Side Effects of topiramate: A Synthesis of Findings from 12 Studies

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Original Abstract of the Article

Main Research Findings

Topiramate is an anti-epileptic drug that can cause weight loss as a side effect. 5 . Topiramate has been shown to reduce appetite and increase energy expenditure in animal models of obesity. 5 . Topiramate has also been reported to cause visual disturbances, particularly visual field defects and myopic shift. 4 . In addition, topiramate can cause cognitive impairment, particularly language dysfunction. 8 . Topiramate can also cause other side effects such as fatigue, confusion, and memory problems. 1 .

Reasons for side effects

The side effects of topiramate are thought to be due to its mechanism of action. Topiramate has multiple mechanisms of action, including carbonic anhydrase inhibitor, sodium channel blocker, potassium channel enhancer, and postsynaptic gamma-aminobutyric acid (GABA) receptor stimulator. 3 . These mechanisms of action can cause side effects such as weight loss, visual disturbances, and cognitive impairment.

Common side effects

Weight loss

Topiramate can cause weight loss by reducing appetite and increasing energy expenditure. 5 . This side effect is seen in about half of people taking topiramate. 5 . Weight loss can lead to health problems, so it is important to be aware of this side effect.

Visual disturbances

Topiramate can cause visual disturbances such as visual field defects and myopic shift. 4 . These side effects are seen in about 20% of people taking topiramate. 4 . Visual disturbances can interfere with daily life, so it is important to be aware of this side effect.

Cognitive impairment

Topiramate can cause cognitive impairment such as language dysfunction. 8 . These side effects are seen in about 50% of people taking topiramate. 8 . Cognitive impairment can interfere with learning and work, so it is important to be aware of this side effect.

Fatigue, confusion, memory problems

Topiramate can cause other side effects such as fatigue, confusion, and memory problems. 1 . These side effects are seen in about 10% of people taking topiramate. 1 . These side effects can interfere with daily life, so it is important to be aware of this side effect.

Measures for side effects

Weight loss

Weight loss caused by topiramate can be improved by diet and exercise. 5 . If weight loss is significant, you should consult your doctor and have the dosage adjusted.

Visual disturbances

Visual disturbances caused by topiramate can be improved by adjusting the dosage or trying other treatments. 4 . If visual disturbances do not improve, you should consult your doctor and consider other treatment options.

Cognitive impairment

Cognitive impairment caused by topiramate can be improved by adjusting the dosage or trying other treatments. 8 . If cognitive impairment does not improve, you should consult your doctor and consider other treatment options.

Fatigue, confusion, memory problems

Fatigue, confusion, and memory problems caused by topiramate can be improved by adjusting the dosage or trying other treatments. 1 . If these side effects do not improve, you should consult your doctor and consider other treatment options.

Comparison between studies

Commonalities between studies

Multiple studies have shown that topiramate can cause side effects such as weight loss, visual disturbances, and cognitive impairment.

Differences between studies

The incidence and severity of topiramate side effects vary from study to study. This is thought to be due to factors such as the age, sex, type of epilepsy, and dosage of topiramate of the study participants.

Precautions for real-life application

Topiramate can cause side effects such as weight loss, visual disturbances, and cognitive impairment. These side effects can interfere with daily life, so it is important to be aware of them. When taking topiramate, it is important to consult your doctor and understand the side effects well.

Limitations of current research

Research on the side effects of topiramate is still insufficient. In particular, research on long-term side effects is lacking. Also, many things are still unknown about the factors that affect the incidence and severity of topiramate side effects.

Future research directions

Research on the long-term side effects of topiramate needs to be advanced. Research is also needed to clarify the factors that affect the incidence and severity of topiramate side effects.

Conclusion

Topiramate is an effective drug for treating epilepsy, but it can cause side effects such as weight loss, visual disturbances, and cognitive impairment. When taking topiramate, it is important to consult your doctor and understand the side effects well.

