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Prenatal exposure to ethanol increases ethanol consumption: a conditioned response?

Author: AriasCarlos, ChotroM Gabriela

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that prenatal ethanol exposure in rats increased ethanol consumption in offspring, suggesting a conditioned preference learned in utero. This preference was mediated by the opioid system and could be reduced by administering naloxone to the pregnant dam or to the pups after birth.
Paper Details　
Original Abstract of the Article :
Administration of a moderate dose (2 g/kg) of ethanol to the pregnant rat during the last days of gestation (17-20) has been observed to increase the offspring's ethanol consumption on postnatal day 14. This effect was not observed with a 1-g/kg dose (Experiment 1a). When pups were tested during ado...See full text at original site
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引用元：
https://doi.org/10.1016/s0741-8329(03)00037-5

データ提供：米国国立医学図書館（NLM）

Prenatal Ethanol Exposure and Ethanol Consumption

This study ventures into the fascinating world of prenatal exposure to ethanol and its potential impact on an individual's affinity for alcohol later in life. It’s like exploring the intricate connection between the desert sands and the roots of a desert plant – tracing the influence of early experiences on later behavior.

Early Experiences and Alcohol Consumption

This research provides compelling evidence that prenatal ethanol exposure can significantly influence an individual's ethanol consumption in later life. The study found that rats exposed to ethanol during gestation exhibited increased ethanol intake both during their pre-weanling period and adolescence. It’s a reminder that even seemingly subtle influences during early development can have significant lasting effects.

Understanding the Roots of Alcohol Consumption

The study’s findings suggest that prenatal ethanol exposure may create a conditioned preference for alcohol, potentially mediated by the opioid system. It’s a glimpse into the complex interplay between early experiences, neurobiology, and behavior. Understanding these connections can provide valuable insights into the development of alcohol-related problems.

Dr.Camel's Conclusion

This research sheds light on the complex relationship between prenatal ethanol exposure and later alcohol consumption. The findings underscore the importance of understanding the lasting impact of early experiences on behavior, particularly in relation to substance use. It’s a reminder that we must be mindful of the subtle but significant influences that shape our lives, just as a desert traveler must be aware of the forces that shape the landscape.
Date :
  1. Date Completed 2004-03-16
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

12878271

DOI: Digital Object Identifier

10.1016/s0741-8329(03)00037-5

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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