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Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors.
Author: KellyCurtis R, SharifNajam A, WilliamsGary W
Original Abstract of the Article :
The ability of a number of prostaglandin F 2 alpha (PGF 2 alpha) analogs to mobilize intracellular Ca2+[Ca2+]iand to compete for [3H]PGF 2 alpha binding to prostaglandin F 2 alpha receptors (FP) was evaluated. Radioligand binding studies measuring displacement of [3H]PGF 2 alpha by a variety of FP p...See full text at original site
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引用元：
https://doi.org/10.1124/jpet.102.042556
データ提供：米国国立医学図書館（NLM）
Prostaglandin F2α Analogs: A Desert Oasis for Intraocular Pressure
Prostaglandin F2α (PGF2α) analogs are widely used to lower intraocular pressure in patients with glaucoma. This article investigates the ability of a number of PGF2α analogs, including travoprost acid, bimatoprost, and unoprostone, to mobilize intracellular calcium ([Ca2+]i) via endogenous mouse, rat, and cloned human FP prostaglandin receptors. The authors highlight the potency of these analogs at the FP receptor and their potential for treating glaucoma.
Travoprost Acid: A Potential Oasis in the Desert of Glaucoma Treatment
The study findings suggest that travoprost acid is the most potent of the synthetic FP prostaglandin analogs tested, demonstrating its potential for effectively lowering intraocular pressure. The authors also highlight the potency of other PGF2α analogs, such as bimatoprost and unoprostone, at the FP receptor, supporting their use as glaucoma treatments.
Prostaglandin F2α Analogs: A Deep Dive into the Desert of Glaucoma Research
This study underscores the importance of understanding the mechanisms of action of PGF2α analogs in the context of glaucoma treatment. The authors highlight the potential of these analogs for effectively lowering intraocular pressure and for improving outcomes for patients with glaucoma. The study also provides valuable insights into the relative potencies of different PGF2α analogs, contributing to our understanding of the optimal treatment strategies for glaucoma.
Dr.Camel's Conclusion
This study provides a comprehensive analysis of the ability of PGF2α analogs to mobilize intracellular calcium via FP prostaglandin receptors. The authors highlight the potential of these analogs for effectively lowering intraocular pressure and for improving outcomes for patients with glaucoma. The study also provides valuable insights into the relative potencies of different PGF2α analogs, contributing to our understanding of the optimal treatment strategies for glaucoma.
Date :
- Date Completed 2003-01-23
- Date Revised 2017-11-16
Further Info :
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