Effects of mometasone oral inhalation: A Synthesis of Findings from 29 Studies

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Original Abstract of the Article

Major Research Findings

Mometasone furoate, when administered as an inhaled corticosteroid (ICS), has been shown to be effective in treating asthma in both adults and children. 13 、 14 、 8 、 24 、 18 Studies have shown that mometasone furoate significantly improves lung function, reduces asthma symptoms, and enhances quality of life. 13 、 14 、 8 、 24 Moreover, it has been proven to be comparable in efficacy to other commonly used ICS medications, such as fluticasone propionate, beclomethasone dipropionate, and budesonide. 11 、 17 、 25 In severe asthma cases, mometasone furoate has demonstrated the ability to decrease or even eliminate the need for oral corticosteroids. 20 、 12

While generally considered safe and well-tolerated, there are potential risks associated with high doses of mometasone furoate. 13 、 14 、 8 、 24 These include adrenal suppression and growth retardation in children. 10 、 4 、 6 Common side effects may include headache, pharyngitis, and oral candidiasis. 13

Benefits and Risks

Benefit Summary

Mometasone furoate inhalation effectively reduces asthma symptoms, improves lung function, and may reduce the need for oral corticosteroids in severe cases.

Risk Summary

While generally safe, high doses of mometasone furoate can lead to adrenal suppression and growth issues in children. Common side effects include headache, sore throat, and oral thrush.

Comparison Across Studies

Commonalities

Multiple studies consistently demonstrate the efficacy of mometasone furoate inhalation in improving lung function and reducing asthma symptoms in patients. These studies also generally highlight the drug's safety and good tolerability.

Differences

Variation exists across studies regarding the optimal dosage of mometasone furoate and the specific effects observed, both positive and negative. Additionally, discrepancies in study populations and evaluation methodologies may influence interpretation of results.

Consistency and Inconsistencies

While several studies provide evidence for the effectiveness of mometasone furoate in treating asthma, variations in effects and side effects across studies necessitate a thorough understanding of consistency and inconsistencies in the findings.

Practical Applications and Considerations

Mometasone furoate inhalation offers a valuable treatment option for asthma, but it's crucial to consider the potential risks associated with high doses and long-term use. It is imperative to adhere to a doctor's instructions for safe and effective use.

Limitations of Current Research

Further research is needed to fully understand the long-term effects of mometasone furoate inhalation, including its impact on different patient populations.

Future Research Directions

Future research should focus on long-term effects of mometasone furoate inhalation, its effectiveness in specific patient groups, and potential interactions with other treatments.

Conclusion

Mometasone furoate inhalation demonstrates promise as an effective treatment for asthma, but it's essential to be aware of the potential risks associated with higher doses and prolonged use. Always consult a physician for appropriate guidance and management.

Keywords
Benefit Keywords
Asthma control
1
Treat asthma
2
Anti-inflammatory actions
3
No effect on growth
4
Allergic rhinitis
Nasal polyps treatment
Rhinosinusitis treatment
5
Asthma treatment
Improved lung function
Reduced airway inflammation
6
Treat asthma
7
Asthma control
Improved lung function
Quality of life
Symptom control
8
Treat respiratory diseases
9
Treats persistent asthma
10
Effective asthma treatment
11
Improved asthma symptoms
Reduced steroid use
12
Improved lung function
Well tolerated
13
Asthma treatment
14
Asthma treatment
COPD treatment
15
Reduced sinusitis symptoms
16
Asthma treatment
17
Asthma treatment
18
Improved HRQL
Reduced OCS use
20
Improved asthma treatment
21
Manages asthma
22
Decreased oral corticosteroid requirements
Improved pulmonary function
Persistent asthma treatment
Reduced asthma symptoms
23
Asthma control
24
Improved lung function
Reduced asthma symptoms
Reduced oral corticosteroid use
25
Asthma treatment
Rhinitis treatment
26
Allergic rhinitis treatment
Nasal polyposis treatment
27
Improved lung function
Improved respiratory health
Reduced exacerbations
28
No bone loss
29
Risk Keywords
Cortisol suppression
2
Diabetogenic actions
3
Reduced growth velocity
4
Epistaxis
Nasal irritation
5
Adrenal suppression
Growth suppression
6
Side effects
7
No significant side effects
8
Adrenal suppression
Dental erosion
Dysphonia
Fractures
Growth suppression
Thrush
10
Oral candidiasis
11
Headache
Oral candidiasis
Pharyngitis
13
Oral candidiasis
17
Candidiasis
18
Growth reduction
22
Systemic glucocorticoid effects
24
Mild or moderate adverse events
25
Epistaxis
Headache
Pharyngitis
27
Dysphonia
Lenticular opacities
Oral candidiasis
28
Literature analysis of 29 papers
Positive Content
29
Neutral Content
0
Negative Content
0
Article Type
12
0
1
13
29
1.

