Effects of bimatoprost ophthalmic: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major Research Findings

Bimatoprost is an ophthalmic solution that has been shown to be effective in lowering intraocular pressure in patients with glaucoma or ocular hypertension. 19 , 14 In addition to lowering intraocular pressure, bimatoprost has also been shown to promote eyelash growth. 17 , 15 , 13 , 11 Bimatoprost can also improve the appearance of the periorbital area, beyond eyelash enhancement. 7 Bimatoprost has shown potential effectiveness in treating alopecia areata. , 10 Bimatoprost has shown potential effectiveness in treating vitiligo. 4 , 3 , 1

Benefits and Risks

Benefits Summary

Bimatoprost is an effective treatment for glaucoma and ocular hypertension, lowering intraocular pressure. 19 , 14 It also promotes eyelash growth, which can be beneficial for individuals concerned about eyelash appearance. 17 , 15 , 13 , 11 Additionally, bimatoprost may improve the appearance of the periorbital area. 7 Bimatoprost has shown potential effectiveness in treating alopecia areata. , 10 Bimatoprost has shown potential effectiveness in treating vitiligo. 4 , 3 , 1

Risks Summary

Bimatoprost may cause side effects such as changes in eyelid color, eyelid swelling, and eye redness. 5 , 2

Comparison of Studies

Similarities

Many studies have found that bimatoprost is effective in lowering intraocular pressure and promoting eyelash growth.

Differences

The reported incidence and types of side effects vary between studies. 18 , 5 , 2 Additionally, the application site and method of administration of bimatoprost differ between studies. 17 , 7 , 4 , 3

Consistency and Contradictions of Findings

There is consistency in findings across multiple studies regarding the effectiveness of bimatoprost in lowering intraocular pressure and promoting eyelash growth. However, there are some inconsistencies in the reported incidence and types of side effects across studies.

Considerations for Real-Life Application

It is important to use bimatoprost as directed by your doctor. In particular, pregnant or breastfeeding women should consult their doctor before using bimatoprost.

Limitations of Current Research

There is a need for more research on the long-term safety of bimatoprost. Additionally, further investigation is required to understand how bimatoprost is absorbed and metabolized in the body.

Future Research Directions

Further research on the long-term safety of bimatoprost and its absorption and metabolism is needed. Research on new methods of administration and formulations to enhance the efficacy of bimatoprost is also essential.

Conclusion

Bimatoprost has been shown to be effective in lowering intraocular pressure and promoting eyelash growth. However, the potential for side effects exists, so it is important to use bimatoprost as directed by your doctor.

Literature analysis of 22 papers
Positive Content
21
Neutral Content
0
Negative Content
1
Article Type
7
0
0
4
22
1.

The efficacy of bimatoprost ophthalmic solution combined with NB-UVB phototherapy in non-segmental and segmental vitiligo: a single-blind randomized controlled study.

Author: Silpa-ArchaNarumol, LikittanasombatSurachanee, ApinunthamChalermkwan, PruksaeakananChutipon, CharoenpipatsinNorramon, ChaiyabutrChayada, WongpraparutChanisada

Safe treatment
Vitiligo treatment

Bimatoprost ophthalmic solution combined with narrowband ultraviolet B (NB-UVB) phototherapy has shown promise in treating vitiligo. This study compared the efficacy and safety of bimatoprost combined with NB-UVB, bimatoprost monotherapy, and placebo in Thai patients with vitiligo. The study found that bimatoprost combined with NB-UVB was safe and effective for treating non-segmental vitiligo in non-face/neck areas, offering a promising treatment option for patients with this condition.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Clinical outcomes of topical bimatoprost for nonsegmental facial vitiligo: A preliminary study.

Author: KanokrungseeSilada, PruettivorawongseDuangrat, RajatanavinNatta

vitiligo treatment
burning
itching

This study investigated the efficacy and safety of bimatoprost ophthalmic solution compared to tacrolimus ointment for treating nonsegmental facial vitiligo. Both treatments showed significant improvement in vitiligo surface area and repigmentation, with comparable results. Bimatoprost was found to be safe and can be considered an alternative treatment option for facial vitiligo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Bimatoprost ophthalmic solution in facial vitiligo.

Author: JhaAbhijeet K, PrasadSmita, SinhaRajesh

Repigmentation

Bimatoprost seems to be promising in treating stable vitiligo, but large-scale studies are required.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Management of hypotrichosis of the eyelashes: focus on bimatoprost.

Author: FagienSteven

Eyelash growth

Applying bimatoprost ophthalmic solution 0.03% to the upper eyelid margin safely and effectively enhances eyelash growth, increasing length, thickness, and darkness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Bimatoprost-induced chemical blepharoplasty.

Author: SarnoffDeborah S, GotkinRobert H

Improved appearance
Rejuvenating effect
Periorbital disfigurement

Topical application of bimatoprost ophthalmic solution (Latisse) can improve the appearance of the periorbital area beyond just eyelash enhancement. This effect is being explored as a potential "chemical blepharoplasty", but it is important to be aware of the risk of periorbital disfigurement.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Long-term safety and efficacy of bimatoprost solution 0·03% application to the eyelid margin for the treatment of idiopathic and chemotherapy-induced eyelash hypotrichosis: a randomized controlled trial.

