient cooperation, as well as the importance of training in specific treatment methods.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

3.

Schizophrenia--a follow-up study of results of treatment.

Author: MayP R, TumaA H, YaleC, PotepanP, DixonW J

Shorter hospital stay

A study of patients with schizophrenia found that those treated initially with drugs or ECT spent less time in hospital after their release than those treated with psychotherapy alone or milieu therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

[A critical study of conditions for prescription and evaluation criteria of neuroleptic treatment in resistant schizophrenia].

Author: PetitM, DollfusS

Improved treatment of resistant schizophrenia

A critical analysis of studies on clozapine for treatment-resistant schizophrenia highlighted the need for stringent criteria, including a longer duration of past neuroleptic treatment (more than 6 months), a longer placebo wash-out period (more than 6 weeks), and improvement with a second treatment after a first failed one. The study also pointed out that doses of neuroleptics used in comparison with clozapine are often too high, leading to side effects and reducing the benefits of clozapine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

5.

When symptoms persist: choosing among alternative somatic treatments for schizophrenia.

Author: ChristisonG W, KirchD G, WyattR J

Schizophrenia treatment

Patients with schizophrenia who are resistant to traditional neuroleptics may benefit from alternative treatments. This paper reviews eight potential treatments and suggests a framework for choosing among them.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Measurement of therapeutic response in schizophrenia. A critical survey.

Author: CollinsE J, HoganT P, DesaiH

Schizophrenia treatment measurement

Schizophrenia research often focuses on symptom reduction, but broader assessments, including patient functioning and subjective experiences, are needed to fully understand treatment effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Continuous versus targeted medication in schizophrenic outpatients: outcome results.

Author: CarpenterW T, HanlonT E, HeinrichsD W, SummerfeltA T, KirkpatrickB, LevineJ, BuchananR W

A study of 116 patients with chronic schizophrenia found that continuous medication was better than a targeted medication approach in preventing decompensation, hospitalizations, and improving employment over 2 years. The targeted approach reduced overall medication usage.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

8.

Family psychoeducation, social skills training, and maintenance chemotherapy in the aftercare treatment of schizophrenia. I. One-year effects of a controlled study on relapse and expressed emotion.

Author: HogartyG E, AndersonC M, ReissD J, KornblithS J, GreenwaldD P, JavnaC D, MadoniaM J

Schizophrenia relapse prevention

This study investigated the effectiveness of two treatments for schizophrenia patients living in high-stress (high EE) families: family therapy and social skills training. Patients were randomly assigned to receive one of these treatments, both treatments combined, or medication alone. The study found that both family therapy and social skills training significantly reduced relapse rates in the first year compared to medication alone. Combining both treatments resulted in no relapses at all. The study also found that a reduction in family stress was associated with a lower risk of relapse. However, the combined treatment only seemed to delay relapses in families that remained high in stress. This suggests that while these treatments can be effective, ongoing support is crucial for maintaining recovery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

Negative symptoms: a path analytic approach to a double-blind, placebo- and haloperidol-controlled clinical trial with olanzapine.

Author: TollefsonG D, SangerT M

Improved negative symptoms
Treatment-responsive symptoms

Olanzapine was more effective than placebo or haloperidol in treating negative symptoms of schizophrenia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Three-year trials of personal therapy among schizophrenic patients living with or independent of family, I: Description of study and effects on relapse rates.

Author: HogartyG E, KornblithS J, GreenwaldD, DiBarryA L, CooleyS, UlrichR F, CarterM, FlesherS

Improved schizophrenia treatment

This study aims to develop and test a new, effective individual therapy for schizophrenia. Previous research on individual therapies for schizophrenia has yielded mixed results, partly due to methodological issues. The effectiveness of psychosocial treatments in preventing relapse also tends to decrease over time.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

Generic substitution--comparing the clinical efficacy of a generic substitute for fluphenazine decanoate with the original product.

Author: VersterG C, JoubertG, StevensM, van der MerweH

Improved compliance

This study found that generic fluphenazine decanoate was as effective as the original product in treating chronic schizophrenia. The study suggests that generic substitution could be a cost-saving measure for treating schizophrenia in South Africa.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Positive and negative symptom response to clozapine in schizophrenic patients with and without the deficit syndrome.

Author: BuchananR W, BreierA, KirkpatrickB, BallP, CarpenterW T

Improved symptoms

This study investigated the effectiveness of clozapine for treating both positive and negative symptoms of schizophrenia, including those with and without the deficit syndrome. The researchers also looked at the long-term effects of clozapine on various aspects of the illness, including social and occupational functioning, and quality of life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Olanzapine versus haloperidol treatment in first-episode psychosis.

Author: SangerT M, LiebermanJ A, TohenM, GrundyS, BeasleyC, TollefsonG D

First-episode psychosis treatment

This study examined the efficacy and safety of olanzapine and haloperidol treatment in patients with first-episode psychosis, emphasizing the importance of early intervention for preventing morbidity and mortality associated with schizophrenia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

A randomised controlled trial of home-based rehabilitation versus outpatient-based rehabilitation for patients suffering from chronic schizophrenia.

Author: SellwoodW, ThomasC S, TarrierN, JonesS, ClewesJ, JamesA, WelfordM, PalmerJ, McCarthyE

Schizophrenia treatment

This study aimed to address the limitations of outpatient-based treatment for chronic schizophrenia, exploring the potential benefits of a community-based team approach.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Antipsychotic medication for those with both schizophrenia and learning disability.

Author: DugganL, BrylewskiJ

There is no randomized controlled trial evidence to guide the use of antipsychotic medication for people with both learning disability and schizophrenia. More research is urgently needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Clozapine versus typical neuroleptic medication for schizophrenia.

Author: WahlbeckK, CheineM, EssaliM A

Improved efficacy
Reduced motor effects
Blood disorders

While traditional antipsychotics are used to treat schizophrenia, 25-33% of patients don't respond well to these medications. Clozapine, an atypical antipsychotic, may be more effective and cause fewer movement problems in these treatment-resistant patients. However, it carries a serious risk of blood disorders, requiring weekly blood monitoring, especially during the initial months of treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Chlorpromazine versus placebo for schizophrenia.

Author: ThornleyB, AdamsC E, AwadG

Improved symptoms
Reduced relapse
Acute movement disorders
Dizziness
Low blood pressure
Parkinsonism
Sedation
Seizures
Weight gain

Chlorpromazine is a well-established treatment for schizophrenia, but it is associated with many adverse effects, including sedation, movement disorders, and weight gain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Carbamazepine for schizophrenia and schizoaffective psychoses.

Author: LeuchtS, McGrathJ, WhiteP, KisslingW

Carbamazepine is not recommended for routine clinical use for treatment or augmentation of antipsychotic treatment of schizophrenia. However, a trial may be warranted for those with a past history of response to carbamazepine or EEG abnormalities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Individual psychodynamic psychotherapy and psychoanalysis for schizophrenia and severe mental illness.

Author: MalmbergL, FentonM

Improved schizophrenia treatment

People with schizophrenia often require ongoing support from healthcare professionals. While medication is the primary treatment, research on the effectiveness of psychotherapy for schizophrenia has produced mixed results. This study explores the potential benefits of treatments focusing on social and psychological factors that affect schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Depot haloperidol decanoate for schizophrenia.

Author: QuraishiS, DavidA

Improved schizophrenia treatment

Antipsychotic medications are the primary treatment for schizophrenia. While oral medications are common, adherence can be a challenge. Depot injections, introduced in the 1960s, have become a widely used method for long-term management. Haloperidol decanoate is one such depot medication available for clinical use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Risperidone versus typical antipsychotic medication for schizophrenia.

Author: KennedyE, SongF, HunterR, ClarkeA, GilbodyS

Improved schizophrenia treatment

"Conventional" antipsychotics like haloperidol and chlorpromazine are commonly used for schizophrenia, but 5-25% of patients respond poorly. Side effects also lead to compliance issues. While these drugs are effective for "positive" symptoms, there is little evidence they improve "negative" symptoms. Risperidone, a "new generation" antipsychotic, is believed to cause fewer movement disorders and potentially improve negative symptoms.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Ziprasidone for schizophrenia and severe mental illness.

Author: BagnallA, LewisR A, LeitnerM L, KleijnenJ

Reduced side effects
Schizophrenia treatment

This study discusses the use of atypical antipsychotic drugs in treating schizophrenia, highlighting the benefits of atypical drugs, such as ziprasidone, in terms of reduced side effects and potential for greater patient acceptance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Zotepine in the prevention of recurrence: a randomised, double-blind, placebo-controlled study for chronic schizophrenia.

Author: CooperS J, ButlerA, TweedJ, WelchC, RaniwallaJ

Effective recurrence prevention
Side effects

Zotepine is effective in preventing recurrence in patients with chronic schizophrenia. The 26-week risk of recurrence was six times lower in the zotepine group than in the placebo group. There was no significant difference between the groups with respect to extrapyramidal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Ziprasidone for schizophrenia and severe mental illness.

Author: BagnallA, LewisR A, LeitnerM L

Improved patient acceptance
Lower prolactin levels
Reduced movement disorders

This study discusses the use of atypical antipsychotic drugs in treating schizophrenia, highlighting the benefits of atypical drugs, such as ziprasidone, in terms of reduced side effects and potential for greater patient acceptance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Psychoeducation for schizophrenia.

Author: PekkalaE, MerinderL

Improved compliance with treatment
Reduced relapse rates

Psychoeducational interventions significantly decreased relapse or readmission rates in patients with schizophrenia compared to standard care. While compliance with medication was improved in one study, other studies provided equivocal or skewed data.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Refractory schizophrenia and atypical antipsychotics.