The efficacy and tolerability of inhaled montelukast plus inhaled mometasone compared with mometasone alone in patients with chronic asthma.

Author: PhilipGeorge, VillaránCésar, ShahShailen R, VandormaelKristel, SmugarSteven S, ReissTheodore F

Asthma control

This study evaluated the efficacy of inhaled montelukast added to inhaled mometasone in patients with chronic asthma. The efficacy of oral montelukast in chronic asthma is well established, and inhaled montelukast has been shown to provide significant bronchodilation compared with placebo.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Mometasone furoate has minimal effects on the hypothalamic-pituitary-adrenal axis when delivered at high doses.

Author: AffrimeM B, KosoglouT, ThonoorC M, FlanneryB E, HerronJ M

Treat asthma
Cortisol suppression

Mometasone furoate (MF) administered by dry powder inhaler (DPI) or metered-dose inhaler (MDI) did not exert significant systemic effects at the highest projected clinical dosage. A series of randomized, controlled trials involving 44 patients with asthma found that MF DPI 800 microg bid (1,600 microg/d) was the lower limit for consistently detectable systemic effects, while MF MDI at 800 microg bid caused even less systemic exposure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Oral mometasone furoate administration preserves anti-inflammatory action with fewer metabolic adverse effects in rats.

Author: ZimathPriscila L, AlmeidaMilena S, BruxelMaciel A, RafachoAlex

Anti-inflammatory actions
Diabetogenic actions

This study investigates the effects of mometasone furoate (MF), a glucocorticoid, on inflammation and metabolism. It examines whether MF can maintain anti-inflammatory effects without significant metabolic side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Relationship between systemic corticosteroid exposure and growth velocity: development and validation of a pharmacokinetic/pharmacodynamic model.

Author: Daley-YatesPeter T, RichardsDavid H

No effect on growth
Reduced growth velocity

High-dose oral corticosteroids can slow growth in children, but low-dose topical corticosteroids have little or no effect on growth. More research is needed to determine the long-term effects of corticosteroid use on growth.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Validation StudyResearch to assess the validity and reliability of new measurement methods or diagnostic tests.

Language : English

5.

Local and systemic safety of intranasal corticosteroids.

Author: SastreJ, MosgesR

Allergic rhinitis
Nasal polyps treatment
Rhinosinusitis treatment
Epistaxis
Nasal irritation

Intranasal corticosteroids (INCs) are effective and safe treatments for allergic rhinitis, rhinosinusitis, and nasal polyps. While some concerns exist about systemic side effects, a review of the literature indicates that INCs primarily have local side effects, such as nasal irritation and epistaxis, and have a favorable safety profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Inhaled corticosteroids in children with asthma: pharmacologic determinants of safety and efficacy and other clinical considerations.

Author: GulliverTanya, MortonRonald, EidNemr

Asthma treatment
Improved lung function
Reduced airway inflammation
Adrenal suppression
Growth suppression

This study reviewed the role of inhaled corticosteroids (ICS) in the treatment of childhood asthma. The study found that ICS are effective in improving lung function, reducing symptoms, and decreasing inflammation in children with asthma. While ICS have a good safety profile, potential adverse effects include adrenal suppression and growth suppression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma.

Author: UmlandShelby P, SchleimerRobert P, JohnstonSebastian L

Treat asthma
Side effects

Glucocorticoids (GCs) are the most effective treatment for asthma, working by modulating gene transcription and regulating inflammatory mediators. Newer GCs, such as mometasone furoate, are being developed to enhance potency and topical activity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Lung Delivery of Indacaterol and Mometasone Furoate Following Inhalation of QMF149 in Healthy Volunteers.

Author: VaidyaSoniya S, KhindriSanjeev, MaahsSuzanne, MachineniSurendra, HaraHisanori, JuanAxel, KaiserGünther

Treat respiratory diseases

This study evaluated the pharmacokinetics (PK) of indacaterol maleate and mometasone furoate (MF) after inhalation of a fixed-dose combination (QMF149) via the Twisthaler (TH) device with and without activated charcoal and postdose mouth rinsing. Systemic exposure to indacaterol was 25% due to pulmonary absorption and 75% due to gastrointestinal absorption. Systemic exposure to MF was 70% due to pulmonary absorption and 30% due to gastrointestinal absorption. Mouth rinsing reduced systemic exposure of indacaterol by approximately 35%, but had no relevant effect on MF exposure. Lung delivery of indacaterol was more efficient with the Breezhaler (BRZ) device than the TH device.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Safety of the newer inhaled corticosteroids in childhood asthma.

