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Cardiovascular effects of ophthalmic 0.5% timolol aqueous solution and 0.1% timolol hydrogel.

Author: Hutri-KähönenN, KailaT, KuuselaT, KähönenM, NiñoJ, RopoA, TahvanainenK, TurjanmaaV, UusitaloH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Timolol aqueous solution (0.5%) decreased heart rate by 3 bpm in supine position and by 7 bpm in head-up tilted position, while timolol hydrogel (0.1%) had no significant effects on heart rate. The aqueous solution also slightly decreased QTc and increased atrioventricular conduction during tilt tests, suggesting more pronounced cardiac beta-blocking effects compared to the hydrogel.
Paper Details　
Original Abstract of the Article :
The objective of this randomized, double-masked, cross-over study was to compare the cardiovascular effects of two glaucoma formulations, ophthalmic 0.5% timolol aqueous solution and 0.1% timolol hydrogel. Twenty-four young healthy subjects received for 2 weeks either twice daily 0.5% timolol soluti...See full text at original site
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引用元：
https://doi.org/10.1046/j.1475-097x.2002.00430.x

データ提供：米国国立医学図書館（NLM）

Timolol: Navigating the Cardiovascular Effects of Glaucoma Medications

This study examines the cardiovascular effects of two glaucoma medications, timolol aqueous solution and timolol hydrogel. It's like navigating a treacherous desert, where different pathways lead to varying outcomes. The researchers conduct a randomized, double-masked, cross-over study to carefully compare the effects of these two formulations on heart rate, blood pressure, and other cardiovascular parameters. The study's findings suggest that the aqueous solution produces more pronounced cardiac beta-blocking effects than the hydrogel formulation.

A Careful Approach to Glaucoma Treatment

The study's findings highlight the importance of carefully considering the potential cardiovascular effects of glaucoma medications. It's like choosing the right camel for a long desert journey, where the best choice depends on the specific needs and terrain. Healthcare providers should work closely with patients to select the most appropriate treatment option, minimizing potential risks and maximizing benefits. This study provides valuable insights into the complex interplay between glaucoma medications and cardiovascular health.

Glaucoma and Cardiovascular Health: A Delicate Balance

Glaucoma, a condition that affects the optic nerve, can lead to vision loss if left untreated. It's like a slow-moving sandstorm, gradually eroding the landscape of vision. While glaucoma medications are essential for preserving vision, it's important to be aware of their potential side effects and to work closely with your healthcare provider to manage any risks. This study serves as a reminder of the delicate balance between treating glaucoma and protecting cardiovascular health.

Dr. Camel's Conclusion

This study is a reminder that even in the seemingly straightforward world of glaucoma treatment, there are complex considerations to navigate. It highlights the importance of carefully selecting medications and monitoring for potential cardiovascular side effects. It's a journey that requires a collaborative effort between patients and healthcare providers, ensuring a safe and effective path to preserving vision.

Date :
  1. Date Completed 2003-02-04
  2. Date Revised 2019-11-06
Further Info :

Pubmed ID

12402450

DOI: Digital Object Identifier

10.1046/j.1475-097x.2002.00430.x

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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