Effective treatment of breast cancer: A Synthesis of Findings from 143 Studies

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Original Abstract of the Article

Major Research Findings

The combination of conservation surgery and radiation therapy for early breast cancer is gaining acceptance as an alternative to radical mastectomy. 48 This article reviews the results of randomized trials showing that there is no advantage to a radical mastectomy in patients with early breast cancer. 48 In addition, the article will review multiple reports concerning the local and regional tumor control and survival of patients treated with conservation surgery and irradiation as well as a comparison of 1073 patients with TIS T1 T2 N0 N1 breast cancer treated at University of Texas (UT) M. D. Anderson Hospital between 1955 and 1980, of whom 345 were treated with conservation surgery and irradiation and 728 were treated with radical or modified radical mastectomy alone. The locoregional recurrence in the patients treated with an intact breast is 4.9%, and 5.6% in patients treated with radical or modified radical mastectomy. There is no significant difference in the 10-year disease-free survival rates between the two groups of patients. In addition, a comparison of 2467 patients with Stage I and Stage II breast cancer treated at the UT M. D. Anderson Hospital shows no significant difference in the incidence of consecutive second breast carcinoma as a result of the use of radiation therapy in the treatment of the first breast cancer.

Adjuvant systemic treatment for resectable breast cancer changes the natural history of the disease but provides only a small and delayed effect on survival. 61 Evaluation of the types of first relapse avoided by available treatments may explain why effects on mortality are small and appear late during follow-up. In randomised clinical trials done by the International Breast Cancer Study Group (IBCSG) between 1978 and 1985, 2108 patients with node-positive disease received more-effective treatments (6 or more cycles of cyclophosphamide, methotrexate, fluorouracil and prednisone; with or without tamoxifen, or tamoxifen and prednisone alone), and 722 patients received less-effective treatments (no treatment or a single cycle of chemotherapy). 3 main categories of first site of relapse were defined and evaluated by cumulative incidence analysis: local or regional, and distant soft tissue, bone, and viscera. The more-effective treatments reduced the cumulative incidence of first relapse in local or regional and distant soft tissue sites at 10 years from 36% to 18% (p = 0.0001); first relapse in bone and viscera was not altered by the more-effective treatments. These results were similar for premenopausal and postmenopausal women, and for patients with oestrogen-receptor-positive or oestrogen-receptor-negative tumours. Adjuvant systemic treatments in current use improve patient outcome mainly by reducing the incidence of first local or regional and distant soft-tissue relapses, while first recurrences in bone or viscera are influenced much less. More intensive treatments at present being tested in clinical trials might affect bone and visceral relapses and have a greater and earlier influence on survival.

Seventy patients with breast cancer (stage IIIb--IV) were randomized by an "envelope" method into 2 groups, each including 35 persons. 3 Patients of the first group were injected vincristin, 5-fluoruracil, methotrexate (once a week), cyclophosphane (3 times a week) and prednisolone daily during 3 weeks. The duration of the course of treatment was 4 weeks. The therapy course was repeated with an interval of 1--2 months. Patients of the second group in addition to the analogous treatment were subjected to ovariectomy with subsequent continuous administration of prednisolone, testosterone-propionate or synoestrol. An objective effect was noted in 24 patients of the first group (71.4%), the complete remission being gained in 4 of them. An average duration of the remission--7.6 months. An objective effect was noted in 31 patients of the second group (88.5%), the complete remission--in 4 of them. An average duration of the remission--10.7 months. Primary mammary tumors and metastases in regional lymph nodes proved to be mostly susceptible to the conducted therapy. Lung and pleural metastases were found to be less susceptible. No grave complications due to this kind of treatment were noted.

Treatment Summary

The combination of conservation surgery and radiation therapy is a viable alternative to radical mastectomy for early stage breast cancer patients. 48 In addition, effective adjuvant systemic treatments, such as chemotherapy, have been shown to reduce the risk of relapse, particularly in the local or regional areas and distant soft tissue. 61 For advanced stages of breast cancer (Stage IIIb-IV), combined drug treatment, including vincristin, 5-fluorouracil, methotrexate, cyclophosphane, and prednisolone, can be effective. 3

Benefits and Risks

Benefit Summary

Conservation surgery and radiation therapy offer a less invasive treatment option compared to radical mastectomy, potentially leading to better cosmetic outcomes and reduced physical and psychological burden for patients. 48 Adjuvant systemic treatments, particularly chemotherapy, can effectively reduce the risk of recurrence, especially for local, regional, and distant soft tissue relapse. 61

Risk Summary

Radiation therapy carries the risk of long-term effects on the heart and lungs. 94 Chemotherapy can cause various side effects such as bone marrow suppression, gastrointestinal issues, cystitis, and hair loss. 36

Comparison of Studies

Commonalities of Studies

Multiple studies consistently demonstrate the effectiveness of conservation surgery and radiation therapy as an alternative to radical mastectomy for early-stage breast cancer. Additionally, they emphasize the importance of adjuvant systemic treatments, particularly chemotherapy, in reducing the risk of recurrence.

Differences in Studies

48 primarily focuses on comparing the effectiveness of conservation surgery and radiation therapy with radical mastectomy, while 61 analyzes the impact of chemotherapy on different relapse sites. 36 investigates the efficacy of combining chemotherapy and hormone therapy for breast cancer.

Consistency and Contradictions of Results

While various studies confirm the benefits of conservation surgery with radiation therapy and adjuvant chemotherapy, they also highlight the potential risks associated with these treatments. Radiation therapy can impact the heart and lungs, and chemotherapy can cause side effects. 94 36

Implications for Real-Life Applications

For early breast cancer patients, conservation surgery and radiation therapy, along with adjuvant chemotherapy, can be effective treatment options. 94 36 However, it is crucial to consider the potential risks and discuss them with your doctor to make informed decisions about your treatment plan.

Limitations of Current Research

Many studies involve relatively small sample sizes, raising concerns about the generalizability of their findings. Additionally, some studies require long-term follow-up, so their results are not yet fully available.

Future Directions for Research

Large-scale clinical trials with larger patient populations are needed to validate the findings of existing studies. Furthermore, continued research is essential to better understand the long-term effects and side effects of breast cancer treatments.

Conclusion

Conservation surgery with radiation therapy and adjuvant chemotherapy are valuable treatment options for early breast cancer patients. 94 36 However, it is essential to consider the potential risks and discuss them with your doctor to make informed decisions about your treatment plan. Future research will hopefully lead to the development of even more effective and safer treatment options for breast cancer.

List of Treatments

Conservation surgery, radiation therapy, chemotherapy, hormone therapy, tamoxifen, cyclophosphamide, methotrexate, fluorouracil, prednisone, vincristin, 5-fluorouracil, cyclophosphane, mitomycin C, thiotepa, vindesine, epirubicin, vincristine, paclitaxel, docetaxel

Keywords
Benefit Keywords
Breast cancer treatment
Reduced local recurrence
1
Longer survival
Remission rates
2
Breast cancer remission
3
Breast cancer treatment
4
Breast cancer survival
5
Breast cancer treatment
6
Higher remission rates
Prolonged tumor control
7
Conservative primary treatment
Reduced local recurrence
9
Improved duration of response
Improved response rate
Improved survival
10
Breast cancer treatment
11
Reduced breast relapse
12
Breast cancer treatment
13
Breast cancer survival
Local control
14
Identical overall survival
15
Breast cancer survival
16
Breast cancer treatment
Survival improvement
17
Improved disease-free survival
Improved local control
18
Breast cancer treatment
19
Breast cancer treatment
20
Improved management
Rapid tumor regression
21
Reduced recurrence risk
22
Comparable outcomes to mastectomy
Reduced local relapse
23
Reduced recurrence risk
24
Good cosmetic result
No difference in self-evaluation
25
Improved local control
26
Palliation of symptoms
27
Breast cancer treatment
28
Delayed progression
29
Comparable survival rates
Good cosmetic results
Uncommon complications
30
Improved survival
Reduced tumor mortality
31
Improved survival
32
Few side effects
Improved response rates
33
Improved survival
34
Improved breast cancer outcomes
35
Breast cancer treatment
36
Breast cancer treatment
37
Breast cancer treatment
38
Breast cancer treatment
39
Breast cancer treatment
41
Increased response rate
Longer survival
43
Increased disease-free survival
44
Faster remission
Improved response rate
45
Equivalent survival rates to mastectomy
Good cosmetic results
Improved local tumor control
46
Improved survival
Reduced relapses
47
No advantage to radical mastectomy
Similar survival rates
48
Improved breast cancer outcomes
49
Improved breast cancer outcomes
50
Effective treatment
Improved survival
51
Beneficial effects
52
Increased response rate
Longer survival
Reduced hypercalcaemia
Reduced tumour flare
53
Breast cancer treatment
54
Improved survival
55
Breast cancer survival
Local recurrence reduction
56
Improved breast cancer prognosis
58
Disease-free survival
Prolonged survival
59
Effective treatment
60
Improved breast cancer outcomes
61
Effective treatment
62
Effective treatment
Prolonged survival
Reduced tumor size
63
Effective treatment
Well-tolerated
64
Improved understanding of breast cancer treatment
65
Improved breast cancer outcomes
66
Improved breast cancer outcomes
68
Delayed recurrence
Prolonged survival
Reduced contralateral breast cancer
70
Effective treatment
71
Low risk of recurrence
72
Improved breast cancer treatment
73
Chemotherapy effective
Ovarian ablation effective
Tamoxifen effective
74
Improved breast cancer treatment
75
Prolonged survival
76
Reduced mortality rates
77
Improved breast cancer treatment
78
Improved breast cancer treatment
80
Reduced breast cancer recurrence
81
Improved outcome
82
Improved survival
83
Improved survival
Reduced recurrence
84
Improved quality of life
Improved survival
85
Breast cancer treatment
86
Breast cancer treatment
88
Improved response rate
89
Breast cancer treatment
90
Improved communication
Improved decision-making
91
Breast cancer treatment
92
Breast cancer treatment
93
Breast cancer treatment
94
Improved breast cancer treatment
95
Breast cancer survival improvement
96
Improved early-stage breast cancer treatment
97
Improved breast cancer treatment
98
Improved metastatic breast cancer treatment
99
Improved disease-free survival
Improved survival
100
Breast cancer treatment
101
Improved breast cancer treatment
102
Reduced risk of death
Reduced risk of relapse
103
Improved access to radiation therapy
104
Improved breast cancer treatment
105
Lapatinib reduces progression
106
Breast cancer treatment
107
Extended survival
108
Breast cancer treatment
109
Cure from breast cancer
Long-term survival
110
Improved breast cancer survival
111
Improved breast cancer treatment
112
Improved breast cancer management
113
breast cancer survival
114
Partial breast irradiation
115
Locoregional treatment for metastatic breast cancer
116
Breast cancer treatment
117
Breast cancer treatment
119
Improved recurrence-free survival
Reduced IBTR
120
Better outcomes
121
HER2-targeted treatment
122
Improved breast cancer treatment
123
CTC clearance
Good tolerability
124
Improved breast cancer treatment
125
Breast cancer treatment
Targeted therapies
126
breast cancer narrative understanding
127
Improved lymphoedema treatment
128
Improved breast cancer treatment
129
Improved breast cancer treatment
130
Better prediction of outcomes
Improved survival
131
BC rehabilitation
132
Improved disease-free survival
133
BC treatment
134
Adjuvant therapy for TNBC
135
Breast conservation
Improved survival
136
Breast irradiation for axillary recurrence
137
Genomically directed therapy for TNBC
138
BCS for early-stage BC
139
HER2-targeted therapy for HER2+ EBC
140
RT for breast cancer
141
Breast cancer treatment
142
dnMBC treatment
143
Risk Keywords
Adriamycin side effects
5
Long-term risks of cytotoxic therapy
7
Radiation pneumonitis
Treatment discontinuation
14
Alopecia
Haematologic toxicity
Local breast relapses
Neurotoxicity
15
New primary malignancies
16
Mastectomy needed
No long-term benefit
21
Recurrence despite favorable prognosis
22
Need for further trials for small invasive carcinomas
Uncertain influence on distant metastases
Unclear need for booster dose
Unclear treatment for infiltration at resection line
23
Impact on quality of life
No improvement in overall survival
Toxic effects of therapy
24
Impact of treatment needs evaluation
Longer treatment time
More trips
25
Toxicity from chemotherapy
27
Marginal improvement
29
Long-term toxicity
31
Side effects
36
Acute toxicity
Second neoplasms
51
Increased risk of recurrence
72
Cardiovascular disease
73
Chemotherapy side effects
Ovarian ablation side effects
Tamoxifen side effects
74
Toxic side effects
81
No good evidence for adjuvant systemic treatment
87
Alopecia
Increased toxicity
Nausea
Vomiting
89
Cardiac toxicity
Contralateral breast cancer
Pulmonary toxicity
94
Breast cancer
95
Early-stage breast cancer
97
Locally advanced breast cancer
98
Metastatic breast cancer
99
Breast cancer
102
Breast cancer
105
High cost
108
Breast cancer recurrence
Death from breast cancer
110
Increased IBTR risk
112
decreased WBC count
nausea
114
Breast cancer
115
Increased breast cancer mortality
120
HER2-positive breast cancer
122
none
127
Hand-foot syndrome
133
Distant metastasis
Locoregional recurrence
136
Controversial prognostic value of LVI
139
Restricted shoulder mobility
Shoulder pain
142
Literature analysis of 143 papers
Positive Content
132
Neutral Content
10
Negative Content
1
Article Type
99
29
30
31
141
1.

