Cardiac Ca(2+) channel-blocking effects of the cyproheptadine derivative AH-1058 in isolated guinea pig cardiomyocytes.

Author: DohmotoHideki, TakaharaAkira, UneyamaHisayuki, YoshimotoRyota

Paper Details 
Original Abstract of the Article :
The Ca(2+) channel-blocking efficacy of the cyproheptadine derivative AH-1058 (4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-[(E)-3-(3-methoxy-2-nitro)phenyl-2-propenyl]piperidine hydrochloride) was quantitatively assessed using isolated guinea pig cardiomyocytes. AH-1058 (0.001 - 10 microM) and its mo...See full text at original site
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引用元:
https://doi.org/10.1254/jphs.91.163

データ提供:米国国立医学図書館(NLM)

AH-1058: A Potent Calcium Channel Blocker

Calcium channel blockers are a class of medications used to treat cardiovascular conditions by blocking the flow of calcium into cells. This study investigates the calcium channel-blocking effects of AH-1058, a derivative of the drug cyproheptadine. The study utilized isolated guinea pig cardiomyocytes to examine the effects of AH-1058 on calcium currents. The results revealed that AH-1058 significantly reduced calcium currents, demonstrating potent calcium channel-blocking activity comparable to the well-established calcium channel blocker, verapamil. This discovery is like finding a hidden spring of knowledge in the desert of cardiovascular research, offering a potential new approach for treating cardiovascular conditions.

AH-1058: A Promising New Calcium Channel Blocker

The study's findings suggest that AH-1058 could be a promising new calcium channel blocker, potentially providing an alternative treatment option for cardiovascular conditions. This discovery is like finding a hidden spring of knowledge in the desert of cardiovascular research, offering a potential new approach for treating cardiovascular conditions.

Exploring New Treatment Options

The study highlights the importance of exploring new drug candidates for treating cardiovascular conditions. The findings encourage further research into the potential of AH-1058 and other calcium channel blockers, potentially leading to more effective and personalized treatment strategies for patients with cardiovascular disease.

Dr.Camel's Conclusion

This study provides valuable insights into the calcium channel-blocking effects of AH-1058, suggesting its potential as a new treatment option for cardiovascular conditions. It's like finding a hidden oasis in the vast desert of cardiovascular research, offering a potential new source of relief for those battling heart disease. This research encourages continued investigation into the therapeutic potential of AH-1058, ultimately improving the lives of patients with cardiovascular conditions.

Date :
  1. Date Completed 2003-05-08
  2. Date Revised 2019-09-10
Further Info :

Pubmed ID

12686762

DOI: Digital Object Identifier

10.1254/jphs.91.163

Related Literature

SNS
PICO Info
in preparation
Languages

English

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