Author: TaylorD M, Duncan-McConnellD

Effective treatment
Toxicity

Clozapine remains the standard treatment for refractory schizophrenia, showing consistent effectiveness compared to other atypical antipsychotics like olanzapine and risperidone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

28.

Antipsychotic medication for those with both schizophrenia and learning disability.

Author: DugganL, BrylewskiJ

Insufficient evidence

There is no randomized controlled trial evidence to guide the use of antipsychotic medication for people with both learning disability and schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Antipsychotic medication for those with both schizophrenia and learning disability.

Author: DugganL, BrylewskiJ

Antipsychotic efficacy
Insufficient evidence

There was insufficient evidence from randomized controlled trials to guide the use of antipsychotic medication for those with both learning disability and schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Early intervention and a five year follow up in young adults with a short duration of untreated psychosis: ethical implications.

Author: LinszenD, DingemansP, LeniorM

Low relapse rate
Low social functioning

An early intervention program for patients with a first episode of schizophrenia was initially promising in reducing relapse rates in the short term. However, this benefit was not sustained long-term, highlighting the need for continued, comprehensive care beyond the initial intervention.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Antipsychotic medication for those with both schizophrenia and learning disability.

Author: DugganL, BrylewskiJ

No randomized controlled trials were found to guide the use of antipsychotic medications for people with both learning disability and schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Individual psychodynamic psychotherapy and psychoanalysis for schizophrenia and severe mental illness.

Author: MalmbergL, FentonM

Mixed results of psychotherapy

People with schizophrenia often need ongoing support from healthcare professionals. While medication is the main treatment, research on the effectiveness of psychotherapy for schizophrenia has been mixed. This study explores the potential benefits of treatments focusing on social and psychological factors that affect schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Cognitive behaviour therapy for schizophrenia.

Author: CormacI, JonesC, CampbellC

Improved schizophrenia treatment
Side effects of medication

Medication is the primary treatment for schizophrenia. However, many people with schizophrenia still experience symptoms and side effects. In addition to medication, talking therapies such as cognitive behavioral therapy can help people with schizophrenia understand how their thoughts and feelings contribute to their distress.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder.

Author: BilderRobert M, GoldmanRobert S, VolavkaJan, CzoborPal, HoptmanMatthew, SheitmanBrian, LindenmayerJean-Pierre, CitromeLeslie, McEvoyJoseph, KunzMichal, ChakosMiranda, CooperThomas B, HorowitzTerri L, LiebermanJeffrey A

Improved cognitive function

Patients with a history of suboptimal response to conventional treatments may show cognitive benefits from newer antipsychotic drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

35.

Amisulpride for schizophrenia.

Author: MotaN E, LimaM S, SoaresB G

Effective for negative symptoms
Reduced movement disorders

Atypical antipsychotic amisulpride is said to be more effective for treating negative symptoms of schizophrenia and causes less movement disorders compared to typical antipsychotics like haloperidol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Psychoeducation for schizophrenia.

Author: PekkalaE, MerinderL

Schizophrenia treatment

Schizophrenia is a serious, long-term condition often marked by a lack of awareness of the illness and difficulty following treatment. Psychoeducational programs aim to improve patients' understanding of their illness and treatment, hoping that increased knowledge will help them manage their condition better, ultimately improving their long-term outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Carbamazepine for schizophrenia and schizoaffective psychoses.

Author: LeuchtS, McGrathJ, WhiteP, KisslingW

Superior augmentation
No effect as sole treatment
Not recommended for routine use

Carbamazepine is not recommended for routine clinical use for sole treatment or augmentation of antipsychotic treatment of schizophrenia. Larger, simple, well-designed, and reported trials focusing on those with violent episodes, people with schizoaffective disorders, or those with both schizophrenia and EEG abnormalities are justified.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms.

Author: McGorryPatrick D, YungAlison R, PhillipsLisa J, YuenHok Pan, FranceyShona, CosgraveElizabeth M, GermanoDominic, BravinJenny, McDonaldTony, BlairAlison, AdlardStephen, JacksonHenry

Psychosis prevention

Specific preventive intervention, comprising low-dose risperidone therapy and cognitive behavior therapy, effectively reduces the risk of early transition to psychosis in young people at ultra-high risk compared to needs-based intervention alone. While the relative contributions of pharmacotherapy and psychotherapy could not be determined, the intervention resulted in at least a delay in the onset of psychosis, and potentially a reduction in its incidence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Chlorpromazine versus placebo for schizophrenia.

Author: ThornleyB, RathboneJ, AdamsC E, AwadG

Improves functioning
Improves symptoms
Reduces relapse
Dizziness
Fits
Low blood pressure
Movement disorders
Parkinsonism
Sedation
Weight gain

Chlorpromazine, a benchmark treatment for psychosis, effectively reduces relapse and improves symptoms and functioning in patients with schizophrenia. However, placebo response is also significant. Chlorpromazine causes numerous adverse effects, including sedation, movement disorders, parkinsonism, fits, hypotension, dizziness, and weight gain. Judicious use of chlorpromazine, based on the best available evidence, is recommended for improved clinical decision-making.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Maintenance treatment of schizophrenia with risperidone or haloperidol: 2-year outcomes.

Author: MarderStephen R, GlynnShirley M, WirshingWilliam C, WirshingDonna A, RossDoreen, WidmarkClifford, MintzJim, LibermanRobert P, BlairKaren E

Schizophrenia treatment

The study compared symptom outcomes, side effects, and social adjustment in stable schizophrenia outpatients who received 2 years of maintenance treatment with risperidone or haloperidol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

41.

Lithium for schizophrenia.

Author: LeuchtS, McGrathJ, KisslingW

Improved treatment response
Lower acceptability

Lithium alone is not an effective treatment for people with schizophrenia. The evidence on augmentation of antipsychotics with lithium is inconclusive, but further research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Randomized controlled trial of occupational therapy in patients with treatment-resistant schizophrenia.

Author: BuchainPatrícia Cardoso, VizzottoAdriana Dias Barbosa, Henna NetoJorge, ElkisHelio

Improved treatment of TRS

The best treatment for schizophrenia often involves a combination of medications and psychosocial therapies like talking therapy, family support, and occupational therapy (OT). However, for people with treatment-resistant schizophrenia (TRS), mostly medication is used, as OT hasn't been shown to be effective. This study aims to see if adding OT to medication treatment for TRS is helpful.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

44.

Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial.

Author: TiihonenJari, HallikainenTero, RyynänenOlli-Pekka, Repo-TiihonenEila, KotilainenIrma, EronenMarkku, ToivonenPäivi, WahlbeckKristian, PutkonenAnu

Reduced schizophrenia symptoms

This study investigates the effectiveness of lamotrigine as an add-on treatment to clozapine in patients with clozapine-resistant schizophrenia, exploring the potential benefit of targeting glutamate receptors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Valproate for schizophrenia.

Author: BasanA, LeuchtS

Quicker onset of action
Sedation

This review evaluated the effectiveness of valproate for treating schizophrenia. The limited evidence available showed no support or refutation for its use as a sole agent. There was some evidence for a quicker improvement with valproate augmentation, but this effect vanished over time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Non-neuroleptic approaches to treating negative symptoms in schizophrenia.

Author: MöllerHans-Jürgen

Negative symptoms treatment

The study presented a systematic review of non-neuroleptic drug treatments for negative symptoms in schizophrenia, finding that SSRIs show promise but other treatments are still in the experimental phase.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Antipsychotic medication versus placebo for people with both schizophrenia and learning disability.

Author: DugganL, BrylewskiJ

Insufficient evidence

There is currently no randomized controlled trial evidence to guide the use of antipsychotic medication for people with both learning disability and schizophrenia. Further research is urgently needed to address this gap in knowledge.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Is there evidence that cognitive behaviour therapy is an effective treatment for schizophrenia? A cautious or cautionary tale?

Author: TarrierNicholas, WykesTil

Schizophrenia treatment

The review of 20 randomized controlled trials indicated that cognitive behavior therapy for psychosis (CBTp) is effective in the treatment of schizophrenia, with the strongest evidence for chronic patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

49.

Risperidone versus olanzapine for schizophrenia.

Author: JayaramM B, HosalliP

Reduced schizophrenia symptoms
Extrapyramidal symptoms
Sexual dysfunction
Weight gain

Risperidone and olanzapine were found to be equally effective in treating schizophrenia. However, risperidone was associated with more movement disorders and sexual dysfunction, while olanzapine caused more weight gain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Quality of life during treatment with haloperidol or olanzapine in the year following a first psychotic episode.

Author: StrakowskiStephen M, JohnsonJacqueline L, DelbelloMelissa P, HamerRobert M, GreenAlan I, TohenMauricio, LiebermanJeffrey A, GlickIra, PatelJayendra K,

Better treatment approaches
Improved quality of life
Schizophrenia

Schizophrenia severely affects quality of life. While treatments have improved, focus now shifts towards helping patients rejoin society, not just managing symptoms. The development of newer antipsychotic medications offered hope for better quality of life, especially early in the illness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

51.

Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison.

Author: ShawPhilip, SpornAlex, GogtayNitin, OvermanGerald P, GreensteinDeanna, GochmanPeter, TossellJulia W, LenaneMarge, RapoportJudith L

Improved negative symptoms
Sustained clinical improvement
Lipid anomalies
More adverse events
Seizures

Clozapine was more effective than olanzapine in reducing symptoms of childhood-onset schizophrenia, but it was also associated with more side effects. While clozapine was associated with a significant reduction in all outcome measures, olanzapine showed a less consistent profile of clinical improvement. Clozapine was associated with more overall adverse events.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

52.

Compliance therapy for schizophrenia.

Author: McIntoshA M, ConlonL, LawrieS M, StanfieldA C

One randomized controlled trial found no evidence that compliance therapy is beneficial for people with schizophrenia. More research is needed to fully examine the effectiveness of this intervention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Antidepressants for the negative symptoms of schizophrenia.