Manchester regional breast study. Preliminary results.

Author: LythgoeJ P

Breast cancer treatment
Reduced local recurrence

Simple mastectomy with or without radiotherapy did not affect survival in patients with stage I breast cancer, but radiotherapy reduced local recurrence. Stage II breast cancer patients treated with simple mastectomy and radiotherapy had similar survival rates to those treated with radical mastectomy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Comparative trial of endocrine versus cytotoxic treatment in advanced breast cancer.

Author: PriestmanT, BaumM, JonesV, ForbesJ

Longer survival
Remission rates

A study of 92 women with advanced breast cancer found that cytotoxic treatment resulted in a significantly higher response rate than endocrine treatment, especially in premenopausal women.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

[Combined drug treatment of far-advanced forms of breast cancer].

Author: BorisovA I

Breast cancer remission

A study of 70 patients with advanced breast cancer compared two treatment regimens: chemotherapy alone and chemotherapy plus ovariectomy with hormone therapy. The chemotherapy regimen included vincristine, 5-fluorouracil, methotrexate, cyclophosphamide, and prednisolone. Chemotherapy alone achieved objective responses in 71.4% of patients, with a median remission duration of 7.6 months. The group receiving chemotherapy plus ovariectomy and hormone therapy had an 88.5% objective response rate with a median remission duration of 10.7 months. Both regimens were effective in treating primary tumors and regional lymph node metastases, but less effective in treating lung and pleural metastases. No serious treatment-related complications were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

4.

Treatment and survival on advanced breast cancer.

Author: PriestmanT, BaumM, JonesV, ForbesJ

Breast cancer treatment

A study of patients with advanced breast cancer found that cytotoxic treatment resulted in a higher response rate, but the sequence of treatment did not influence survival except in women with rapidly progressing disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Pilot study on adjuvant chemotherapy and hormonal therapy for irradiated inoperable breast cancer.

Author: SchaakeC, EngelsmanE, HamersmaE

Breast cancer survival
Adriamycin side effects

A pilot study of adjuvant chemotherapy and hormonal therapy for inoperable breast cancer found that the treated group showed a better relapse-free survival than the control group, particularly for premenopausal women. However, there was no significant difference in overall survival between the groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Radiotherapy in the postoperative treatment of operable cancer of the breast. Part I. Critique of the clinical and biometric aspects of the trials.

Author: LevittS H, McHughR B

Breast cancer treatment

A review of several randomized clinical trials on breast cancer treatment concluded that: - Postoperative radiation to lymph nodes and/or the chest wall does not significantly impact overall survival. - Postoperative radiation does reduce the rate of local recurrence. - Treatment of local recurrence is successful in only 50% of cases. - Radiation plus simple mastectomy is as effective as radical mastectomy alone. The review supports the continued use of radiation as a valuable adjunct in breast cancer treatment, as it does not negatively affect survival and can be beneficial in specific cases.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

[Therapeutic advances in breast neoplasms achieved through multimodal treatment].

Author: SennH J

Higher remission rates
Prolonged tumor control
Long-term risks of cytotoxic therapy

A review of breast cancer epidemiology and treatment found that adjuvant chemotherapy added to radical mastectomy shows promising results in reducing recurrence rates and possibly increasing survival. However, more controlled studies are needed to clarify mode of administration, duration, and patient selection before routine use of adjuvant chemotherapy can be advocated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

8.

On the diagnosis and treatment of breast cancer.

Author: FoxM S

Randomized trials comparing surgical treatments for breast cancer show that radical mastectomy offers no greater benefit than simple mastectomy followed by radiotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

Management of early cancer of the breast. Report on an international multicentre trial supported by the Cancer Research Campaign.

Author:

Conservative primary treatment
Reduced local recurrence

A large controlled clinical study comparing radical mastectomy with radiotherapy to simple mastectomy alone found that postoperative radiotherapy reduced the incidence of local recurrence but did not improve survival or distant recurrence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Systemic therapy of advanced breast cancer.

Author: MouridsenH T

Improved duration of response
Improved response rate
Improved survival

Combination therapy with cytotoxic agents, particularly cyclophosphamide and anthracyclines, generally outperforms single-agent treatment for advanced breast cancer. The optimal duration of treatment remains uncertain, while higher doses combined with colony-stimulating factors and bone marrow transplantation may increase response rates, but long-term survival benefits require further investigation. Tamoxifen is the preferred first-line endocrine treatment, with progestins and aromatase inhibitors as alternatives. Combining chemotherapy and endocrine therapy may improve response rates, but further research is needed on the ideal sequence of these treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

[Neoadjuvant chemotherapy in combined treatment of breast cancer].

Author: SemiglazovV F, TopuzovE E, BavliIa L, IvanovaO A, SeleznevI K, GolubevaO M, OrlovA A, ChepikO F

Breast cancer treatment

A study of 387 patients with stage III breast cancer found that neoadjuvant chemotherapy combined with preoperative radiotherapy was more effective than either treatment alone in reducing tumor and lymph node size, and increasing the duration of recurrence-free survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

12.

Randomized clinical trial to assess the effectiveness of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer.

Author: ClarkR M, McCullochP B, LevineM N, LipaM, WilkinsonR H, MahoneyL J, BasrurV R, NairB D, McDermotR S, WongC S

Reduced breast relapse

Breast irradiation significantly reduced the risk of breast cancer recurrence after lumpectomy and axillary dissection for node-negative breast cancer, but did not influence survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Patient and anatomical selectivity in postoperative radiotherapy for early breast cancer: a British perspective.

Author: EbbsS R, YarnoldJ R

Breast cancer treatment

A study of 307 patients with early breast cancer treated with breast-conserving surgery and radiotherapy, without axillary or internal mammary lymphatic irradiation, found that local recurrence occurred in 15 patients, with only 4 experiencing persistent symptoms after further treatment. Patients with large, poorly differentiated tumors benefitted most from radiotherapy in reducing local recurrence, with the lowest risk of mortality associated with the treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

14.

The combination of radiotherapy, adjuvant chemotherapy (cyclophosphamide-doxorubicin-ftorafur) and tamoxifen in stage II breast cancer. Long-term follow-up results of a randomised trial.

Author: BlomqvistC, TiusanenK, ElomaaI, RissanenP, HietanenT, HeinonenE, GröhnP

Breast cancer survival
Local control
Radiation pneumonitis
Treatment discontinuation

A study of 200 patients with node-positive stage II breast cancer compared the effects of radiotherapy, chemotherapy, and tamoxifen. Chemotherapy improved relapse-free survival compared to radiotherapy alone, and tamoxifen benefited estrogen receptor-positive patients. The combination of radiotherapy and chemotherapy was associated with better local control.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Randomized trial of adjuvant chemotherapy for operable breast cancer comparing i.v. CMF to an epirubicin-containing regimen [see comment].

Author: MauriacL, DurandM, ChauvergneJ, DilhuydyJ M, BonichonF

Identical overall survival
Alopecia
Haematologic toxicity
Local breast relapses
Neurotoxicity

A study of 228 women with early breast cancer compared 9 courses of CMF chemotherapy (cyclophosphamide, methotrexate, 5FU) with a combination of 3 courses of MTV (mitomycin C, thiotepa, vindesine) plus 3 courses of EVM (epirubicin, vincristine, methotrexate). CMF had higher local breast relapse rates, but regional and metastatic recurrences, as well as overall survival, were similar in both groups. Toxicity differed, with MTV+EVM causing more alopecia and neurotoxicity, while CMF resulted in greater hematologic toxicity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Long-term effects of adjuvant tamoxifen and/or radiotherapy. The South Sweden Breast Cancer Trial.

Author: RydénS, FernöM, MöllerT, AspegrenK, BergljungL, KillanderD, LandbergT

Breast cancer survival
New primary malignancies

A study of 719 postmenopausal women with stage II breast cancer found no significant difference in survival or recurrence-free survival between radiotherapy alone, radiotherapy plus tamoxifen, or tamoxifen alone after 12 years. However, the combination of radiotherapy and tamoxifen had a lower rate of local recurrence. Tamoxifen reduced the risk of bilateral breast cancer but slightly increased the risk of other cancers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

The effect of systemic therapy on local-regional control in locally advanced breast cancer.

Author: PierceL J, LippmanM, Ben-BaruchN, SwainS, O'ShaughnessyJ, BaderJ L, DanforthD, VenzonD, CowanK H

Breast cancer treatment
Survival improvement

This study evaluated the effectiveness of a multimodality treatment protocol for locally advanced breast cancer, including chemohormonal therapy, surgery, and radiation. The study found that patients with Stage IIIA disease had significantly lower local-regional failure rates compared to patients with Stage IIIB inflammatory cancer (3% vs. 21% at 5 years). Pathologic complete response achieved through chemotherapy did not consistently predict local-regional control. While radiation alone resulted in a higher local-regional failure rate (23% at 5 years) compared to mastectomy and postoperative radiotherapy (5%), the difference was not statistically significant. Overall, patients with Stage IIIA disease had better relapse-free and overall survival compared to patients with Stage IIIB disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Radiotherapy in breast cancer.

Author: McCormickB

Improved disease-free survival
Improved local control

This review examines the role of radiation therapy in treating breast cancer, including the use of radiation for ductal carcinoma in situ and invasive breast cancer, as well as in unique situations. Radiation therapy after mastectomy is recommended for high-risk patients, and combining it with systemic therapy may improve disease-free survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Surgery for early breast cancer.

