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Actigraphic measurement of the effects of single-dose haloperidol and olanzapine on spontaneous motor activity in normal subjects.

Author: ChristensenBruce K, DaskalakisZ Jeff, KapurShitij, KiangMichael, RemingtonGary

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Olanzapine decreased total motor activity by increasing the amount of time subjects were immobile, while haloperidol did not have a significant effect.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To quantitatively examine the effects of haloperidol and olanzapine on spontaneous motor activity in normal subjects. DESIGN: Randomized, double-blind, placebo-controlled medication study. PARTICIPANTS: Normal volunteers (n = 30). INTERVENTIONS: Subjects received 1 dose of either halop...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165794/

データ提供：米国国立医学図書館（NLM）

Haloperidol and Olanzapine: Exploring Their Effects on Movement

This study investigates the effects of haloperidol and olanzapine, two antipsychotic medications, on spontaneous motor activity in healthy individuals. The study utilized actigraphy, a non-invasive method for measuring movement.

Quantifying Movement: A Non-Invasive Approach

The researchers aimed to understand how haloperidol and olanzapine affect movement patterns in individuals without mental health conditions. They used actigraphy to track movement over a 24-hour period.

Impact on Motor Activity

The study found that olanzapine significantly reduced total motor activity compared to placebo, primarily by increasing the duration of immobility. Haloperidol had a lesser effect on movement.

Health Implications and Medication Monitoring

This study suggests that olanzapine may have a greater impact on spontaneous motor activity compared to haloperidol, highlighting the need for careful monitoring of movement patterns in patients taking these medications.

Dr.Camel's Conclusion

Imagine a desert sandstorm, where the wind can either sweep you along or keep you grounded. This study investigates how medications can affect movement, showing that olanzapine can act like a strong wind, reducing movement, while haloperidol has a more subtle effect.
Date :
  1. Date Completed 2003-10-14
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

12921224

DOI: Digital Object Identifier

PMC165794

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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