Author: RummelC, KisslingW, LeuchtS

Improved negative symptoms

The combination of antipsychotics and antidepressants may be effective for treating negative symptoms of schizophrenia, but more research is needed to confirm this.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Lamotrigine for schizophrenia.

Author: PremkumarT S, PickJ

Reduced PANSS scores
Nausea

This review of five trials comparing lamotrigine with placebo or other antipsychotic augmentation strategies for people with schizophrenia found that lamotrigine was associated with a significant reduction in PANSS total scores, positive symptom sub-scale scores, and negative symptom sub-scale scores. However, the evidence for lamotrigine as an adjuvant for people with schizophrenia is not robust, and large well-designed, conducted, and reported real-world randomized trials are needed to determine its place in everyday clinical practice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Cessation of medication for people with schizophrenia already stable on chlorpromazine.

Author: AlmerieM Q, AlkhateebH, EssaliA, MatarH E, RezkE

Improved schizophrenia treatment
Schizophrenia

Chlorpromazine, an older type of antipsychotic medication, is effective in treating schizophrenia. While schizophrenia is a lifelong illness for most people, about 25% of those who experience a first psychotic episode don't have further episodes. Most people with schizophrenia are prescribed antipsychotics, but they often stop taking them. The effects of stopping these medications are not well-studied.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

Chlorpromazine versus placebo for schizophrenia.

Author: AdamsC E, AwadG, RathboneJ, ThornleyB

Reduced trial discontinuation
Relapse reduction
Symptom improvement
Acute movement disorders
Dizziness
Lowered blood pressure
Parkinsonism
Sedation
Weight gain

Chlorpromazine reduces relapse over the short and medium term, and provides a global improvement in symptoms and functioning. It is also associated with adverse effects such as sedation, acute movement disorders, parkinsonism, lowered blood pressure, and weight gain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Selective serotonin reuptake inhibitor (SSRI) add-on therapy for the negative symptoms of schizophrenia: a meta-analysis.

Author: SepehryAmir Ali, PotvinStéphane, ElieRobert, StipEmmanuel

Schizophrenia treatment

The study discussed the potential for selective serotonin reuptake inhibitor (SSRI) augmentation therapy to provide greater relief of negative symptoms in schizophrenia, noting conflicting results from published studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

58.

A systematic review of the Soteria paradigm for the treatment of people diagnosed with schizophrenia.

Author: CaltonTim, FerriterMichael, HubandNick, SpandlerHelen

Reduced medication use

The Soteria paradigm, a minimal medication approach for schizophrenia spectrum disorders, may yield equal or better results than conventional treatments with lower medication use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Carbamazepine for schizophrenia.

Author: LeuchtS, KisslingW, McGrathJ, WhiteP

Global improvement
Insufficient evidence

Carbamazepine cannot be recommended for routine clinical use for treatment or augmentation of antipsychotic treatment of schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Lithium for schizophrenia.

Author: LeuchtS, KisslingW, McGrathJ

Clinical response
Inconclusive evidence
Low acceptability

Lithium as a sole treatment for schizophrenia was not effective in any of the outcomes analyzed in 3 studies. Lithium was less effective than antipsychotics in 8 studies, but more people had a clinically significant response when lithium was used as an augmentation to antipsychotics in 11 studies. However, this statistical significance became borderline when people with schizoaffective disorders were excluded. Lithium augmentation was associated with a lower acceptability compared to antipsychotics alone. There were no differences between groups for adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia.

Author: MortimerAnn M, JoyceEileen, BalasubramaniamKrishnapillai, ChoudharyPrasoon C, SaleemPackeeruther T,

Cognitive improvement
Schizophrenia treatment

Both amisulpride and olanzapine showed sustained improvement in certain neuropsychological functions in patients with schizophrenia after 6 months of treatment. However, only amisulpride resulted in a significant improvement in Auditory Verbal Learning Test (AVLT) scores.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

Social outcomes in schizophrenia.

Author: PriebeStefan

Social outcomes assessment

Concepts of social outcomes in schizophrenia lack agreed definitions and theoretical models.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

Clinical, functional, and economic ramifications of early nonresponse to antipsychotics in the naturalistic treatment of schizophrenia.

Author: Ascher-SvanumHaya, NyhuisAllen W, FariesDouglas E, KinonBruce J, BakerRobert W, ShekharAnantha

Schizophrenia treatment

Early nonresponse to antipsychotics appears to predict subsequent nonresponse to treatment in patients with schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

64.

A randomized, double-blind comparison of clozapine and high-dose olanzapine in treatment-resistant patients with schizophrenia.

Author: MeltzerHerbert Y, BoboWilliam V, RoyAjanta, JayathilakeKaru, ChenYuejin, ErtugrulAygun, Anil YağcioğluA Elif, SmallJoyce G

Improved schizophrenia treatment
Schizophrenia

Clozapine, despite its side effects, is often considered the best treatment for schizophrenia when other antipsychotics are not effective. Research on the effectiveness of olanzapine for treatment-resistant schizophrenia at doses higher than those typically used (10-20 mg per day) has produced mixed results.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

65.

[Schizophrenia as a brain disorder and its development].

Author: FalkaiP, WobrockT, Schneider-AxmannT, GruberO

Schizophrenia is a mental illness characterized by structural and functional brain abnormalities, particularly in the frontal lobe. These abnormalities can be caused by factors related to vulnerability to the disease, its manifestation, or treatment.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

66.

Valproate for schizophrenia.

Author: SchwarzChristian, VolzAnja, LiChunbo, LeuchtStefan

Quicker onset of action
Reduced aggression
Reduced tardive dyskinesia
Sedation

There is no evidence to support or refute valproate as a sole agent for schizophrenia. There is some evidence for positive effects on aggression and tardive dyskinesia, but further research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

67.

An evaluation of a medication management training programme for community mental health professionals; service user level outcomes: a cluster randomised controlled trial.

Author: HarrisNeil, LovellKarina, DayJennifer, RobertsChristopher

Improved psychopathology
Increased involvement in treatment

Training community mental health professionals in medication management has a positive impact on clinical outcomes and service user involvement in treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

68.

Clozapine versus typical neuroleptic medication for schizophrenia.

Author: EssaliAdib, Al-Haj HaasanNahla, LiChunbo, RathboneJohn

Improved schizophrenia treatment
Schizophrenia

Long-term treatment for schizophrenia with traditional antipsychotics has limitations, as 25-33% of patients do not respond well. Clozapine is an antipsychotic that is thought to be more effective and to cause fewer movement problems than traditional medications in people with treatment-resistant schizophrenia. However, clozapine carries a significant risk of serious blood disorders, requiring weekly blood tests, especially during the initial months of treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Schizophrenia (maintenance treatment).

Author: SmithThomas E, WestonChristi A, LiebermanJeffrey A

Schizophrenia treatment
Disability
Relapse

About 1% of people will develop schizophrenia. About 75% experience relapses and ongoing disability, with one-third not responding to standard treatments. Symptoms like hearing voices, delusions, and disorganized thoughts are considered positive symptoms, while symptoms like lack of motivation, self-neglect, and reduced emotions are called negative symptoms. No treatment has consistently improved negative symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

70.

Clozapine combined with different antipsychotic drugs for treatment resistant schizophrenia.

Author: CiprianiAndrea, BosoMarianna, BarbuiCorrado

Schizophrenia treatment

Clozapine is often considered the best treatment for schizophrenia when other medications are not effective, but 33% to 66% of people continue to have symptoms even after taking clozapine at a proper dose for a sufficient time. The most common reason for adding a second antipsychotic medication to clozapine is to find a treatment that works better for people who are not fully responding to clozapine alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Repetitive transcranial magnetic stimulation for refractory symptoms in schizophrenia.

Author: BlumbergerDaniel M, FitzgeraldPaul B, MulsantBenoit H, DaskalakisZafiris J

Potential treatment for schizophrenia

This review discusses the use of repetitive transcranial magnetic stimulation (rTMS) in patients with schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

72.

Sulpiride augmentation for schizophrenia.

Author: WangJijun, OmoriIchiro M, FentonMark, SoaresBernardo

Improved clinical response
Increased prolactin
Movement disorders

Sulpiride plus clozapine is probably more effective than clozapine alone in producing clinical improvement in some people whose illness has been resistant to other antipsychotic drugs including clozapine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

73.

Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: A randomized, 1-year study.

Author: GuoXiaofeng, ZhaiJinguo, LiuZhening, FangMaosheng, WangBo, WangChuanyue, HuBin, SunXueli, LvLuxian, LuZheng, MaCui, HeXiaolin, GuoTiansheng, XieShiping, WuRenrong, XueZhimin, ChenJindong, TwamleyElizabeth W, JinHua, ZhaoJingping

Improved insight
Improved quality of life
Improved social functioning
Increased employment/education
Reduced relapse risk
Reduced treatment discontinuation

Early-stage schizophrenia patients receiving antipsychotic medication combined with psychosocial intervention had a lower rate of treatment discontinuation, lower risk of relapse, and better insight, quality of life, and social functioning than those receiving medication alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

74.

[Pharmacological treatment of negative symptoms in schizophrenia; research and practice].

Author: JiawanV C R, ArendsJ, SlooffC J, KnegteringH

Negative symptom treatment

Negative symptoms in people with schizophrenia are linked to poorer social outcomes. Treatment options for negative symptoms are very limited. This study examines various treatment approaches that involve adding different medications to standard antipsychotics in an attempt to improve negative symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Dutch

75.

Randomized controlled trial of interventions for young people at ultra high risk for psychosis: 6-month analysis.

