The use of a laboratory school protocol to evaluate concepts about efficacy and side effects of new formulations of stimulant medications.

Author: FreidJ, GreenhillL, LernerM, PosnerK, SteinhoffK, SwansonJ M, WigalS, WigalT

Paper Details 
Original Abstract of the Article :
Recently, new long-acting formulations of racemic methylphenidate (MPH: Ritalin LA, Metadate CD and Concerta) and amphetamine (AMP: Adderall XR) were developed and are now approved by the Food and Drug Administration (FDA). In addition, dexmethylphenidate (Focalin), the pharmacologically active d-th...See full text at original site
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引用元:
https://doi.org/10.1177/070674370200601s10

データ提供:米国国立医学図書館(NLM)

Stimulant Medications for ADHD: A Journey Through Controlled Environments

The journey of finding effective treatments for attention-deficit/hyperactivity disorder (ADHD) is a complex one. This research explores the development and evaluation of new long-acting formulations of stimulant medications, using a controlled laboratory setting to assess their efficacy and side effects. The study highlights the importance of understanding the basic pharmacokinetic (PK) and pharmacodynamic (PD) properties of these medications before they are introduced into clinical practice.

Navigating the Labyrinth of Medication Development

The study describes the use of the University of California, Irvine (UCI) Laboratory School Protocol (LSP) to evaluate the efficacy and safety of new stimulant medications. The LSP provides a controlled environment for assessing the effects of these medications, offering valuable insights into their basic properties. This controlled environment, much like a laboratory in a desert oasis, allows researchers to carefully analyze the effects of the medication without the confounding variables of a real-world setting.

The Impact of Medication Development on Patient Care

The findings of this research have directly impacted the development of new, long-acting formulations of stimulant medications for ADHD. This research serves as a reminder that rigorous preclinical testing is essential for ensuring the safety and efficacy of new medications. The desert of medication development requires meticulous attention to detail, careful consideration, and a commitment to achieving the best possible outcomes for patients.

Dr.Camel's Conclusion

The research highlights the importance of rigorous testing and the need for controlled environments in developing effective medications. This research, like a camel caravan carefully traversing the desert, underscores the critical role of research in shaping the future of medication development and improving patient care.

Date :
  1. Date Completed 2003-05-22
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

12685522

DOI: Digital Object Identifier

10.1177/070674370200601s10

Related Literature

SNS
PICO Info
in preparation
Languages

English

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