Effects of mesoridazine: A Synthesis of Findings from 27 Studies

  1. Home
  2. Effects of mesoridazine
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of mesoridazine: A Synthesis of Findings from 27 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of mesoridazine: A Synthesis of Findings from 27 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Mesoridazine is a phenothiazine antipsychotic drug that has been used to treat mental illness. 26 reports on the effectiveness of mesoridazine in the treatment of schizophrenia and other psychiatric disorders. 19 studies the interaction of mesoridazine and other phenothiazines with carbamazepine, finding that carbamazepine accelerates the metabolism of these neuroleptics, except for perazine. 7 suggests that mesoridazine can prolong the QT interval of the heart, which can increase the risk of arrhythmias and sudden death. 11 shows that mesoridazine can act as a partial agonist at dopamine receptors. 1 indicates that mesoridazine can stimulate the rat organic cation transporter 2, but not its human ortholog. 3 suggests that mesoridazine can photodegrade, producing transformation products that may persist in the environment and have potential ecotoxicity.

Benefits and Risks

Benefits Summary

Mesoridazine has been shown to be effective in treating mental illnesses such as schizophrenia. 26 highlights its effectiveness compared to other antipsychotics. Mesoridazine may have fewer side effects, such as movement disorders, compared to other antipsychotics. 22 shows that mesoridazine can enhance latent inhibition, a cognitive process involved in focusing attention. Mesoridazine may have analgesic properties. 5 suggests this effect.

Risks Summary

Mesoridazine can affect the heart's electrical activity and prolong the QT interval. 7 This can increase the risk of arrhythmias and sudden death. Mesoridazine may be more likely to prolong the QT interval in patients with low potassium levels. 8 explains this risk. Mesoridazine can inhibit gap junctions, which are important for cell-to-cell communication. 9 reports on this inhibition. Mesoridazine may alter serotonin receptor activity. 16 This could lead to mental health problems. Mesoridazine can act as an inverse agonist at serotonin 2C receptors. 17 Mesoridazine can photodegrade, producing transformation products that may persist in the environment and have potential ecotoxicity. 3

Comparison between Studies

Similarities

Mesoridazine has been shown to be effective in treating mental illness. 26 22 Mesoridazine can affect dopamine receptor activity. 11 Mesoridazine can affect the heart's electrical activity. 7 8

Differences

Mesoridazine may affect serotonin receptor activity. 16 However, it can also act as an inverse agonist at serotonin 2C receptors. 17 1 suggests that mesoridazine can stimulate the rat organic cation transporter 2. 3 indicates that mesoridazine can photodegrade.

Consistency and Discrepancies

Mesoridazine is an effective treatment for mental illness. 26 However, it can prolong the QT interval of the heart. 7 8 The mechanism of action of mesoridazine on serotonin receptor activity remains unclear. 16 17 Mesoridazine can photodegrade and generate transformation products that may persist in the environment. 3

Real-World Application Considerations

While mesoridazine can be an effective treatment for mental illness, it is important to consider the potential risks associated with its use. 26 The drug can prolong the QT interval, leading to an increased risk of arrhythmias and sudden death. 7 8 Monitoring the heart's health is crucial while taking mesoridazine. 3 highlights the environmental concerns with mesoridazine and its potential to persist in the environment. It's essential to minimize environmental impact.

Limitations of Current Research

More research is needed to fully understand the effects of mesoridazine. 26 Further studies should focus on the drug's effects on the heart and its environmental impact. 7 3 Larger studies with more participants are also necessary for a more comprehensive understanding of mesoridazine's effects.

Future Research Directions

Further research is required to better understand mesoridazine's effects, especially its effects on the heart. 7 8 Research focusing on the environmental impact of mesoridazine is also needed. 3 Additionally, more research on mesoridazine's side effects and its interaction with other medications is necessary.

Conclusion

Mesoridazine can be an effective treatment for mental illness, but it is important to consider the potential risks associated with its use. 26 The drug can affect the heart's electrical activity and prolong the QT interval, potentially increasing the risk of arrhythmias and sudden death. 7 8 The mechanism by which mesoridazine affects serotonin receptor activity is not fully understood. 16 17 3 Additionally, the drug can photodegrade and generate transformation products that may persist in the environment. Monitoring heart health is crucial during mesoridazine treatment. It is essential to minimize the environmental impact of the drug. Further research is necessary to gain a complete understanding of the effects of mesoridazine.

Literature analysis of 27 papers
Positive Content
12
Neutral Content
2
Negative Content
13
Article Type
1
0
0
2
27
1.

