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Language Disturbances as Side Effects of Topiramate and Zonisamide Therapy.

Author: CrawfordCarol A., DodrillCarl B., DudleyDonald L., HolmesMark D., OjemannGeorge A., OjemannLinda M.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Topiramate (TPM) and zonisamide (ZNS), two sulfa-containing antiepileptic drugs, have been linked to reversible side effects, primarily language impairment. This study reports on the side effects observed in patients taking TPM and ZNS.
Paper Details　
Original Abstract of the Article :
Reversible side effects of two sulfa-containing antiepileptic drugs (AEDs), topiramate (TPM) and zonisamide (ZNS), are reported. These effects differ from those of other AEDs in that language impairment was the predominant cognitive complaint. Information was available for 42 patients exposed to TPM...See full text at original site
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引用元：
https://doi.org/10.1006/ebeh.2001.0285

データ提供：米国国立医学図書館（NLM）

Topiramate and Zonisamide: A Look at Language Side Effects

This [clinical study] explores the [potential side effects] of topiramate (TPM) and zonisamide (ZNS), two sulfa-containing antiepileptic drugs (AEDs), focusing on [language disturbances] as a [unique] side effect. The authors found that [language impairment] was a [common] complaint among patients taking these drugs. This research highlights the [importance] of [monitoring] for [cognitive side effects] in patients taking these AEDs.

Unveiling the [Hidden Impact] of Antiepileptic Drugs

This research highlights the [potential] for [cognitive side effects] to [arise] from the use of antiepileptic drugs. The study found that topiramate and zonisamide, two [sulfa-containing AEDs], can [negatively impact] language processing. This underscores the [importance] of [monitoring] for [cognitive changes] in patients taking these medications.

Navigating the [Complexities] of [Drug Therapy]

This research underscores the [importance] of [individualized care] in [managing] chronic conditions like epilepsy. The study highlights the [need] for [careful monitoring] of [cognitive function] in patients taking [antiepileptic drugs], particularly those containing [sulfa]. This research reminds us that [drug therapy] can have [unanticipated effects], and it is [essential] to [be vigilant] in [assessing] patient [response].

Dr. Camel's Conclusion

This research sheds light on the [potential side effects] of topiramate and zonisamide, two antiepileptic drugs. The study highlights the [importance] of [monitoring] for [cognitive side effects] in patients taking these medications. Just as a [camel] adapts to the [changing landscape] of the desert, healthcare providers must [adapt] their approach to [managing] epilepsy and [carefully monitor] for [unanticipated effects] of [drug therapy].
Date :
  1. Date Completed n.d.
  2. Date Revised 2019-11-20
Further Info :

Pubmed ID

12609393

DOI: Digital Object Identifier

10.1006/ebeh.2001.0285

Related Literature

Article Analysis
・Side Effects of topiramate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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