Effects of hydroxyzine: A Synthesis of Findings from 21 Studies

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Original Abstract of the Article

Major research findings

Hydroxyzine, a medication commonly used for anxiety and allergic reactions, has shown a range of effects across various studies. 3 suggests that it may be beneficial in reducing anxiety in mice. Furthermore, 18 indicates that hydroxyzine could be beneficial in treating anxiety when combined with antidepressants. 10 highlights the potential for hydroxyzine to improve tolerance to face masks during anesthetic induction in children. 15 reports that hydroxyzine can effectively minimize movement during brain blood flow mapping. However, 5 indicates that hydroxyzine may have an impact on electrical activity in the heart, while suggests potential effects on the central nervous system.

Benefits and Risks

Benefit Summary

Hydroxyzine has shown potential benefits in treating anxiety and allergic reactions, as well as in improving mask tolerance during anesthesia and reducing movement during brain scans. 3 , 18 , 10 , 15

Risk Summary

Hydroxyzine might have negative impacts on heart function and the central nervous system. 5 , Therefore, careful monitoring and following your doctor's instructions are crucial when taking this medication.

Comparison between studies

Commonalities between studies

Many studies have shown the potential of hydroxyzine to be effective in treating anxiety and allergic reactions. Some studies also suggest its benefits in reducing anxiety during anesthesia and minimizing movement during medical procedures.

Differences between studies

Research findings concerning hydroxyzine's side effects vary. There is a need for further research to clarify the potential effects on the heart and central nervous system.

Consistency and Contradictions in the Results

While hydroxyzine demonstrates the potential for treating anxiety and allergic reactions, research findings regarding its effects on the heart and central nervous system are inconsistent. More research is required for a comprehensive understanding of hydroxyzine's safety.

Cautionary Notes on Real-World Applications

Hydroxyzine offers potential benefits for anxiety and allergic reaction management; however, its use involves potential side effects. Consult your physician for guidance and adhere to their instructions. Individuals with pre-existing heart or neurological conditions should seek medical consultation before taking hydroxyzine.

Limitations of current research

Many studies on hydroxyzine are relatively small, requiring larger-scale research for a more comprehensive understanding. The long-term effects of hydroxyzine remain unclear. Regular consultations with your doctor are essential for those taking it long-term.

Future research directions

Further research is crucial to investigate hydroxyzine's side effects, particularly its impacts on the heart and central nervous system. Long-term effects need additional study. Research on optimal dosage methods and combinations with other medications is essential to maximize efficacy and minimize risk.

Conclusion

Hydroxyzine shows promise in treating anxiety and allergic reactions, but further research is essential to clarify its effects on the heart and central nervous system. Always follow your doctor's instructions when taking hydroxyzine.

Literature analysis of 21 papers
Positive Content
17
Neutral Content
1
Negative Content
3
Article Type
14
0
0
0
21
4.

Psychomotor and subjective effects of bilastine, hydroxyzine, and cetirizine, in combination with alcohol: a randomized, double-blind, crossover, and positive-controlled and placebo-controlled Phase I clinical trials.

Author: García-GeaConsuelo, MartínezJoan, BallesterMaria Rosa, GichIgnasi, ValienteRomán, AntonijoanRosa Maria

CNS safety

Bilastine (at therapeutic dose) combined with alcohol did not produce greater central nervous system depressant effects than alcohol alone.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration.

Author: LeeByung Hoon, LeeSeung Ho, ChuDaehyun, HyunJin Won, ChoeHan, ChoiBok Hee, JoSu-Hyun

Hydroxyzine proarrhythmic

Hydroxyzine blocked hERG channels and prolonged action potential duration in a concentration- and time-dependent manner. This suggests that hydroxyzine may have proarrhythmic effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.

Author: KönerOzge, TüreHatice, MercanArzu, MendaFerdi, SözübirSelami

Emergence agitation reduction
Premedication quality improvement

Combining hydroxyzine and midazolam premedication was more effective than midazolam alone in reducing sevoflurane-induced emergence agitation in children undergoing infraumbilical surgery with a caudal block. This combination also provided better premedication quality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Short-term effects of morning versus evening dose of hydroxyzine 50 mg on cognition in healthy volunteers.

