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Evaluation of the efficacy and tolerability of the combination delapril plus indapamide in the treatment of mild to moderate essential hypertension: a randomised, multicentre, controlled study.

Author: , RizzoniD, RoseiE A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

The combination of delapril and indapamide (D+I) was found to be more effective than captopril and hydrochlorothiazide (C+H) in reducing blood pressure in patients with mild to moderate essential hypertension. Both treatments were well tolerated.
Paper Details　
Original Abstract of the Article :
The aim of the study was to evaluate efficacy and tolerability of two different fixed combinations of an angiotensin-converting enzyme inhibitor and a diuretic: delapril+indapamide (D+I) and captopril+hydrochlorothiazide (C+H) administered for 6 months to patients with mild to moderate essential hyp...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12574793

データ提供：米国国立医学図書館（NLM）

Delapril Plus Indapamide: A Combo for Mild to Moderate Hypertension

The field of [hypertension] is constantly seeking better ways to control blood pressure. This study compares the efficacy and tolerability of two fixed-dose combinations of [angiotensin-converting enzyme inhibitor] and [diuretic] in treating [mild to moderate essential hypertension]. The researchers conducted a [randomized, multicenter, controlled study] involving [829 patients] and found that the combination of [delapril plus indapamide] was more effective than [captopril plus hydrochlorothiazide], demonstrating its potential as a valuable treatment option for [hypertension].

A Winning Combination: Delapril Plus Indapamide Takes the Lead

The researchers found that the combination of [delapril plus indapamide] led to a significantly greater reduction in [blood pressure] compared to the other medication combination. The [responder rates] were [72.6%] for [delapril plus indapamide] and [62.9%] for [captopril plus hydrochlorothiazide] after [60 days of treatment]. This suggests that [delapril plus indapamide] could be a more effective treatment for individuals seeking to control their [blood pressure].

Camel's Thoughts on Hypertension Management

Just as a camel needs a steady source of water in the desert, individuals with [hypertension] need a reliable way to manage their [blood pressure]. This research suggests that the combination of [delapril plus indapamide] might offer a valuable solution, providing a greater chance of achieving [blood pressure] control without increasing the risk of side effects.

Dr. Camel's Conclusion

This research highlights the importance of considering different medication combinations in the treatment of [hypertension]. The study suggests that [delapril plus indapamide] may be a more effective option for managing [mild to moderate essential hypertension] than [captopril plus hydrochlorothiazide], offering a winning combination for those seeking to control their blood pressure and lead healthier lives.

Date :
  1. Date Completed 2003-05-23
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

12574793

DOI: Digital Object Identifier

1001514

Related Literature

Article Analysis
・Effects of captopril and hydrochlorothiazide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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