Author: ForbesJ F

Breast cancer treatment

This abstract discusses the optimization of breast cancer surgery, emphasizing factors like local disease control, minimizing patient morbidity, and efficient resource utilization. The paper addresses the importance of tumor recurrence biology for treatment planning, the management of subclinical abnormalities on imaging, the potential impact of surgical timing within the menstrual cycle, and the value of axillary dissection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Neoadjuvant chemotherapy in operable breast cancer.

Author: SchollS M, AsselainB, PalangieT, DorvalT, JouveM, Garcia GiraltE, VilcoqJ, DurandJ C, PouillartP

Breast cancer treatment

This study compared neoadjuvant chemotherapy (before surgery) to adjuvant chemotherapy (after surgery) in 196 patients with operable breast cancer. While neoadjuvant chemotherapy resulted in a greater tumor response, particularly for patients receiving higher doses, there was no significant difference in survival between the two groups. The study concluded that neoadjuvant chemotherapy was safe and at least as effective as adjuvant chemotherapy, supporting further research into chemotherapy as a first-line treatment option for breast cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Randomised trial of chemotherapy versus endocrine therapy in patients presenting with locally advanced breast cancer (a pilot study).

Author: GazetJ C, FordH T, CoombesR C

Improved management
Rapid tumor regression
Mastectomy needed
No long-term benefit

A study of 60 patients with locally advanced breast cancer compared primary endocrine therapy with chemotherapy. Chemotherapy led to a faster reduction in tumor size, but there was no significant difference in disease-free survival, local recurrence, distant recurrence, or mortality after 65 weeks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Adjuvant systemic therapy of stage I and II breast cancer.

Author: GoodmanM

Reduced recurrence risk
Recurrence despite favorable prognosis

Adjuvant systemic therapy has been proven effective for both node-positive and node-negative breast cancer patients. However, some women with favorable prognoses still experience recurrence. Identifying high-risk patients for recurrence and developing targeted treatments are ongoing research priorities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

24.

Systemic adjuvant therapy in women with resected node-negative breast cancer.

Author: HartmannL C, MarschkeR F, SchaidD J, IngleJ N

Reduced recurrence risk
Impact on quality of life
No improvement in overall survival
Toxic effects of therapy

Adjuvant systemic therapy has shown moderate benefit in reducing recurrence risk in node-negative breast cancer patients, but overall survival has not been consistently improved. Identifying high-risk patients for relapse and understanding the balance between treatment benefits, risks, and quality of life are key research areas.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

[Impact of induction chemotherapy in the treatment of breast cancer].

Author: OrgerieM B, AvrilA, DurandM

Good cosmetic result
No difference in self-evaluation
Impact of treatment needs evaluation
Longer treatment time
More trips

A study of 206 women with breast cancer compared mastectomy with breast conservation. While breast conservation required longer treatment and more travel, it resulted in good cosmetic outcomes and similar self-reported quality of life at 1 year.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

26.

Clinical trials in locally advanced breast cancer.

Author: WallgrenA

Improved local control

Survival after treatment of locally advanced breast cancer remains poor. While retrospective studies suggest that systemic treatment might be beneficial, a review of clinical trials failed to show consistent survival benefits. Increasing radiotherapy doses or adding endocrine or cytostatic treatment may improve local control. Further research is needed to identify more effective treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

27.

The use of chemotherapy in metastatic breast cancer.

Author: GarberJ E, HendersonI C

Palliation of symptoms
Toxicity from chemotherapy

Recurrent breast cancer is incurable. Treatment focuses on symptom palliation, and single-agent chemotherapies may be as effective as combinations. New approaches to managing metastatic disease are being explored.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

The role of surgery in the combined treatment of locally advanced breast cancer.

Author: CanaveseG, CatturichA, BattistiniG, CarotiC, PronzatoP, GardinG, AmorosoD, BertelliG, ConteP F, TomaoS

Breast cancer treatment

This study evaluated a combined treatment approach for 60 patients with advanced stage breast cancer. After three cycles of chemotherapy, 74.5% of patients experienced tumor shrinkage, and 98.3% were free of detectable disease after surgery or radiation. At four years, 71.5% of patients were alive, and 43% were disease-free. These results are significantly better than previous treatment outcomes and suggest that advanced breast cancer can now be considered a potentially curable disease with aggressive, multi-modal therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Locally advanced breast cancer: the contribution of cytotoxic and endocrine treatment to radiotherapy. An EORTC Breast Cancer Co-operative Group Trial (10792).

Author: RubensR D, BartelinkH, EngelsmanE, HaywardJ L, RotmenszN, SylvesterR, van der SchuerenE, PapadiamantisJ, VassilarosS D, WildiersJ

Delayed progression
Marginal improvement

A study of 363 patients with locally advanced breast cancer found that both endocrine therapy and chemotherapy significantly delayed time to progression, with the combination of both treatments being most effective. The study suggests that current treatments only modestly improve prognosis for this stage of cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Local therapy of invasive disease.

Author: BoyagesJ, HarrisJ R

Comparable survival rates
Good cosmetic results
Uncommon complications

Mastectomy and conservative surgery with radiation therapy (CS and RT) are both effective treatment options for early breast cancer, with comparable survival rates. CS and RT are preferred for smaller tumors and breasts, where good cosmetic results are possible.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

31.

Systemic therapy in resectable breast cancer.

Author: BonadonnaG, ValagussaP

Improved survival
Reduced tumor mortality
Long-term toxicity

Adjuvant systemic therapy has been proven to significantly reduce tumor mortality in high-risk breast cancer patients. The benefit is moderate but clinically important. While primary chemotherapy may allow conservative surgery for some tumors, this approach is still considered experimental.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

32.

The Cancer Research Campaign trials of adjuvant therapy for early breast cancer.

Author: BaumM, EbbsS R, HoughtonJ, A'HernR P, RileyD

Improved survival

Systemic treatment is needed to cure early breast cancer, as tumor spread is common. The Cancer Research Campaign Breast Adjuvant Trial found that both perioperative cyclophosphamide and long-term tamoxifen improved outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

Endocrine management of advanced breast cancer.

Author: RoseC, MouridsenH T

Few side effects
Improved response rates

Tamoxifen has become the standard first-line endocrine therapy for advanced breast cancer. Oophorectomy and aminoglutethimide or progestins are effective as second-line therapies. Combined endocrine therapy has not shown consistent benefit.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

34.

[Cancers of the breast at metastatic high-risk: prediction of survival by steroidal receptors].

Author: MauriacL, DurandM, ChauvergneJ, DavidM, WafflartJ

Improved survival

A study of 279 patients with locally advanced breast cancer found that patients with estrogen and progesterone receptors (EPR) had better survival and relapse-free survival. Hormonal therapy may offer similar benefits to induction chemotherapy for these patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

35.

[Cooperative research into the treatment of breast cancer].

Author: DemidovV P, OstrovtsevL D, KovalevB N, PakD D, StranadkoE F

Improved breast cancer outcomes

This paper discusses the results of surgical treatment for early breast cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

36.

A randomized trial of adjuvant endocrine therapy, chemotherapy, and chemoendocrine therapy for operable breast cancer stratified by estrogen receptors.

Author: NomuraY, TashiroH, HisamatsuK, ShinozukaK

Breast cancer treatment
Side effects

This study compared the effectiveness of hormone therapy (tamoxifen), chemotherapy, and combined hormone and chemotherapy in 692 patients with operable breast cancer. Patients were divided into groups based on estrogen receptor (ER) status and menopausal status. The study found no significant difference in disease-free survival or overall survival between the treatment groups for either ER-positive or ER-negative patients. While the combination therapy group had more side effects, the study suggests that hormone therapy may be a reasonable choice for ER-positive patients, and chemotherapy for ER-negative patients, due to the lower risk of side effects with hormone therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Long-term survival following relapse after 5-FU but not CMF adjuvant breast cancer therapy.

Author: ChlebowskiR T, WeinerJ M, ReynoldsR, LuceJ, BulcavageL, BatemanJ R

Breast cancer treatment

This study compared the long-term outcomes of two chemotherapy regimens for 112 patients with advanced breast cancer: 5-FU and CMF. While CMF initially showed better results in preventing cancer recurrence, more patients treated with 5-FU are currently alive. The study found that using combination chemotherapy after 5-FU failure often resulted in long-term survival, while long-term survival was uncommon after CMF failure. Patients receiving 5-FU were more likely to have relapses detected during regular checkups, suggesting a potential difference in tumor burden at the time of recurrence. Hormonal therapy or radiation therapy as initial treatment after relapse did not improve long-term survival. The study concludes that initial improvements in relapse-free survival may not predict long-term survival, as both the initial adjuvant therapy and the subsequent treatment after relapse can influence outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

38.

Adjuvant chemotherapy in the treatment of breast cancer: results of a multicentre study.

Author: SpittleM F, OstrowskiM J, HillB T, MacRaeK D, BatesT D, MartinW M, NicolN T, KitchenG, BuchananR B, EdelstynG A

Breast cancer treatment

This study compared the effectiveness of chemotherapy to no further treatment in 248 patients with early-stage breast cancer who had undergone surgery. Those who received chemotherapy had a significantly longer time before cancer recurrence compared to those who did not (31 months vs. 50 months). While there was a trend towards longer survival in the chemotherapy group, this difference was not statistically significant. The chemotherapy regimen used was well-tolerated, with only a small percentage of patients experiencing significant side effects. The study concludes that chemotherapy can delay cancer recurrence in patients with early-stage breast cancer and that the regimen used is suitable for both general and specialized hospitals.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Local control and survival in early breast cancer: the Milan trial.

Author: VeronesiU, ZucaliR, LuiniA

Breast cancer treatment

This study compared the effectiveness of Halsted mastectomy (removal of the entire breast) to a less extensive procedure (quadrantectomy) with lymph node removal and radiation for 701 patients with small (less than 2 cm) breast cancer without lymph node involvement. After 8 years, there was no significant difference in disease-free or overall survival between the two groups, with both groups achieving high survival rates (77-80% for disease-free survival and 83-85% for overall survival). The study concludes that smaller breast cancers can be safely and effectively treated with a less invasive procedure, and that extensive surgery is not necessary.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Adjuvant chemo- and hormonal therapy in locally advanced breast cancer: a randomized clinical study.

Author: Schaake-KoningC, van der LindenE H, HartG, EngelsmanE

A study of 118 patients with locally advanced breast cancer found that adjuvant chemotherapy and hormonal therapy did not improve overall survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Adjuvant CMFP versus CMFP plus tamoxifen versus observation alone in postmenopausal, node-positive breast cancer patients: three-year results of an Eastern Cooperative Oncology Group study.

Author: TaylorS G, KalishL A, OlsonJ E, CummingsF, BennettJ M, FalksonG, TormeyD C, CarboneP P

Breast cancer treatment

A study of 265 postmenopausal women with node-positive breast cancer compared chemotherapy (CMFP or CMFPT) to observation after mastectomy. Chemotherapy significantly reduced the risk of early relapse (within the first year) across all prognostic subgroups. However, the benefit of chemotherapy diminished over time, with similar relapse-free survival rates at 3 years for all groups. Adding tamoxifen to chemotherapy did not provide additional benefit. Chemotherapy was particularly effective in preventing early relapse in patients with ER-negative tumors. While chemotherapy did not affect early survival, longer-term follow-up is needed to determine its impact on late relapse patterns.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

42.

Ten-year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with or without radiation.

