Effective treatment of coping with chronic illness: A Synthesis of Findings from 116 Studies

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Original Abstract of the Article

Major Research Findings

Chronic obstructive pulmonary disease (COPD) is a common, chronic inflammatory lung disease that causes airflow obstruction and breathing difficulties. 103 It affects over 200 million people worldwide. 46 COPD is associated with cough, phlegm, shortness of breath, and a reduction in lung function, quality of life, and life expectancy. 103

Treatment for COPD aims to improve patients' well-being, reduce mortality, morbidity, and exacerbations. 77 Guidelines recommend an individualized step-up approach, where treatment is intensified if initial results are unsatisfactory. 46

Many clinical trials have confirmed the long-term effectiveness of combining inhaled corticosteroids and long-acting β2-agonists for COPD treatment. 82

Up to 80% of individuals with COPD may experience symptoms of depression. 96 This comorbidity is often poorly managed and can worsen quality of life, reduce adherence to treatment plans, increase exacerbations, hospitalizations, and healthcare costs. 96 However, current COPD guidelines lack conclusive treatment recommendations for antidepressants in COPD patients, relying instead on findings from trials in the general population. This is problematic due to the increased risk of respiratory issues associated with antidepressants and COPD. 96

Roflumilast, an oral phosphodiesterase-4 (PDE4) inhibitor, has shown efficacy in treating COPD, especially in preventing acute exacerbations. 76

Tiotropium plus olodaterol, administered once daily, has demonstrated improvements in lung function and other benefits in a large Phase III clinical program. 71 This combination may be a suitable option for initiating maintenance treatment in COPD. 71

Combined aclidinium bromide and long-acting beta2-agonist (LABA) therapy is approved for stable COPD patients. 95

The combination of inhaled corticosteroids (ICS) and LABAs is an effective treatment for asthma-COPD overlap (ACO). 106

The combination of LABA and a long-acting muscarinic antagonist (LAMA) in a single inhaler is a viable treatment option for COPD. 89

Long-term domiciliary oxygen therapy has become a primary treatment for COPD patients with hypoxemia. 6

treatmentまとめ

Treatment for COPD includes a variety of medications, including inhaled corticosteroids, long-acting β2-agonists, long-acting anticholinergics, phosphodiesterase-4 inhibitors, and oxygen therapy. 46 , 103 , 82 , 76 , 77 , 71 , 6 , 61

Treatment aims to improve symptoms, maintain lung function, and prevent exacerbations. 46

Guidelines recommend a step-up approach where treatment is intensified based on individual patient needs and response. 46

Depression is a significant comorbidity in COPD, often poorly managed and associated with negative outcomes. 96

Benefits and Risks

Benefits Summary

COPD treatment can improve symptoms, maintain lung function, and prevent exacerbations. 46 , 103

Inhaled corticosteroids combined with long-acting β2-agonists have proven effective in treating COPD. 82

Tiotropium plus olodaterol, administered once daily, has shown benefits beyond lung function improvement, making it a potential option for initiating maintenance treatment. 71

Combined aclidinium bromide and long-acting beta2-agonist therapy is an approved treatment for stable COPD patients. 95

The combination of ICS and LABAs is an effective treatment for asthma-COPD overlap (ACO). 106

The combination of LABA and LAMA in a single inhaler is a viable treatment option for COPD. 89

Long-term domiciliary oxygen therapy is a primary treatment for COPD patients with hypoxemia. 6

Risks Summary

COPD treatment carries the risk of side effects. 46 , 103

Inhaled corticosteroids are generally less effective in COPD compared to asthma and may have more severe side effects. 73

Untreated COPD-related depression can lead to poor quality of life, decreased treatment adherence, increased exacerbations, hospitalizations, and higher healthcare costs. 96

Research Comparisons

Commonalities

Numerous studies highlight the goal of COPD treatment as symptom improvement, lung function maintenance, and exacerbation prevention. 46 , 103 , 82 , 76 , 77 , 71 , 6 , 61

Several studies have identified inhaled corticosteroids combined with long-acting β2-agonists, long-acting anticholinergics, and oxygen therapy as effective treatment options. 46 , 103 , 82 , 76 , 77 , 71 , 6 , 61

Differences

Variations in patient populations, treatment methods, and assessed outcomes can lead to discrepancies in research findings on COPD treatment. 46 , 103 , 82 , 76 , 77 , 71 , 6 , 61

Consistency and Contradictions in Findings

Research on COPD treatment reveals both consistent and contradictory findings. 46 , 103 , 82 , 76 , 77 , 71 , 6 , 61

Practical Implications and Considerations

Research findings on COPD treatment may not directly translate to real-world clinical practice. 46 , 103 , 82 , 76 , 77 , 71 , 6 , 61

Therefore, COPD treatment should be individualized based on the specific needs and characteristics of each patient. 46

Limitations of Current Research

Research on COPD treatment is still ongoing, and more research is needed to fully understand the effectiveness and safety of different treatments. 46 , 103 , 82 , 76 , 77 , 71 , 6 , 61

Future Research Directions

Further research on COPD treatment is essential. 46 , 103 , 82 , 76 , 77 , 71 , 6 , 61

Conclusion

COPD is a common and serious chronic lung disease that affects over 200 million people worldwide. 103

COPD is associated with cough, phlegm, shortness of breath, and a reduction in lung function, quality of life, and life expectancy. 103

Treatment for COPD aims to improve symptoms, maintain lung function, and prevent exacerbations. 46

Treatment options include inhaled medications, oral medications, and oxygen therapy. 46

Guidelines recommend an individualized step-up approach where treatment is intensified based on individual patient needs and response. 46

More research is needed to better understand the effectiveness and safety of different COPD treatments. 46 , 103 , 82 , 76 , 77 , 71 , 6 , 61

Ongoing research is crucial to improve the management of COPD and provide better outcomes for patients. 46 , 103 , 82 , 76 , 77 , 71 , 6 , 61

Treatment List

Inhaled corticosteroids, long-acting β2-agonists, long-acting anticholinergics, phosphodiesterase-4 inhibitors, oxygen therapy