Author: YungAlison R, PhillipsLisa J, NelsonBarnaby, FranceyShona M, PanYuenHok, SimmonsMagenta B, RossMargaret L, KellyDaniel, BakerKathryn, AmmingerG Paul, BergerGregor, ThompsonAndrew D, ThampiAnnette, McGorryPatrick D

Schizophrenia prevention

This study discusses the use of cognitive therapy and/or low-dose antipsychotics in preventing or delaying the onset of full-blown schizophrenia during the prodromal phase. While both treatments show promise, further research is needed to determine their optimal use and long-term effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

76.

Treatment of shizophrenic patients and rTMS.

Author: PouletEmmanuel, HaesebaertF, SaoudM, Suaud-ChagnyM F, BrunelinJerome

Enhanced treatment efficacy
Improved brain function
Reduced symptoms

This article discusses the use of repetitive transcranial magnetic stimulation (rTMS) for the treatment of drug-resistant schizophrenia symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Challenges in the design and conduct of controlled clinical effectiveness trials in schizophrenia.

Author: RosenheckRobert A, KrystalJohn H, LewRobert, BarnettPaul G, ThwinSoe Soe, FioreLouis, ValleyDanielle, HuangGrant D, NealCarla, VertreesJulia E, LiangMatthew H,

Reduced schizophrenia relapse

This study examines the effectiveness of long-acting intramuscular antipsychotic medication in improving medication adherence and reducing relapse in patients with schizophrenia, recognizing that this approach is widely considered to be beneficial but lacking robust evidence.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

78.

Schizophrenia: a systematic review of the disease state, current therapeutics and their molecular mechanisms of action.

Author: ShinJ K, MaloneD T, CrosbyI T, CapuanoB

Improved schizophrenia treatment

While schizophrenia is a serious illness, its cause remains unknown. The most widely accepted theories are related to imbalances in dopamine and serotonin in the brain. This review discusses these theories, current medications, and promising new treatments for schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

79.

Repetitive transcranial magnetic stimulation and treatment of negative symptoms of schizophrenia.

Author: PrikrylRadovan

Improved schizophrenia treatment

This study discusses the use of repetitive transcranial magnetic stimulation (rTMS) in treating negative symptoms of schizophrenia. While rTMS shows promise in this area, more research is needed to confirm its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

80.

[Specialised first-episode psychosis services: a systematic review of the literature].

Author: SkalliL, NicoleL

Improved psychosis treatment

Schizophrenia is a common, disabling, and expensive condition. Research shows that the first few years after diagnosis are critical, with significant worsening of symptoms and functioning. This suggests that early and intensive intervention during this period might improve long-term outcomes and prevent social and mental challenges.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : French

81.

Effects of antipsychotic treatment on psychopathology and motor symptoms. A placebo-controlled study in healthy volunteers.

Author: VeselinovićTanja, SchornHolger, VernalekenIngo, SchifflKatharina, HiemkeChristoph, ZernigGerald, GurRuben, GründerGerhard

Schizophrenia treatment

There's growing interest in understanding the various symptoms of schizophrenia and how they respond to medication. Negative symptoms and cognitive problems in particular are often resistant to current antipsychotic treatments. Interestingly, some negative symptoms of psychosis resemble the side effects of antipsychotic medications that block dopamine.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

82.

Psychoeducation for schizophrenia.

Author: XiaJun, MerinderLars Bertil, BelgamwarMadhvi R

Improved schizophrenia management

Schizophrenia is a serious, long-term condition often marked by a lack of awareness of the illness and difficulty following treatment. Psychoeducational programs aim to improve patients' understanding of their illness and treatment, hoping that increased knowledge will help them manage their condition better, ultimately improving their long-term outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

Antipsychotic medication for early episode schizophrenia.

Author: BolaJohn, KaoDennis, SoydanHaluk

Schizophrenia treatment

Many people with early-onset schizophrenia are treated with antipsychotic medications for a long period, but how these medications affect the course of the illness in the short and long term is not fully understood. Research suggests that people with early-onset schizophrenia may respond differently to treatment compared to those with multiple previous episodes. This suggests that the number of episodes a person has experienced might influence how well they respond to medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Acetylcholinesterase inhibitors for schizophrenia.

Author: SinghJasvinder, KourKamalpreet, JayaramMahesh B

Improved schizophrenia treatment

While antipsychotic medications are the primary treatment for schizophrenia, they are not always effective in improving thinking and other cognitive problems. This study highlights the ongoing search for new medications that can address these cognitive deficits. The study notes that medications that increase acetylcholine levels (acetylcholinesterase inhibitors), which have been used to treat dementia, may be potential options for treating cognitive difficulties in schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

The nature of dopamine dysfunction in schizophrenia and what this means for treatment.

Author: HowesOliver D, KambeitzJoseph, KimEuitae, StahlDaniel, SlifsteinMark, Abi-DarghamAnissa, KapurShitij

Improved schizophrenia treatment

Current medications for schizophrenia are not effective for many patients. Despite decades of research, all available treatments rely on the same mechanism: blocking dopamine receptors. Understanding the underlying causes of schizophrenia is crucial for developing new and better treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

86.

Patients' beliefs about the causes, persistence and control of psychotic experiences predict take-up of effective cognitive behaviour therapy for psychosis.

Author: FreemanD, DunnG, GaretyP, WeinmanJ, KuipersE, FowlerD, JolleyS, BebbingtonP

Improved outcomes for schizophrenia

The study found that patients with schizophrenia benefit from standard cognitive behaviour therapy (CBT) only when active techniques are used ("full therapy"). Patients who received "partial therapy" (engagement and assessment strategies only) or "no therapy" did not show significant improvements. The study suggests that patients' initial understanding of their problems is crucial for their engagement in CBT and that a good match between their perceptions and the treatment principles leads to better outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

87.

[Cognitive-behavioral group treatment for schizophrenia and other psychotic disorders- a systematic review].

Author: Mortan SeviOya, Tekinsav SütcüSerap

Decrease anxiety
Improve hopelessness
Reduce psychosis symptoms

Cognitive-behavioral therapies plus standard treatment are effective in decreasing the symptoms of schizophrenia and other psychotic disorders (positive and negative symptoms) and/or the problems that accompany the disorder (anxiety, hopelessness).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Turkish

88.

Efficacy of olanzapine in comparison with clozapine for treatment-resistant schizophrenia: evidence from a systematic review and meta-analyses.

Author: SouzaJuliano S, KayoMonica, TassellIvson, MartinsCamila Bertini, ElkisHelio

Improved schizophrenia symptoms

This systematic review compared clozapine with olanzapine in patients with TRS. Clozapine was significantly more efficacious than olanzapine in improving positive and negative symptoms in TRS patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Meta-Analysis of Efficacy of Mirtazapine as an Adjunctive Treatment of Negative Symptoms in Schizophrenia.

Author: VidalCarol, ReeseCarla, FischerBernard A, ChiapelliJoshua, HimelhochSeth

Improved negative symptoms

The meta-analysis assessed the efficacy of mirtazapine as an adjunctive treatment for negative symptoms in schizophrenia. Adding mirtazapine to antipsychotic treatment resulted in improvement in negative symptoms. Further studies are needed with more stringent selection criteria and homogeneous use of antipsychotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Nidotherapy for people with schizophrenia.

Author: ChamberlainIan J, SampsonStephanie

Mental illness management

Nidotherapy is a therapeutic approach that focuses on improving the environment of people with mental illness. Instead of directly treating the illness, nidotherapy aims to help individuals identify and address environmental factors that may be contributing to their symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

91.

Pharmacological approaches to the management of schizophrenia: 10 years on.

Author: CastleDavid, KeksNicholas, NewtonRichard, SchweitzerIsaac, CopolovDavid, PaolettiNick, BurrowsGraham, TillerJohn

Schizophrenia treatment
Hyperprolactinemia
Metabolic side effects

Newer antipsychotics have been developed to treat schizophrenia, but they have not led to significant improvements in overall treatment efficacy. While some newer agents might be better than older ones for negative and cognitive symptoms, they still have metabolic side effects and hyperprolactinaemia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

92.

A systematic review of psychostimulant treatment of negative symptoms of schizophrenia: challenges and therapeutic opportunities.

Author: LindenmayerJean-Pierre, NasrallahHenry, PucciMichael, JamesSteven, CitromeLeslie

Improved NSS
Psychotic symptoms

This study examines the potential use of psychostimulants in treating negative symptoms of schizophrenia. While these drugs may show promise, their use requires careful consideration due to the risk of triggering psychotic symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

93.

Rapid improvement of acute schizophrenia symptoms after intravenous sodium nitroprusside: a randomized, double-blind, placebo-controlled trial.

Author: HallakJaime E C, Maia-de-OliveiraJoao Paulo, AbraoJoao, EvoraPaulo R, ZuardiAntonio W, CrippaJose A S, Belmonte-de-AbreuPaulo, BakerGlen B, DursunSerdar M

Improved symptoms

A single intravenous administration of sodium nitroprusside (0.5 μg/kg/min for 4 hours) resulted in a rapid improvement in positive, negative, anxiety, and depressive symptoms in patients with schizophrenia. The improvement was observed within 4 hours and persisted for 4 weeks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

94.

Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies.

Author: Fusar-PoliP, SmieskovaR, KemptonM J, HoB C, AndreasenN C, BorgwardtS

Gray matter volume decrease
Lateral ventricular volume increase

Schizophrenia is characterized by progressive gray matter volume decreases and lateral ventricular volume increases. Some of these neuroanatomical alterations may be associated with antipsychotic treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

95.

Early antipsychotic response to aripiprazole in adolescents with schizophrenia: predictive value for clinical outcomes.

Author: CorrellChristoph U, ZhaoJoan, CarsonWilliam, MarcusRon, McQuadeRobert, ForbesRobert A, MankoskiRaymond

Symptom decreases
Nonresponse prediction

Most symptom improvements in adults with chronic schizophrenia occur within the first few weeks of antipsychotic treatment. Nonresponse at week 2 predicts later nonresponse. This study investigates the trajectory of antipsychotic response and the predictive value of early effects in adolescent schizophrenia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

96.

