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Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivity.

Author: ChenBin, DemidenkoEugene, GoodwinIsak A, HasanTayyaba, O'HaraJulia A, PogueBrian W, SwartzHarold M, WilmotCarmen M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study explores the use of photodynamic therapy (PDT) with verteporfin for treating radiation-induced fibrosarcoma tumors. PDT was shown to increase tumor oxygenation and enhance the effectiveness of radiation therapy when given simultaneously.
Paper Details　
Original Abstract of the Article :
Photodynamic therapy (PDT) with verteporfin (lipid form of benzoporphyrin derivative,benzoporphyrin derivative monoacid ring A) was used to treat radiation-induced fibrosarcoma tumors before X-ray treatment. When verteporfin was injected 3 h before light irradiation, the tumor partial pressure of ox...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12615718

データ提供：米国国立医学図書館（NLM）

Photodynamic Therapy: Boosting Radiation Sensitivity in Cancer Treatment

Photodynamic therapy (PDT) is a promising cancer treatment that uses light and a photosensitizing agent to destroy tumor cells. This study investigates the potential of combining PDT with radiation therapy to enhance tumor sensitivity and improve treatment outcomes.

PDT and Radiation: A Synergistic Approach to Cancer Treatment?

The study found that PDT with verteporfin, administered before radiation therapy, significantly increased the tumor's oxygen level. This enhanced oxygenation led to increased radiation sensitivity and improved tumor control. The combination treatment showed a greater than additive effect, suggesting a potential synergistic benefit for treating radiation-induced fibrosarcoma.

A New Era of Personalized Cancer Treatment?

This research explores the potential of combining PDT and radiation therapy to improve cancer treatment outcomes. The findings suggest that this combination approach could enhance tumor sensitivity and lead to more effective cancer control. Further research is needed to validate these findings and explore the application of this synergistic approach in other types of cancer.

Dr.Camel's Conclusion

This study is like a desert oasis, offering a refreshing alternative to traditional cancer treatment. The combination of PDT and radiation therapy shows promise for improving treatment outcomes. However, we must remember that the desert is vast, and more research is needed to fully understand the potential of this approach. Just as a camel relies on its instincts to find water, we must continue our journey of exploration and discovery in the field of cancer research.

Date :
  1. Date Completed 2003-04-01
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

12615718

DOI: Digital Object Identifier

12615718

Related Literature

Article Analysis
・Effects of verteporfin injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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