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Systemic therapy of advanced breast cancer.

Author: MouridsenH T

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Combination therapy with cytotoxic agents, particularly cyclophosphamide and anthracyclines, generally outperforms single-agent treatment for advanced breast cancer. The optimal duration of treatment remains uncertain, while higher doses combined with colony-stimulating factors and bone marrow transplantation may increase response rates, but long-term survival benefits require further investigation. Tamoxifen is the preferred first-line endocrine treatment, with progestins and aromatase inhibitors as alternatives. Combining chemotherapy and endocrine therapy may improve response rates, but further research is needed on the ideal sequence of these treatments.
Paper Details　
Original Abstract of the Article :
Many cytotoxic agents have demonstrated activity in advanced breast cancer, the more active agents being cyclophosphamide and the anthracyclines doxorubicin and epirubicin. Combinations of drugs are generally superior to single agents in terms of response rate, duration of response and survival. The...See full text at original site
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引用元：
https://doi.org/10.2165/00003495-199200444-00003

データ提供：米国国立医学図書館（NLM）

Systemic Therapy for Advanced Breast Cancer: A Complex Landscape

The treatment of [advanced breast cancer] is a complex and challenging endeavor, requiring careful consideration of various therapeutic options. This research explores the effectiveness of [systemic therapy] in managing [advanced breast cancer], including the use of [cytotoxic agents] and [endocrine therapy]. Imagine this as a journey through a desert of potential treatments, where each path offers different challenges and possibilities.

The study reviewed the effectiveness of various [systemic therapies] for [advanced breast cancer], analyzing the results of clinical trials and evaluating the [response rates, duration of response, and survival] associated with different treatment approaches. This research is like mapping the pathways through the desert, understanding the strengths and limitations of each route.

Navigating Treatment Options

The study found that [combinations of drugs] generally outperformed [single agents] in terms of [efficacy], indicating that a multi-pronged approach may be more effective in managing this complex disease. This underscores the need for individualized treatment plans that consider the specific characteristics of each patient and their disease.

Improving Outcomes

This research highlights the importance of [ongoing research and innovation] in the field of [breast cancer treatment]. By continuously exploring new treatment strategies and understanding the complexities of this disease, we can improve outcomes for patients and offer them a brighter future.

Dr. Camel's Conclusion

This research is like a desert guide, helping us navigate the complex landscape of advanced breast cancer treatment. It highlights the importance of a multi-pronged approach, tailored to each individual's needs, and underscores the ongoing quest for more effective therapies. As a wise camel, I encourage everyone to stay informed and seek the guidance of experts when facing this challenging journey.

Date :
  1. Date Completed 1993-03-23
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

1283847

DOI: Digital Object Identifier

10.2165/00003495-199200444-00003

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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