Schizophrenia.

Author: BarrySarah Je, GaughanTracey M, HunterRobert

Schizophrenia treatment

Schizophrenia affects approximately 0.7% of people, with about 75% experiencing relapses and ongoing disability. While standard treatments exist, one third of people don't respond well. Schizophrenia is characterized by positive symptoms like hallucinations and delusions, as well as negative symptoms like apathy and lack of emotion. No treatment has consistently improved negative symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Adjuvant therapy with minocycline for schizophrenia (The MINOS Trial): study protocol for a double-blind randomized placebo-controlled trial.

Author: FekaduAbebaw, MesfinMiraf, MedhinGirmay, AlemAtalay, TeferraSolomon, Gebre-EyesusTsehaysina, SeboxaTeshale, AssefaAbraham, HusseinJemal, LemmaMartha T, BorbaChristina, HendersonDavid C, HanlonCharlotte, ShibreTeshome

Schizophrenia treatment
Negative symptoms

Minocycline is being investigated as a potential add-on treatment for schizophrenia, particularly in patients who do not respond well to standard antipsychotic medications. This study aims to evaluate the effectiveness of minocycline in reducing positive, negative, and cognitive symptoms of schizophrenia in patients who have failed to respond to conventional therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

98.

Anticholinergic medication for non-clozapine neuroleptic-induced hypersalivation in people with schizophrenia.

Author: EssaliAdib, RihawiAnas, AltujjarMohammad, AlhafezBishr, TarboushAmjad, Alhaj HasanNahla

Schizophrenia treatment

While medications called neuroleptics are commonly used to treat schizophrenia, they can cause excessive saliva production, which can be embarrassing and difficult to manage. This side effect can impact quality of life and even lead to people stopping their medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

99.

Chlorpromazine versus placebo for schizophrenia.

Author: AdamsClive E, AwadGeorge A, RathboneJohn, ThornleyBen, Soares-WeiserKarla

schizophrenia treatment
low blood pressure
movement disorders
parkinsonism
sedation
weight gain

Chlorpromazine was found to reduce relapse rates in patients with schizophrenia compared to placebo. Chlorpromazine was also associated with sedation, acute movement disorders, parkinsonism, lower blood pressure, and weight gain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

100.

Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial.

Author: MorrisonAnthony P, TurkingtonDouglas, PyleMelissa, SpencerHelen, BrabbanAlison, DunnGraham, ChristodoulidesTom, DudleyRob, ChapmanNicola, CallcottPauline, GraceTim, LumleyVictoria, DrageLaura, TullySarah, IrvingKerry, CummingsAnna, ByrneRory, DaviesLinda M, HuttonPaul

Schizophrenia treatment

This study investigates whether cognitive therapy can help reduce mental health symptoms in people with schizophrenia who choose not to take antipsychotic medications, as many patients decline or discontinue these medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

101.

Cognitive model and cognitive behavior therapy for schizophrenia: an overview.

Author: SarinFreddy, WallinLennart

Schizophrenia treatment

Schizophrenia causes significant suffering for both patients and their families. While medication is used, many people continue to have symptoms and a reduced quality of life. Cognitive behavioral therapy (CBT) has shown promise for schizophrenia, but more research is needed to improve its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

102.

Cognitive behavioural therapy (brief versus standard duration) for schizophrenia.

Author: NaeemFarooq, FarooqSaeed, KingdonDavid

Schizophrenia treatment

Cognitive behavioral therapy (CBT) can be helpful for people with schizophrenia, but its availability is limited by resources and training. A brief version of CBT may be a solution to this problem.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

103.

Carbamazepine for schizophrenia.

Author: LeuchtStefan, HelferBartosz, DoldMarkus, KisslingWerner, McGrathJohn

Improve global improvement
Movement disorders
Parkinsonism
Relapse

Carbamazepine is not recommended for routine clinical use for treatment or augmentation of antipsychotic treatment of schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

104.

Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: a prospective, randomized study.

Author: PetridesGeorgios, MalurChitra, BragaRaphael J, BailineSamuel H, SchoolerNina R, MalhotraAnil K, KaneJohn M, SanghaniSohag, GoldbergTerry E, JohnMajnu, MendelowitzAlan

Improved cognition
Safe and effective treatment
Mild confusion

Electroconvulsive therapy (ECT) is a safe and effective treatment option for augmentation of clozapine in patients with treatment-resistant schizophrenia. Further research is needed to determine the long-term effectiveness and potential need for maintenance treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

105.

Treatment resistant schizophrenia: a comprehensive survey of randomised controlled trials.

Author: SinclairDiarmid, AdamsClive E

Schizophrenia treatment

Schizophrenia is a serious mental health condition that causes significant suffering and costs. While antipsychotic medications are the main treatment, about a third of people don't respond well. This review examines research on treatments for people with schizophrenia who don't respond to standard medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

106.

Treatments of Negative Symptoms in Schizophrenia: Meta-Analysis of 168 Randomized Placebo-Controlled Trials.

Author: Fusar-PoliPaolo, PapanastasiouEvangelos, StahlDaniel, RocchettiMatteo, CarpenterWilliam, ShergillSukhwinder, McGuirePhilip

Reduced negative symptoms

While most treatments for schizophrenia reduced negative symptoms compared to placebo, none reached the threshold for clinically significant improvement.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

107.

Neuroimaging findings in treatment-resistant schizophrenia: A systematic review: Lack of neuroimaging correlates of treatment-resistant schizophrenia.

Author: NakajimaShinichiro, TakeuchiHiroyoshi, PlitmanEric, FervahaGagan, GerretsenPhilip, CaravaggioFernando, ChungJun Ku, IwataYusuke, RemingtonGary, Graff-GuerreroAriel

Improved understanding of schizophrenia

This study aimed to identify neuroimaging characteristics unique to treatment-resistant schizophrenia (TRS) and clozapine's efficacy in TRS. There were no replicated neuroimaging findings specific to TRS. Clozapine may increase prefrontal hypoactivation in TRS, but this was not related to clinical improvement. Clozapine efficacy was linked to decreased metabolism in the basal ganglia and thalamus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

108.

First rank symptoms for schizophrenia.

Author: Soares-WeiserKarla, MaayanNicola, BergmanHanna, DavenportClare, KirkhamAmanda J, GrabowskiSarah, AdamsClive E

Psychotic disorders
Schizophrenia

Early and accurate diagnosis of schizophrenia is important for better long-term outcomes. Delaying treatment can lead to more severe symptoms and slower recovery. This study aims to determine whether specific symptoms, known as First Rank Symptoms (FRS), are helpful in distinguishing schizophrenia from other psychotic disorders, as there is uncertainty about how accurate these symptoms are in making diagnoses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

109.

A randomized pilot study of MOtiVation and Enhancement (MOVE) Training for negative symptoms in schizophrenia.

Author: VelliganDawn I, RobertsDavid, MintzJim, MaplesNatalie, LiXueying, MedellinElisa, BrownMatt

Negative symptoms
Schizophrenia

This research focuses on persistent and clinically significant negative symptoms (PNS) in schizophrenia. PNS significantly impact quality of life and functional outcomes, but current treatments are limited. The study highlights the need for new treatment models addressing the full spectrum of PNS.

AddressRefers to the affiliation address of the author associated with a paper or article. This may include information such as the name of the institution or university where the author conducted the research, department, postal code, and country. This information is useful when evaluating the credibility of a paper or when tracking research activities in a specific field or region.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

110.

Randomized Controlled Trials of Add-On Antidepressants in Schizophrenia.

Author: TerevnikovViacheslav, JoffeGrigori, StenbergJan-Henry

Cognitive symptoms
Depressive symptoms
Extrapyramidal symptoms
Negative symptoms
Schizophrenia treatment

Add-on antidepressants for schizophrenia may offer benefits for specific symptoms, such as negative symptoms (mirtazapine and mianserin), antipsychotic-induced extrapyramidal symptoms (trazodone and nefazodone), and depressive symptoms (imipramine and duloxetine). However, overall efficacy remains uncertain due to methodological limitations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

111.

Transcranial magnetic stimulation (TMS) for schizophrenia.

Author: DougallNadine, MaayanNicola, Soares-WeiserKarla, McDermottLisa M, McIntoshAndrew

Reduced hallucinations
Headaches

There is insufficient evidence to support or refute the use of TMS to treat symptoms of schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

112.

The Use of Continuous Treatment Versus Placebo or Intermittent Treatment Strategies in Stabilized Patients with Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with First- and Second-Generation Antipsychotics.

Author: De HertMarc, SermonJan, GeertsPaul, VansteelandtKristof, PeuskensJoseph, DetrauxJohan

Schizophrenia treatment

While continuous antipsychotic medication is the standard treatment for schizophrenia, some doctors question if it's always necessary or justified for everyone who has been stabilized on these medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

113.

Cognitive behavioural therapy (brief versus standard duration) for schizophrenia.

Author: NaeemFarooq, FarooqSaeed, KingdonDavid

Schizophrenia treatment

Cognitive behavioral therapy (CBT) can be helpful for people with schizophrenia, but its availability is limited due to resources and training. A brief version of CBT may be a solution to this problem.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

114.

Lithium for schizophrenia.

Author: LeuchtStefan, HelferBartosz, DoldMarkus, KisslingWerner, McGrathJohn J

Improved response
Side effects

This review concluded that there is no evidence that lithium is an effective treatment for schizophrenia on its own. There is some evidence that lithium may be effective when used as an augmentation therapy with antipsychotic medications, but this evidence is of low quality and further research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

115.