Author: GlaserD A, HossainP, PerkinsW, GriffithsT, AhluwaliaG, WengE, BeddingfieldF C

Hypotrichosis treatment

This multicenter, double-masked, randomized study of 127 patients with idiopathic or chemotherapy-induced hypotrichosis found that daily treatment with bimatoprost ophthalmic solution 0.03% for 1 year was effective and well tolerated. Treatment effects were maintained for approximately 2 months after treatment cessation in patients with idiopathic hypotrichosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

A retrospective review and observational study of outcomes and safety of bimatoprost ophthalmic solution 0.03% for treating eyelash hypotrichosis.

Author: YoelinSteven G, FagienSteven, CoxSue Ellen, DavisPaula G, CampoAntoinette, CaulkinsCarrie A, GallagherConor J

Hypotrichosis treatment
AEs

A retrospective chart review of 585 patients with hypotrichosis found that treatment with bimatoprost 0.03% for at least 12 months was safe and associated with high patient satisfaction. No instances of iris hyperpigmentation occurred.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Safety and efficacy of bimatoprost solution 0.03% topical application in patients with chemotherapy-induced eyelash loss.

Author: AhluwaliaGurpreet S

Restores eyelash growth
Well tolerated

This study investigated the efficacy and safety of bimatoprost 0.03% solution for treating eyelash loss in patients who had undergone chemotherapy. Bimatoprost restored eyelash growth and prominence more quickly than placebo, demonstrating its effectiveness in restoring eyelash appearance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Patient-reported outcomes of bimatoprost for eyelash growth: results from a randomized, double-masked, vehicle-controlled, parallel-group study.

Author: FagienSteven, WaltJohn G, CarruthersJean, CoxSue Ellen, WirtaDavid, WengEmily, BeddingfieldFrederick C

Eyelash growth

Bimatoprost ophthalmic solution 0.03% has been associated with increased eyelash prominence.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Clinical management of trichotillomania with bimatoprost.

Author: PeabodyTodd, ReitzSarah, SmithJedidiah, TetiBrittany

Eyelash growth

This case report presents the use of bimatoprost 0.03% to regrow eyelashes in a patient with trichotillomania. Topical bimatoprost may be a helpful treatment option for patients who pull their eyelashes, as it can increase eyelash growth, length, thickness, and darkness.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Treatment of eyebrow hypotrichosis using bimatoprost: a randomized, double-blind, vehicle-controlled pilot study.

Author: BeerKenneth R, JuliusHillary, DunnMonica, WilsonFred

Eyebrow growth
Improved appearance
No side effects

Bimatoprost 0.03% ophthalmic solution applied daily for 9 months improved the appearance of eyebrows noticeably more than vehicle, without side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Enhancing the growth of natural eyelashes: the mechanism of bimatoprost-induced eyelash growth.

Author: CohenJoel L

Darker lashes
Fuller lashes
Longer lashes
Thicker lashes

The study found that bimatoprost ophthalmic solution 0.03% is a safe and effective means of enhancing eyelash growth by influencing the eyelash hair cycle and follicles.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Aqueous humor concentrations of bimatoprost free acid, bimatoprost and travoprost free acid in cataract surgical patients administered multiple topical ocular doses of LUMIGAN or TRAVATAN.

Author: FaulknerRobert, SharifNajam A, OrrSusan, SallKenneth, DubinerHarvey, WhitsonJess T, MosterMarlene, CravenE Randy, CurtisMichael, PailliotetCynthia, MartensKimberly, DahlinDavid

This study quantified the aqueous humor (AH) concentrations of bimatoprost (amide), travoprost (isopropyl ester), and their hydrolysis products, bimatoprost free acid (BFA) and travoprost free acid (TFA), after multiple topical ocular doses of LUMIGAN and TRAVATAN, respectively, in patients awaiting cataract surgery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Bimatoprost: a pharmacoeconomic review of its use in open-angle glaucoma and ocular hypertension.

Author: PloskerGreg L, KeamSusan J

Cost-effective
IOP reduction
Conjunctival hyperemia

Bimatoprost, a prostamide analogue, was shown to be more effective than timolol, latanoprost, or travoprost in reducing intraocular pressure in patients with glaucoma or ocular hypertension. While bimatoprost was associated with a higher incidence of conjunctival hyperemia, cost-effectiveness analyses indicated that it was less expensive than other treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Estimated comparative costs of achieving a 20% reduction in intraocular pressure with bimatoprost or latanoprost in patients with glaucoma or ocular hypertension.

Author: FiscellaRichard, WaltJohn

Glaucoma treatment
Ocular hypertension treatment

This study compared the cost effectiveness of bimatoprost with that of latanoprost in the treatment of glaucoma and ocular hypertension.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Ocular effects of topical 0.03% bimatoprost solution in normotensive feline eyes.

Author: RegnierAlain, LemagneCapucine, PonchetAlice, CazalotGuillaume, ConcordetDidier, GelattKirk N

Miosis

Topical bimatoprost produced miosis but had no significant effect on intraocular pressure (IOP) in healthy cats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Unilateral trichomegaly induced by bimatoprost ophthalmic solution.

Author: HempsteadNancy, HempsteadRichard W

Unilateral trichomegaly

This case report describes an 80-year-old woman with unilateral trichomegaly, a rare condition characterized by excessive hair growth on one side of the body.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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