Paper Details

  1. Home
  2. Paper Details

Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT).

Author: , AlphsLarry, AltamuraA Carlo, AnandRavi, BertoldiAlberto, BourgeoisMarc, ChouinardGuy, GreenAlan I, IslamM Zahur, KaneJohn, KrishnanRanga, LindenmayerJ P, MeltzerHerbert Y, PotkinSteven

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Clozapine therapy was superior to olanzapine therapy in preventing suicide attempts in patients with schizophrenia and schizoaffective disorder at high risk for suicide.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Approximately 50% of patients with schizophrenia or schizoaffective disorder attempt suicide, and approximately 10% die of suicide. Study results suggest that clozapine therapy significantly reduces suicidal behavior in these patients. METHODS: A multicenter, randomized, international, ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1001/archpsyc.60.1.82

データ提供：米国国立医学図書館（NLM）

Clozapine: A Potential Lifeline for Suicidal Schizophrenia Patients

Mental health, particularly schizophrenia, is a vast and complex desert, often leaving patients feeling lost and hopeless. This study dives into the potential of clozapine, a medication often used to manage schizophrenia, as a potential oasis for those struggling with suicidal thoughts and behaviors. Using a meticulous randomized controlled trial involving over 980 patients, researchers compared the impact of clozapine to olanzapine, another common schizophrenia medication. The study concluded that clozapine significantly reduced suicidal behavior, offering a glimmer of hope in the face of a challenging mental health condition.

Clozapine's Superiority: A Promising New Approach

The study found that patients on clozapine experienced a statistically significant decrease in suicidal behaviors, including attempted suicides and hospitalizations for suicidal thoughts. This suggests that clozapine may offer a better treatment option for high-risk patients who are struggling with suicidal ideation. This finding is particularly encouraging, as a significant portion of the study participants had a history of suicidal attempts or were actively experiencing suicidal thoughts.

A Beacon of Hope in a Difficult Journey

The study highlights the need for tailored treatment approaches to address the complex needs of individuals with schizophrenia. Clozapine's potential to reduce suicidal behavior is a positive step forward, but it's crucial to remember that this medication is not a magic bullet. Patients with schizophrenia often require a multifaceted approach that includes therapy, medication, and a strong support system. This study reminds us of the importance of ongoing research and innovation in mental health, offering hope for more effective treatments and interventions in the future.

Dr.Camel's Conclusion

This research, like a refreshing desert breeze, offers a potential solution for a challenging issue. Clozapine's effectiveness in reducing suicidal behavior is promising news, but we must be cautious and remember the importance of a comprehensive approach to treating mental health conditions.

Date :
  1. Date Completed 2003-01-23
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

12511175

DOI: Digital Object Identifier

10.1001/archpsyc.60.1.82

Related Literature

Article Analysis
・Effective treatment of suicide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.