A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car.

Author: HindmarchIan, JohnsonSigurd, MeadowsRobert, RidoutFran, ShamsiZiba

Paper Details 
Original Abstract of the Article :
Antihistamines (H(1)-receptor antagonists) are the mainstay of symptomatic therapy for allergic disorders. Antihistamines are needed that cause no disruptive effects on cognitive and psychomotor function. It is essential that antihistamines maintain the integrity of the cognitive system, not only in...See full text at original site
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引用元:
https://doi.org/10.1016/s0149-2918(03)80137-6

データ提供:米国国立医学図書館(NLM)

Fexofenadine Hydrochloride: Impact on Cognitive and Psychomotor Function

Antihistamines are commonly used for allergy relief, but their effects on cognitive and psychomotor function can be a concern, particularly for individuals engaging in tasks requiring alertness and quick reactions, such as driving. This study investigates the impact of fexofenadine hydrochloride on cognitive and psychomotor function, including driving-related tasks. The researchers conducted a randomized, double-blind, placebo-controlled, crossover study involving participants who received either fexofenadine hydrochloride 180 mg alone or with a 'social' dose of alcohol. The results showed that fexofenadine hydrochloride, even in combination with alcohol, had minimal effects on cognitive and psychomotor function related to driving. This suggests that fexofenadine hydrochloride may be a safer option for allergy management in individuals who need to remain alert and perform tasks requiring cognitive function.

A Safer Option for Allergy Relief: Fexofenadine Hydrochloride's Effects on Driving-Related Functions

This study provides reassuring evidence for the safety of fexofenadine hydrochloride in terms of its impact on cognitive and psychomotor function, particularly in relation to driving. The findings suggest that fexofenadine hydrochloride, even when combined with a 'social' dose of alcohol, does not significantly impair driving-related skills. This information is valuable for individuals who rely on antihistamines for allergy relief and need to maintain alertness and cognitive function for activities like driving.

Staying Safe and Alert: Navigating the Use of Antihistamines

This study highlights the importance of understanding the effects of medications on cognitive and psychomotor function, especially for individuals who engage in activities that require alertness and quick reactions. The study's findings provide valuable insights into the safety of fexofenadine hydrochloride in relation to driving, offering reassurance for those who use this medication for allergy relief.

Dr.Camel's Conclusion

This study offers valuable insights into the impact of fexofenadine hydrochloride on cognitive and psychomotor function, particularly in relation to driving. The findings suggest that fexofenadine hydrochloride may be a safer option for allergy relief in individuals who need to remain alert and perform tasks requiring cognitive function. This research underscores the importance of understanding the potential effects of medications on cognitive function and making informed choices about medication use based on individual needs and activities.

Date :
  1. Date Completed 2003-09-09
  2. Date Revised 2019-09-22
Further Info :

Pubmed ID

12867226

DOI: Digital Object Identifier

10.1016/s0149-2918(03)80137-6

Related Literature

SNS
PICO Info
in preparation
Languages

English

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