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Safety of the newer inhaled corticosteroids in childhood asthma.

Author: AmblerGeoffrey R, CowellChristopher T, DonaghueKim C, FitzgeraldDominic A, RandellTabitha L, van AsperenPeter P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Inhaled corticosteroids (ICS) are commonly used to treat asthma in children. This review examines the safety of newer ICSs, including fluticasone propionate, mometasone, and beclomethasone, in relation to older ICSs. The newer ICSs appear to be safer, but there is still a risk of serious adverse effects, including adrenal suppression and growth suppression. It is important to use ICS appropriately and at the lowest possible dose.
Paper Details　
Original Abstract of the Article :
Inhaled corticosteroids (ICS) remain a vital part of the management of persistent asthma, but concerns have been raised about their potential adverse effects in children. This review examines the safety data on three new ICS - fluticasone propionate, mometasone, and extrafine beclomethasone in hydro...See full text at original site
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引用元：
https://doi.org/10.2165/00128072-200305070-00005

データ提供：米国国立医学図書館（NLM）

Navigating the desert of asthma treatment: Inhaled corticosteroids

Asthma is a chronic respiratory condition that can be like a never-ending sandstorm, leaving sufferers gasping for breath. Inhaled corticosteroids (ICS) are a vital weapon in the arsenal against asthma, but their use in children has raised concerns about potential side effects. This study dives into the safety data of three newer ICS - fluticasone propionate, mometasone, and extrafine beclomethasone - comparing them to older corticosteroids. It's like comparing different camels for navigating the desert - some might be faster, others might be more hardy.

Finding the right camel for the journey

The researchers found that topical adverse effects like thrush and dysphonia are rare with the newer ICS, but dental erosion is a possibility with powder forms due to their low pH. This is like choosing the right camel for a desert crossing - some might be better suited for sandy terrain, others for rocky paths. The study also found that biochemical adrenal suppression, a potential concern with ICS, can be readily demonstrated, particularly with high doses. This is like being aware of the potential risks associated with a long desert journey, like dehydration or encountering dangerous predators. However, the clinical relevance of this finding is still uncertain.

Navigating the desert of asthma treatment

This study provides important insights for managing asthma in children, particularly when it comes to the use of inhaled corticosteroids. It's like having a trusted guide in the vast desert of asthma treatment, offering valuable information and helping you make informed decisions. Choosing the right ICS, using it appropriately, and carefully monitoring potential side effects are crucial for ensuring the best possible outcomes for children with asthma.

Dr.Camel's Conclusion

This study dives into the safety data of three newer ICS - fluticasone propionate, mometasone, and extrafine beclomethasone - comparing them to older corticosteroids. It's like comparing different camels for navigating the desert - some might be faster, others might be more hardy. This study provides important insights for managing asthma in children, particularly when it comes to the use of inhaled corticosteroids. It's like having a trusted guide in the vast desert of asthma treatment, offering valuable information and helping you make informed decisions. Choosing the right ICS, using it appropriately, and carefully monitoring potential side effects are crucial for ensuring the best possible outcomes for children with asthma.
Date :
  1. Date Completed 2003-11-28
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

12837120

DOI: Digital Object Identifier

10.2165/00128072-200305070-00005

Related Literature

Article Analysis
・Effects of mometasone oral inhalation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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