Keywords
Benefit Keywords
COPD treatment
1
Asthma treatment
COPD treatment
2
Reduced drop out due to pulmonary problems
Reduced lung function decline
Reduced symptoms
3
COPD management
4
Improved COPD treatment
5
Improved survival
Reduced mortality
6
Improved survival in severe hypoxemia
7
Fewer exacerbations
Improved lung function
Reduced symptoms
8
Improved lung function
9
Treat mild acute exacerbations of COPD
10
Improved lung function
Improved quality of life
Reduced exacerbations
11
Improved lung function
12
Improved COPD symptoms
13
Improved blood gas tensions
Improved lung function
15
Improved COPD treatment
16
Improved smoking cessation
17
COPD treatment
20
COPD treatment
21
Improved lung function
Rapid effect
22
COPD treatment
23
Improved life quality
24
Improved survival
Severe hypoxaemia treatment
25
Exacerbation reaction
Self-management knowledge
26
Bronchodilation
27
Reduced COPD exacerbations
28
Improved lung function
Reduced need for rescue medication
29
Improved COPD treatment
30
Improved health
Reduced exacerbations
31
Improved COPD treatment
32
Improved COPD treatment
33
COPD exacerbation treatment
34
COPD treatment
Exacerbation prevention
Health status improvement
35
Improved lung function
36
Improved Respiratory Function
Improved Sputum Viscosity
Reduced Cough Symptoms
37
COPD treatment
38
Reduced exacerbations requiring oral corticosteroids
39
Bronchodilation
Enhanced mucus clearance
40
Improved COPD treatment
41
Reduced adverse effects
42
COPD treatment
Improves lung function
Reduces dyspnea
43
Improved COPD outcomes
44
Bronchodilator effect
45
Treatment of chronic obstructive pulmonary disease
46
Improved CRQ
Reduced corticosteroid use
47
Improved dyspnea
Reduced hyperinflation
48
Reduced COPD exacerbations
Relief of COPD symptoms
49
Improved health status
Improved lung function
Reduced dyspnea
50
COPD symptom control
Disease progression management
51
Reduced exacerbations
52
Exacerbation reduction
FEV1 improvement
53
Improved COPD management
54
COPD treatment
55
COPD treatment
Exacerbation reduction
56
Treatment approach
57
COPD treatment
58
Improved lung function
Improved quality of life
Reduced exacerbations
Reduced hospital admissions
59
Improved exercise tolerance
Improved quality of life
Symptom relief
60
Reduced airway inflammation
Reduced bronchoconstriction
61
COPD treatment
62
COPD treatment
63
Improved lung function
Improved quality of life
Reduced rescue medication
64
Reduced COPD exacerbation duration
Reduced corticosteroid side effects
65
Improved patient preference
Improved patient satisfaction
67
COPD management
Hospitalization reduction
ICU admission reduction
68
Improved lung function
Improved quality of life
Reduced hospital admissions
69
COPD survival
70
Tiotropium + olodaterol for COPD
71
Improved quality of life
Reduced exacerbations
73
Improved COPD treatment
74
Roflumilast effective
75
COPD exacerbation prevention
Improved quality of life
Improved spirometry
76
Improved well-being
Reduced morbidity
Reduced mortality
77
Increased quit rate
78
COPD treatment
79
COPD treatment
80
COPD exacerbation management
81
Significant treatment effects
82
COPD treatment
84
Efficacy enhancement
85
Better sleep quality
Improved alveolar ventilation
86
Prolonged time to readmission or death
87
COPD treatment
88
COPD treatment
89
Accurate diagnosis
90
Reduced COPD exacerbations
91
Reduced airway inflammation
Reduced bronchoconstriction
92
Reduced adverse effects
93
Improved lung function
94
COPD exacerbation reduction
Lung function improvement
Quality of life improvement
97
Lung function improvement
98
Reduced COPD exacerbation rate
99
Improved COPD treatment
101
Improved COPD treatment
102
Improved COPD treatment
103
Improved COPD treatment
104
COPD treatment
Symptom relief
105
Improved lung function
106
COPD exacerbation prevention
107
COPD treatment
108
Reduced treatment failure
109
Pharmacological treatments for COPD
110
COPD treatment
Inhaled bronchodilator effectiveness
111
Reduced resistance
Short course antibiotics
112
COPD treatment
Improved pulmonary function
Reduced airway hyperreactivity
115
COPD treatment
116
Risk Keywords
Systemic effects
4
No survival improvement in moderate hypoxemia
7
Drug-related adverse events
8
Adverse drug reactions
9
Dry mouth
Tremor
14
Nausea
15
No effect on FEV1 decline
18
Increasing disease burden
21
Unclear if withdrawal of ICS will result in disease deterioration
23
Chronic obstructive pulmonary disease
30
Increased candidiasis
Increased pneumonia
31
Chronic obstructive pulmonary disease
32
Chronic obstructive pulmonary disease
33
Oral steroid safety
34
Gastrointestinal Side Effects
37
Increased all-cause hospital admissions
Increased deaths
Increased exacerbations requiring antibiotics
Increased pneumonia
Uncertainty regarding efficacy and safety
39
Serious adverse effects
43
Diarrhea
Headache
Insomnia
Nausea
Weight loss
53
Under-diagnosis
54
Deaths
Hospital admissions
Pneumonia
56
Action plans unsafe
57
COPD symptoms
Reduced lung function
61
Similar adverse events
64
AE-COPD
Antibiotic-resistant bacteria
66
Critical inhaler technique errors
67
Pneumonia
73
Back pain
Gastrointestinal AEs
Headache
Insomnia
75
Adverse drug reactions
76
None mentioned
80
COPD exacerbation severity
81
Incorrect treatment
Misdiagnosis
90
Respiratory issues
96
Pneumonia
97
COPD
98
Increased disease burden
100
COPD exacerbations
105
None mentioned
109
Non-adherence
Suboptimal therapy
110
Recurrent AE-COPD
113
COPD medication
114
Literature analysis of 116 papers
Positive Content
108
Neutral Content
3
Negative Content
5
Article Type
56
44
50
46
116
1.

Efficacy of inhaled salmeterol in the management of smokers with chronic obstructive pulmonary disease: a single centre randomised, double blind, placebo controlled, crossover study.

Author: UlrikC S

COPD treatment

Treatment with salmeterol produced an improvement in respiratory symptoms and morning PEF values in patients with moderate to severe COPD.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Slowing the deterioration of asthma and chronic obstructive pulmonary disease observed during bronchodilator therapy by adding inhaled corticosteroids. A 4-year prospective study.

Author: DompelingE, van SchayckC P, van GrunsvenP M, van HerwaardenC L, AkkermansR, MolemaJ, FolgeringH, van WeelC

Asthma treatment
COPD treatment

Adding beclomethasone, 800 micrograms daily, slowed the unfavorable course of asthma or COPD seen with bronchodilator therapy alone. This effect was most evident in asthmatic patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of long-term treatment with corticosteroids in COPD.

Author: RenkemaT E, SchoutenJ P, KoëterG H, PostmaD S

Reduced drop out due to pulmonary problems
Reduced lung function decline
Reduced symptoms

Long-term treatment with inhaled corticosteroids demonstrated beneficial effects in patients with COPD, including a reduction in symptoms and a potential decrease in lung function decline.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

The effect of high-dose inhaled beclomethasone dipropionate in patients with stable COPD.

Author: NishimuraK, KoyamaH, IkedaA, TsukinoM, HajiroT, MishimaM, IzumiT

COPD management
Systemic effects

This study discusses the benefits and potential risks of inhaled corticosteroids in the management of COPD, highlighting the need to understand the maximum benefits to weigh them against the potential adverse systemic effects of high-dose inhaled corticosteroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

The response to inhaled and oral steroids in patients with stable chronic obstructive pulmonary disease.

Author: WeinerP, WeinerM, RabnerM, WaizmanJ, MagadleR, ZamirD

Improved COPD treatment

While some people with COPD respond well to corticosteroid treatment, a significant number do not. The potential benefits of corticosteroids may be outweighed by their side effects. Long-term use of inhaled steroids is generally safe, however, the effectiveness of inhaled corticosteroids for COPD remains unclear, with conflicting findings from studies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Domicilary oxygen for chronic obstructive pulmonary disease.

Author: CrockettA J, MossJ R, CranstonJ M, AlpersJ H

Improved survival
Reduced mortality

Long-term oxygen therapy improved survival in patients with severe hypoxaemia, but not in those with moderate hypoxaemia or nocturnal desaturation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Domiciliary oxygen for chronic obstructive pulmonary disease.

Author: CrockettA J, CranstonJ M, MossJ R, AlpersJ H

Improved survival in severe hypoxemia
No survival improvement in moderate hypoxemia

Long-term domiciliary oxygen therapy improves survival in COPD patients with severe hypoxemia (arterial PO2 less than 8.0 kPa). However, it does not appear to improve survival in patients with moderate hypoxemia or only nocturnal desaturation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Salmeterol plus theophylline combination therapy in the treatment of COPD.

Author: ZuWallackR L, MahlerD A, ReillyD, ChurchN, EmmettA, RickardK, KnobilK

Fewer exacerbations
Improved lung function
Reduced symptoms
Drug-related adverse events

Combination treatment with salmeterol plus theophylline significantly improved pulmonary function, decreased symptoms, and reduced the number of COPD exacerbations in patients with COPD. Compared to theophylline alone, salmeterol plus theophylline resulted in greater improvements in lung function and satisfaction with treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Oral corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.

Author: Wood-BakerR, WaltersE H, GibsonP

Improved lung function
Adverse drug reactions

Corticosteroids were found to increase the rate of lung function improvement in the first 72 hours of an exacerbation of chronic obstructive pulmonary disease (COPD) but at an increased risk of adverse drug reactions. There was no evidence that this benefit was maintained after 72 hours.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Formoterol as dry powder oral inhalation compared with salbutamol metered-dose inhaler in acute exacerbations of chronic obstructive pulmonary disease.

Author: CazzolaM, D'AmatoM, CalifanoC, Di PernaF, CalderaroE, MateraM G, D'AmatoG

Treat mild acute exacerbations of COPD

Formoterol, a bronchodilator, was compared to salbutamol for treating mild exacerbations of COPD. The study found that cumulative doses of both drugs were similar in effectiveness, but no clear superiority of one over the other was established.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

The addition of salmeterol 50 microg bid to anticholinergic treatment in patients with COPD: a randomized, placebo controlled trial. Chronic obstructive pulmonary disease.

Author: ChapmanKenneth R, ArvidssonPeter, ChuchalinA G, DhillonD P, FaurschouPeter, GoldsteinRoger S, KuipersA F,

Improved lung function
Improved quality of life
Reduced exacerbations

This double-blind, randomized, parallel-group study compared the effect of adding salmeterol (50 microg bid) or placebo to concurrent anticholinergic therapy on symptom scores, quality of life, prebronchodilator lung function, and exacerbations in 408 patients with moderately severe chronic obstructive pulmonary disease (COPD). Salmeterol has a beneficial effect when added to existing anticholinergic therapy in patients with COPD. The regular use of salmeterol for six months was not associated with worsening of the underlying airflow obstruction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effects of fluticasone propionate in COPD patients with bronchial hyperresponsiveness.

Author: VerhoevenG T, HegmansJ P J J, MulderP G H, BogaardJ M, HoogstedenH C, PrinsJ-B

Improved lung function

Inhaled corticosteroids may not be as effective for chronic obstructive pulmonary disease (COPD) as they are for asthma. Only certain groups of COPD patients benefit from steroid treatment. A study examined the effects of inhaled fluticasone propionate (FP) on lung function and inflammation in COPD patients with bronchial hyperresponsiveness (BHR).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

An evaluation of salmeterol in the treatment of chronic obstructive pulmonary diseases.

