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Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial.

Author: FeaganBrian G, GalankoJoseph, GreenbergEugene, HanauerStephen B, IsaacsKim L, JohnsonTherese, MartinChristopher, MayerLloyd, PresentDaniel H, SandbornWilliam J, SandlerRobert S, WolfDouglas C

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Oral tacrolimus is effective for fistula improvement, but not fistula remission, in patients with perianal Crohn's disease. Adverse events can be managed by dose reduction.
Paper Details　
Original Abstract of the Article :
BACKGROUND & AIMS: This study determined the effectiveness of tacrolimus for the treatment of Crohn's disease fistulas. METHODS: The study was a randomized, double-blind, placebo-controlled, multicenter clinical trial. Forty-eight patients with Crohn's disease and draining perianal or enterocutaneo...See full text at original site
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引用元：
https://doi.org/10.1016/s0016-5085(03)00877-1

データ提供：米国国立医学図書館（NLM）

Tacrolimus for Crohn's Disease Fistulas: A Randomized, Placebo-Controlled Trial

This study explores the effectiveness of tacrolimus, an immunosuppressant drug, in treating fistulas, a common complication of Crohn's disease. Think of it as a desert healer seeking to heal a wound in the body, carefully evaluating the potential benefits of a new medicine. The researchers conducted a randomized, placebo-controlled trial, finding that tacrolimus was effective in improving fistulas in patients with Crohn's disease. While it did not lead to complete fistula remission, it demonstrated a significant improvement in fistula closure. This research offers a promising new treatment option for individuals with Crohn's disease fistulas.

Tacrolimus: A Potential Solution for Crohn's Disease Fistulas

This study suggests that tacrolimus can be an effective treatment option for improving fistulas in patients with Crohn's disease. The study found that tacrolimus was significantly more effective than placebo in improving fistula closure, highlighting its potential as a valuable therapeutic tool.

Managing Crohn's Disease

Crohn's disease is a chronic inflammatory bowel disease that can significantly impact quality of life. This research emphasizes the importance of early diagnosis and personalized treatment plans, tailored to each individual's needs and goals.

Dr. Camel's Conclusion

This study offers a ray of hope for individuals with Crohn's disease fistulas, demonstrating the potential of tacrolimus as a promising new treatment option. It underscores the ongoing need for research to develop even more effective therapies for managing this complex condition.

Date :
  1. Date Completed 2003-09-25
  2. Date Revised 2019-07-07
Further Info :

Pubmed ID

12891539

DOI: Digital Object Identifier

10.1016/s0016-5085(03)00877-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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