The conditional stimulation of rat organic cation transporter 2, but not its human ortholog, by mesoridazine: the possibility of the involvement of the high-affinity binding site of the transporter in the stimulation.

Author: HyungSungwoo, PyeonWonji, ParkJi Eun, SongYoo-Kyung, ChungSuk-Jae

Drug interaction insight

Mesoridazine may conditionally stimulate rOCT2, but not hOCT2. This may be of practical relevance as OCT2 is involved in some drug-drug interactions.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

A subset of N-substituted phenothiazines inhibits NADPH oxidases.

Author: SeredeninaTamara, ChirianoGianpaolo, FilippovaAleksandra, NayerniaZeynab, MahioutZahia, Fioraso-CartierLaetitia, PlastreOlivier, ScapozzaLeonardo, KrauseKarl-Heinz, JaquetVincent

NOX inhibition

This study investigated the effects of 10 phenothiazine compounds on the activity of NADPH oxidases (NOXs), enzymes that generate reactive oxygen species. The study found that certain phenothiazines, particularly those with an aliphatic amine chain on the nitrogen atom of the B ring, exhibited inhibitory activity towards NOX enzymes. These findings suggest that phenothiazines may have potential as therapeutic agents in treating conditions associated with oxidative stress.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Determination of mesoridazine by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats.

Author: ImSo Hee, ParkMyoung Joo, SeoHyewon, ChoiSung Heum, KimSang Kyum, AhnSung-Hoon

Pharmacokinetic studies

This study describes a validated LC-MS/MS method for quantifying mesoridazine in rat plasma. The method showed good linearity, accuracy, and precision, making it suitable for pharmacokinetic and toxicokinetic studies of mesoridazine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Validation StudyResearch to assess the validity and reliability of new measurement methods or diagnostic tests.

Language : English

5.

Phenothiazine-type antipsychotics elicit cutaneous analgesia in rats.

Author: ChenYu-Wen, ChuChin-Chen, ChuKoung-Shing, ShiehJa-Ping, ChienChih-Chiang, WangJhi-Joung, KaoCheng-Hsing

Analgesic effect

Phenothiazine-type antipsychotics, like chlorpromazine, are known to block sodium channels in the nervous system. This study investigates whether these drugs have analgesic effects on the skin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients.

Author: AparasuRajender R, JanoElda, JohnsonMichael L, ChenHua

Antipsychotic adverse effects

Antipsychotic medications can have adverse effects in elderly patients, who are more susceptible due to age-related changes in drug metabolism and response. This abstract highlights the need for more research on the impact of antipsychotics on hospitalizations in the elderly.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Factors affecting drug concentrations and QT interval during thioridazine therapy.

Author: ThanacoodyR H K, DalyA K, ReillyJ G, FerrierI N, ThomasS H L

QTc prolongation

This study investigated factors affecting steady-state plasma concentrations of thioridazine. Age, smoking, and CYP2D6 genotype influenced thioridazine concentrations, but CYP2D6 genotype did not appear to influence on-treatment QTc interval.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Effect of thioridazine on gap junction intercellular communication in connexin 43-expressing cells.

Author: MatesicD F, AbifadelD N, GarciaE L, JannM W

Cardiac conduction side effects

This study tested the effect of thioridazine and mesoridazine on gap junction-mediated intercellular communication between cells. The drugs inhibited gap junction-mediated intercellular communication, which may contribute to the cardiac side-effects observed in patients taking these medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

10.

Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine.

Author: WójcikowskiJacek, MaurelPatrick, DanielWładysława A

Neuroleptic metabolism understanding
Cardiotoxicity
Drug interactions

CYP1A2 and CYP3A4 are the main enzymes responsible for 5-sulfoxidation and N-demethylation of thioridazine, while CYP2D6 is the basic enzyme that catalyzes mono-2- and di-2-sulfoxidation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist.

Author: BursteinE S, MaJ, WongS, GaoY, PhamE, KnappA E, NashN R, OlssonR, DavisR E, HacksellU, WeinerD M, BrannM R

Antipsychotic effect
Low EPS
Extrapyramidal symptoms

This study examines the molecular basis of extrapyramidal symptoms (EPS) associated with antipsychotic drugs. It finds that atypical antipsychotics like clozapine and aripiprazole have partial agonist properties at D2 and D3 receptors, which may contribute to their lower EPS incidence.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Schizophrenia, antipsychotic drugs, and cardiovascular disease.