Author: GuptaRakesh K, ChhabraSunil K

Improved COPD symptoms

This study assessed the effectiveness of salmeterol as an add-on drug to ipratropium in the treatment of chronic obstructive pulmonary disease (COPD).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Anti-cholinergic bronchodilators versus beta2-sympathomimetic agents for acute exacerbations of chronic obstructive pulmonary disease.

Author: McCroryD C, BrownC D

Dry mouth
Tremor

Ipratropium bromide was not more effective than short-acting beta2-agonists in treating acute exacerbations of COPD. The combination of ipratropium bromide and a beta2-agonist did not increase the effect on FEV1 more than either used alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Oral theophylline for chronic obstructive pulmonary disease.

Author: RamF S, JonesP W, CastroA A, De BritoJ A, AtallahA N, LacasseY, MazziniR, GoldsteinR, CendonS

Improved blood gas tensions
Improved lung function
Nausea

Theophylline has a modest effect on FEV1 and FVC and slightly improves arterial blood gas tensions in moderate to severe COPD. Improvement in exercise performance depended on the method of testing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial.

Author: CalverleyPeter, PauwelsRomain, VestboJørgen, JonesPaul, PrideNeil, GulsvikAmund, AndersonJulie, MadenClaire,

Improved COPD treatment

Inhaled long-acting beta2 agonists improve lung function and overall health in people with COPD, while inhaled corticosteroids reduce the frequency of flare-ups and slow down disease progression. This study hypothesized that combining these treatments would be more beneficial than using either medication alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Smoking cessation for chronic obstructive pulmonary disease.

Author: van der MeerR M, WagenaE J, OsteloR W J G, JacobsJ E, van SchayckC P

Improved smoking cessation

Combining psychosocial interventions with pharmacological interventions is more effective than no treatment or psychosocial interventions alone in smoking cessation for patients with chronic obstructive pulmonary disease (COPD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Long-term effects of inhaled corticosteroids on FEV1 in patients with chronic obstructive pulmonary disease. A meta-analysis.

Author: HighlandKristin B, StrangeCharlie, HeffnerJohn E

No effect on FEV1 decline

Inhaled corticosteroids were not associated with a slower rate of FEV1 decline in patients with chronic obstructive pulmonary disease (COPD). This conclusion was based on six randomized, placebo-controlled trials involving 3571 patients followed for 24 to 54 months.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

19.

Oxygen supplementation before or after submaximal exercise in patients with chronic obstructive pulmonary disease.

Author: NandiK, SmithA A, CrawfordA, MacRaeK D, GarrodR, SeedW A, RobertsC M

This study found that patients with COPD derived no physiological or symptomatic benefit from short-term use of oxygen before or after submaximal exercise.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Efficacy of inhaled steroids in undiagnosed subjects at high risk for COPD: results of the detection, intervention, and monitoring of COPD and asthma program.

Author: AlbersMieke, SchermerTjard, van den BoomGuido, AkkermansReinier, van SchayckConstant, van HerwaardenCees, van WeelChris

COPD treatment

COPD causes a gradual worsening of lung function. Family doctors see many COPD patients and are encouraged to start treatment early. This study examines whether starting inhaled corticosteroids early affects how quickly lung function declines in people with COPD.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.

Author: Wood-BakerR R, GibsonP G, HannayM, WaltersE H, WaltersJ A E

COPD treatment
Increasing disease burden

COPD is a common condition, primarily linked to smoking, and its impact is growing. COPD flare-ups, often caused by infections, are common and typically treated with systemic corticosteroids, antibiotics, oxygen, and bronchodilators.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Early onset of effect of salmeterol and fluticasone propionate in chronic obstructive pulmonary disease.

Author: VestboJ, PauwelsR, AndersonJ A, JonesP, CalverleyP,

Improved lung function
Rapid effect

The effects of salmeterol and fluticasone propionate, alone or in combination, on peak expiratory flow (PEF) and breathlessness are seen within days and most of the obtainable effect on these parameters is reached within 2 weeks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial.

Author: WoutersE F M, PostmaD S, FokkensB, HopW C J, PrinsJ, KuipersA F, PasmaH R, HensingC A J, CreutzbergE C,

COPD treatment
Unclear if withdrawal of ICS will result in disease deterioration

Inhaled corticosteroids (ICS) are recommended for people with COPD who have poor lung function and frequent flare-ups, but they only slightly slow the decline in lung function. Combining ICS with a long-acting beta2 agonist (LABA) might help stabilize COPD, but it's unclear what happens if you stop taking ICS.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Different bronchodilator combinations have similar effects on health status in COPD.

Author: YildizFusun, BasyigitIlknur, YildirimElif, BoyaciHasim, IlgazliAhmet

Improved life quality

Combined bronchodilator treatments (ipratropium + theophylline, formoterol + theophylline, and ipratropium + formoterol) were found to have a significant effect on life quality in COPD, with similar effects between the three different combinations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Domiciliary oxygen for chronic obstructive pulmonary disease.

Author: CranstonJ M, CrockettA J, MossJ R, AlpersJ H

Improved survival
Severe hypoxaemia treatment

Long-term home oxygen therapy improved survival in a selected group of COPD patients with severe hypoxaemia (arterial PaO2 less than 55 mm Hg (8.0 kPa)). Home oxygen therapy did not appear to improve survival in patients with mild to moderate hypoxaemia or in those with only arterial desaturation at night.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Action plans for chronic obstructive pulmonary disease.

Author: TurnockA C, WaltersE H, WaltersJ A E, Wood-BakerR

Exacerbation reaction
Self-management knowledge

Action plans aided people with COPD in recognizing and reacting appropriately to an exacerbation of their symptoms via the self-initiation of antibiotics or steroids. Further research is needed to determine whether this results in significantly decreased morbidity and/or mortality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Onset and duration of action of formoterol and tiotropium in patients with moderate to severe COPD.

Author: RichterKai, StengleinStephan, MückeMarion, SiederChristian, SchmidtmannSören, HarnestUlf, WeidingerGottfried, MagnussenHelgo

Bronchodilation

Formoterol has faster onset of action and greater bronchodilation than tiotropium in patients with moderate to severe COPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Impact of salmeterol/fluticasone propionate versus salmeterol on exacerbations in severe chronic obstructive pulmonary disease.

Author: KardosPeter, WenckerMarion, GlaabThomas, VogelmeierClaus

Reduced COPD exacerbations

The study assessed the impact of combination therapy with salmeterol/fluticasone propionate compared with salmeterol alone on moderate and severe exacerbations in patients with severe COPD and a history of repeated exacerbations. The results showed that combination therapy significantly reduced the frequency of moderate/severe exacerbations, improved health-related quality of life, peak expiratory flow, and use of rescue medication, and was well tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Improvements with tiotropium in COPD patients with concomitant asthma.

Author: MagnussenH, BugnasB, van NoordJ, SchmidtP, GerkenF, KestenS

Improved lung function
Reduced need for rescue medication

This study found that patients with COPD and concomitant asthma achieve spirometric improvements with tiotropium along with symptomatic benefit as seen by reduced need for rescue medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Management of stable chronic obstructive pulmonary disease: a systematic review for a clinical practice guideline.

Author: WiltTimothy J, NiewoehnerDennis, MacDonaldRoderick, KaneRobert L

Improved COPD treatment
Chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a common and disabling condition in adults. More information is needed about the effectiveness and side effects of common COPD treatments and how patient characteristics influence treatment outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis.

Author: SobierajDiana M, WhiteC Michael, ColemanCraig I

Improved health
Reduced exacerbations
Increased candidiasis
Increased pneumonia

Adding an inhaled corticosteroid (ICS) to a long-acting bronchodilator was associated with a reduced risk of exacerbations but an increased risk of pneumonia and oral candidiasis in patients with severe or very severe chronic obstructive pulmonary disease (COPD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

32.

Faster onset of action of formoterol versus salmeterol in patients with chronic obstructive pulmonary disease: a multicenter, randomized study.

Author: CoteClaudia, PearleJames L, SharafkhanehAmir, SpangenthalSelwyn

Improved COPD treatment
Chronic obstructive pulmonary disease

COPD is a growing health concern that affects men and women, especially smokers. Treatment aims to improve lung function, reduce symptoms, prevent flare-ups, and improve overall health. Bronchodilators are the foundation of COPD treatment, and the long-acting medications formoterol and salmeterol are recommended for regular use in people with stable COPD.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.

Author: WaltersJulia Ae, GibsonPeter G, Wood-BakerRichard, HannayMairi, WaltersE Haydn

Improved COPD treatment
Chronic obstructive pulmonary disease

COPD is a common condition primarily caused by smoking. COPD flare-ups, often due to infections, are frequent and are typically treated with systemic corticosteroids, antibiotics, oxygen, and bronchodilators.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Budesonide/formoterol as effective as prednisolone plus formoterol in acute exacerbations of COPD. A double-blind, randomised, non-inferiority, parallel-group, multicentre study.