Author: FisherB, RedmondC, FisherE R, BauerM, WolmarkN, WickerhamD L, DeutschM, MontagueE, MargoleseR, FosterR

A study of 1,665 women with breast cancer found that different variations of local and regional treatment did not significantly influence survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

43.

Chemotherapy versus chemotherapy plus hormonotherapy in postmenopausal advanced breast cancer patients. A randomized trial.

Author: ViladiuP, AlonsoM C, AvellaA, BeltránM, BorrásJ, OjedaB, BoschF X

Increased response rate
Longer survival

A study of 117 postmenopausal women with advanced breast cancer compared three chemotherapy regimens: CMF, CMF plus tamoxifen (TMX), and CMF plus medroxyprogesterone (MAP). CMF plus TMX and CMF plus MAP had higher overall response rates than CMF alone, but there was no difference in complete response rates. After treatment failure, all patients received a second regimen (Adriamycin, vincristine, and either TMX or MAP). Response rates to the second regimen were similar across groups. Patients who responded to both regimens had longer survival compared to those who did not respond or only responded to one regimen. Overall survival was not significantly different between the initial treatment groups. These findings suggest that adding tamoxifen or medroxyprogesterone to CMF may increase response rates, but overall survival may be more dependent on the patient's response to treatment rather than the specific regimen used.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

44.

Randomised trial of chemo-endocrine therapy, endocrine therapy, and mastectomy alone in postmenopausal patients with operable breast cancer and axillary node metastasis.

Author:

Increased disease-free survival

A study of 463 postmenopausal women with breast cancer compared three adjuvant treatments following mastectomy and lymph node removal: chemo-endocrine therapy (CMFp+T), endocrine therapy (p+T), and no treatment. Chemo-endocrine therapy significantly improved disease-free survival compared to both endocrine therapy and no treatment, and endocrine therapy also showed improved disease-free survival compared to no treatment. While there was no difference in overall survival between groups, chemo-endocrine therapy reduced all types of relapse (local, regional, and distant), while endocrine therapy only reduced local and regional relapses. These findings suggest that chemo-endocrine therapy offers the greatest benefit in preventing recurrence after breast cancer surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

45.

Treatment of disseminated breast cancer with tamoxifen, aminoglutethimide, hydrocortisone, and danazol, used in combination or sequentially.

Author: PowlesT J, AshleyS, FordH T, GazetJ C, NashA G, NevilleA M, CoombesR C

Faster remission
Improved response rate

A study of 222 patients with metastatic breast cancer compared a combination of hormone therapies (TAD) to tamoxifen alone. The combination therapy resulted in a significantly higher response rate (43% vs. 31%). While the duration of response was similar for both groups, patients receiving TAD achieved remission faster. Overall, patients in the TAD group had a longer cumulative time in endocrine remission (303 months vs. 264 months). However, there was no difference in survival between the two groups. These findings suggest that the combination therapy may be a more effective initial treatment for metastatic breast cancer, potentially leading to faster remission and longer time in remission.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

46.

Primary radiation therapy for early breast cancer.

Author: HarrisJ R, HellmanS

Equivalent survival rates to mastectomy
Good cosmetic results
Improved local tumor control

A review of studies using primary radiation therapy for early breast cancer found that it achieved high levels of local tumor control with good cosmetic results. A randomized clinical trial suggested that primary radiation therapy is as effective as mastectomy in terms of survival rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Adjuvant chemotherapy for operable breast cancer in postmenopausal women.

Author: FalksonH C, FalksonG, SchoemanH S, LouwE M, PortugalM A

Improved survival
Reduced relapses

A study of 105 postmenopausal women with operable breast cancer found that adjuvant chemotherapy significantly improved survival rates. The study also identified specific patient groups who may benefit most from adjuvant chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

48.

Conservation surgery and irradiation as an alternative to mastectomy in the treatment of clinically favorable breast cancer.

Author: MontagueE D, AmesF C, SchellS R, RomsdahlM M

No advantage to radical mastectomy
Similar survival rates

This review found that conservation surgery and radiation therapy are as effective as radical mastectomy for early breast cancer, with no significant difference in locoregional recurrence or 10-year disease-free survival rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

49.

[Present status of endocrine therapy of breast cancer: a surgeon's view].

Author: NomuraY

Improved breast cancer outcomes

While major endocrine ablation therapy (oophorectomy, adrenalectomy, hypophysectomy) was once common for advanced breast cancer, the use of tamoxifen, a less toxic antiestrogen, has become more prevalent. This study found that major endocrine ablation therapy remained effective as a second-line treatment for advanced breast cancer, particularly in ER-positive cancers, even after tamoxifen resistance developed. A randomized study of adjuvant endocrine and chemotherapy for operable breast cancer, stratified by ER status, showed that tamoxifen alone (20mg/day for 2 years) had a similar recurrence rate to other treatment groups in ER-positive patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Japanese

50.

[Surgical therapy of breast cancer: to operate radically or to preserve the breast?].

Author: KolbR, JakeszR, ReinerG, RainerH, MoserK, SchemperM

Improved breast cancer outcomes

A study of 241 breast cancer patients compared different surgical treatments and adjuvant therapies. Modified radical mastectomy (M) showed better outcomes than partial resection (R) in lymph node-negative patients, but no significant difference was found between M and the classical Halsted procedure (RM) in lymph node-positive cases. Chemotherapy and chemoimmunotherapy did not significantly reduce the recurrence rate in the R group. A separate retrospective study found a high local recurrence rate (23.6%) after breast resection. Based on these findings and data from other studies, the authors recommend modified radical mastectomy as the standard treatment for primary operable breast cancer. Breast-conserving treatments should only be used in controlled clinical trials.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

51.

Multimodal treatment in operable breast cancer: five-year results of the CMF programme.

Author: RossiA, BonadonnaG, ValagussaP, VeronesiU

Effective treatment
Improved survival
Acute toxicity
Second neoplasms

Adjuvant chemotherapy with cyclophosphamide, methotrexate, and fluorouracil (CMF) significantly improved relapse-free survival (59.5% vs. 44.6%) and total survival (78.4% vs. 66.2%) in patients with breast cancer compared to radical mastectomy alone. The benefits were associated with the number of diseased axillary nodes and the amount of drug administered. The chemotherapy had moderate and reversible side effects with no observed chronic organ damage or increased second neoplasms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

52.

Chemoendocrine therapy in advanced breast cancer.

Author: KiangD T, KennedyB J

Beneficial effects

This study explored the combination of hormone therapy and chemotherapy in treating breast cancer in both rats and humans. While some interference between these treatments was observed in highly hormone-dependent tumors, combining these therapies can be beneficial in human breast cancer when treatment plans are tailored to the individual patient's hormone receptor status and the presence or absence of distant metastases.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

53.

Contribution of prednisolone to the primary endocrine treatment of advanced breast cancer.

Author: StewartJ F, RubensR D, KingR J, MintonM J, SteinerR, TongD, WinterP J, KnightR K, HaywardJ L

Increased response rate
Longer survival
Reduced hypercalcaemia
Reduced tumour flare

The study found that tamoxifen combined with prednisolone was more effective in inducing responses in postmenopausal patients with advanced breast cancer compared to tamoxifen alone. The combination also showed a trend towards longer survival and mitigated hypercalcemia and tumor flare seen with tamoxifen alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

54.

Adjuvant chemotherapy for operable breast cancer in premenopausal women.

Author: FalksonH C, FalksonG, PortugalM A, SchoemanH S, LouwE M

Breast cancer treatment

This study of 81 premenopausal women with operable breast cancer found that CMFVP was superior to CMF with or without MER in terms of disease-free survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

55.

[Simultaneous or sequential hormono/chemotherapy and a comparison of various polychemotherapies in the treatment of metastatic breast cancer].

Author: CavalliF, BeerM, MartzG, JungiW F, AlbertoP, ObrechtJ P, MermillodB, BrunnerK W

Improved survival

A study of 396 patients with advanced breast cancer compared combined chemo/hormonotherapy to hormonotherapy alone, followed by chemotherapy when tumor progression occurred. Premenopausal patients tended to live longer with the combined approach, while postmenopausal patients fared better with delayed chemotherapy. The difference in survival was statistically significant only in postmenopausal patients with less aggressive tumors. More intensive chemotherapy resulted in higher response rates, but only marginally improved survival. These findings suggest that the optimal treatment strategy for advanced breast cancer may vary depending on patient characteristics and tumor aggressiveness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

56.

Manchester regional breast study--5 and 10 year results.

Author: LythgoeJ P, PalmerM K

Breast cancer survival
Local recurrence reduction

This study of 1022 patients with early breast cancer found that postoperative radiotherapy significantly reduced the frequency of local recurrence in patients with clinical stage I cancer who underwent simple mastectomy. However, there was no difference in overall survival between those who received radiotherapy and those who did not. In patients with clinical stage II cancer, there was no significant difference in survival or local recurrence between simple mastectomy with radiotherapy and radical mastectomy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

57.

The prognosis of stage III breast cancer treated with postoperative radiotherapy and adriamycin-based chemotherapy with and without tamoxifen. Eight year follow-up results of a randomized trial.

Author: SaartoT, BlomqvistC, TiusanenK, GröhnP, RissanenP, ElomaaI

In a study of 61 patients with stage III breast cancer, adjuvant radiotherapy and chemotherapy with or without tamoxifen did not show significant differences in survival or local control. The prognosis for stage III breast cancer remains challenging, highlighting the need for more effective treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

58.

[Adjuvant systemic treatment of primary breast cancer].

Author: MouridsenH T

Improved breast cancer prognosis

Adjuvant therapy for breast cancer has improved survival rates, with studies showing a reduction of about 25% in deaths among younger women receiving combination chemotherapy and older women taking tamoxifen. However, despite the progress, optimal treatment remains a complex issue, considering the physical, psychological, and socioeconomic consequences. This review examines open questions about adjuvant therapy's effectiveness in reducing recurrence rates and mortality.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Danish

59.

The International (Ludwig) Breast Cancer Study Group Trials I-IV: 15 years follow-up.

Author: Castiglione-GertschM, JohnsenC, GoldhirschA, GelberR D, RudenstamC M, CollinsJ, LindtnerJ, HackingA, Cortes-FunesH, ForbesJ

Disease-free survival
Prolonged survival

Adjuvant systemic therapy improves disease-free and overall survival for breast cancer, with benefits from multi-agent chemotherapy, prolonged tamoxifen treatment, and ovarian ablation. Combining chemotherapy and endocrine therapy may provide additional benefits.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer.

Author: JacobsonJ A, DanforthD N, CowanK H, d'AngeloT, SteinbergS M, PierceL, LippmanM E, LichterA S, GlatsteinE, OkunieffP

Effective treatment

This study compared lumpectomy with radiation to mastectomy for early-stage breast cancer in 1,843 women. The study, conducted between 1979 and 1987, is now updated with a median follow-up of over 10 years. The results of this long-term follow-up will be described in the rest of the paper.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

61.

Effect of systemic adjuvant treatment on first sites of breast cancer relapse.

Author: GoldhirschA, GelberR D, PriceK N, CastiglioneM, CoatesA S, RudenstamC M, CollinsJ, LindtnerJ, HackingA, MariniG

Improved breast cancer outcomes

A study of 2,830 women with node-positive breast cancer found that more intensive adjuvant therapy (multiple cycles of chemotherapy with or without tamoxifen) significantly reduced the incidence of local or regional and distant soft-tissue relapses at 10 years (36% to 18%). However, there was no effect on bone or visceral relapses. These findings suggest that current adjuvant treatments primarily benefit patients by reducing early-stage recurrence in specific areas, while having a smaller impact on later relapses in bone and internal organs. More intensive treatments currently being investigated may affect bone and visceral relapses and potentially lead to earlier and greater improvements in survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

Conservative surgery for the management of invasive and noninvasive carcinoma of the breast: NSABP trials. National Surgical Adjuvant Breast and Bowel Project.

