Paper Details

  1. Home
  2. Paper Details

[Effects of benazepril on apoptosis in the kidney of diabetic rats].

Author: DuanHui-jun, LiYing-min, LiuFang, ShiYong-hong, ZhangYan-ling

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Angiotensin-converting enzyme inhibitor (ACEI) benazepril demonstrated a renal protective effect on diabetic nephropathy in rats. It reduced the number of apoptotic cells and the expression of Fas and Fas-L in the kidneys of diabetic rats, suggesting a mechanism of action through inhibition of apoptosis.
Paper Details　
Original Abstract of the Article :
AIM: To investigate the effects of angiotensin converting enzyme inhibitor (ACEI) on apoptosis and the expression of Fas and Fas-L in the kidney of diabetic rats. METHODS: Uninephrectomized Spraque-Dawley rats were used to induce diabetes by intraperitoneal injection of streptozotocin (65 mg.kg-1)....See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/12579793

データ提供：米国国立医学図書館（NLM）

Benazepril: A Potential Renal Protector in Diabetic Rats

Diabetic nephropathy, a kidney complication of diabetes, can lead to serious health problems. This study investigates the effects of benazepril, an angiotensin-converting enzyme inhibitor (ACEI), on apoptosis in the kidneys of diabetic rats. The researchers, like careful physicians monitoring their patients' health, sought to understand how benazepril could potentially protect the kidneys from damage in diabetic rats.

Unveiling the Protective Effects of Benazepril

The study found that benazepril significantly reduced apoptosis in the kidneys of diabetic rats. This suggests that benazepril could have a protective effect on the kidneys in diabetic individuals. The study also observed that benazepril downregulated the expression of Fas and Fas-L, molecules involved in apoptosis. This research highlights the potential of benazepril to mitigate kidney damage in diabetes.

Potential for Improved Kidney Health in Diabetes

This study provides valuable insights into the potential benefits of benazepril for managing diabetic nephropathy. The findings suggest that benazepril could play a role in protecting the kidneys from damage in diabetic individuals. This research encourages further investigation into the use of ACEIs for preventing and managing kidney complications in diabetes.

Dr. Camel's Conclusion

This study reveals the potential of benazepril, an angiotensin-converting enzyme inhibitor (ACEI), to reduce apoptosis in the kidneys of diabetic rats, suggesting a protective effect on kidney health. This research highlights the potential of ACEIs for managing diabetic nephropathy and underscores the need for further investigation into their therapeutic benefits for preventing and managing kidney complications in diabetes.

Date :
  1. Date Completed 2003-12-08
  2. Date Revised 2020-09-14
Further Info :

Pubmed ID

12579793

DOI: Digital Object Identifier

12579793

Related Literature

Article Analysis
・Effects of benazepril
SNS
PICO Info
in preparation
Languages

Chinese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.