Author: ConenSilke, TheunissenEef L, VermeerenAnnemiek, RamaekersJohannes G

Cognitive impairment

This study investigated the cognitive effects of hydroxyzine, a first-generation antihistamine, in the evening and morning. Hydroxyzine impaired performance on cognitive tasks in both scenarios, but the impairment was generally larger after morning doses. The results suggest that hydroxyzine-induced impairment is more prominent after morning doses compared to evening doses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Acute and subchronic effects of bilastine (20 and 40 mg) and hydroxyzine (50 mg) on actual driving performance in healthy volunteers.

Author: ConenSilke, TheunissenEef L, Van OersAnita C M, ValienteRomán, RamaekersJohannes G

Safe driving
Hydroxyzine driving impairment

This study assessed the effects of two doses of bilastine (20 and 40 mg) on actual driving after single and repeated administration. Hydroxyzine 50 mg was included as an active control. Bilastine did not produce any driving impairment after single and repeated doses and can be safely used in traffic in doses up to 40 mg.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Effects of dexamethasone and hydroxyzine treatment on intradermal testing and allergen-specific IgE serum testing results in horses.

Author: PetersenAnnette, SchottHarold C

This study investigated the effects of dexamethasone and hydroxyzine on intradermal testing (IDT) and allergen-specific IgE serum testing (ASIST) results in horses. Both medications decreased IDT wheal diameters, suggesting a need for withdrawal times of 14 days for dexamethasone and 7 days for hydroxyzine before IDT.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

[Effects of hydroxyzine on tolerance of facial mask during induction in children].

Author: TrifaM, KhalifaS Ben, GargouriF, KaouechN, FriaaM

Improved mask acceptance

Hydroxyzine premedication significantly improved the acceptance of facial masks during induction of general anesthesia in children. Children receiving hydroxyzine showed better tolerance of the facial mask compared to those receiving placebo.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

11.

Comparison of peripheral and central effects of single and repeated oral dose administrations of bilastine, a new H1 antihistamine: a dose-range study in healthy volunteers with hydroxyzine and placebo as control treatments.

Author: García-GeaConsuelo, Martínez-ColomerJoan, AntonijoanRosa M, ValienteRomán, BarbanojManuel-José

Dissociation of peripheral and CNS effects
No tolerance or sensitization
Peripheral anti-H1 effects
CNS impairment
Sedation

This crossover study assessed the peripheral anti-H1 and central nervous system (CNS) effects of bilastine (BIL) in 20 healthy volunteers. BIL demonstrated significant and sustained peripheral anti-H1 activity with minimal CNS effects at the therapeutic dose of 20 mg. Higher doses (40 mg and 80 mg) produced subjective sedation and objective CNS side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effects of fexofenadine and hydroxyzine on brake reaction time during car-driving with cellular phone use.

Author: TashiroManabu, HorikawaEtsuo, MochizukiHideki, SakuradaYumiko, KatoMotohisa, InokuchiTakatoshi, RidoutFran, HindmarchIan, YanaiKazuhiko

Improved driving performance
Reduced sedation
Impaired driving
Sedation

This study examined the effects of fexofenadine and hydroxyzine, antihistamines, on driving performance with and without cellular phone usage. The study found that fexofenadine did not impair CNS function, even when driving while using a cell phone. Hydroxyzine, however, significantly increased sedation and slowed brake reaction time, suggesting impaired driving performance, particularly when combined with cell phone use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car.

Author: RidoutFran, ShamsiZiba, MeadowsRobert, JohnsonSigurd, HindmarchIan

No cognitive impairment
No psychomotor impairment

This study investigated the effects of fexofenadine hydrochloride on cognitive and psychomotor performance in drivers. The results showed that fexofenadine had no significant effects on cognitive performance or driving ability.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Comparison of the effects of clonidine and hydroxyzine on haemodynamic and catecholamine reactions to microlaryngoscopy.