Author: FisherB, AndersonS

Effective treatment

This study analyzed the long-term results of a 10-year follow-up of a randomized trial comparing lumpectomy with or without radiation therapy to modified radical mastectomy for stages I and II breast cancer. The study found that lumpectomy with radiation therapy was as effective as mastectomy in preventing tumor recurrence in the same breast and in overall survival. The results support the use of lumpectomy and radiation therapy as a standard treatment for invasive breast cancer and potentially for localized ductal carcinoma in situ.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

63.

Prospective randomized clinical trial of primary treatment in breast cancer stages T3/4, N+/-, MO. Chemotherapy vs. radiotherapy. Arbeitskreis für Perioperative Chemotherapie.

Author: RainerH

Effective treatment
Prolonged survival
Reduced tumor size

Preoperative chemotherapy followed by surgery (treatment A) resulted in significantly better relapse-free survival and overall survival compared to preoperative radiotherapy followed by surgery (treatment B). Responders to chemotherapy had significantly better outcomes than non-responders.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

64.

Primary endocrine therapy for advanced breast cancer: to start with tamoxifen or with medroxyprogesterone acetate?

Author: Castiglione-GertschM, PampallonaS, VariniM, CavalliF, BrunnerK, SennH J, GoldhirschA, MetzgerU

Effective treatment
Well-tolerated

Tamoxifen has become the standard treatment for advanced breast cancer due to its effectiveness against metastatic disease and its good tolerability, even with long-term use. This has led to limited testing of other drugs or hormonal treatments as initial therapy for advanced breast cancer, particularly compared to tamoxifen.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

65.

Mastectomy versus conservative surgery and radiation therapy. Psychosocial consequences.

Author: SchainW S, d'AngeloT M, DunnM E, LichterA S, PierceL J

Improved understanding of breast cancer treatment

Studies comparing mastectomy to conservative surgery plus radiation therapy for early-stage breast cancer have shown similar survival rates. The research focuses on understanding the psychological impact of each treatment option, exploring whether conservative surgery plus radiation therapy offers greater psychological comfort than mastectomy for women diagnosed with early-stage breast cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

66.

[Breast cancer: results of breast saving treatment].

Author: von FournierD, AntonH W

Improved breast cancer outcomes

A study of breast cancer patients in Heidelberg found that two-thirds received breast-preserving therapy (BCT), with pre-operative chemotherapy increasing the number of patients eligible for this treatment. BCT involved wide surgical margins and high-dose radiation. A prospective study showed a 10% higher five- to ten-year survival rate for BCT compared to mastectomy. Local recurrence occurred in 4-6% of BCT cases, compared to 9% after mastectomy without radiation. Local recurrence did not affect survival rates. However, distant metastases were significantly higher in patients who did not receive radiation after breast-conserving surgery. Therefore, radiation is generally recommended after BCT. The majority of women (98%) indicated a preference for BCT over mastectomy two years after treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

67.

Radiotherapy after breast-preserving surgery in women with localized cancer of the breast.

Author: VeronesiU, LuiniA, Del VecchioM, GrecoM, GalimbertiV, MersonM, RilkeF, SacchiniV, SaccozziR, SavioT

A randomized trial comparing quadrantectomy with radiotherapy to quadrantectomy without radiotherapy for small breast cancers showed no difference in outcomes at a median follow-up of 39 months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

68.

[The adjuvant treatment of operable breast carcinoma. The current status and outlook].

Author: PennaA, ScorpiglioneN, NicolucciA, AngioliniC, MaininiF, GrilliR, LiberatiA

Improved breast cancer outcomes

Breast cancer is a common cancer in Italy, with 25,000 new cases and over 9,000 deaths annually. Treatment practices for breast cancer vary widely across hospitals and depend on patient factors and doctor's preferences. Post-surgical treatment, including hormonal therapy or chemotherapy, has been shown to improve survival and reduce recurrence. A review of studies indicated that these treatments reduced mortality by 15-20%, potentially saving over 1,000 lives per year in Italy. Hormonal therapy was found to be beneficial for postmenopausal women, even those with estrogen receptor-negative tumors. Ovarian ablation and chemotherapy were effective for premenopausal women. While adjuvant therapy is recommended for women with no lymph node involvement to reduce the risk of recurrence, more research is needed to refine treatment guidelines and identify high-risk patients. More patients should be included in clinical trials to improve our understanding of breast cancer treatment.

EditorialAn article in which the editor or publisher expresses their opinion or perspective on a particular topic or issue. Its purpose is to convey a specific message or idea to the reader.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Italian

69.

Risk of new primaries after chemotherapy and/or tamoxifen treatment for early breast cancer.

Author: RubagottiA, PerrottaA, CasellaC, BoccardoF

This study investigates the incidence of new cancers in patients with early-stage breast cancer who received either chemotherapy, tamoxifen, or a combination of both after mastectomy. While both treatments have been shown to cause cancer in laboratory models, there is limited data on their impact on developing new cancers in humans with breast cancer. The study aims to provide more information about the risk of developing new cancers after these treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

70.

Ovarian irradiation and prednisone following surgery and radiotherapy for carcinoma of the breast.

Author: MeakinJ W, HaywardJ L, PanzarellaT, AlltW E, BealeF A, BulbrookR D, BushR S, ClarkR M, FitzpatrickP J, HawkinsN V, JenkinR D, PringleJ F, RiderW D

Delayed recurrence
Prolonged survival
Reduced contralateral breast cancer

A randomized study of 703 patients with operable breast cancer following mastectomy found that ovarian irradiation combined with prednisone significantly delayed recurrence and prolonged survival compared to no further therapy or ovarian irradiation alone. This benefit was particularly observed in premenopausal women aged 45 years or more.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

71.

Locally advanced breast cancer: early results of a randomised trial of multimodal therapy versus initial hormone therapy.

Author: WillsherP C, RobertsonJ F, ChanS Y, JacksonL, BlameyR W

Effective treatment

This study compared two approaches for treating locally advanced breast cancer: 1) "multimodal" therapy (initial chemotherapy, surgery, radiation, and hormone therapy), and 2) "hormone" therapy alone, with other therapies added as needed. After 30 months, there was no significant difference in the development of metastases or overall survival between the two groups. However, the "hormone" group required fewer treatments to control the disease locally. This suggests that a sequential treatment approach, starting with hormone therapy, may be effective and could potentially avoid unnecessary treatments for some patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

72.

Risk factors for local recurrence after conservative treatment in stage I breast cancer. Definition of a subgroup not requiring radiotherapy.

Author: LiljegrenG, LindgrenA, BerghJ, NordgrenH, TabárL, HolmbergL

Low risk of recurrence
Increased risk of recurrence

Low age, comedo and lobular cancers, and mammographic appearance of the tumor as a stellate lesion with microcalcifications inside the lesion indicate an increased risk for local recurrence after sector resection in stage 1 tumors at five years. Patients > 60 years of age without comedo or lobular cancers are at low risk for local recurrence at five years even without postoperative radiotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

74.

Adjuvant systemic therapy for women with node-positive breast cancer. The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer.

Author:

Chemotherapy effective
Ovarian ablation effective
Tamoxifen effective
Chemotherapy side effects
Ovarian ablation side effects
Tamoxifen side effects

Chemotherapy is recommended for all premenopausal women with stage II node-positive breast cancer, with CMF or AC being acceptable regimens. Tamoxifen is recommended for postmenopausal women with stage II, estrogen receptor-positive cancer. Ovarian ablation is an alternative for premenopausal women who decline chemotherapy.

GuidelineRecommendations and best practices developed by experts for healthcare professionals to refer to when making clinical judgments and providing care.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

76.

Direct comparisons of adjuvant endocrine therapy, chemotherapy, and chemoendocrine therapy for operable breast cancer patients stratified by estrogen receptor and menopausal status.

Author: NomuraY, ShirouzuM, TakayamaT

Prolonged survival

This study found that hormone therapy alone was as effective as chemotherapy or a combination of hormone therapy and chemotherapy in preventing cancer recurrence and extending survival for premenopausal women with estrogen receptor-positive breast cancer. However, for postmenopausal women with the same type of cancer, combining hormone therapy with chemotherapy resulted in a significantly higher survival rate and a lower risk of cancer recurrence compared to hormone therapy or chemotherapy alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

77.

[The effectiveness of adjuvant systemic therapy in organ-preserving therapy of breast cancer].

Author: SemiglazovV F, KanaevS V, BugrovaI L, ChagunavaO L

Reduced mortality rates

This study looked at the effectiveness of additional treatment (adjuvant therapy) after surgery for early-stage breast cancer in 360 women. Postmenopausal women who received tamoxifen had a 17% lower death rate, while premenopausal women who received chemotherapy (CMF) or tamoxifen had a 34% and 36% lower death rate, respectively.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

78.

[Breast cancer: new therapeutic strategies].

Author: EspieM

Improved breast cancer treatment

Metastatic breast cancer is a challenging condition. Without additional treatment after surgery, about 30% of women with no lymph node involvement and 50% of women with lymph node involvement develop metastatic disease within 10 and 5 years, respectively. Hormonal and chemotherapy treatments have shown to reduce breast cancer death by 10%. New medications like taxanes and aromatase inhibitors are showing promise in clinical trials, and may be used as additional treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

79.

[Introduction of studies by the German Breast Center Study Group (GBSG)].

Author: RauscheckerH F

This study investigates the necessity of radiation therapy after tumor removal in breast-conserving treatment for early stage breast cancer. The study also examines whether tamoxifen can replace radiation therapy as a long-term treatment option.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

80.

Neoadjuvant chemotherapy for operable breast carcinoma larger than 3 cm: a unicentre randomized trial with a 124-month median follow-up. Institut Bergonié Bordeaux Groupe Sein (IBBGS).

Author: MauriacL, MacGroganG, AvrilA, DurandM, FloquetA, DebledM, DilhuydyJ M, BonichonF

Improved breast cancer treatment

Chemotherapy before surgery (neoadjuvant chemotherapy) has been shown to improve survival and allow breast-conserving surgery for patients with large, locally advanced breast tumors. This study investigated the effectiveness of this approach for smaller tumors that were initially too large for breast-conserving surgery. Initial results were published in Annals of Oncology in 1991.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

81.

[Adjuvant systemic therapy of breast cancer--prognostic and predictive factors].

Author: RochlitzC

Reduced breast cancer recurrence
Toxic side effects

Additional treatment (adjuvant therapy) with Tamoxifen and/or chemotherapy after surgery for breast cancer has significantly reduced the risk of the cancer returning by 20-35%. However, further improvements are needed. New drugs, like taxanes, vinorelbine, and capecitabine, higher doses of chemotherapy for specific patients, immunotherapy using monoclonal antibodies, and gene therapy may help achieve this in the future. Researchers are also working to identify biological markers that can predict which patients will benefit most from a specific treatment, allowing for more targeted therapies and minimizing side effects for those who might not respond well.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

82.

Early start of adjuvant chemotherapy may improve treatment outcome for premenopausal breast cancer patients with tumors not expressing estrogen receptors. The International Breast Cancer Study Group.