Author: RandellTabitha L, DonaghueKim C, AmblerGeoffrey R, CowellChristopher T, FitzgeraldDominic A, van AsperenPeter P

Treats persistent asthma
Adrenal suppression
Dental erosion
Dysphonia
Fractures
Growth suppression
Thrush

Inhaled corticosteroids (ICS) are commonly used to treat asthma in children. This review examines the safety of newer ICSs, including fluticasone propionate, mometasone, and beclomethasone, in relation to older ICSs. The newer ICSs appear to be safer, but there is still a risk of serious adverse effects, including adrenal suppression and growth suppression. It is important to use ICS appropriately and at the lowest possible dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Comparison of the efficacy and safety of mometasone furoate dry powder inhaler to budesonide Turbuhaler.

Author: BousquetJ, D'UrzoA, HebertJ, BarrazaC H, BouletL P, Suárez-ChacónR, HarnestU, LundbäckB, Martinez MoralesG, NieminenM M, NolopK B, VisserS, LutskyB N

Effective asthma treatment
Oral candidiasis

This study compared the effectiveness and tolerability of mometasone furoate (MF) administered by dry powder inhaler (DPI) and budesonide (BUD) Turbuhaler in patients with moderate persistent asthma. MF DPI 200 and 400 microg b.i.d showed significantly better improvement in lung function compared to BUD Turbuhaler 400 microg b.i.d. MF DPI was well tolerated and the incidence of oral candidiasis was low.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Inhaled mometasone furoate reduces oral prednisone usage and improves lung function in severe persistent asthma.

Author: KarpelJill P, NayakAnjuli, LumryWilliam, CraigTimothy J, KerwinEdward, FishJames E, LutskyBarry

Improved asthma symptoms
Reduced steroid use

Mometasone furoate delivered by HFA-227 metered dose inhaler significantly reduces daily oral corticosteroid use and facilitates elimination of oral corticosteroid use in patients with severe persistent asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Dose-ranging study of a new steroid for asthma: mometasone furoate dry powder inhaler.

Author: BernsteinD I, BerkowitzR B, ChervinskyP, DvorinD J, FinnA F, GrossG N, KaretzkyM, KempJ P, LaforceC, LumryW, MendelsonL M, NelsonH, PearlmanD, RachelefskyG, RatnerP, RepsherL, SegalA T, SelnerJ C, SettipaneG A, WandererA, CussF M, NolopK B, HarrisonJ E

Improved lung function
Well tolerated
Headache
Oral candidiasis
Pharyngitis

Mometasone furoate administered by dry powder inhaler was found to be effective and well-tolerated in patients with moderate persistent asthma. The optimal dose in this study was 200 mcg b.i.d.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

The efficacy and safety of mometasone furoate delivered via a dry powder inhaler for the treatment of asthma.

Author: MeltzerEli O, WenzelSally

Asthma treatment

This review examined the efficacy and safety of mometasone furoate, a new inhaled corticosteroid for the treatment of asthma. Clinical trials showed that mometasone furoate was effective in patients with mild to moderate asthma, and it improved lung function, asthma symptoms, and quality of life in patients with severe asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Evaluation of potential for pharmacokinetic interaction between mometasone furoate and formoterol fumarate after oral inhalation from a fixed-dose combination metered-dose inhaler device.

Author: KosoglouTeddy, HubbellJames, Johnson-LevonasAmy O, YunanMona, KantesariaBhavna S, CutlerDavid L

Asthma treatment
COPD treatment

This study compared the pharmacokinetics of a fixed-dose combination (FDC) containing mometasone furoate (MF) and formoterol fumarate (F) in a pressurized metered dose inhaler (MDI) with the individual administration of MF and F. Systemic exposures to MF and formoterol were similar following treatment with the FDC MDI device versus individual or concomitant use of single-ingredient MDI devices.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Added relief in the treatment of acute recurrent sinusitis with adjunctive mometasone furoate nasal spray. The Nasonex Sinusitis Group.

Author: MeltzerE O, CharousB L, BusseW W, ZinreichS J, LorberR R, DanzigM R

Reduced sinusitis symptoms

Intranasal mometasone furoate nasal spray significantly reduced symptoms of acute sinusitis when added to antibiotics, compared to antibiotic treatment alone. The spray effectively decreased inflammatory symptoms associated with the obstruction process, such as headache, congestion, and facial pain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Dose-ranging study of mometasone furoate dry powder inhaler in the treatment of moderate persistent asthma using fluticasone propionate as an active comparator.

Author: O'ConnorB, BonnaudG, HaahtelaT, LunaJ M, QuerfurtH, WegenerT, LutskyB N

Asthma treatment
Oral candidiasis

Mometasone furoate dry powder inhaler (MF-DPI) at a total daily dose of 400 microg provides clinical benefit comparable to fluticasone propionate Diskhaler 250 microg twice daily in patients with moderate persistent asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Inhaled mometasone furoate: a review of its use in adults and adolescents with persistent asthma.

