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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.

Author: DasPritam, EriksenJason L, GoldeTodd E, JessingKevin W, KooEdward H, McLendonD C, OzolsVictor V, SagiSarah A, SmithTawnya E, WeggenSascha, ZavitzKenton H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Some NSAIDs have been shown to lower levels of amyloid beta protein (Abeta42), a protein that is thought to be involved in the development of Alzheimer's disease. Flurbiprofen and its enantiomers were particularly effective in lowering Abeta42 levels.
Paper Details　
Original Abstract of the Article :
Epidemiologic studies demonstrate that long-term use of NSAIDs is associated with a reduced risk for the development of Alzheimer disease (AD). In this study, 20 commonly used NSAIDs, dapsone, and enantiomers of flurbiprofen were analyzed for their ability to lower the level of the 42-amino-acid for...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC166298/

データ提供：米国国立医学図書館（NLM）

A Desert Oasis of NSAIDs: Exploring Their Role in Alzheimer's Disease

Alzheimer's disease, a debilitating neurodegenerative disorder, is a complex enigma in the desert of medical research. This study dives deep into the potential therapeutic effects of NSAIDs, a common class of drugs used to alleviate pain and inflammation. The researchers investigated whether NSAIDs could lower the levels of a key protein associated with Alzheimer's, amyloid beta protein (Abeta42).

NSAIDs: A Potential Weapon in the Fight Against Alzheimer's?

The study found that several NSAIDs, including flurbiprofen and its enantiomers, were able to effectively lower Abeta42 levels both in cell cultures and in mice. This discovery offers a glimmer of hope in the desert of Alzheimer's research. However, the researchers emphasize the need for further research and clinical trials to validate these findings and explore the potential of these drugs as therapeutic agents.

A Promising Path Forward

This research suggests that NSAIDs may hold potential for managing Alzheimer's disease, but it's important to note that further studies are needed to confirm their efficacy. Like a thirsty traveler finding a watering hole, we must continue to investigate the therapeutic potential of NSAIDs in the quest for a cure for Alzheimer's disease.

Dr.Camel's Conclusion

This research offers a promising path forward in our search for effective treatments for Alzheimer's disease. The study's findings suggest that NSAIDs may have a role to play in managing this complex disorder, but further investigation is essential to determine their efficacy and safety.
Date :
  1. Date Completed 2003-09-11
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

12897211

DOI: Digital Object Identifier

PMC166298

Related Literature

Article Analysis
・Side Effects of flurbiprofen
SNS
PICO Info
in preparation
Languages

English

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