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Variability of serum estrogens among postmenopausal women treated with the same transdermal estrogen therapy and the effect on androgens and sex hormone binding globulin.

Author: CastracaneV Daniel, GimpelTerry L, KilpatrickRobin E, KraemerGinger R, KraemerRobert R, OgdenBeverly W

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Transdermal estrogen replacement therapy (ET) was found to be effective in increasing estrogen levels in postmenopausal women. However, the response to identical treatment doses varied greatly among individuals, with significant differences in estradiol (E(2)) values and E(2) increases above baseline. While continuous ET treatment increased sex hormone binding globulin (SHBG) and decreased androstenedione levels, it had minimal effects on circulating androgens such as testosterone (T), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and the free androgen index.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To examine the variability of serum estrogens in response to transdermal estrogen replacement therapy (ET), and to determine the effects on androgens and sex hormone binding globulin (SHBG). DESIGN: Randomized, double-blind, placebo-controlled study. SETTING: Women's hospital. PATIENT(...See full text at original site
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引用元：
https://doi.org/10.1016/s0015-0282(02)04755-6

データ提供：米国国立医学図書館（NLM）

Estrogen Replacement Therapy: Understanding Variability and Effects

Estrogen replacement therapy (ET) is commonly used to manage symptoms of menopause. This study investigates the variability in estrogen levels among postmenopausal women receiving transdermal ET. The researchers also explored the impact of ET on androgen and sex hormone binding globulin (SHBG) levels. They analyzed data from two groups of postmenopausal women: one group not on ET and another group receiving continuous transdermal ET.

Estrogen Levels: A Shifting Desert Landscape

The study revealed significant intrapatient and interpatient variability in estrogen levels, with considerable variation in response to identical treatment doses. Continuous ET led to an increase in SHBG levels and a decrease in androstenedione levels, while levels of other androgens, such as testosterone, remained unchanged. These findings highlight the need for individualized treatment approaches and careful monitoring of hormone levels during ET.

Navigating the Complexities of Hormonal Health

Understanding the variability in estrogen response to ET is crucial for optimizing treatment outcomes. Like a camel navigating a desert with shifting sands, we must adjust our course as needed to ensure the best possible care for patients. Regular monitoring of hormone levels and individualized treatment strategies are essential for maintaining optimal health and well-being during menopause.

Dr.Camel's Conclusion

The study provides valuable insights into the complex dynamics of hormone levels during ET. It reminds us that navigating the desert of hormonal health requires a personalized approach. Careful monitoring and individualized therapy can help us find the right balance and optimize the benefits of ET while minimizing potential risks.

Date :
  1. Date Completed 2003-04-04
  2. Date Revised 2019-07-07
Further Info :

Pubmed ID

12620436

DOI: Digital Object Identifier

10.1016/s0015-0282(02)04755-6

SNS
PICO Info
in preparation
Languages

English

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