Author: StällbergBjörn, SelroosOlof, VogelmeierClaus, AnderssonEva, EkströmTommy, LarssonKjell

COPD exacerbation treatment
Oral steroid safety

This study evaluated whether a 2-week course of inhaled budesonide/formoterol would be equally effective for treatment of acute COPD exacerbations as standard therapy in patients not requiring hospitalization.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

35.

Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial.

Author: DecramerMarc, CelliBartolome, KestenSteven, LystigTheodore, MehraSunil, TashkinDonald P,

COPD treatment
Exacerbation prevention
Health status improvement

Tiotropium treatment in patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage II COPD seemed to reduce the rate of decline of postbronchodilator forced expiratory volume in 1 second (FEV(1)) by 6 mL per year. This suggests that treatment of COPD should begin at an early stage of the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials.

Author: FabbriLeonardo M, CalverleyPeter M A, Izquierdo-AlonsoJosé Luis, BundschuhDaniela S, BroseManja, MartinezFernando J, RabeKlaus F,

Improved lung function

This study investigated the effect of roflumilast on lung function in patients with moderate-to-severe COPD who are already being treated with salmeterol or tiotropium.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data.

Author: CazzolaM, FlorianiI, PageC P

Improved Respiratory Function
Improved Sputum Viscosity
Reduced Cough Symptoms
Gastrointestinal Side Effects

Erdosteine, a drug used to treat chronic bronchitis or COPD (CB/COPD), significantly improved symptoms compared to placebo or mucolytics. The treatment was well tolerated.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

38.

Action plans with limited patient education only for exacerbations of chronic obstructive pulmonary disease.

Author: WaltersJulia Ae, TurnockAllison C, WaltersE Haydn, Wood-BakerRichard

COPD treatment

COPD is a progressive lung disease characterized by flare-ups, often caused by infections, that worsen symptoms and quality of life. Action plans can help people with COPD recognize when their symptoms are worsening and take steps to adjust their treatment early, which may reduce the severity of the flare-up.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease.

Author: WelshEmma J, CatesChristopher J, PoolePhillippa

Reduced exacerbations requiring oral corticosteroids
Increased all-cause hospital admissions
Increased deaths
Increased exacerbations requiring antibiotics
Increased pneumonia
Uncertainty regarding efficacy and safety

The relative efficacy and safety of combined inhalers and tiotropium for chronic obstructive pulmonary disease (COPD) remain uncertain due to a large proportion of missing outcome data. Further large, long-term randomised controlled trials with adequate follow-up are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Effects of formoterol and tiotropium bromide on mucus clearance in patients with COPD.

Author: MeyerThomas, ReitmeirPeter, BrandPeter, HerpichChristiane, SommererKnut, SchulzeAnja, ScheuchGerhard, NewmanStephen

Bronchodilation
Enhanced mucus clearance

Formoterol has been shown to enhance mucus clearance in patients with mild to moderate COPD when given as a single dose and may do so when given for 14 days. While a study of 24 patients found that tiotropium increased radioaerosol retention in the lungs, it is likely that this is due to the bronchodilating effects of the drug, which would increase the distance that the radioaerosol needs to travel to be cleared.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease.

Author: ChongJimmy, PoolePhillippa, LeungBonnie, BlackPeter N

Improved COPD treatment

This study discusses the use of oral phosphodiesterase 4 (PDE(4)) inhibitors, roflumilast and cilomilast, in treating chronic obstructive pulmonary disease (COPD), acknowledging that smoking cessation is the only treatment proven to slow lung function decline.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease.

Author: WaltersJulia Ae, WangWendy, MorleyCarla, SoltaniAmir, Wood-BakerRichard

Reduced adverse effects

This review examines the rationale for shorter systemic corticosteroid (SC) treatment duration for acute exacerbations of chronic obstructive pulmonary disease (COPD) to reduce the risk of adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Comparison of three combined pharmacological approaches with tiotropium monotherapy in stable moderate to severe COPD: a systematic review.

Author: RodrigoGustavo J, PlazaVicente, Castro-RodríguezJosé A

COPD treatment
Improves lung function
Reduces dyspnea
Serious adverse effects

Dual and triple therapy seem like the most promising for patients with moderate to very severe COPD. However, data are still scarce and studies too short to generate a strong recommendation. Future studies should examine long-term efficacy and safety.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Impact of pharmaceutical care on health outcomes in patients with COPD.

Author: JarabAnan S, AlqudahSalam G, KhdourMaher, ShamssainMohammed, MukattashTareq L

Improved COPD outcomes

Despite effective treatments for chronic obstructive pulmonary disease (COPD), treatment goals are often not met. This study explored the potential of clinical pharmacist interventions to improve clinical and humanistic outcomes in COPD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Onset of action of formoterol versus salmeterol via dry powder inhalers in moderate chronic obstructive pulmonary disease: a randomized, placebo-controlled, double-blind, crossover study.

Author: CazzolaMario, PaggiaroPierluigi, PalangePaolo, BjermerLeif, AusinPilar, CarlssonLars-Goran, EkelundJan, LotvallJan

Bronchodilator effect

Formoterol 9 μg has a more rapid onset of bronchodilatory effect than salmeterol 50 μg in patients with moderate chronic obstructive pulmonary disease (COPD), as measured by FEV1 at 5 minutes post-dose.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

46.

Cost effectiveness of pharmacological maintenance treatment for chronic obstructive pulmonary disease: a review of the evidence and methodological issues.

Author: Rutten-van MölkenMaureen P M H, GoossensLucas M A

Treatment of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) affects over 200 million people globally and is associated with significant illness and mortality. Treatment guidelines for COPD recommend a step-by-step approach, gradually increasing treatment intensity when initial approaches are ineffective.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial.

Author: BafadhelMona, McKennaSusan, TerrySarah, MistryVijay, PancholiMitesh, VengePer, LomasDavid A, BarerMichael R, JohnstonSebastian L, PavordIan D, BrightlingChristopher E

Improved CRQ
Reduced corticosteroid use

The peripheral blood eosinophil count is a promising biomarker to direct corticosteroid therapy during COPD exacerbations, but larger studies are required.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Effect of combination treatment on lung volumes and exercise endurance time in COPD.

Author: MagnussenHelgo, PaggiaroPierluigi, SchmidtHendrik, KestenSteven, MetzdorfNorbert, MaltaisFrançois

Improved dyspnea
Reduced hyperinflation

Two bronchodilators (tiotropium and salmeterol) decreased hyperinflation significantly more than one bronchodilator plus inhaled corticosteroid (salmeterol and fluticasone) in patients with chronic obstructive pulmonary disease (COPD). However, this difference was not reflected in exercise endurance time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

Effect of traditional Chinese medicine on outcomes in patients with mild/moderate chronic obstructive pulmonary disease: study protocol for a randomized placebo-controlled trial.

Author: WangMinghang, LiJiansheng, LiSuyun, WangHaifeng, YuXueqing, ZhangHailong

Reduced COPD exacerbations
Relief of COPD symptoms

Traditional Chinese medicine (TCM) may offer potential benefits for patients with chronic obstructive pulmonary disease (COPD), particularly in the early stages or before the disease develops. This study suggests that TCM treatment based on syndrome differentiation could alleviate symptoms and reduce the incidence of COPD exacerbations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

Indacaterol therapy in patients with COPD not receiving other maintenance treatment.

Author: DecramerMarc, RossiAndrea, LawrenceDavid, McBryanDanny

Improved health status
Improved lung function
Reduced dyspnea

Indacaterol, a long-acting beta2-agonist, significantly improved lung function, dyspnea, and health status in COPD patients not receiving other maintenance therapies. It was more effective than placebo and comparable to tiotropium.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

51.

Rationale for earlier treatment in COPD: a systematic review of published literature in mild-to-moderate COPD.

Author: MaltaisFrançois, DennisNatalie, ChanCharles K N

COPD symptom control
Disease progression management

Early intervention in patients with mild-to-moderate COPD can significantly impact disease progression and improve outcomes. Smoking cessation, symptom management, and treatment of activity limitations and exacerbations are crucial for controlling disease progression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Influence of salmeterol/fluticasone via single versus separate inhalers on exacerbations in severe/very severe COPD.

Author: HagedornCordula, KässnerFrank, BanikNorbert, NtampakasParis, FielderKarin

Reduced exacerbations

Patients with severe chronic obstructive pulmonary disease (COPD) often experience repeated exacerbations, leading to high healthcare costs. This study explored the potential of using a combined corticosteroid and bronchodilator inhaler to reduce exacerbations and improve patient compliance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

53.

Efficacy and safety of roflumilast in patients with stable chronic obstructive pulmonary disease: a meta-analysis.