Literature analysis of 12 papers
Positive Content
5
Neutral Content
4
Negative Content
3
Article Type
1
1
0
3
11
1.

Cognitive and fatigue side effects of anti-epileptic drugs: an analysis of phase III add-on trials.

Author: SarkisRani A, GoksenYazel, MuYi, RosnerBernard, LeeJong Woo

Cognitive side effects
Fatigue

This study analyzes the terms used to refer to cognitive and fatigue-related side effects in phase III add-on clinical trials of anti-epileptic drugs (AEDs). The findings indicate a significant dose-response effect for most AEDs, suggesting that physicians should consider aiming for lower drug loads to improve tolerability.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

The Ophthalmic Side Effects of Topiramate: A Review.

Author: MechrguiMonia, KananiSuleman

Migraine prevention
Coordination issues
Diarrhea
Dizziness
Fatigue
Mental health issues
Ocular side effects
Sleepiness
Weight loss

This article reviews the ocular side effects of topiramate (TPM), including choroidal effusion syndrome, angle-closure glaucoma, and myopic shift.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Evaluation of Ocular Side Effects in the Patients on Topiramate Therapy for Control of Migrainous Headache.

Author: HesamiOmid, HosseiniSeyedeh Simindokht, KazemiNasim, Hosseini-ZijoudSeyed-Mostafa, MoghaddamNahid Beladi, AssarzadeganFarhad, MokhtariSara, FakhraeeShahrzad

Migraine control
Myopic shift
Visual field defect

This study aimed to investigate the alterations in refractive error, corneal properties, and anterior chamber changes in patients receiving topiramate for migraine control.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Weight-reducing side effects of the antiepileptic agents topiramate and zonisamide.

Author: AntelJ, HebebrandJ

Weight loss

Topiramate and zonisamide, two antiepileptic drugs, can cause significant weight loss. This review discusses potential molecular mechanisms responsible for this effect and examines clinical studies on these drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

The efficacy and side effects of topiramate on refractory epilepsy in infants and young children: a multi-center clinical trial.

Author: Al AjlouniS, ShormanA, DaoudA S

Effective refractory epilepsy treatment
Anorexia
Hypothyroidism
Nervousness
Somnolence

Topiramate was effective in treating refractory epilepsies in infants and young children, with a 60% satisfactory response rate. Common side effects included somnolence, anorexia, and nervousness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

7.

Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy.

Author: FritzN, GlogauS, HoffmannJ, RademacherM, ElgerC E, HelmstaedterC

Epilepsy treatment
Cognitive side effects

Newer antiepileptic drugs are effective, but their cognitive side effects are still being studied. A randomized trial compared the cognitive effects of two newer antiepileptic drugs, TPM and TGB, on cognition, mood, and health-related quality of life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Language Disturbances as Side Effects of Topiramate and Zonisamide Therapy.

Author: OjemannLinda M., OjemannGeorge A., DodrillCarl B., CrawfordCarol A., HolmesMark D., DudleyDonald L.

Language impairment

Topiramate (TPM) and zonisamide (ZNS), two sulfa-containing antiepileptic drugs, have been linked to reversible side effects, primarily language impairment. This study reports on the side effects observed in patients taking TPM and ZNS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Treatment of cluster headache with topiramate: effects and side-effects in five patients.

Author: FörderreutherS, MayerM, StraubeA

Prophylactic treatment for cluster headache
Intolerable side effects

This study examined the effectiveness of topiramate in treating cluster headaches. Topiramate was effective in some patients but not in others, and side effects were a concern. Topiramate may have potential in treating cluster headaches, but further research is needed to optimize its use.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Topiramate enhances the risk of valproate-associated side effects in three children.

Author: LonginElke, TeichMartin, KoelfenW, KönigStefan

Apathy
Elevated ammonia levels
Hypothermia
Liver problems
Thrombocytopenia

Topiramate may enhance the risk of side effects usually attributed to valproate.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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