Predictors for symptom re-exacerbation after targeted stepwise drug discontinuation in first-episode schizophrenia: Results of the first-episode study within the German research network on schizophrenia.

Author: GaebelWolfgang, RiesbeckMathias, WölwerWolfgang, KlimkeAnsgar, EickhoffMatthias, von WilmsdorffMartina, de MillasWalter, MaierWolfgang, RuhrmannStephan, FalkaiPeter, SauerHeinrich, SchmittAndrea, RiedelMichael, KlingbergStefan, MöllerHans-Jürgen

IT for schizophrenia
Relapse rates

This research examines the use of targeted intermittent treatment (IT) for schizophrenia, specifically after a first episode. While maintenance treatment (MT) is generally recommended, the study investigates the feasibility of IT, considering the potential adverse effects of antipsychotics and patient preferences.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

116.

A Systematic Review and Network Meta-Analysis to Assess the Relative Efficacy of Antipsychotics for the Treatment of Positive and Negative Symptoms in Early-Onset Schizophrenia.

Author: HarveyRebecca C, JamesAnthony C, ShieldsGemma E

Early diagnosis
Effective treatment
Debilitating disorder
Reduced life expectancy
Worse functional outcomes

Early-onset schizophrenia (EOS) is a serious disorder with significant morbidity. This study examines the efficacy of antipsychotics used to treat EOS, focusing on their impact on positive and negative symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

117.

Adherence therapy versus routine psychiatric care for people with schizophrenia spectrum disorders: a randomised controlled trial.

Author: ChienWai Tong, MuiJolene, GrayRichard, CheungEric

Motivational interviewing for schizophrenia

This study evaluates the effects of a motivational-interviewing-based adherence therapy for improving medication adherence in patients with schizophrenia spectrum disorders. The study explores strategies for improving adherence to antipsychotic medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

118.

Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial.

Author: BarnesThomas R E, LeesonVerity C, PatonCarol, CostelloeCéire, SimonJudit, KissNoemi, OsbornDavid, KillaspyHelen, CraigTom K J, LewisShôn, KeownPatrick, IsmailShajahan, CrawfordMike, BaldwinDavid, LewisGlyn, GeddesJohn, KumarManoj, PathakRudresh, TaylorSimon

Schizophrenia treatment

Negative symptoms of schizophrenia, such as lack of motivation and social engagement, are a major obstacle to recovery. While no specific medications are approved for treating these symptoms, some evidence suggests a combination of antipsychotics and antidepressants might be helpful. However, more research is needed to confirm this and develop effective treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

119.

[Duration of untreated psychosis: A state-of-the-art review and critical analysis].

Author: SouaibyL, GaillardR, KrebsM-O

Improved prognosis

While research on schizophrenia continues, long-term outcomes haven't improved much. There's often a delay between the first signs of the illness and starting treatment. The length of time someone experiences symptoms before treatment (DUP) has been studied to understand the impact of early intervention. However, there are different ways to define when the illness starts and when treatment begins, and these assessments are often based on people's memories, making it difficult to accurately measure DUP.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

120.

Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial.

Author: PyleMelissa, NorrieJohn, SchwannauerMatthias, KingdonDavid, GumleyAndrew, TurkingtonDouglas, ByrneRory, SyrettSuzy, MacLennanGraeme, DudleyRobert, McLeodHamish J, GriffithsHelen, BoweSamantha, BarnesThomas R E, FrenchPaul, HuttonPaul, DaviesLinda, MorrisonAnthony P

Schizophrenia treatment

About one-third of people with schizophrenia do not respond well to typical or atypical antipsychotic medications, a condition called treatment-resistant schizophrenia. Clozapine is the only antipsychotic medication consistently effective for this group, but even then, about 30-40% do not see sufficient improvement. While cognitive behavioral therapy (CBT) is a proven treatment for schizophrenia when combined with antipsychotics, evidence for its effectiveness in treatment-resistant schizophrenia is limited. Further research is needed to find better treatments for this challenging group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

121.

Valproate for schizophrenia.

Author: WangYijun, XiaJun, HelferBartosz, LiChunbo, LeuchtStefan

Effective for aggression/agitation
Effective for clinical response
Limited evidence
Sedation and dizziness

Adding valproate to antipsychotic treatment resulted in more clinically significant response than adding placebo to antipsychotic drugs (14 RCTs, n = 1049, RR 1.31, 95% CI 1.16 to 1.47, I2 = 55%). However, this evidence was entirely based on open RCTs. Moreover, valproate was associated with a number of adverse events among which sedation and dizziness appeared significantly more frequently than in the control groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

122.

Bitopertin in Negative Symptoms of Schizophrenia-Results From the Phase III FlashLyte and DayLyte Studies.

Author: Bugarski-KirolaDragana, BlaettlerThomas, ArangoCelso, FleischhackerWolfgang W, GaribaldiGeorge, WangAlice, DixonMark, BressanRodrigo A, NasrallahHenry, LawrieStephen, NapieralskiJulie, Ochi-LohmannTania, ReidCarol, MarderStephen R

Schizophrenia treatment
No efficacy

Three phase III studies evaluating the efficacy of adjunctive bitopertin in patients with persistent predominant negative symptoms of schizophrenia showed no evidence for superior efficacy over placebo in any of the doses tested. Bitopertin was well tolerated.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

123.

Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia.

Author: BarberSarah, OlotuUwaila, CorsiMartina, CiprianiAndrea

Weight gain risk

This review examined five studies on the use of clozapine in combination with other antipsychotic medications for treatment-resistant schizophrenia. The review found that clozapine plus amisulpride was more effective than clozapine plus quetiapine in the short term. However, the review concluded that more research is needed to determine the best combination therapy for treatment-resistant schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

124.

Chlorpromazine versus clotiapine for schizophrenia.

Author: MazhariShahrzad, EsmailianSaeed, Shah-EsmaeiliArmita, GoughariAli S, BazrafshanAzam, ZareMorteza

Improved mental state
Dyskinesia

This systematic review compared the clinical effects, safety, and cost-effectiveness of chlorpromazine and clotiapine for adults with schizophrenia. The review found that limited data suggested that clotiapine may be more effective than chlorpromazine in improving mental state, but that the quality of evidence was very low. Both medications were associated with similar adverse effects. This suggests that more research is needed to determine the relative effectiveness of these two antipsychotics for schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

125.

Clozapine dose for schizophrenia.

Author: SubramanianSelvizhi, VöllmBirgit A, HubandNick

Schizophrenia treatment

Schizophrenia is a serious mental illness that affects thoughts, emotions, behavior, and sense of self. Clozapine is a medication that can be helpful for schizophrenia, especially when other medications haven't worked, improving both positive symptoms (like delusions and hallucinations) and negative symptoms (like withdrawal and difficulty speaking). However, the best dose of clozapine to achieve the most benefit with the fewest side effects is still uncertain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

126.

Antipsychotic combinations for schizophrenia.

Author: Ortiz-OrendainJavier, Castiello-de ObesoSantiago, Colunga-LozanoLuis Enrique, HuYue, MaayanNicola, AdamsClive E

Multidimensional view
Public education needed

A combination of antipsychotics may improve clinical response in patients with schizophrenia, but the evidence is very low quality. A combination of antipsychotics may not be superior or inferior to antipsychotic monotherapy in preventing participants from leaving the study early, preventing relapse, or causing more serious adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

127.

Effectiveness of a treatment guideline for schizophrenia in adolescents: Lessons from a middle-income country.

Author: UlloaRosa-Elena, ArceSofía, VictoriaGamaliel, SarmientoEmmanuel, JiménezIsrael, ArroyoEduardo, Díaz CalvoAna-Teresa, Del ValleMiriam, SantosGabriela, RosettiMarcos, ApiquianRogelio

Psychosocial functioning

This study compared the efficacy of guideline-based treatment with treatment as usual for adolescents with schizophrenia. There were no differences between groups in the pharmacological treatment, reduction in symptom severity or cognition. However, the guideline-based treatment group showed better psychosocial functioning at months 3 and 6.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

128.

Community-based psychosocial interventions for people with schizophrenia in low and middle-income countries: systematic review and meta-analysis.

Author: AsherLaura, PatelVikram, De SilvaMary J

Improved schizophrenia treatment

This research discusses the need for community-based psychosocial interventions for people with schizophrenia in low and middle-income countries and highlights the limited evidence on the effectiveness of these interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

129.

Antipsychotic drugs for patients with schizophrenia and predominant or prominent negative symptoms: a systematic review and meta-analysis.

Author: KrauseMarc, ZhuYikang, HuhnMaximilian, Schneider-ThomaJohannes, BighelliIrene, NikolakopoulouAdriani, LeuchtStefan

Amisulpride for negative symptoms
Cariprazine for negative symptoms
Amisulpride depression risk
Cariprazine manufacturer sponsored

Amisulpride is the only antipsychotic that outperformed placebo in the treatment of predominant negative symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

130.

Non-invasive brain stimulation for negative symptoms in schizophrenia: An updated systematic review and meta-analysis.

Author: OsoegawaCaio, GomesJuly Silveira, GrigolonRuth Bartelli, BrietzkeElisa, GadelhaAry, LacerdaAcioly L T, DiasÁlvaro Machado, CordeiroQuirino, LaranjeiraRonaldo, de JesusDanilo, DaskalakisZafiris Jeff, BrunelinJerome, CordesJoachim, TrevizolAlisson Paulino

Negative symptom improvement

Both rTMS and tDCS were superior to sham stimulation for ameliorating negative symptoms in schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

131.

Moderate effects of noninvasive brain stimulation of the frontal cortex for improving negative symptoms in schizophrenia: Meta-analysis of controlled trials.