Author: YanJun-Hong, GuWan-Jie, PanLei

Exacerbation reduction
FEV1 improvement
Diarrhea
Headache
Insomnia
Nausea
Weight loss

Roflumilast significantly reduces the mean exacerbation rate in COPD patients. Although there are insufficient clinical evidence on other clinical endpoints and high risk of some adverse events, roflumilast therapy may benefit COPD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

54.

The study design and rationale of the randomized controlled trial: translating COPD guidelines into primary care practice.

Author: ParkerDonna R, EatonCharles B, AhernDavid K, RobertsMary B, RaffertyCaitlin, GoldmanRoberta E, McCoolF Dennis, WroblewskiJoseph

Improved COPD management
Under-diagnosis

This review highlights the under-diagnosis and sub-optimal treatment of chronic obstructive pulmonary disease (COPD). Despite international guidelines, many primary care physicians are not translating evidence into effective clinical practice for COPD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

55.

Chronic obstructive pulmonary disease self-management activation research trial (COPD-SMART): design and methods.

Author: AshmoreJamile, RussoRennie, PeoplesJennifer, SloanJohn, JacksonBradford E, BaeSejong, SinghKaran P, BlairSteven N, CoultasDavid

COPD treatment

COPD is a chronic lung disease that is often accompanied by physical inactivity. This study will investigate the use of pulmonary rehabilitation in treating COPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

56.

Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease.

Author: WelshEmma J, CatesChristopher J, PoolePhillippa

COPD treatment
Exacerbation reduction
Deaths
Hospital admissions
Pneumonia

The relative efficacy and safety of combined inhalers and tiotropium remains uncertain. Further large, long-term randomised controlled trials are required, including adequate follow-up of all participants randomised.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

A self-management approach using self-initiated action plans for symptoms with ongoing nurse support in patients with Chronic Obstructive Pulmonary Disease (COPD) and comorbidities: the COPE-III study protocol.

Author: LenferinkAnke, FrithPeter, van der ValkPaul, BuckmanJulie, SladekRuth, CafarellaPaul, van der PalenJob, EffingTanja

Treatment approach
Action plans unsafe

Chronic obstructive pulmonary disease (COPD) often occurs alongside other health conditions. While current COPD management plans are helpful, they might not be ideal or safe for people with multiple health problems. This study investigates whether a new approach that combines self-managed action plans and nurse support can reduce the number of days of worsening COPD symptoms. The study aims to determine if this approach leads to quicker and more effective treatment for patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

58.

Putting health status guided COPD management to the test: protocol of the MARCH study.

Author: KocksJanwillem, de JongCorina, BergerMarjolein Y, KerstjensHuib A M, van der MolenThys

COPD treatment

This study proposes a new approach to treating chronic obstructive pulmonary disease (COPD) based on a simple questionnaire about how the disease impacts patients' lives, rather than relying solely on lung function tests. The researchers believe this approach could improve patient well-being, reduce exacerbations, increase patient satisfaction, and optimize healthcare use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

59.

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease.

Author: CheyneLeanne, Irvin-SellersMelanie J, WhiteJohn

Improved lung function
Improved quality of life
Reduced exacerbations
Reduced hospital admissions

This review compared the effects of tiotropium to ipratropium bromide in patients with stable chronic obstructive pulmonary disease (COPD). Tiotropium treatment was associated with improved lung function, fewer hospital admissions, fewer exacerbations of COPD, and improved quality of life. Tiotropium was also associated with fewer serious adverse events and disease-specific events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Long-acting beta2-agonists for chronic obstructive pulmonary disease.

Author: KewKayleigh M, MavergamesChris, WaltersJulia A E

Improved exercise tolerance
Improved quality of life
Symptom relief

Inhaled long-acting beta2-agonists (LABAs) are widely prescribed to manage the symptoms of chronic obstructive pulmonary disease (COPD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease.

Author: ChongJimmy, LeungBonnie, PoolePhillippa

Reduced airway inflammation
Reduced bronchoconstriction
COPD symptoms
Reduced lung function

Chronic obstructive pulmonary disease (COPD) is associated with cough, sputum production, dyspnea, and a reduction in lung function, quality of life, and life expectancy. While smoking cessation is crucial, there are no other treatments that slow lung function decline. Roflumilast and cilomilast, oral phosphodiesterase 4 (PDE4) inhibitors, are being investigated for their potential to reduce airway inflammation and bronchoconstriction in COPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis.

Author: KewKayleigh M, DiasSofia, CatesChristopher J

COPD treatment

Treatment for chronic obstructive pulmonary disease (COPD) aims to ease symptoms, improve quality of life, and prevent or manage flare-ups. Treatment typically starts with one inhaler, and additional medications are added as needed. Long-acting inhalers are generally preferred over short-acting ones for ongoing or worsening symptoms. While studies have compared different long-acting inhalers to placebo or other treatments, there's a need for research comparing different types of long-acting inhalers to determine which class of medication is most beneficial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

Prevention of acute exacerbations of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline.

Author: CrinerGerard J, BourbeauJean, DiekemperRebecca L, OuelletteDaniel R, GoodridgeDonna, HernandezPaul, CurrenKristen, BalterMeyer S, BhutaniMohit, CampPat G, CelliBartolome R, DechmanGail, DransfieldMark T, FielStanley B, ForemanMarilyn G, HananiaNicola A, IrelandBelinda K, MarchettiNathaniel, MarciniukDarcy D, MularskiRichard A, OrnelasJoseph, RoadJeremy D, SticklandMichael K

COPD treatment

Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, leading to many hospitalizations and increased healthcare costs. Flare-ups (exacerbations) of COPD are a major contributor to the worsening of lung function and quality of life. Recent research has improved our understanding of COPD and how to prevent these exacerbations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

Efficacy and safety of umeclidinium/vilanterol 62.5/25 mcg and tiotropium 18 mcg in chronic obstructive pulmonary disease: results of a 24-week, randomized, controlled trial.

Author: Maleki-YazdiM Reza, KaelinThomas, RichardNathalie, ZvarichMichael, ChurchAlison

Improved lung function
Improved quality of life
Reduced rescue medication
Similar adverse events

Umeclidinium bromide and vilanterol (UMEC/VI) was associated with statistically significant and clinically meaningful improvements in lung function versus tiotropium (TIO) in patients with moderate-to-very severe COPD. UMEC/VI was well tolerated.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

65.

Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease.

Author: WaltersJulia A E, TanDaniel J, WhiteClinton J, Wood-BakerRichard

Reduced COPD exacerbation duration
Reduced corticosteroid side effects

Current guidelines recommend systemic corticosteroid treatment for seven to 14 days for patients with acute exacerbations of chronic obstructive pulmonary disease (COPD). This review explores the potential for shorter treatment durations to reduce the risk of adverse effects associated with prolonged corticosteroid use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Randomized double blind placebo-controlled study to demonstrate that antibiotics are not needed in moderate acute exacerbations of COPD--the ABACOPD study.

Author: RohdeGernot G U, KochArmin, WelteTobias,

AE-COPD
Antibiotic-resistant bacteria

This research examines the effectiveness of antibiotics in treating acute exacerbations of COPD (AE-COPD). While antibiotics are commonly used, there is limited evidence supporting their efficacy in AE-COPD, particularly when considering the role of respiratory viruses and the use of corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

67.

Preference, satisfaction and critical errors with Genuair and Breezhaler inhalers in patients with COPD: a randomised, cross-over, multicentre study.

Author: PascualSergi, FeimerJan, De SoyzaAnthony, Sauleda RoigJaume, HaughneyJohn, PadullésLaura, SeoaneBeatriz, RekedaLudmyla, RiberaAnna, ChrystynHenry

Improved patient preference
Improved patient satisfaction
Critical inhaler technique errors

In patients with chronic obstructive pulmonary disease (COPD), Genuair (a multidose inhaler) was preferred over Breezhaler (a single-dose inhaler) for its higher patient satisfaction and overall preference. There was no significant difference in the number of patients making critical inhaler technique errors with either device.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

68.

Can early introduction of specialized palliative care limit intensive care, emergency and hospital admissions in patients with severe and very severe COPD? a randomized study.

Author: WeberCatherine, StirnemannJerome, HerrmannFrançois R, PautexSophie, JanssensJean-Paul

COPD management
Hospitalization reduction
ICU admission reduction

COPD is a serious lung disease with high mortality rates. While current treatments can manage symptoms, there is a need for more effective palliative care interventions. This trial will assess the impact of specialized palliative care on hospital admissions for patients with severe COPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

69.

Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease.

Author: CheyneLeanne, Irvin-SellersMelanie J, WhiteJohn

Improved lung function
Improved quality of life
Reduced hospital admissions

Tiotropium treatment was associated with improved lung function, fewer hospital admissions, fewer exacerbations of COPD, and improved quality of life compared to ipratropium bromide. There were fewer serious adverse events and disease-specific events in the tiotropium group, but no significant difference in deaths.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

70.