Author: SharpeM, JarvisB

Asthma treatment
Candidiasis

This review article discusses the efficacy and safety of mometasone furoate, a corticosteroid used to treat asthma. Mometasone furoate was found to be effective in improving lung function and asthma symptoms, and was generally well tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Inhaled corticosteroids for asthma: are they all the same?

Author: BaptistA P, ReddyR C

Currently available inhaled corticosteroids (ICS) and their delivery systems differ in ways that can potentially affect both safety and therapeutic effectiveness for individual patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Reduction in oral corticosteroid use with mometasone furoate dry powder inhaler improves health-related quality of life in patients with severe persistent asthma.

Author: SchmierJordana, LeidyNancy Kline, GowerRichard

Improved HRQL
Reduced OCS use

This study investigated the impact of mometasone furoate dry powder inhaler (MF DPI) on health-related quality of life (HRQL) in patients with severe persistent asthma. The results showed that MF DPI significantly improved HRQL, particularly in the physical domain, and this improvement was maintained during the open-label extension period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Comparative pharmacology, bioavailability, pharmacokinetics, and pharmacodynamics of inhaled glucocorticosteroids.

Author: HübnerMelanie, HochhausGünther, DerendorfHartmut

Improved asthma treatment

Inhaled corticosteroids (ICS) are effective for asthma treatment, with newer formulations showing improved efficacy and safety. ICS like beclomethasone dipropionate and ciclesonide minimize side effects by being inactive prodrugs or having better lung deposition. Fluticasone propionate and ciclesonide maximize pulmonary efficacy through slow dissolution in the lungs and lipid conjugation, respectively.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Inhaled mometasone furoate: A review of its use in persistent asthma in adults and adolescents.

Author: McCormackPaul L, PloskerGreg L

Decreased oral corticosteroid requirements
Improved pulmonary function
Persistent asthma treatment
Reduced asthma symptoms

Inhaled mometasone furoate is a synthetic corticosteroid effective in treating persistent asthma in adults and adolescents. It is a potent anti-inflammatory agent with low systemic bioavailability and minimal systemic activity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

Mometasone furoate: an inhaled glucocorticoid for the management of asthma in adults and children.

Author: CowieRobert L, GiembyczMark A, LeighRichard

Asthma control
Systemic glucocorticoid effects

Mometasone furoate, an inhaled glucocorticoid, has demonstrated comparable efficacy to fluticasone propionate in managing asthma and can allow for the reduction or withdrawal of oral glucocorticoid therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

26.

A review of the pharmacology and pharmacokinetics of inhaled fluticasone propionate and mometasone furoate.

Author: CrimC, PierreL N, Daley-YatesP T

Asthma treatment
Rhinitis treatment

Fluticasone propionate is a corticosteroid used for the treatment of rhinitis and asthma. This abstract introduces mometasone furoate, a closely related corticosteroid, and its potential as an oral inhalation treatment for asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Mometasone furoate nasal spray: a review of safety and systemic effects.

Author: ZittMyron, KosoglouTeddy, HubbellJames

Allergic rhinitis treatment
Nasal polyposis treatment
Epistaxis
Headache
Pharyngitis

This article discusses the systemic safety of intranasal corticosteroids, particularly mometasone furoate nasal spray. The low systemic exposure and lack of clinical evidence for suppression of the hypothalamus-pituitary-adrenal axis confirm its favorable benefit-risk ratio.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

Effects of mometasone furoate/formoterol fumarate fixed-dose combination formulation on chronic obstructive pulmonary disease (COPD): results from a 52-week Phase III trial in subjects with moderate-to-very severe COPD.

Author: DohertyDennis E, TashkinDonald P, KerwinEdward, KnorrBarbara A, ShekarTulin, BanerjeeSibabrata, StaudingerHeribert

Improved lung function
Improved respiratory health
Reduced exacerbations
Dysphonia
Lenticular opacities
Oral candidiasis

Mometasone furoate/formoterol fumarate (MF/F) significantly improved lung function, respiratory health status, and reduced exacerbations in patients with moderate-to-very severe chronic obstructive pulmonary disease (COPD). The combination was well tolerated.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Effects of mometasone, fluticasone, and montelukast on bone mineral density in adults with asthma.

Author: MasperoJorge, BackerVibeke, YaoRuji, StaudingerHeribert, TeperAriel

No bone loss

No detrimental effects on lumbar BMD were observed after up to 1 year of treatment with mometasone furoate in comparison with montelukast sodium for patients who received calcium and vitamin D supplements.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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