Author: GlassmanAlexander H

Antipsychotic effect
Cardiovascular events
QTc prolongation

This article discusses the growing concern about the cardiovascular risks associated with antipsychotic drugs. The article focuses on the potential for atypical antipsychotics to prolong the QT interval, potentially leading to torsades de pointes and sudden death. While atypical antipsychotics may increase the QT interval, current evidence suggests they do not cause torsades de pointes. However, the article highlights the need to monitor cardiovascular health in psychiatric patients treated with these drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.

Author: LLerenaAdrián, BereczRoland, de la RubiaAlfredo, DoradoPedro

Cardiac dysrhythmia
QTc prolongation

The QTc interval was prolonged in patients receiving thioridazine, a medication used to treat psychiatric disorders. This lengthening was correlated with thioridazine dose and plasma concentration. Patients with impaired CYP2D6 enzyme activity may be at higher risk for QTc prolongation and associated cardiac dysrhythmias.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes.

Author: LLerenaA, BereczR, de la RubiaA, Fernández-SalgueroP, DoradoP

Cardiotoxicity
Drug interaction

This study investigates the effects of thioridazine, an antipsychotic drug, on CYP2D6 enzyme activity, demonstrating that thioridazine can inhibit CYP2D6 metabolism in a dose-dependent manner, potentially affecting the metabolism of other drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.

Author: RauserL, SavageJ E, MeltzerH Y, RothB L

This study examined the relationship among 5-HT2C inverse agonist potency, efficacy, and atypical antipsychotic drug status in HEK-293 cells of a large number of typical and atypical antipsychotic drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

18.

The influence of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics of thioridazine and its metabolites: in vivo and in vitro studies.

Author: DanielW A, SyrekM, HaduchA, WójcikowskiJ

Dangerous combination
Serious side effects

Fluoxetine significantly increased the plasma concentrations of thioridazine and its metabolites, while sertraline tended to decrease thioridazine concentrations. Coadministration of thioridazine and sertraline seems to be safe.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Clonidine does not potentiate the antipsychotic effects of neuroleptics in chronically ill patients.

Author: HedgesS, El-MallakhR S, IssaF, ElkashefA, BigelowL B, WyattR J

Antipsychotic treatment
Side effects

Combining clonidine with neuroleptics did not provide greater effectiveness than neuroleptics alone in treating chronic psychotic patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs.

Author: RothB L, TandraS, BurgessL H, SibleyD R, MeltzerH Y

D4 receptor affinity not distinctive

D4 dopamine receptor affinity alone does not differentiate between typical and atypical antipsychotic drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

22.

Effects of antipsychotic drugs on latent inhibition: sensitivity and specificity of an animal behavioral model of clinical drug action.

Author: DunnL A, AtwaterG E, KiltsC D

Schizophrenia treatment

Latent inhibition, a measure of selective attention, is enhanced by antipsychotic drugs like haloperidol, fluphenazine, chlorpromazine, thiothixene, thioridazine, mesoridazine, and metoclopramide but not clozapine. This parallels the clinical pharmacology of schizophrenia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

23.

Cardiac conduction and rhythm disturbances following suicidal ingestion of mesoridazine.

Author: NiemannJ T, StapczynskiJ S, RothsteinR J, LaksM M

Cardiac arrhythmia
Electrocardiographic abnormalities

Mesoridazine can induce life-threatening arrhythmias.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

A comparison of the effects of neuroleptics on phencyclidine-induced behaviors in the rat.

Author: SturgeonR D, FesslerR G, LondonS F, MeltzerH Y

Butyrophenone neuroleptics demonstrated dose-dependent antagonism of phencyclidine-induced behavioral effects in rats, while other neuroleptics had no consistent effect or even enhanced some effects. Atropine sulfate pretreatment increased PCP-induced locomotor activity and stereotyped behaviors, while physostigmine had the opposite effect.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

26.

Mesoridazine -- a pharmacodynamic and pharmacokinetic profile.

Author: GershonS, SakalisG, BowersP A

Effective for other psychiatric disorders
Effective for schizophrenia

Mesoridazine was effective in treating schizophrenia and other psychiatric disorders. Its effectiveness in patients refractory to other neuroleptics may be related to its slow rate of inactivation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

27.

Interactions of neuroleptic metabolites with dopaminergic, alpha adrenergic and muscarinic cholinergic receptors.

Author: BylundD B

Autonomic side effects
Extrapyramidal side effects

Metabolite potency at dopaminergic, alpha adrenergic, and muscarinic cholinergic receptors correlated with clinical data on drug potency and side effects. The findings suggest that metabolites contribute significantly to both therapeutic and side effects of neuroleptics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.