Author: AlemanAndré, Enriquez-GeppertStefanie, KnegteringHenderikus, Dlabac-de LangeJozarni J

Improved functioning

This abstract explores the potential of noninvasive neurostimulation using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) as novel approaches for treating negative symptoms in schizophrenia, highlighting the limited effectiveness of existing treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

132.

Mirtazapine adjunct for people with schizophrenia.

Author: PerryLuke A, RamsonDhruvesh, StricklinSuzanne

Improved schizophrenia treatment

Schizophrenia can cause a range of distressing symptoms, including delusions, hallucinations, problems with thinking, and reduced emotional expression. While medications can be helpful, they don't always address negative symptoms. This study investigates the potential benefit of adding the antidepressant mirtazapine to antipsychotic medications to help with these symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

133.

Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS): an assessor-blinded, randomised controlled trial.

Author: MorrisonAnthony P, PyleMelissa, GumleyAndrew, SchwannauerMatthias, TurkingtonDouglas, MacLennanGraeme, NorrieJohn, HudsonJemma, BoweSamantha E, FrenchPaul, ByrneRory, SyrettSuzy, DudleyRobert, McLeodHamish J, GriffithsHelen, BarnesThomas R E, DaviesLinda, KingdonDavid,

Improved schizophrenia treatment

Cognitive behavioral therapy (CBT) may be an effective treatment for clozapine-resistant schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

134.

Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study.

Author: KahnRené S, Winter van RossumInge, LeuchtStefan, McGuirePhilip, LewisShon W, LeboyerMarion, ArangoCelso, DazzanPaola, DrakeRichard, HeresStephan, Díaz-CanejaCovadonga M, RujescuDan, WeiserMark, GalderisiSilvana, GlenthøjBirte, EijkemansMarinus J C, FleischhackerW Wolfgang, KapurShitij, SommerIris E,

Schizophrenia remission
Simple treatment algorithm
Epileptic seizure
Psychotic symptoms
Suicide attempts

A simple treatment algorithm using sequential administration of amisulpride and clozapine achieved symptomatic remission in most patients in the early stages of schizophrenia. Switching to olanzapine did not improve outcome, suggesting that clozapine should be used after patients fail a single antipsychotic trial, not after two.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

135.

Occupational therapy delivered by specialists versus non-specialists for people with schizophrenia.

Author: MorrisKaren, ReidGraeme, SpencerSally

Improved schizophrenia treatment

Occupational therapy is a common add-on intervention for patients with schizophrenia, aiming to improve occupational function and participation rather than just symptom treatment. This review highlights the importance and impact of occupational therapy for individuals with schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

136.

Treatment resistant schizophrenia - review and a call to action.

Author: LallyJ, GaughranF

Clozapine
TRS treatment

Recovery rates for schizophrenia are not ideal, with about one-third of people not responding to standard treatments. Clozapine is the only proven treatment for treatment-resistant schizophrenia (TRS), but it's often used too late. Starting clozapine earlier might improve outcomes. Research suggests that treatment resistance can occur early on in psychosis. This review examines treatment-resistant schizophrenia, its prevalence, and treatment options, including the best use of clozapine and how to treat people who don't respond to clozapine.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

137.

Cognitive behavioural therapy plus standard care versus standard care plus other psychosocial treatments for people with schizophrenia.

Author: JonesChristopher, HackerDavid, MeadenAlan, CormacIrene, IrvingClaire B, XiaJun, ZhaoSai, ShiChunhu, ChenJue

Reduce distress

Cognitive behavioral therapy (CBT) is recommended as an add-on treatment for schizophrenia, but other less expensive psychosocial therapies are also available. This review assesses the efficacy of CBT for schizophrenia, comparing it to other psychosocial therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

138.

Maximizing response to first-line antipsychotics in schizophrenia: a review focused on finding from meta-analysis.

Author: SmithRobert C, LeuchtStefan, DavisJohn M

Improved schizophrenia treatment

This study discussed the selection of first-line antipsychotic treatment for patients with schizophrenia, considering the balance between differential efficacy and potential side effects of different psychotropic drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

139.

Cognitive behavioral therapy for social activation in recent-onset psychosis: Randomized controlled trial.

Author: PosKarin, FrankeNathalie, SmitFilip, WijnenBen F M, StaringAnton B P, Van der GaagMark, MeijerCarin, de HaanLieuwe, VelthorstEva, SchirmbeckFrederike

Improved psychotic disorder treatment

Negative symptoms in psychosis are difficult to treat and contribute to poor outcomes. A cognitive-behavioral approach has shown promise for people with chronic schizophrenia. This study investigates whether a combination of group and individual therapy focused on social engagement (CBTsa) could benefit people recently diagnosed with psychosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

140.

Cognitive-behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT.

Author: MorrisonAnthony P, PyleMelissa, GumleyAndrew, SchwannauerMatthias, TurkingtonDouglas, MacLennanGraeme, NorrieJohn, HudsonJemma, BoweSamantha, FrenchPaul, HuttonPaul, ByrneRory, SyrettSuzy, DudleyRobert, McLeodHamish J, GriffithsHelen, BarnesThomas Re, DaviesLinda, ShieldsGemma, BuckDeborah, TullySarah, KingdonDavid

Improved CRS treatment

There is limited evidence regarding the effectiveness of pharmacological or psychological interventions for clozapine-resistant schizophrenia (CRS), a condition that occurs in patients with inadequate response to clozapine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

141.

Haloperidol discontinuation for people with schizophrenia.

Author: EssaliAdib, TurkmaniKhaled, AboudamaahShaimaa, AbouDamaahAlaa, Diaa AldeenMohammad Reyad, MarwaMohamad Essam, AlMounayerNawar

Improved schizophrenia treatment

Haloperidol is effective in treating schizophrenia, but can have side effects. This review investigates the effects of stopping haloperidol in people with schizophrenia who are stable on their prescription.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

142.

[Efficacy of cognitive behavioural therapy in the treatment of psychosis: a meta-review].

Author: BarbieriAlberto, Visco-ComandiniFederica

CBT for psychosis

Cognitive behavioral therapy (CBT) was effective for treating psychosis, particularly positive symptoms. However, CBT did not show a clear advantage over other psychosocial therapies for symptom reduction, relapse prevention, social functioning, or quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Italian

143.

Prodopaminergic Drugs for Treating the Negative Symptoms of Schizophrenia: Systematic Review and Meta-analysis of Randomized Controlled Trials.

Author: SabeMichel, KirschnerMatthias, KaiserStefan

Prodopaminergic agents for negative symptoms

This meta-analysis of prodopaminergic agents for treating negative symptoms in schizophrenia found no significant effect overall. However, modafinil/armodafinil showed a small but significant effect in studies defining a minimum threshold for negative symptom severity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

144.

A systematic review of randomized controlled trials of psychoeducation interventions for patients diagnosed with schizophrenia.

Author: AlhadidiMajdi Mb, Lim AbdullahKhatijah, YoongTang Li, Al HadidLourance, DanaeeMahmoud

Schizophrenia treatment

Schizophrenia is a complex mental health condition. While medication is important, therapy can also play a vital role. Psychoeducation, which helps people understand their illness and how to manage it, is a recognized approach for people with schizophrenia, but we need more information about how it helps.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

145.

Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis.

Author: RubioJose M, SchoretsanitisGeorgios, JohnMajnu, TiihonenJari, TaipaleHeidi, GuinartDaniel, MalhotraAnil K, CorrellChristoph U, KaneJohn M

Improved schizophrenia treatment

This study aims to generate reliable estimates of the incidence and predictors of relapse during assured antipsychotic treatment for schizophrenia-spectrum disorders.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

146.

Schizophrenia.

Author: HasanAlkomiet, FalkaiPeter, LehmannIsabell, GaebelWolfgang

Reduced schizophrenia relapses

Antipsychotic drug treatment is recommended for acute schizophrenia with a number needed to treat (NNT) of 5 to 8. Ongoing treatment is recommended to prevent relapses (NNT: 3) and should be combined with psychotherapy and psychosocial therapy, such as cognitive behavioral therapy or psycho-education.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

147.

CBTp for people with treatment refractory schizophrenia on clozapine: a systematic review and meta-analysis.

Author: TodorovicAleksandar, LalSweta, DarkFrances, De MonteVeronica, KiselySteve, SiskindDan

Positive symptoms improvement

Cognitive behavioral therapy for psychosis (CBTp) may offer small benefits for positive symptoms refractory to clozapine in patients with treatment-refractory schizophrenia.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

148.

Dose-dependent effects of antipsychotics on efficacy and adverse effects in schizophrenia.

Author: YoshidaKazunari, TakeuchiHiroyoshi

Antipsychotic efficacy
Antipsychotic side effects

This narrative review summarizes current evidence on the dose-response relationship of antipsychotics in patients with schizophrenia. The review found that the efficacy of antipsychotics generally appeared to be highly dose-dependent in the acute phase of schizophrenia. The relationship between dose and adverse effects varied, with some being dose-related and others showing mixed findings. The review highlights the importance of balancing risks and benefits when optimizing antipsychotic treatment in patients with schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

149.

New Pharmacological Targets for the Treatment of Schizophrenia: A Literature Review.

Author: VentriglioAntonio, BellomoAntonello, RicciFabiana, MagnificoGiuseppe, RinaldiAngelo, BorraccinoLuisa, PiccininniCarla, CuocoFederica, GianfeliceGiulia, FornaroMichele, Delle MonacheSonia, De BerardisDomenico

Schizophrenia treatment

Schizophrenia is treated with antipsychotic medications that block dopamine and serotonin. However, 20-40% of people with schizophrenia don't respond well to these medications or continue to have symptoms. We need new ways to treat schizophrenia that can improve their thinking skills and daily functioning.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

150.

Strategies for Psychiatric Rehabilitation and their Cognitive Outcomes in Schizophrenia: Review of Last Five-year Studies.

