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Inhibitory effects of pimozide on cloned and native voltage-gated potassium channels.

Author: ArgentieriThomas M, LeeYan T, RhodesKenneth, WangKewei, WangQiang, ZhangZhi-Hao

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study examined the effects of pimozide, an antipsychotic drug, on neuronal Kv channels. Pimozide blocked Kv2.1 and Kv1.1 channels, but had minimal effects on Kv1.4, KCNQ2, and KCNQ3.
Paper Details　
Original Abstract of the Article :
The primary goal of this study was to use the cloned neuronal Kv channels to test if pimozide (PMZD), an antipsychotic drug, modulates the activity of Kv channels. In CHO cells, PMZD blocked Kv2.1, a major neuronal delayed rectifier, in a manner that depends upon time and concentration. The estimate...See full text at original site
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引用元：
https://doi.org/10.1016/s0169-328x(03)00175-x

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of Pimozide's Action on Potassium Channels

[Pimozide], an antipsychotic drug, has long been used to treat various mental health conditions. This research explores the specific effects of [pimozide] on [voltage-gated potassium channels], proteins that play a crucial role in regulating nerve cell communication. The study investigated the interaction of [pimozide] with different types of potassium channels, both cloned and native, to understand how this drug might influence neuronal activity.

Pimozide Selectively Targets Potassium Channels

This research reveals that [pimozide] can selectively inhibit certain types of potassium channels, particularly those involved in delayed rectification. The study found that [pimozide] had a minimal effect on other types of potassium channels, such as the M-current candidates, suggesting a specific mode of action. The authors propose that [pimozide]'s ability to block these potassium channels may contribute to its therapeutic effects by increasing the release of neurotransmitters such as serotonin and glutamate.

Unraveling the Mechanisms of Antipsychotic Action

This research offers a glimpse into the complex mechanisms underlying the therapeutic effects of antipsychotic drugs. By understanding how [pimozide] interacts with specific potassium channels, we can gain a deeper insight into the neurological processes involved in mental health disorders. This knowledge may lead to the development of new and more targeted treatments for these challenging conditions.

Dr.Camel's Conclusion

This research, like a camel traversing the vast desert of neuronal pathways, reveals the intricate connections between different types of potassium channels and the action of [pimozide]. This knowledge may guide us towards a better understanding of [mental health disorders] and the development of more effective treatments, allowing us to navigate this challenging landscape with greater clarity and compassion.

Date :
  1. Date Completed 2003-09-05
  2. Date Revised 2019-08-27
Further Info :

Pubmed ID

12824052

DOI: Digital Object Identifier

10.1016/s0169-328x(03)00175-x

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・Effects of pimozide
SNS
PICO Info
in preparation
Languages

English

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