Author: ColleoniM, BonettiM, CoatesA S, Castiglione-GertschM, GelberR D, PriceK, RudenstamC M, LindtnerJ, CollinsJ, ThürlimannB, HolmbergS, VeronesiA, MariniG, GoldhirschA

Improved outcome

The study suggests that early initiation of adjuvant chemotherapy may improve outcome for premenopausal, node-positive breast cancer patients whose tumors do not express estrogen receptors (ER).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

83.

[Adjuvant treatment of breast cancer: meta-analysis and therapeutic recommendations].

Author: JerusalemG, BoursV, FilletG

Improved survival

The importance of adjuvant chemotherapy and hormonotherapy in treating early-stage breast cancer is highlighted, emphasizing the need for increased public and medical community participation in clinical trials.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : French

84.

Estrogen-receptor-directed neoadjuvant therapy for breast cancer: results of a randomised trial using formestane and methotrexate, mitozantrone and mitomycin C (MMM) chemotherapy.

Author: GazetJ C, FordH T, GrayR, McConkeyC, SutcliffeR, QuilliamJ, MakindeV, LowndesS, CoombesR C

Improved survival
Reduced recurrence

The study investigates the effectiveness of neoadjuvant systemic chemoendocrine therapy guided by estrogen receptor (ER) status compared to conventional postoperative treatment for breast cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

85.

A systematic overview of chemotherapy effects in breast cancer.

Author: BerghJ, JönssonP E, GlimeliusB, NygrenP,

Improved quality of life
Improved survival

This review of chemotherapy trials for breast cancer found that adjuvant chemotherapy improves survival, especially for younger patients and those with node-positive disease. Anthracycline-containing regimens offer greater survival benefit compared to non-anthracycline regimens. Adding tamoxifen enhances survival for receptor-positive tumors. While high-dose therapy is being studied, evidence does not currently support its routine use. For locally advanced breast cancer, neoadjuvant chemotherapy increases the chance for breast-conserving surgery. Metastatic breast cancer patients experience a median survival of 12-24 months with conventional chemotherapy. Polychemotherapy improves survival compared to single-agent therapy, and anthracycline-containing regimens offer greater survival benefit than non-anthracycline regimens, except for CMF with prednisone/prednisolone. Second-line therapy with vinorelbine or docetaxel has shown a survival advantage. While breast cancer shows a dose-response relationship with chemotherapy, there appears to be a plateau in survival benefit beyond a certain dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

86.

Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial.

Author: VeronesiU, MarubiniE, MarianiL, GalimbertiV, LuiniA, VeronesiP, SalvadoriB, ZucaliR

Breast cancer treatment

Radiotherapy appears indicated after breast-conserving surgery in patients up to 55 years of age, those with positive axillary nodes, and those with extensive intraductal component at histology. Radiotherapy may be avoided in patients older than 65 and may be optional in women aged 56-65 years with negative nodes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

87.

Systemic therapy for treating locoregional recurrence in women with breast cancer.

Author: RauscheckerH, ClarkeM, GatzemeierW, RechtA

No good evidence for adjuvant systemic treatment

Between 10% and 35% of women who have had surgery for breast cancer experience a recurrence of the cancer in the same area. There is no strong evidence that additional treatments are effective for these recurrences, and no standard treatment exists for women with this situation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

88.

Randomized adjuvant trial of tamoxifen and goserelin versus cyclophosphamide, methotrexate, and fluorouracil: evidence for the superiority of treatment with endocrine blockade in premenopausal patients with hormone-responsive breast cancer--Austrian Breast and Colorectal Cancer Study Group Trial 5.

Author: JakeszRaimund, HausmaningerHubert, KubistaErnst, GnantMichael, MenzelChristian, BauernhoferThomas, SeifertMichael, HaiderKarin, MlineritschBrigitte, SteindorferPeter, KwasnyWerner, FridrikMichael, StegerGuenther, WetteViktor, SamoniggHellmut,

Breast cancer treatment

This study compared the effectiveness of standard chemotherapy with a combination of hormone therapies in premenopausal women with breast cancer. The study aimed to determine if combining hormone therapies with chemotherapy would improve outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

89.

Chemotherapy alone versus endocrine therapy alone for metastatic breast cancer.

Author: WilckenN, HornbuckleJ, GhersiD

Improved response rate
Alopecia
Increased toxicity
Nausea
Vomiting

In women with metastatic breast cancer and positive hormone receptors, endocrine therapy is recommended as a first-line treatment, except in cases of rapidly progressive disease. Chemotherapy may offer a greater response rate but is associated with higher toxicity. Further research is needed to assess the long-term effects of both treatments on survival and quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Adjuvant endocrine therapy compared with no systemic therapy for elderly women with early breast cancer: 21-year results of International Breast Cancer Study Group Trial IV.

Author: CrivellariDiana, PriceKaren, GelberRichard D, Castiglione-GertschMonica, RudenstamCarl-Magnus, LindtnerJurij, FeyMartin F, SennHans-Jörg, CoatesAlan S, CollinsJohn, GoldhirschAron,

Breast cancer treatment

The study reviewed the long-term outcome of a trial comparing endocrine treatment versus no adjuvant therapy in older women with node-positive breast cancer, highlighting the continued debate about the role of adjuvant therapy in this population.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

91.

Effect of a decision aid on knowledge and treatment decision making for breast cancer surgery: a randomized trial.

Author: WhelanTimothy, LevineMark, WillanAndrew, GafniAmiram, SandersKen, MirskyDoug, ChambersShelley, O'BrienMary Ann, ReidSusan, DuboisSacha

Improved communication
Improved decision-making

A decision aid, called the decision board, was helpful in improving communication and enabling women to make a choice regarding breast cancer treatment. Patients who used the decision board were more likely to choose breast-conserving therapy (BCT).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

92.

Treatment of lymph-node-negative, oestrogen-receptor-positive breast cancer: long-term findings from National Surgical Adjuvant Breast and Bowel Project randomised clinical trials.

Author: FisherBernard, JeongJong-Hyeon, BryantJohn, AndersonStewart, DignamJames, FisherEdwin R, WolmarkNorman,

Breast cancer treatment

The study presented long-term findings from the National Surgical Adjuvant Breast and Bowel Project B-14 and B-20 trials, showing that tamoxifen benefited women with estrogen-receptor-positive tumors and negative axillary nodes, and that chemotherapy plus tamoxifen was more effective than tamoxifen alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

93.

Neoadjuvant versus adjuvant systemic treatment in breast cancer: a meta-analysis.

Author: MauriDavide, PavlidisNicholas, IoannidisJohn P A

Breast cancer treatment

This study compared the outcomes of patients with breast cancer who received chemotherapy before surgery (neoadjuvant therapy) versus those who received chemotherapy after surgery (adjuvant therapy). The study aimed to determine if receiving chemotherapy before surgery, which has the potential to reduce the extent of surgery needed, had a significant impact on overall treatment outcomes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

95.

Exercise for women receiving adjuvant therapy for breast cancer.

Author: MarkesM, BrockowT, ReschK L

Improved breast cancer treatment
Breast cancer

A large database of research on breast cancer treatment shows improvements in outcomes like recurrence and death rates. However, these treatments, which include hormone therapy, chemotherapy, and radiation therapy, can significantly affect quality of life due to short-term and long-term side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

96.

Polychemotherapy for early breast cancer: results from the international adjuvant breast cancer chemotherapy randomized trial.

Author:

Breast cancer survival improvement

Chemoendocrine therapy, consisting of chemotherapy and tamoxifen, was found to provide modest but sustained benefits for women with early-stage breast cancer. This randomized phase III trial involving 1991 patients demonstrated that chemoendocrine therapy improved relapse-free survival and overall survival compared to tamoxifen alone, particularly in younger women and premenopausal women not receiving ovarian ablation or suppression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

97.

Ovarian ablation or suppression in premenopausal early breast cancer: results from the international adjuvant breast cancer ovarian ablation or suppression randomized trial.

Author:

Improved early-stage breast cancer treatment
Early-stage breast cancer

Women with early-stage breast cancer who receive treatment with tamoxifen, ovarian suppression, or chemotherapy have improved survival rates. This study, known as the Adjuvant Breast Cancer (ABC) Trials, was conducted to see if combining these treatments offered additional benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

98.

Preoperative chemotherapy for women with operable breast cancer.

Author: MieogJ S D, van der HageJ A, van de VeldeC J H

Improved breast cancer treatment
Locally advanced breast cancer

Currently, chemotherapy is given before surgery for advanced breast cancer to shrink the tumor and make surgery possible. Studies have investigated whether chemotherapy before surgery is also beneficial for early-stage breast cancer. Potential advantages include starting systemic treatment early, understanding how the tumor responds to chemotherapy, shrinking the tumor, and possibly reducing the complexity of surgery. However, concerns exist about whether chemotherapy before surgery might affect local control and whether delaying surgery could be harmful in patients whose tumors don't respond to chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

100.

Taxanes for adjuvant treatment of early breast cancer.

Author: FergusonT, WilckenN, VaggR, GhersiD, NowakA K

Improved disease-free survival
Improved survival

This meta-analysis supports the use of taxane containing adjuvant chemotherapy regimens for women with operable early breast cancer, as they improve overall survival and disease-free survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

102.

[Neoadjuvant treatment for locally advanced breast cancer. Comparison of two schemes based on docetaxel-epirubicin vs. 5-fluorouracil-epirubicin-cyclophosphamide].

Author: Cortés-FloresAna Olivia, Morgan-VillelaGilberto, Castro-CervantesJuan Manuel, Vázquez-CamachoGonzalo, Fuentes-OrozcoClotilde, González-OjedaAlejandro

Improved breast cancer treatment
Breast cancer

Breast cancer is the most common type of cancer in women globally. In Mexico, over 34% of women are diagnosed with advanced breast cancer. Chemotherapy given before surgery (neoadjuvant chemotherapy) is used to control the cancer, make surgery possible, and increase the chance of preserving breast tissue.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

103.

Randomized phase 3 trial of fluorouracil, epirubicin, and cyclophosphamide alone or followed by Paclitaxel for early breast cancer.

Author: MartínMiguel, Rodríguez-LescureAlvaro, RuizAmparo, AlbaEmilio, CalvoLourdes, Ruiz-BorregoManuel, MunárrizBlanca, RodríguezCésar A, CrespoCarmen, de AlavaEnrique, López García-AsenjoJosé Antonio, GuitiánMaría Dolores, AlmenarSergio, González-PalaciosJesús Fernando, VeraFrancisco, PalaciosJosé, RamosManuel, Gracia MarcoJose Manuel, LluchAna, AlvarezIsabel, SeguíMiguel Angel, MayordomoJosé Ignacio, AntónAntonio, BaenaJosé Manuel, PlazaolaArrate, ModolellAlfonso, PelegríAmadeu, MelJose Ramón, ArandaEnrique, AdroverEncarna, AlvarezJosé Valero, García PucheJosé Luis, Sánchez-RoviraPedro, GonzalezSonia, López-VegaJosé Manuel,

Reduced risk of death
Reduced risk of relapse

A study of 1246 women with breast cancer found that adding paclitaxel to standard chemotherapy significantly reduced the risk of the cancer returning.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

104.

Fraction size in radiation treatment for breast conservation in early breast cancer.