Author: RampinoAntonio, FalconeRosa M, GiannuzziArianna, MasellisRita, AntonucciLinda A, TorrettaSilvia

Rehabilitative approaches for schizophrenia

This review discussed the need for individualized rehabilitative approaches to address cognitive deficits in individuals with schizophrenia. Cognitive deficits are a core feature of schizophrenia and often show poor response to antipsychotic treatment.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

151.

Structural and Functional MRI Brain Changes in Patients with Schizophrenia Following Electroconvulsive Therapy: A Systematic Review.

Author: JiangYuchao, DuanMingjun, HeHui, YaoDezhong, LuoCheng

ECT efficacy

Schizophrenia (SZ) is a serious mental disorder with complex symptoms. Electroconvulsive therapy (ECT) is used to treat SZ patients who don't respond to medications or experience severe symptoms. While ECT has been shown to be effective, how it works in the brain is not fully understood.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

152.

Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis.

Author: Schneider-ThomaJohannes, ChalkouKonstantina, DörriesCarola, BighelliIrene, CerasoAnna, HuhnMaximilian, SiafisSpyridon, DavisJohn M, CiprianiAndrea, FurukawaToshi A, SalantiGeorgia, LeuchtStefan

Schizophrenia treatment

This study aimed to compare the effectiveness and side effects of different antipsychotic medications used to prevent relapses in people with schizophrenia who are not resistant to treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

153.

Findings, limitations and new directions in tACS studies in schizophrenia research: A scoping review.

Author: FarcasAdriana, IfteneFelicia

tACS for SZ

Schizophrenia is a serious mental illness that significantly impacts individuals and their families. While current treatments have limitations, research is exploring non-invasive brain stimulation methods like transcranial alternating current stimulation (tACS) as a potential add-on to existing treatments for schizophrenia. tACS is considered safe and shows promise for improving outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

154.

Cariprazine for treating psychosis: an updated meta-analysis.

Author: GenerosoMarcelo B, TaiarIvan, CordeiroQuirino, ShiozawaPedro, KasperSiegfried

Reduced psychosis

This systematic review and meta-analysis evaluated the efficacy of cariprazine for acute psychosis, regardless of the primary psychiatric diagnosis. Cariprazine was found to be significantly superior to placebo in treating acute psychosis, including both schizophrenia and bipolar disorder. This suggests that cariprazine may be a valuable option for treating psychosis in patients with unclear diagnoses.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

155.

Comparison of Acute Followed by Maintenance ECT vs Clozapine on Psychopathology and Regional Cerebral Blood Flow in Treatment-Resistant Schizophrenia: A Randomized Controlled Trial.

Author: MishraBiswa Ranjan, AgrawalKanhaiyalal, BiswasTathagata, MohapatraDebadatta, NathSantanu, MaitiRituparna

Better perfusion
Improved function
Reduced symptoms
Side effects

This open-label trial compared the efficacy of maintenance electroconvulsive therapy (M-ECT) with clozapine for treatment-resistant schizophrenia (TRS). 60 TRS patients were randomly assigned to either M-ECT or clozapine. M-ECT demonstrated greater efficacy in reducing positive and negative symptoms, improving global functionality, and increasing regional cerebral perfusion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

156.

Effect of Integrated Psychobehavioral Care on Emotional-Behavioral Responses, Cognitive Changes in Outpatients with Schizophrenia Followed Up: Based on a Prospective Randomized Controlled Study.

Author: YaoYao, XuYali, GuoHongyan, HanKunxiu, DaiZhuo

Schizophrenia treatment

People are demanding better healthcare, and treating schizophrenia is increasingly important. While medications are used to treat schizophrenia, therapy can help people cooperate with their treatment and improve outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

157.

Systematic Review of Real-World Treatment Patterns of Oral Antipsychotics and Associated Economic Burden in Patients with Schizophrenia in the United States.

Author: MartinAmber, BessonovaLeona, HughesRachel, DoaneMichael J, O'SullivanAmy K, SnookKassandra, CichewiczAllie, WeidenPeter J, HarveyPhilip D

Improved schizophrenia treatment
High costs of care

This systematic review examined treatment patterns and associated costs of oral antipsychotics for schizophrenia. Olanzapine, risperidone, and quetiapine were the most frequently prescribed second-generation antipsychotics. Suboptimal adherence, switching, and augmentation were associated with increased costs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

158.

Antipsychotics for schizophrenia spectrum disorders with catatonic symptoms.

Author: HuangMichael W, GibsonRoger Carl, JayaramMahesh B, CaroffStanley N

Antipsychotics for catatonic schizophrenia

This review examines the efficacy and safety of antipsychotics for treating catatonic symptoms in schizophrenia. While antipsychotics are the mainstay of treatment for schizophrenia, their effectiveness in this specific subtype of the disorder needs further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

159.

Cognitive behavioural therapy (group) for schizophrenia.

Author: GuaianaGiuseppe, AbbatecolaMassimiliano, AaliGhazaleh, TarantinoFederica, EbuenyiIkenna D, LucariniValeria, LiWei, ZhangCaidi, PintoAntonio

CBTp for schizophrenia

This review explores the evidence for group cognitive behavioral therapy (CBTp) for treating psychotic symptoms in individuals with schizophrenia. CBTp is a promising add-on therapy to medication, but its effectiveness in group settings requires further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

160.

[Non-pharmacological therapies show effect in the treatment of schizophrenia].

Author: StarzerMarie Kejser, NordholmDorte, HansenHelene Gjervig, NordentoftMerete

Schizophrenia treatment

Schizophrenia requires both medication and therapy. Research suggests that family therapy, education about the illness, and cognitive behavioral therapy are particularly effective at preventing relapse and reducing symptoms. While these therapies are included in the Danish OPUS treatment program, many people with schizophrenia don't receive them, highlighting the need to prioritize access to these interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Danish

161.

Cognitive Enhancement Therapy vs social skills training in schizophrenia: a cluster randomized comparative effectiveness evaluation.

Author: SchuttRussell K, XieHaiyi, MueserKim T, KillamMatthew A, DelmanJonathan, EackShaun M, Mesholam-GatelyRaquelle, PrattSarah I, SandovalLuis, SantosMeghan M, GoldenLaura R, KeshavanMatcheri S

Social function improvement

This study compared the effectiveness of two treatments for improving social and community functioning in patients with schizophrenia and related disorders: Cognitive Enhancement Therapy (CET) and a version of Social Skills Training (HOPES/SST).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

162.

Effects of clozapine treatment on the improvement of substance use disorders other than nicotine in individuals with schizophrenia spectrum disorders: A systematic review and meta-analysis.

Author: RafizadehReza, DanilewitzMarlon, BousmanChad A, MathewNickie, WhiteRandall F, BahjiAnees, HonerWilliam G, SchützChristian G

Reduced overall mortality
Reduced psychiatric hospitalization

This study examines the potential benefits of antipsychotic medications, particularly clozapine, in improving comorbid substance use disorders in patients with schizophrenia.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

163.

Systematic review and meta-analysis on predictors of prognosis in patients with schizophrenia spectrum disorders: An overview of current evidence and a call for prospective research and open access to datasets.

Author: van DeeViolet, SchnackHugo G, CahnWiepke

SSD treatment

This study discussed the importance of identifying predictors of outcome in schizophrenia spectrum disorders (SSD) to personalize and optimize treatment.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

164.

[Towards personalized treatment with clozapine].

Author: Okhuijsen-PfeiferC, van der HorstM Z, LuykxJ J

Clozapine efficacy
Agranulocytosis
Neutropenia

A meta-analysis of over 800 clozapine users diagnosed with a schizophrenia spectrum disorder found that clozapine was more effective when used as a first- or second-line treatment. Younger age, less negative symptoms, and the paranoid subtype of schizophrenia were associated with a better response. Genetic associations were identified for clozapine-induced agranulocytosis and neutropenia, and polygenic risk scores were associated with symptom severity.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Dutch

165.

Psychosocial and behavioural interventions for the negative symptoms of schizophrenia: a systematic review of efficacy meta-analyses.

Author: CellaMatteo, RobertsSafina, PillnyMatthias, RiehleMarcel, O'DonoghueBrian, LyneJohn, TomlinPaul, ValmaggiaLucia, PretiAntonio

Negative symptom reduction

This meta-analytic study examined the evidence for psychosocial and behavioral interventions used to reduce the burden of negative symptoms in schizophrenia, which currently lacks a first-line treatment for this symptom.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

166.

Clinical insight among persons with schizophrenia spectrum disorders treated with amisulpride, aripiprazole or olanzapine: a semi-randomised trial.

Author: StabellL A, JohnsenE, KrokenR A, LøbergE M, BlindheimA, JoaI, ReitanS K, RettenbacherM, Munk-JørgensenP, GjestadR

Improved clinical insight

Antipsychotics may improve clinical insight in people with schizophrenia spectrum disorders, but more research is needed, especially in mixed populations of first- and multiepisode patients.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

167.

Non-Psychosis Symptoms of Clozapine Withdrawal: a Systematic Review.

Author: YeeB, LooiJ C L, AgaciakM, AllisonS, ChanS K W, BastiampillaiT

Improved psychosis
Withdrawal symptoms

Non-psychosis symptoms following clozapine withdrawal are common, and clinicians should be aware of these symptoms to ensure early recognition and management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

168.

Cognitive behavioural therapy plus standard care versus standard care for persistent aggressive behaviour or agitation in people with schizophrenia.

Author: BallesterosJavier, Moreno-CalveteMaria Concepcion, Santos-ZorrozúaBorja, González-FraileEduardo

Reduced aggression

This study investigates the frequency and variability of violent episodes in people with schizophrenia who have chronic aggression. The study also explores the potential benefits of cognitive behavioral therapy (CBT) in managing aggressive behaviors in this population.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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