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The anatomy of a clinical trial. The West of Scotland Coronary Prevention Study.

Author: , GawA, ShepherdJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Before the development of statins, treatment for high cholesterol to prevent heart disease had limited success. Studies using clofibrate, cholestyramine, and gemfibrozil showed only small reductions in heart events and did not improve overall survival or reduce cardiovascular deaths. Concerns also arose about possible links between cholesterol lowering and cancer or aggressive behavior. This led to the need to investigate whether statins could be effective in preventing heart attacks.
Paper Details　
Original Abstract of the Article :
Treatment of hyperlipidemia to reduce the risk of ischemic heart disease was, prior to the statin era, disappointingly limited in its ability to yield the benefits expected from the strong relationship known to exist between serum cholesterol and coronary death. Three primary prevention trials, usin...See full text at original site
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引用元：
https://doi.org/10.1159/000066408

データ提供：米国国立医学図書館（NLM）

The West of Scotland Coronary Prevention Study: A Groundbreaking Clinical Trial

The study of cardiovascular disease is a vast and ever-evolving field, with numerous clinical trials conducted to uncover effective preventative and therapeutic strategies. This article delves into the historical context of the West of Scotland Coronary Prevention Study, a groundbreaking clinical trial that paved the way for the use of statins in preventing ischemic heart disease. The study, much like a camel caravan traversing a vast and unforgiving desert, sought to determine the effectiveness of statins in reducing the risk of heart disease.

Paving the Way for Statin Therapy: The West of Scotland Coronary Prevention Study

The West of Scotland Coronary Prevention Study played a pivotal role in establishing the effectiveness of statins in preventing ischemic heart disease. This research, much like a camel caravan discovering a new and fertile oasis in the desert, transformed the landscape of cardiovascular disease management. The study's findings provided strong evidence supporting the use of statins for primary prevention of heart disease, contributing significantly to the advancement of cardiovascular health.

The Oasis of Cardiovascular Health: Strategies for Prevention

Individuals seeking to reduce their risk of cardiovascular disease should consult with a healthcare professional to discuss appropriate lifestyle modifications and potential medications. This approach, much like a camel seeking a safe and sustainable route through the desert, requires a multifaceted approach, incorporating healthy dietary habits, regular exercise, and appropriate medical interventions.

Dr.Camel's Conclusion

The West of Scotland Coronary Prevention Study stands as a testament to the importance of rigorous clinical research in advancing medical knowledge. It's like a landmark discovery in the vast desert, guiding us towards a better understanding of cardiovascular disease and its prevention. The study's findings have had a profound impact on cardiovascular health, leading to the widespread use of statins for primary prevention of heart disease. This research serves as a reminder of the vital role of clinical trials in improving health outcomes and shaping the future of medicine.

Date :
  1. Date Completed 2003-04-10
  2. Date Revised 2017-11-01
Further Info :

Pubmed ID

12444307

DOI: Digital Object Identifier

10.1159/000066408

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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