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Oral theophylline for chronic obstructive pulmonary disease.

Author: AtallahA N, CastroA A, CendonS, De BritoJ A, GoldsteinR, JonesP W, LacasseY, MazziniR, RamF S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Theophylline has a modest effect on FEV1 and FVC and slightly improves arterial blood gas tensions in moderate to severe COPD. Improvement in exercise performance depended on the method of testing.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Oral theophylline has, for many years, been used as a bronchodilator in patients with COPD. Despite the introduction of new drugs, and its narrow therapeutic index, theophylline is still recommended for COPD treatment. OBJECTIVES: To determine the effectiveness of oral theophylline when...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047557/

データ提供：米国国立医学図書館（NLM）

Oral Theophylline for COPD: A Time-Tested Bronchodilator

Chronic obstructive pulmonary disease (COPD) is a serious lung disease that causes airflow obstruction. Oral theophylline, a bronchodilator, has been used for many years to manage COPD. This research reviews the effectiveness of oral theophylline compared to placebo in patients with stable COPD.

Theophylline: A Modest but Effective Bronchodilator for COPD

The researchers found that oral theophylline had a modest but significant positive effect on lung function, as measured by forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Theophylline also improved arterial blood gas tensions, indicating better oxygenation. However, it was associated with an increased risk of nausea. Interestingly, patients reported a preference for theophylline over placebo.

Navigating the Desert of COPD: Theophylline as a Potential Oasis

This research reminds us that even with newer medications available, older treatments like theophylline can still play a valuable role in managing COPD. While theophylline's benefits may be modest, it offers a potential solution for patients who may not tolerate or respond well to newer therapies. Just as a camel seeks out an oasis to quench its thirst, COPD patients may find relief in theophylline, even if it's not a perfect solution.

Dr. Camel's Conclusion

In the vast desert of COPD, theophylline may not be the most glamorous oasis, but it can provide a much-needed source of relief for those seeking a respite from the harsh conditions of this chronic lung disease.

Date :
  1. Date Completed 2003-02-21
  2. Date Revised 2023-11-13
Further Info :

Pubmed ID

12519617

DOI: Digital Object Identifier

PMC7047557

SNS
PICO Info
in preparation
Languages

English

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