Paper Details

  1. Home
  2. Paper Details

QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.

Author: BereczRoland, DoradoPedro, LLerenaAdrián, de la RubiaAlfredo

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The QTc interval was prolonged in patients receiving thioridazine, a medication used to treat psychiatric disorders. This lengthening was correlated with thioridazine dose and plasma concentration. Patients with impaired CYP2D6 enzyme activity may be at higher risk for QTc prolongation and associated cardiac dysrhythmias.
Paper Details　
Original Abstract of the Article :
Thioridazine cardiotoxicity has been associated with a prolonged heart-rate corrected QT (QTc) interval. However, no systematic studies have been performed on patients at therapeutic doses. The present study aimed to evaluate the influence of dose and plasma concentration of thioridazine and CYP2D6 ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1177/026988110201600411

データ提供：米国国立医学図書館（NLM）

The Complex Relationship Between Thioridazine and QTc Interval

This study investigates the relationship between the antipsychotic medication thioridazine and the QTc interval, a measure of the time it takes for the heart's electrical system to recharge after a heartbeat. The study explores the influence of thioridazine's dose, plasma concentration, and the patient's genetic makeup on the QTc interval. This research is significant because prolonged QTc intervals can increase the risk of dangerous heart rhythms.

Thioridazine's Impact on QTc Interval: A Complex Puzzle

The study reveals a complex relationship between thioridazine and QTc interval, with both dose and plasma concentration playing a role. The study also found that patients with impaired CYP2D6 enzyme activity, a key enzyme involved in metabolizing thioridazine, were more likely to experience prolonged QTc intervals. This research underscores the importance of individualizing treatment based on a patient's genetic makeup, as this can influence their response to medication.

Navigating the Risks of Thioridazine: A Case for Personalized Medicine

This study highlights the importance of personalized medicine in managing patients with mental health conditions. The research suggests that the risk of thioridazine-induced QTc interval prolongation is influenced by genetic factors, highlighting the need for careful monitoring and potentially adjusting medication doses based on individual patient characteristics. This research emphasizes the importance of individualizing treatment strategies to minimize the risk of potential side effects.

Dr. Camel's Conclusion

This study underscores the importance of understanding the complex interplay between medications and genetic factors in determining individual responses to treatment. It highlights the need for a personalized approach to medication management to minimize the risk of potential side effects and ensure patient safety.

Date :
  1. Date Completed 2003-05-19
  2. Date Revised 2017-02-14
Further Info :

Pubmed ID

12503836

DOI: Digital Object Identifier

10.1177/026988110201600411

Related Literature

Article Analysis
・Effects of mesoridazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.