Mortality and drug therapy in patients with chronic obstructive pulmonary disease: a network meta-analysis.

Author: ScottDavid A, WoodsBethan, ThompsonJuliette C, ClarkJames F, HawkinsNeil, ChambersMike, CelliBartolome R, CalverleyPeter

COPD survival

Pharmacological treatments may influence overall survival in patients with Chronic Obstructive Pulmonary Disease (COPD), but individual studies are often underpowered to detect mortality differences.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

The lung function profile of once-daily tiotropium and olodaterol via Respimat(®) is superior to that of twice-daily salmeterol and fluticasone propionate via Accuhaler(®) (ENERGITO(®) study).

Author: BeehKai-Michael, DeromEric, Echave-SustaetaJosé, GrönkeLars, HamiltonAlan, ZhaiDongmei, BjermerLeif

Tiotropium + olodaterol for COPD

Tiotropium plus olodaterol, taken once daily, has shown benefits beyond just lung function for people with COPD, potentially making it a good option for initial treatment. While guidelines recommend combining long-acting beta-agonists and inhaled corticosteroids only for people at high risk of exacerbations, they are often used for those at lower risk. This study aims to compare the effectiveness of this combination therapy with other combination treatments for people at lower risk of COPD exacerbations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

72.

Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD.

Author: WedzichaJadwiga A, BanerjiDonald, ChapmanKenneth R, VestboJørgen, RocheNicolas, AyersR Timothy, ThachChau, FogelRobert, PatalanoFrancesco, VogelmeierClaus F,

This research explores the role of long-acting beta-agonist (LABA) plus long-acting muscarinic antagonist (LAMA) regimens for treating patients with chronic obstructive pulmonary disease (COPD) who have a high risk of exacerbations. The study investigates the potential benefits of combining these treatments.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

73.

The Pharmacological Treatment of Chronic Obstructive Pulmonary Disease.

Author: GillissenAdrian, HaidlPeter, KhlhäuflMartin, KroegelKlaus, VoshaarThomas, GessnerChristian

Improved quality of life
Reduced exacerbations
Pneumonia

This review assessed the effectiveness of inhaled corticosteroids (ICS) in treating chronic obstructive pulmonary disease (COPD). ICS monotherapy has no clinically useful effect on pulmonary function in COPD. ICS are only recommended for patients with grade III or IV COPD to reduce the frequency of exacerbations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

74.

Combination inhaled steroid and long-acting beta₂-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease.

Author: Rojas-ReyesMaria Ximena, García MoralesOlga M, DennisRodolfo J, KarnerCharlotta

Improved COPD treatment

Combining tiotropium, a long-acting bronchodilator, with inhaled corticosteroids and long-acting beta2-agonists (ICS/LABA) may be more effective than administering these treatments individually for chronic obstructive pulmonary disease (COPD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Drug safety evaluation of roflumilast for the treatment of COPD: a meta-analysis.

Author: RoglianiPaola, CalzettaLuigino, CazzolaMario, MateraMaria Gabriella

Roflumilast effective
Back pain
Gastrointestinal AEs
Headache
Insomnia

This review assessed the safety and efficacy of roflumilast, a phosphodiesterase 4 inhibitor approved for COPD. Roflumilast increased the risk of adverse events, especially gastrointestinal, but did not impact the risk of serious adverse events. Roflumilast may be beneficial for patients with a high risk of severe exacerbations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

76.

Potential treatment benefits and safety of roflumilast in COPD: a systematic review and meta-analysis.

Author: YuanLianfang, DaiXuan, YangMeng, CaiQiling, ShaoNa

COPD exacerbation prevention
Improved quality of life
Improved spirometry
Adverse drug reactions

Roflumilast is an effective treatment option for chronic obstructive pulmonary disease (COPD). It helps prevent exacerbations and improve lung function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Compare the efficacy and safety of long-acting anticholinergic and a combination of inhaled steroids and long-acting beta-2 agonist in moderate chronic obstructive pulmonary disease.

Author: SaraçPınar, SayınerAbdullah

Improved well-being
Reduced morbidity
Reduced mortality

This study compared the efficacy and tolerability of salmeterol/fluticasone combination therapy with tiotropium in patients with moderate COPD. The research aimed to determine the most effective and well-tolerated treatment for COPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

78.

Smoking cessation for people with chronic obstructive pulmonary disease.

Author: van EerdEva A M, van der MeerRegina M, van SchayckOnno C P, KotzDaniel

Increased quit rate

A combination of behavioral treatment and pharmacotherapy is effective in helping smokers with chronic obstructive pulmonary disease (COPD) to quit smoking. This was found in a meta-analysis of four studies involving 1,540 participants. However, there is no convincing evidence to support the use of any particular behavioral or pharmacological treatment over others.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

79.

Systematic Review and Quality Appraisal of Cost-Effectiveness Analyses of Pharmacologic Maintenance Treatment for Chronic Obstructive Pulmonary Disease: Methodological Considerations and Recommendations.

Author: van der SchansSimon, GoossensLucas M A, BolandMelinde R S, KocksJanwillem W H, PostmaMaarten J, van BovenJob F M, Rutten-van MölkenMaureen P M H

COPD treatment

Chronic obstructive pulmonary disease (COPD) is a common lung disease with significant impact on health and economics. While the cost-effectiveness of COPD medications has been studied, these studies haven't fully considered the order in which medications are used and the specific stages of the disease they are used for in real-world settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

80.

Effect of ELOM-080 on exacerbations and symptoms in COPD patients with a chronic bronchitis phenotype - a post-hoc analysis of a randomized, double-blind, placebo-controlled clinical trial.

Author: BeehKai-Michael, BeierJutta, CandlerHenning, WittigThomas

COPD treatment
None mentioned

This study explored the potential effects of ELOM-080 in COPD patients, considering its demonstrated efficacy in treating symptoms and preventing exacerbations in individuals with chronic bronchitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

81.

Action plans with brief patient education for exacerbations in chronic obstructive pulmonary disease.

Author: HowcroftMaxwell, WaltersE Haydn, Wood-BakerRichard, WaltersJulia Ae

COPD exacerbation management
COPD exacerbation severity

This study discussed the use of action plans as a form of self-management for chronic obstructive pulmonary disease (COPD) exacerbations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

82.

Early efficacy of budesonide/formoterol in patients with moderate-to-very-severe COPD.

Author: CalverleyPeter M, ErikssonGöran, JenkinsChristine R, AnzuetoAntonio R, MakeBarry J, PerssonAnders, FageråsMalin, PostmaDirkje S

Significant treatment effects

Large studies have shown that combining inhaled corticosteroids and long-acting beta-agonists is effective for treating chronic obstructive pulmonary disease (COPD) over the long term. This study investigated whether significant improvements in a range of health outcomes would be seen within the first three months of treatment, regardless of the severity of COPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

83.

Long-acting muscarinic antagonist (LAMA) plus long-acting beta-agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease (COPD).

Author: HoritaNobuyuki, GotoAtsushi, ShibataYuji, OtaErika, NakashimaKentaro, NagaiKenjiro, KanekoTakeshi

This research examines the choice of combination therapy for patients with chronic obstructive pulmonary disease (COPD) who require two classes of medications. The study highlights the updated GOLD 2017 guidance recommending LAMA+LABA over LABA+ICS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Efficacy and safety of indacaterol/glycopyrronium fixed-dose combination in mild-to-moderate COPD patients symptomatic on tiotropium in Korea: study protocol for a randomized controlled trial.

Author: RheeChin Kook, ParkHye Yun, ParkJeong-Woong, LeeJi-Hyun, KimTae-Hyung, LeeSei Won, JungJi Ye, KimSong, HwangYong Il, JungKi-Suck

COPD treatment

This study highlights the need for alternative therapeutic approaches for patients with chronic obstructive pulmonary disease (COPD) who remain symptomatic despite single bronchodilator therapy.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

85.

Discovering the Relative Efficacy of Inhaled Medications for Chronic Obstructive Pulmonary Disease: Multiple Treatment Comparisons.

Author: ZhuYing, ZhangTong, LiHaiyan, YangYang, ChenQiong, KongLei, TaiBo

Efficacy enhancement

This study discussed the use of combined inhaled medications for chronic obstructive pulmonary disease (COPD), emphasizing the need for clinical evidence to support their widespread use for efficacy enhancement.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

86.

Non-invasive ventilation with intelligent volume-assured pressure support versus pressure-controlled ventilation: effects on the respiratory event rate and sleep quality in COPD with chronic hypercapnia.

Author: NiliusGeorg, KatamadzeNato, DomanskiUlrike, SchroederMaik, FrankeKarl-Josef

Better sleep quality
Improved alveolar ventilation

NIV with intelligent volume-assured pressure support (IVAPS) allowed application of higher nocturnal ventilation pressures versus spontaneous timed (ST) NIV without affecting sleep quality or inducing ventilation-associated events in patients with chronic hypercapnic COPD.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

87.

Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial.

Author: MurphyPatrick B, RehalSunita, ArbaneGill, BourkeStephen, CalverleyPeter M A, CrookAngela M, DowsonLee, DuffyNicholas, GibsonG John, HughesPhilip D, HurstJohn R, LewisKeir E, MukherjeeRahul, NickolAnnabel, OscroftNicholas, PatoutMaxime, PepperellJustin, SmithIan, StradlingJohn R, WedzichaJadwiga A, PolkeyMichael I, ElliottMark W, HartNicholas

Prolonged time to readmission or death

Adding home noninvasive ventilation to home oxygen therapy prolonged the time to readmission or death within 12 months in patients with persistent hypercapnia following an acute exacerbation of chronic obstructive pulmonary disease (COPD).

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

88.

Umeclidinium bromide versus placebo for people with chronic obstructive pulmonary disease (COPD).

Author: NiHan, HtetAung, MoeSoe

COPD treatment

This abstract discusses the importance of umeclidinium, a new long-acting muscarinic antagonist, for the treatment of patients with stable COPD. The abstract highlights the challenges of COPD, including poor quality of life, reduced survival, accelerated lung function decline, and high healthcare costs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Double bronchodilation in chronic obstructive pulmonary disease: a crude analysis from a systematic review.

Author: Lopez-CamposJose Luis, Calero-AcuñaCarmen, Márquez-MartínEduardo, Quintana GallegoEsther, Carrasco-HernándezLaura, Abad ArranzMaria, Ortega RuizFrancisco

COPD treatment

This systematic review examines the efficacy of double bronchodilation, combining a long-acting muscarinic antagonist (LAMA) and a long-acting β2-agonist (LABA) in a single inhaler, for the treatment of COPD. The review focuses on comparing this treatment approach to placebo and monotherapy bronchodilation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Causes of misdiagnosis of chronic obstructive pulmonary disease: A systematic scoping review.

Author: HangaardStine, HelleTina, NielsenCarl, HejlesenOle K

Accurate diagnosis
Incorrect treatment
Misdiagnosis

Misdiagnosis of chronic obstructive pulmonary disease (COPD) is mainly attributable to spirometry and the healthcare professional performing the diagnostic assessment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

91.

Effect of carbocisteine on patients with COPD: a systematic review and meta-analysis.

Author: ZengZheng, YangDan, HuangXiaoling, XiaoZhenliang

Reduced COPD exacerbations

Carbocisteine, a mucoactive medicine, may be effective in reducing exacerbations of COPD, a common, progressive, treatable, and preventable disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease.

Author: ChongJimmy, LeungBonnie, PoolePhillippa

Reduced airway inflammation
Reduced bronchoconstriction

Roflumilast and cilomilast, oral phosphodiesterase 4 (PDE<sub>4</sub>) inhibitors, are being investigated as potential treatments for chronic obstructive pulmonary disease (COPD) to reduce airway inflammation and bronchoconstriction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

93.

Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease.

Author: WaltersJulia Ae, TanDaniel J, WhiteClinton J, Wood-BakerRichard

Reduced adverse effects

This abstract discusses the current guidelines recommending 7-14 days of systemic corticosteroid treatment for acute exacerbations of chronic obstructive pulmonary disease (COPD), highlighting the potential benefits of shorter treatment durations to reduce adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Nebulized Corticosteroids in the Treatment of COPD Exacerbations: Systematic Review, Meta-Analysis, and Clinical Perspective.

Author: PleasantsRoy A, WangTiansheng, XuXiaohan, BeikoTatsiana, BeiHe, ZhaiSuodi, DrummondM Bradley

Improved lung function

High-dose nebulized budesonide was noninferior to systemic corticosteroids for the treatment of COPD exacerbations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

95.

Combined aclidinium bromide and long-acting beta2-agonist for chronic obstructive pulmonary disease (COPD).

Author: NiHan, MoeSoe, SoeZay, MyintKay Thi, ViswanathanK Neelakantan

The study reviews the use of long-acting beta<sub>2</sub>-agonist (LABA)/long-acting muscarinic antagonist (LAMA) combinations in treating stable chronic obstructive pulmonary disease (COPD). It focuses on the fixed-dose combination (FDC) of aclidinium/formoterol, one of the approved LABA/LAMA therapies for COPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

96.

Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease.

Author: PollokJustyna, van AgterenJoep Em, Carson-ChahhoudKristin V

Respiratory issues

This review addresses the issue of depression in patients with chronic obstructive pulmonary disease (COPD), which is often under-managed. Untreated depression in COPD is associated with poorer quality of life, lower treatment compliance, increased exacerbations, hospital admissions, and higher healthcare costs. The review emphasizes the need for effective treatment interventions for depression in COPD patients, considering the potential risks associated with antidepressants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Triple versus dual inhaler therapy in moderate-to-severe COPD: A systematic review and meta-analysis of randomized controlled trials.

Author: ZayedYazan, BarbarawiMahmoud, KheiriBabikir, HaykalTarek, ChahineAdam, RashdanLaith, HamidKewan, SundusSaira, BanifadelMomen, AburahmaAhmed, BachuwaGhassan, ChandranArul

COPD exacerbation reduction
Lung function improvement
Quality of life improvement
Pneumonia

Triple inhaler therapy (ICS, LAMA, and LABA) was associated with a reduction in moderate-to-severe COPD exacerbations, improved lung function, and improved quality of life when compared to dual inhaler therapy. However, triple therapy was associated with an increased risk of pneumonia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

98.

Effect of smoking status on lung function, patient-reported outcomes, and safety among COPD patients treated with glycopyrrolate inhalation powder: pooled analysis of GEM1 and GEM2 studies.

Author: TashkinDonald P, GoodinThomas, BowlingAlyssa, PriceBarry, Ozol-GodfreyAyca, SharmaSanjay, SanjarShahin

Lung function improvement
COPD

Glycopyrrolate significantly improved lung function in patients with moderate-to-severe COPD, regardless of their smoking status. The improvements were less marked in patients receiving background inhaled corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

99.

Decline of COPD exacerbations in clinical trials over two decades - a systematic review and meta-regression.

Author: AndreasStefan, RöverChristian, HeinzJudith, StraubeSebastian, WatzHenrik, FriedeTim

Reduced COPD exacerbation rate

This study investigates the potential decline in exacerbation rates in chronic obstructive pulmonary disease (COPD) clinical trials over time, aiming to improve the design and interpretation of COPD trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

100.

A Smart Mobile Health Tool Versus a Paper Action Plan to Support Self-Management of Chronic Obstructive Pulmonary Disease Exacerbations: Randomized Controlled Trial.

Author: BoerLonneke, BischoffErik, van der HeijdenMaarten, LucasPeter, AkkermansReinier, VercoulenJan, HeijdraYvonne, AssendelftWillem, SchermerTjard

Increased disease burden

A smart mobile health (mHealth) tool did not show beneficial effects on exacerbation-free time, health status, self-efficacy, self-management behavior, and health care utilization in patients with chronic obstructive pulmonary disease (COPD) compared with the use of a paper action plan. However, participants were positive about the supportive function and the usability of the mHealth tool.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

101.

A phase III study of triple therapy with budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler 320/18/9.6 μg and 160/18/9.6 μg using co-suspension delivery technology in moderate-to-very severe COPD: The ETHOS study protocol.

Author: RabeKlaus F, MartinezFernando J, FergusonGary T, WangChen, SinghDave, WedzichaJadwiga A, TrivediRoopa, St RoseEarl, BallalShaila, McLarenJulie, DarkenPatrick, ReisnerColin, DorinskyPaul

Improved COPD treatment

This review examines the optimal patient population and benefit:risk ratio of single inhaler triple therapy (ICS/LAMA/LABAs) for chronic obstructive pulmonary disease (COPD).

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

102.

Use of inhaled devices during a hospital exacerbation of COPD: a summary of an interdisciplinary audit held at ICS Maugeri Pavia, Italy (March-June 2019).

Author: VitaccaMichele, LastoriaCinzia, DelmastroMonica, FiorenzaDomenico, De CataPasquale, Fusar PoliBarbara, GilèSonia, PromettiPaola, PaneroniMara, BianchiCristina, MandoraElena, PorriRoberta, FracchiaClaudio

Improved COPD treatment

This clinical audit examines current practices for treating chronic obstructive pulmonary disease (COPD) patients at hospital admission with exacerbations, comparing these practices to current guidelines and recommending a multidisciplinary approach to care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

103.

Phosphodiesterase-4 inhibitors for chronic obstructive pulmonary disease.

