Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines.

Author: HattoriTakanori, KashimaKei, MitsufujiShoji, NodaMasao, SugiharaHiroyuki, TakamaTakafumi, TatsumiYoichi, TomizawaMuneta

Paper Details 
Original Abstract of the Article :
Recent studies have shown that cyclooxygenase-2 (COX-2) inhibitors may participate in the proliferation of cancer cells. Because the cadherin-catenin complex is not only a key component of the adherens junction but also has been suggested to regulate cell proliferation, modulation of these molecules...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1007/s005350200151

データ提供:米国国立医学図書館(NLM)

Effects of Etodolac, a Selective Cyclooxygenase-2 Inhibitor, on the Expression of E-Cadherin-Catenin Complexes in Gastrointestinal Cell Lines

The intricate world of gastrointestinal cells is like a bustling desert city, where the E-cadherin-catenin complex acts as a vital regulatory system for cell growth and adhesion. This study explores the effects of etodolac, a selective cyclooxygenase-2 (COX-2) inhibitor, on this crucial complex, examining its potential impact on the city's development.

Etodolac: A Potential Influence on Cell Growth

The study found that etodolac can modulate the expression of the E-cadherin-catenin complex in gastrointestinal cell lines. It's like introducing a new desert plant that can influence the city's growth and development, possibly influencing the balance of cell growth and adhesion. The study's findings suggest a potential link between COX-2 inhibition and cell proliferation, highlighting a new area of research in gastrointestinal cell biology.

Understanding the Complexities of Cell Regulation

This research underscores the complex interplay of different molecules and pathways within cells. Understanding the intricate workings of the desert city of gastrointestinal cells is crucial for developing new therapies to combat diseases affecting this vital organ system.

Dr.Camel's Conclusion

This study offers a glimpse into the fascinating and complex world of cellular regulation. Just like a desert oasis, the gastrointestinal system is a delicate balance of intricate pathways and interactions. The study's findings highlight the importance of further research to understand the potential influence of COX-2 inhibitors on cell growth and development, contributing to a deeper understanding of this vital organ system.

Date :
  1. Date Completed 2003-03-12
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

12483244

DOI: Digital Object Identifier

10.1007/s005350200151

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.