Author: JamesMelissa L, LehmanMargot, HiderPhil N, JefferyMark, FrancisDaniel P, HickeyBrigid E

Improved access to radiation therapy

This study explores the potential of shortening radiation therapy for women with early breast cancer who are having breast conservation surgery. The study acknowledges that shorter treatment could improve patient experience and potentially increase access to care, but emphasizes the need to ensure that shorter treatment is equally effective and safe as traditional radiation therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

105.

Progress on BIG 1-02/IBCSG 27-02/NSABP B-37, a prospective randomized trial evaluating chemotherapy after local therapy for isolated locoregional recurrences of breast cancer.

Author: WapnirIrene L, AebiStefan, GelberShari, AndersonStewart J, LángIstván, RobidouxAndré, MamounasEleftherios P, WolmarkNorman

Improved breast cancer treatment
Breast cancer

Whether chemotherapy is beneficial for women whose early breast cancer has returned locally or regionally after initial treatment is uncertain. An international study is underway to determine the effectiveness of chemotherapy in these women, either alone or in combination with hormone therapy and trastuzumab.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

106.

Lapatinib for treatment of advanced or metastasized breast cancer: systematic review.

Author: RieraRachel, SoárezPatrícia Coelho de, PugaMaria Eduarda Dos Santos, FerrazMarcos Bosi

Lapatinib reduces progression

Lapatinib combined with capecitabine was more effective than capecitabine alone in reducing the risk of cancer progression in patients with advanced or metastasized breast cancer, without increasing severe adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

107.

Fraction size in radiation treatment for breast conservation in early breast cancer.

Author: JamesMelissa L, LehmanMargot, HiderPhil N, JefferyMark, HickeyBrigid E, FrancisDaniel P

Breast cancer treatment

This updated Cochrane Review explores the potential benefits of shortening the duration of radiation therapy for women with early breast cancer treated with breast-conserving surgery. The review aims to determine if shorter treatment is as effective and safe as conventional radiation therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

108.

The economic burden of metastatic breast cancer: a systematic review of literature from developed countries.

Author: FosterTalia S, MillerJeffrey D, BoyeMark E, BliedenMarissa B, GidwaniRisha, RussellMason W

Extended survival
High cost

This study investigates the economic impact of metastatic breast cancer (MBC) and its treatment, highlighting the need for careful consideration of the cost-effectiveness of new therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

109.

Timing of breast surgery in premenopausal breast cancer patients.

Author: SamuelMiny, WaiKhin Lay, BrennanVictoria K, YongWei Sean

Breast cancer treatment

Many women with breast cancer receive a combination of surgery, radiation, and/or chemotherapy. Researchers have studied the potential connection between the timing of tumor removal and the menstrual cycle, but the influence of this timing on survival remains uncertain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

111.

Update on adjuvant hormonal treatment of early breast cancer.

Author: Lao RomeraJ, Puertolas HernándezT J, Peláez FernándezI, Sampedro GimenoT, Fernández MartínezR, Fernández PérezI, Iranzo González CruzV, Illarramendi MañasJ J, Garcerá JuanS, Ciruelos GilE M

Improved breast cancer survival

Studies have shown that 5 years of tamoxifen treatment after surgery for early-stage breast cancer in postmenopausal women improves survival. Newer drugs called aromatase inhibitors (AIs) have also been studied, either alone or in combination with tamoxifen. While the best approach is still being determined, AIs have generally shown better outcomes in terms of preventing recurrence, especially in high-risk patients. AIs have also been well-tolerated in the long term, but more research is needed to understand their long-term impact on overall survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

112.

Twenty-five year results of the national cancer institute randomized breast conservation trial.

Author: SimoneNicole L, DanTu, ShihJoanna, SmithSharon L, SciutoLinda, LitaElena, LippmanMarc E, GlatsteinEli, SwainSandra M, DanforthDavid N, CamphausenKevin

Improved breast cancer treatment
Increased IBTR risk

This study reports on the 25-year outcomes of a randomized clinical trial comparing breast conservation therapy (BCT) with mastectomy (MRM) for early-stage breast cancer. The study found that long-term survival was similar between the two treatments, but BCT patients had a higher rate of isolated ipsilateral breast tumor recurrences (IBTRs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

113.

Lapatinib and trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone receptor-positive breast cancer which over-expresses human epidermal growth factor 2 (HER2): a systematic review and economic analysis.

Author: FleemanN, BagustA, BolandA, DicksonR, DundarY, MoonanM, OyeeJ, BlundellM, DavisH, ArmstrongA, ThorpN

Improved breast cancer management

This study discusses metastatic breast cancer (mBC), an advanced stage of breast cancer where the disease has spread beyond the original organ. It highlights the importance of considering hormone receptor status and human epidermal growth factor 2 (HER2) status in predicting prognosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

114.

Tamoxifen versus tamoxifen plus doxorubicin and cyclophosphamide as adjuvant therapy for node-positive postmenopausal breast cancer: results of a Japan Clinical Oncology Group Study (JCOG9401).

Author: ShienTadahiko, IwataHiroji, AogiKenjiro, FukutomiTakashi, InoueKenichi, KinoshitaTakayuki, TakahashiMasato, MatsuiAkira, ShibataTaro, FukudaHaruhiko

breast cancer survival
decreased WBC count
nausea

This randomized trial found that adding doxorubicin (A) and cyclophosphamide (C) to tamoxifen (TAM) (ACT) was not highly effective for estrogen receptor positive (ER+), node-positive postmenopausal breast cancer (PMBC). However, adjuvant ACT therapy was considered to be effective for ER-, node-positive PMBC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

115.

Partial breast irradiation for early breast cancer.

Author: LehmanMargot, HickeyBrigid E, FrancisDaniel P, SeeAdrienne M

Partial breast irradiation
Breast cancer

This Cochrane Review investigates the effectiveness of partial breast irradiation (PBI), including accelerated partial breast irradiation (APBI), for breast cancer. The review examines the role of PBI in reducing the risk of local tumor recurrence, compared to whole breast radiation therapy (RT), and explores the potential benefits and risks of this approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

116.

Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial.

Author: BadweRajendra, HawaldarRohini, NairNita, KaushikRucha, ParmarVani, SiddiqueShabina, BudrukkarAshwini, MittraIndraneel, GuptaSudeep

Locoregional treatment for metastatic breast cancer

This study examines the role of locoregional treatment in women with metastatic breast cancer at first presentation. The study explores the potential benefits and risks of locoregional treatment in this context, contrasting its effects with no treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

117.

Randomized phase 2 neoadjuvant trial evaluating anastrozole and fulvestrant efficacy for postmenopausal, estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer patients: Results of the UNICANCER CARMINA 02 French trial (UCBG 0609).

Author: LereboursFlorence, RiveraSofia, Mouret-ReynierMarie-Ange, AlranSeverine, Venat-BouvetLaurence, KerbratPierre, SalmonRemy, BecetteVeronique, BourgierCéline, CherelPascal, BoussionVéronique, BalleyguierCorinne, ThibaultFabienne, Lavau-DenesSandrine, NabholzJean-Marc, SigalBrigitte, TrassardMartine, MathieuMarie-Christine, MartinAnne-Laure, LemonnierJerome, Mouret-FourmeEmmanuelle

Breast cancer treatment

New treatments for breast cancer in the early 2000s have led to the consideration of using hormone therapy as a pre-surgical treatment for younger women with hormone receptor (HR)-positive breast cancer who are not candidates for breast-conserving surgery. This approach is being explored for women who are too frail for chemotherapy before surgery.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

118.

Zoledronate for patients with invasive residual disease after anthracyclines-taxane-based chemotherapy for early breast cancer - The Phase III NeoAdjuvant Trial Add-oN (NaTaN) study (GBG 36/ABCSG 29).

Author: von MinckwitzG, RezaiM, TeschH, HuoberJ, GerberB, ZahmD M, HilfrichJ, CostaS D, DubskyP, BlohmerJ U, DenkertC, HanuschC, JackischC, KümmelS, FaschingP A, SchneeweissA, PaepkeS, UntchM, BurchardiN, MehtaK, LoiblS,

Zoledronate did not improve disease-free survival or overall survival in patients with invasive residual disease after neoadjuvant chemotherapy for early breast cancer.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

119.

Fraction size in radiation therapy for breast conservation in early breast cancer.

Author: HickeyBrigid E, JamesMelissa L, LehmanMargot, HiderPhil N, JefferyMark, FrancisDaniel P, SeeAdrienne M

Breast cancer treatment

This review updates research on shortening radiation therapy for women with early breast cancer who have had breast-conserving surgery. Shorter treatment could benefit patients and improve access to treatment, but only if it's as effective and safe as standard radiation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

120.

No breast cancer subgroup can be spared postoperative radiotherapy after breast-conserving surgery. Fifteen-year results from the Swedish Breast Cancer Group randomised trial, SweBCG 91 RT.

Author: KillanderF, KarlssonP, AndersonH, MattssonJ, HolmbergE, LundstedtD, HolmbergL, MalmströmP

Improved recurrence-free survival
Reduced IBTR
Increased breast cancer mortality

Radiotherapy (RT) after breast-conserving surgery (BCS) significantly reduced the incidence of ipsilateral breast tumor recurrence (IBTR) at 15 years of follow-up. However, RT did not significantly reduce breast cancer mortality. The study involved 1,187 women with primary T1-2N0M0 breast cancer who were randomized to receive either postoperative whole breast RT or no local treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

121.

Interventions for raising breast cancer awareness in women.

Author: O'MahonyMáirín, ComberHarry, FitzgeraldTony, CorriganMark A, FitzgeraldEileen, GrunfeldElizabeth A, FlynnMaura G, HegartyJosephine

Better outcomes

This study emphasizes the importance of breast cancer awareness for early detection and diagnosis. The study stresses the role of women in recognizing potential breast cancer symptoms and seeking timely medical attention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

122.

Neoadjuvant trastuzumab, pertuzumab, and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer (KRISTINE): a randomised, open-label, multicentre, phase 3 trial.

Author: HurvitzSara A, MartinMiguel, SymmansW Fraser, JungKyung Hae, HuangChiun-Sheng, ThompsonAlastair M, HarbeckNadia, ValeroVicente, StroyakovskiyDaniil, WildiersHans, CamponeMario, BoileauJean-François, BeckmannMatthias W, AfenjarKaren, FrescoRodrigo, HelmsHans-Joachim, XuJin, LinYvonne G, SparanoJoseph, SlamonDennis

HER2-targeted treatment
HER2-positive breast cancer

This phase 3 trial assessed a neoadjuvant regimen for HER2-positive breast cancer that replaces traditional chemotherapy with targeted treatment, aiming to improve outcomes in patients at risk of relapse or death.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

123.

Breast-conserving surgery following neoadjuvant therapy-a systematic review on surgical outcomes.

Author: VoldersJosé H, NegenbornVera L, SpronkPauline E, KrekelNicole M A, SchoonmadeLinda J, MeijerSybren, RubioIsabel T, van den TolM Petrousjka

Improved breast cancer treatment

This study assessed surgical outcomes for patients receiving breast-conserving therapy (BCT) after neoadjuvant chemotherapy (NACT) for breast cancer, evaluating margin status, secondary surgeries, excision volumes, and cosmetic outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

124.

Endocrine Treatment with 2 Years of Tamoxifen versus 2 Years of Exemestane in Postmenopausal Patients with High-Risk Early Breast Cancer and Persisting Circulating Tumor Cells - First Results of the SUCCESS C Endocrine Treatment Sub-Study.

