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Effects of fexofenadine and desloratadine on subjective and objective measures of nasal congestion in seasonal allergic rhinitis.

Author: HaggartK, LipworthB J, SimsE J, WilsonA M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Recommended once-daily doses of fexofenadine and desloratadine are equally effective in improving nasal peak flow and nasal symptoms in seasonal allergic rhinitis (SAR). Both treatments significantly improve nasal flow, reduce nasal blockage and irritation, and alleviate total nasal symptoms, although neither drug shows significant effects on nasal discharge or eye symptoms.
Paper Details　
Original Abstract of the Article :
BACKGROUND: In vitro studies have shown much higher H1-receptor antagonist potency with desloratadine (DL) compared to fexofenadine (FEX), although it is unclear whether this has any clinical relevance on disease control parameters in seasonal allergic rhinitis (SAR), especially for nasal congestion...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2745.2002.01509.x

データ提供：米国国立医学図書館（NLM）

Fexofenadine and Desloratadine: A Head-to-Head Match in Seasonal Allergies

This research investigates the effectiveness of two common [antihistamine medications]—[fexofenadine and desloratadine]—in managing [seasonal allergic rhinitis]. The study employed a [double-blind, placebo-controlled cross-over design] and focused on assessing the impact of these medications on [nasal congestion and other allergy symptoms]. The key finding is that [both fexofenadine and desloratadine were equally effective in improving nasal peak flow and nasal symptoms] in patients with seasonal allergic rhinitis. This suggests that both drugs are viable options for managing this common allergy.

Choosing the Right Antihistamine: Navigating the Desert of Allergy Choices

The study's findings are like a guiding compass in the desert of allergy treatments, pointing toward the equal effectiveness of fexofenadine and desloratadine. While both medications provide relief from allergy symptoms, the choice between them may be influenced by factors such as [cost, side effect profile, and individual patient preferences].

Navigating Seasonal Allergies: A Guide for the Desert Traveler

For those battling seasonal allergies, knowing that both fexofenadine and desloratadine can effectively alleviate nasal congestion and other allergy symptoms can be a relief. This is like discovering a hidden oasis in the midst of a sandstorm. However, remember that [consulting with a healthcare professional is essential] for proper diagnosis, treatment, and management of allergies.

Dr.Camel's Conclusion

Finding the perfect antihistamine for seasonal allergies can feel like searching for a needle in a haystack. But this study sheds light on the effectiveness of fexofenadine and desloratadine, offering hope for those seeking relief from allergy symptoms. Like a wise traveler navigating a desert, remember to consult your healthcare provider to find the best solution for you.
Date :
  1. Date Completed 2003-03-25
  2. Date Revised 2019-09-01
Further Info :

Pubmed ID

12372132

DOI: Digital Object Identifier

10.1046/j.1365-2745.2002.01509.x

Related Literature

Article Analysis
・Effects of desloratadine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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