Author: BoussofaraM, BraccoD, RavussinP

Reduced pressure

Clonidine premedication significantly decreased mean arterial pressure during and after microlaryngoscopy but did not affect heart rate or plasma catecholamine levels compared to hydroxyzine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Effects of premedication with oral hydroxyzine on patient motion during inhalation of 32% xenon for regional cerebral blood flow mapping.

Author: SesayM, TanakaA, DoussetV, CailléJ M, MauretteP

Control motion

Inhalation of 30-35% Xenon is associated with uncontrolled patient motion in 3-15% of the cases, a major setback to regional cerebral blood flow studies with Xenon-enhanced computed tomography (Xe-CT CBF). This study determined the effects of oral premedication with hydroxyzine (H) in the control of motion. Motion was significantly reduced in the H 50 mg group (0.8%) compared to the H 100 mg group (2.5%) and the Placebo group (6.7%).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

The effects of nitrous oxide on pediatric dental patients sedated with chloral hydrate and hydroxyzine.

Author: WilsonS, MatusakA, CasamassimoP S, LarsenP

Behavioral and physiologic parameters

The effect of 50% nitrous oxide (N2O) compared to oxygen (O2) alone on behavioral and physiologic parameters was evaluated in young children receiving chloral hydrate and hydroxyzine for dental procedures.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Effects of premedication on dose requirements for propofol: comparison of clonidine and hydroxyzine.

Author: GuglielminottiJ, DescraquesC, PetitmaireS, AlmenzaL, GrenapinO, MantzJ

Reduced intraoperative propofol requirements

Premedication with clonidine (5 micrograms kg-1) significantly reduced intraoperative propofol requirements compared to hydroxyzine (1 mg kg-1) in patients undergoing elective orthopedic surgery. This reduction in propofol was observed without any adverse effects on recovery or hemodynamic stability.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

[Effects of co-administration of an antidepressant and an anxiolytic drug in the "learned helplessness" paradigm: importance of hydroxyzine].

Author: MartinP, GuillouN, LacroixP, BillardonM

Helpless behavior

This study found that combining benzodiazepines with specific serotonin reuptake inhibitors (SSRIs) should be avoided because it can antagonize the effectiveness of the SSRI. Anxiolytic drugs like hydroxyzine may be a better alternative when coadministered with antidepressants, particularly SSRIs.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

19.

The effects of nitrous oxide on behavior and physiological parameters during conscious sedation with a moderate dose of chloral hydrate and hydroxyzine.

Author: McCannW, WilsonS, LarsenP, StehleB

This study compared the effects of nitrous oxide/oxygen (N2O) and oxygen (O2) alone on physiological and behavioral parameters in children sedated with chloral hydrate and hydroxyzine. While no significant differences were found in any parameter as a function of inhalation agent, N2O resulted in less crying and struggling and more quiet behaviors than O2. This suggests that moderate doses of chloral hydrate and hydroxyzine, combined with N2O, are not associated with significant potentiation effects on physiological parameters compared to the same oral agents with O2 alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

The comparison of the effects of multi and single doses of buspirone, chlordiazepoxide and hydroxyzine on psychomotor function and EEG.

Author: BlomM W, BartelP R, SommersD K, Van der MeydenC H, BeckerP J

No significant differences between single and multiple dose
Impaired saccadic eye movements

Buspirone, chlordiazepoxide, and hydroxyzine, all anxiolytics, were evaluated for their effects on psychomotor function and EEG in healthy volunteers. Hydroxyzine impaired saccadic eye movements after a single dose, while buspirone showed a similar but less significant effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

[Effects of hydroxyzine on attention and memory in elderly subjects].

Author: De BrabanderA, DeberdtW

Preserves attention
Preserves memory
Minimal sedation

Hydroxyzine was found to be better than placebo or lorazepam at preserving memory and attention in elderly volunteers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

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