Author: JanjuaSadia, FortescueRebecca, PoolePhillippa

Improved COPD treatment

This Cochrane Review examines the use of roflumilast and cilomilast, oral phosphodiesterase-4 (PDE₄) inhibitors, as potential treatments for chronic obstructive pulmonary disease (COPD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

104.

Investigational treatments in phase I and II clinical trials: a systematic review in chronic obstructive pulmonary disease (COPD).

Author: CalzettaLuigino, RitondoBeatrice Ludovica, MateraMaria Gabriella, PezzutoGabriella, CazzolaMario, RoglianiPaola

Improved COPD treatment

This systematic review assesses investigational agents in Phase I and II clinical trials for COPD, examining whether these agents offer promising future treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

105.

Impact of baseline COPD symptom severity on the benefit from dual <i>versus</i> mono-bronchodilators: an analysis of the EMAX randomised controlled trial.

Author: VogelmeierClaus F, KerwinEdward M, BjermerLeif H, TombsLee, JonesPaul W, BoucotIsabelle H, NayaIan P, LipsonDavid A, ComptonChris, BarnesNeil, MaltaisFrançois

COPD treatment
Symptom relief
COPD exacerbations

The study aimed to compare treatment responses to bronchodilator therapy in patients with chronic obstructive pulmonary disease (COPD) at low risk of exacerbations with different levels of symptom severity.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

106.

A Randomized, Noninferiority Trial Comparing ICS + LABA with ICS + LABA + LAMA in Asthma-COPD Overlap (ACO) Treatment: The ACO Treatment with Optimal Medications (ATOMIC) Study.

Author: ParkSo-Young, KimSolmi, KimJung-Hyun, KimSae-Hoon, LeeTaehoon, YoonSun-Young, KimMin-Hye, MoonJi-Yong, YangMin-Suk, JungJae-Woo, KimJoo-Hee, ChoiJeong-Hee, ParkChan Sun, KimSujeong, LeeJaechun, KwonJae-Woo, HurGyu Young, KimSang-Ha, KimHee-Kyoo, ShinYoo Seob, KimSang-Hoon, NamYoung-Hee, JangAn-Soo, ParkSeo Young, KimTae-Bum,

Improved lung function

While the study was inconclusive in demonstrating that inhaled corticosteroids (ICSs) plus long-acting β2-agonists (LABAs) plus long-acting muscarinic antagonists (LAMAs) is not inferior to ICSs plus LABAs in terms of exacerbations, it did show improved lung function in patients with asthma and chronic obstructive pulmonary disease overlap (ACO).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

107.

Efficacy and safety of anti-interleukin-5 therapy in patients with chronic obstructive pulmonary disease: A meta-analysis of randomized, controlled trials.

Author: LanShao-Huan, LaiChih-Cheng, ChangShen-Peng, HsuChun-Chun, ChenCheng-Hsin, WangYa-Hui, HuangYueh Lan, WangCheng-Yi, LinYou-Shuei

COPD exacerbation prevention

A meta-analysis of five randomized controlled trials involving 2837 patients with chronic obstructive pulmonary disease (COPD) found that anti-interleukin-5 (IL-5) therapy, including mepolizumab and benralizumab, was associated with a lower risk of COPD exacerbation compared to placebo (rate ratio 0.92, 95% CI 0.86-0.97). Anti-IL-5 therapy was well-tolerated by patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

108.

Pharmacological treatment of stable chronic obstructive pulmonary disease.

Author: SinghDave

COPD treatment

This review discusses the evolution of treatment for chronic obstructive pulmonary disease (COPD), a lung condition. Treatment has shifted towards a personalized approach, considering each patient's unique characteristics. The use of blood eosinophil counts to guide treatment with inhaled corticosteroids is now common practice. The development of new combination medications for COPD has also advanced treatment options, but there are still areas needing more research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

109.

Personalized Variable vs Fixed-Dose Systemic Corticosteroid Therapy in Hospitalized Patients With Acute Exacerbations of COPD: A Prospective, Multicenter, Randomized, Open-Label Clinical Trial.

Author: LiLi, ZhaoNana, MaXiangyu, SunFenfen, HeBinfeng, QinZhen, WuKui, WangXingsheng, ZhaoQian, ZhangShisi, NieNaifu, LuoDong, SunBin, ShenYe, HeYong, WenFuqiang, ZhengJinping, JonesPaul, CaoGuoqiang

Reduced treatment failure
None mentioned

Personalized dosing of corticosteroids reduced the risk of failure in hospitalized patients with COPD exacerbations, with a lower rate of in-hospital treatment failure compared to fixed-dose administration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

110.

Interventions to improve adherence to pharmacological therapy for chronic obstructive pulmonary disease (COPD).

Author: JanjuaSadia, PikeKatharine C, CarrRobin, ColesAndy, FortescueRebecca, BataviaMitchell

Pharmacological treatments for COPD
Non-adherence
Suboptimal therapy

Chronic obstructive pulmonary disease (COPD) is a long-term lung condition causing ongoing breathing problems, shortness of breath, and frequent flare-ups. If people don't take their medications as prescribed or don't follow their treatment plan, their health can be negatively affected.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

111.

TRONARTO: A Randomized, Placebo-Controlled Study of Tiotropium/Olodaterol Delivered via Soft Mist Inhaler in COPD Patients Stratified by Peak Inspiratory Flow.

Author: MahlerDonald A, Ludwig-SengpielAndrea, FergusonGary T, de la HozAlberto, RitzJohn, ShaikhAsif, WatzHenrik

COPD treatment
Inhaled bronchodilator effectiveness

This study explores the clinical significance of low peak inspiratory flow (PIF) in patients with chronic obstructive pulmonary disease (COPD) using inhaled bronchodilator therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

112.

Are short courses of antibiotic therapy as effective as standard courses for COPD exacerbations? A systematic review and meta-analysis.

Author: LlorCarl, MoragasAna, MiravitllesMarc, MesquitaPatrick, CordobaGloria

Reduced resistance
Short course antibiotics

This systematic review and meta-analysis evaluated the effectiveness of short-course antibiotic therapy compared to standard longer courses for chronic obstructive pulmonary disease (COPD) exacerbations. The results showed no significant difference between short-course and standard courses in terms of clinical cure, bacterial eradication, and adverse events. Short-course antibiotic therapy may offer benefits by reducing the risk of antimicrobial resistance and could be considered as a first-line treatment for ambulatory COPD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

113.

Efficacy and Safety Analysis of Piperacillin Tazobactam in Combination With High Frequency Chest Wall Oscillation in Patients With COPD Coupled With Pneumonia.

Author: LiLi, FengQiong, MengQinghua, LiFajiu

Recurrent AE-COPD

Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory lung disease. Acute exacerbation of COPD (AE-COPD) can be complicated by pneumonia, leading to recurrent attacks. Conventional treatments for AE-COPD with pneumonia are often ineffective.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

114.

Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function.

Author: HanMeiLan K, YeWen, WangDi, WhiteEmily, ArjomandiMehrdad, BarjaktarevicIgor Z, BrownStacey-Ann, BuhrRussell G, ComellasAlejandro P, CooperChristopher B, CrinerGerard J, DransfieldMark T, DrescherFrank, FolzRodney J, HanselNadia N, KalhanRavi, KanerRobert J, KannerRichard E, KrishnanJerry A, LazarusStephen C, MaddipatiVeeranna, MartinezFernando J, MathewsAnne, MeldrumCatherine, McEvoyCharlene, NyunoyaToru, RogersLinda, StringerWilliam W, WendtChristine H, WiseRobert A, WisniewskiStephen R, SciurbaFrank C, WoodruffPrescott G,

COPD medication

This study aimed to investigate the evidence supporting the use of medications for chronic obstructive pulmonary disease (COPD) in individuals with a history of smoking tobacco but without airflow obstruction as assessed by spirometry.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

115.

Efficacy of Xiyanping in the Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease and Its Effect on the Expression of GDF-15 and HIF-1<i>&#945;</i> in Serum.

Author: WangJun Xia, ZhangYing, WangShu Fang, LiJuan, LiPeng Cheng

COPD treatment
Improved pulmonary function
Reduced airway hyperreactivity

Xiyanping was found to improve pulmonary function, reduce airway hyperreactivity, and promote sputum excretion in elderly patients with acute exacerbation of COPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

116.

2023 Canadian Thoracic Society Guideline on Pharmacotherapy in Patients With Stable COPD.

Author: BourbeauJean, BhutaniMohit, HernandezPaul, AaronShawn D, BeauchesneMarie-France, KermellySophie B, D'UrzoAnthony, LalAvtar, MaltaisFrançois, MarciniukJeffrey D, MulpuruSunita, PenzErika, SinDon D, Van DamAnne, WaldJoshua, WalkerBrandie L, MarciniukDarcy D

COPD treatment

This guideline provided recommendations for optimizing maintenance pharmacologic therapy for individuals with stable COPD, incorporating new evidence and addressing key clinical questions related to symptom burden, exacerbations, and mortality.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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