Author: SchochterFabienne, RackBrigitte, TzschaschelMarie, PolasikArkadius, AndergassenUlrich, TrappElisabeth, Alunni-FabbroniMarianna, SchneeweissAndreas, MüllerVolkmar, PantelKlaus, GadeJörg, LorenzRalf, RezaiMahdi, TeschHans, SoelingUlrike, FehmTanja, MahnerSven, SchindlbeckChristian, LichteneggerWerner, BeckmannMatthias W, FaschingPeter A, JanniWolfgang, FriedlThomas W P,

CTC clearance
Good tolerability

Similar circulating tumor cell (CTC) clearance rates were observed after 2 years of endocrine therapy with exemestane or tamoxifen in postmenopausal women with hormone receptor-positive breast cancer.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

126.

Target therapy for metastatic breast cancer.

Author: RachdiHaifa, MokraniAmina, BattiRim, AyadiMouna, ChraietNesrine, MezliniAmel

Breast cancer treatment
Targeted therapies

Breast cancer is the most common cancer in women globally, and a significant percentage of women are diagnosed with metastatic breast cancer. While new therapies have greatly improved survival and quality of life for patients with metastatic breast cancer, understanding the specific genes and proteins involved in the disease has led to more tailored treatments. This review examines the different targeted therapies used to treat metastatic breast cancer and how they work.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

127.

Women's stories of living with breast cancer: A systematic review and meta-synthesis of qualitative evidence.

Author: SmitAnri, CoetzeeBronwynè Jo'sean, RoomaneyRizwana, BradshawMelissa, SwartzLeslie

breast cancer narrative understanding
none

This systematic review of 180 qualitative studies synthesized women's breast cancer narratives into an explanatory framework called the Trajectory of Breast Cancer (TBC). The TBC framework identifies eight core themes: the burden of breast cancer, existential ordeal, illness appraisal, sources of support, healthcare system interaction, relationships, self-image changes, and survivor identity. This framework provides a comprehensive understanding of women's experiences with breast cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

128.

Surgical interventions for the prevention or treatment of lymphoedema after breast cancer treatment.

Author: MarkkulaSilja P, LeungNelson, AllenVictoria B, FurnissDominic

Improved lymphoedema treatment

Surgical interventions for the prevention and management of lymphoedema affecting the arm after breast cancer treatment are investigated due to uncertainty surrounding their effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

129.

Taxanes for adjuvant treatment of early breast cancer.

Author: WillsonMelina L, BurkeLucinda, FergusonThomas, GhersiDavina, NowakAnna K, WilckenNicholas

Improved breast cancer treatment

This review examined the role of taxanes in treating early breast cancer, updating a previous Cochrane Review, considering the effectiveness of these chemotherapy agents in improving survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

130.

Postmastectomy radiotherapy in T1-2 patients with one to three positive lymph nodes - Past, present and future.

Author: KaššákFilip, RossierChristine, PicardiCristina, BernierJacques

Improved breast cancer treatment

The role of post-mastectomy radiotherapy (PMRT) for patients with small tumors and positive lymph nodes after axillary dissection is debated. This review discusses existing evidence and ongoing research, including the SUPREMO trial, which may provide more definitive guidance on PMRT indication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

131.

Survival Rate of Breast Cancer in Eastern Mediterranean Region Countries: A Systematic Review and Meta-Analysis.

Author: HassanipourSoheil, MaghsoudiAhmad, RezaeianShahab, Arab-ZozaniMorteza, MokhtariAli Mohammad, AbdzadehElham, RiahiShirin, MohseniShokrollah, SalehiniyaHamid

Better prediction of outcomes
Improved survival

This study found that survival rates of breast cancer in the Eastern Mediterranean region are lower than in more developed countries. The estimated survival rates for different periods were: 1 year, 93.9%; 2 years, 85%; 3 years, 79.8%; 4 years, 72.6%; 5 years, 69.2%; 10 years, 55.5%. Higher survival rates were associated with a higher human development index.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

132.

The sequelae of mastectomy and quadrantectomy with respect to the reaching movement in breast cancer survivors: evidence for an integrated rehabilitation protocol during oncological care.

Author: PaolucciTeresa, BernettiAndrea, BaiArianna V, SegatoriLucia, MontiMassimo, MaggiGiuseppe, IppolitoniGiovanni, TinelliLaura, SantilliValter, PaoloniMarco, AgostiniFrancesco, MangoneMassimiliano

BC rehabilitation

Breast cancer (BC) is the most common cancer in women in developed countries. Surgery, such as mastectomy or removing a section of the breast, is often used, sometimes followed by radiation. Rehabilitation programs can help women who have had breast cancer regain and maintain their physical, social, mental, and work abilities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

133.

Effect of Capecitabine Maintenance Therapy Using Lower Dosage and Higher Frequency vs Observation on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer Who Had Received Standard Treatment: The SYSUCC-001 Randomized Clinical Trial.

Author: WangXi, WangShu-Sen, HuangHeng, CaiLi, ZhaoLi, PengRou-Jun, LinYing, TangJun, ZengJian, ZhangLe-Hong, KeYong-Li, WangXian-Ming, LiuXin-Mei, ChenQian-Jun, ZhangAn-Qin, XuFei, BiXi-Wen, HuangJia-Jia, LiJi-Bin, PangDan-Mei, XueCong, ShiYan-Xia, HeZhen-Yu, LinHuan-Xin, AnXin, XiaWen, CaoYe, GuoYing, SuYan-Hong, HuaXin, WangXin-Yue, HongRuo-Xi, JiangKui-Kui, SongChen-Ge, HuangZhang-Zan, ShiWei, ZhongYong-Yi, YuanZhong-Yu,

Improved disease-free survival
Hand-foot syndrome

This randomized clinical trial of 443 women with early-stage triple-negative breast cancer evaluated the efficacy of low-dose capecitabine maintenance therapy for 1 year after standard adjuvant chemotherapy. Capecitabine maintenance significantly improved 5-year disease-free survival compared to observation. The most common capecitabine-related adverse event was hand-foot syndrome.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

134.

The Global Landscape of Treatment Standards for Breast Cancer.

Author: TrapaniDario, DouillardJean Yves, WinerEric P, BursteinHarold, CareyLisa Anne, CortesJavier, LopesGilberto, GralowJulie R, GradisharWilliam J, MagriniNicola, CuriglianoGiuseppe, IlbawiAndrè M

BC treatment

Breast cancer (BC) is a major health problem for women globally, leading to illness, death, and disability. Treatment outcomes vary widely, with access to care being a significant factor. Establishing standard treatment guidelines is essential for improving quality of care and increasing survival rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

135.

Benefit of adjuvant chemotherapy in patients with special histology subtypes of triple-negative breast cancer: a systematic review.

Author: TrapaniD, GiuglianoF, UlianoJ, ZiaV A A, MarraA, VialeG, FerraroE, EspositoA, CriscitielloC, D'amicoP, CuriglianoG

Adjuvant therapy for TNBC

This review examines the evidence for adjuvant treatments for triple-negative breast cancer (TNBC), a subtype traditionally associated with poorer prognosis. TNBC special histology subtypes exhibit unique clinical and molecular characteristics and varying responses to antineoplastic treatments. However, no consensus exists on the optimal adjuvant therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

136.

Outcomes after breast-conserving surgery or mastectomy in patients with triple-negative breast cancer: meta-analysis.

Author: FancelluA, HoussamiN, SannaV, PorcuA, NinniriC, MarinovichM L

Breast conservation
Improved survival
Distant metastasis
Locoregional recurrence

This meta-analysis of 14 studies involving 19,819 patients with triple-negative breast cancer found that breast-conserving surgery (BCS) was not associated with a worse prognosis compared to mastectomy. While BCS showed a statistically significant lower odds of locoregional recurrence (0.64) and a lower odds of distant metastasis (0.70), the difference in DM diminished with increasing age and follow-up time. Overall, BCS was associated with a significantly lower hazard for all-cause mortality (0.78).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

137.

Incidental axillary dose delivery to axillary lymph node levels I-III by different techniques of whole-breast irradiation: a systematic literature review.

Author: SchmittMartin, PinYvan, PflumioCarole, MathelinCarole, PivotXavier, NoelGeorges

Breast irradiation for axillary recurrence

This study investigates whether including levels I, II, and III in breast irradiation during breast cancer treatment can reduce the risk of axillary recurrence. Axillary recurrence is a concern in patients with invasive breast carcinoma, and the potential benefits of extended irradiation on this specific area are being debated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

138.

BRE12-158: A Postneoadjuvant, Randomized Phase II Trial of Personalized Therapy Versus Treatment of Physician's Choice for Patients With Residual Triple-Negative Breast Cancer.

Author: SchneiderBryan P, JiangGuanglong, BallingerTarah J, ShenFei, ChitambarChristopher, NandaRita, FalksonCarla, LynceFilipa C, GallagherChristopher, IsaacsClaudine, BlayaMarcelo, PaplomataElisavet, WallingRadhika, DailyKaren, MahtaniReshma, ThompsonMichael A, GrahamRobert, CooperMaureen E, PavlickDean C, AlbackerLee A, GreggJeffrey, SolzakJeffrey P, ChenYu-Hsiang, BalesCasey L, CantorErica, HancockBradley A, KassemNawal, HelftPaul, O'NeilBert, StornioloAnna Maria V, BadveSunil, MillerKathy D, RadovichMilan

Genomically directed therapy for TNBC

This phase II, multicenter trial (BRE12-158) compared genomically directed therapy with treatment of physician choice (TPC) in patients with triple-negative breast cancer (TNBC) who had residual disease after neoadjuvant chemotherapy (NAC). Patients with TNBC and residual disease after NAC are at high risk for recurrence.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

139.

Lympho-vascular invasion impacts the prognosis in breast-conserving surgery: a systematic review and meta-analysis.

Author: ZhongYi-Ming, TongFei, ShenJun

BCS for early-stage BC
Controversial prognostic value of LVI

The number of breast cancer cases, particularly early-stage cancers, is increasing due to more widespread screening. While breast-conserving surgery (BCS) is the standard treatment for early breast cancer, the impact of lympho-vascular invasion (LVI), where cancer cells spread into nearby blood vessels and lymph vessels, on outcomes after BCS is unclear. This study investigates the significance of LVI in the prognosis of breast cancer patients who have undergone BCS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

140.

Neoadjuvant and adjuvant treatment of patients with HER2-positive early breast cancer.

Author: HarbeckNadia

HER2-targeted therapy for HER2+ EBC

This review discusses the current landscape of treatment for HER2-positive (HER2+) early breast cancer (EBC), highlighting advancements in neoadjuvant and adjuvant therapies. The availability of HER2-targeted therapies has significantly improved outcomes, leading to personalized treatment approaches based on pathological complete response (pCR) status.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

142.

Effectiveness of Scapular Strengthening Exercises on Shoulder Dysfunction for Pain and Functional Disability after Modified Radical Mastectomy: A Controlled Clinical Trial.

Author: MohitePrajwalraje Pramod, KanaseSuraj Bhimrao

Breast cancer treatment
Restricted shoulder mobility
Shoulder pain

This study discussed the evolution of breast cancer management towards conservation surgery, considering the potential side effects of modified radical mastectomy.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

143.

Aggressive local therapy for <i>de&#160;novo</i> metastatic breast cancer: Challenges and updates (Review).

Author: LiuBailong, LiuHui, LiuMin

dnMBC treatment

This review examines the role of local therapy for the primary tumor (PT) in patients with *de novo* metastatic breast cancer (dnMBC). While systemic therapy is the mainstay for dnMBC, the benefits of PT treatment are debated.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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