Effects of haloperidol: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Major Research Findings

Haloperidol is a widely used antipsychotic medication that has been shown to be effective in treating the symptoms of schizophrenia, particularly hallucinations and delusions. 23 , 18 , 9 However, haloperidol can also cause side effects such as Parkinsonism, akathisia, and acute dystonia. 23 , 18 , 9 In addition, high doses of haloperidol have been linked to cognitive impairment. 19

Haloperidol is also effective in rapidly controlling severe, disruptive symptoms of acute schizophrenia. 21 Studies suggest that low doses of haloperidol may have less of an impact on cognitive function compared to other antipsychotics. 11

While haloperidol can cause an increase in prolactin levels, the use of aripiprazole as an adjunctive treatment has been shown to reduce prolactin levels. 20

The use of intravenous haloperidol (IVH) to manage agitation and psychosis in patients with delirium is common, even though it's not approved by the FDA. However, IVH has been linked to side effects such as QT prolongation, torsades de pointes (TdP), extrapyramidal symptoms, and catatonia. 25

Benefits and Risks

Benefit Summary

Haloperidol is an effective treatment for schizophrenia, particularly in reducing positive symptoms such as hallucinations and delusions. 23 , 18 , 9 It is also effective in rapidly controlling acute schizophrenia symptoms. 21 Low doses of haloperidol may have less of an impact on cognitive function compared to other antipsychotics. 11

Risk Summary

Haloperidol can cause side effects such as Parkinsonism, akathisia, and acute dystonia. 23 , 18 , 9 High doses of haloperidol may be linked to cognitive impairment. 19 Haloperidol can also cause an increase in prolactin levels. 20

Comparison of Studies

Commonalities in Studies

Numerous studies have established the effectiveness of haloperidol in treating schizophrenia. 23 , 18 , 9 Additionally, a consistent finding across many studies is that haloperidol can lead to adverse effects such as extrapyramidal symptoms. 23 , 18 , 9

Differences in Studies

The effects and side effects of haloperidol can vary depending on the dosage and method of administration. 3 , 4 Furthermore, individual patients can experience different responses to haloperidol. 7

Consistency and Discrepancies in Results

While some findings regarding the effects and side effects of haloperidol show consistency across studies, others demonstrate inconsistencies. 19 For instance, while high doses of haloperidol have been associated with cognitive decline, low doses have been suggested to have less of an impact on cognitive function. 11 Moreover, while haloperidol can lead to an increase in prolactin levels, the use of aripiprazole as an adjunctive treatment has been shown to reduce prolactin levels. 20 Further research is needed to clarify these inconsistencies.

Points to Consider for Real-World Application

Haloperidol is an effective treatment for schizophrenia, but it is important to use it cautiously due to the potential for side effects. 25 The optimal dosage and method of administration should be determined on a case-by-case basis. 3 , 4 It's crucial to follow your doctor's instructions carefully when taking haloperidol.

Limitations of Current Research

While numerous studies have investigated haloperidol, there are still unanswered questions. 24 For instance, the long-term effects and side effects of haloperidol, as well as the causes of individual variability in responses, are not fully understood. 7 Further research is needed to address these gaps.

Future Research Directions

More research is required to elucidate the long-term effects and side effects of haloperidol, as well as the factors contributing to individual variability in responses. 24 Additional research is also needed to optimize dosage and administration methods for haloperidol. 3 , 4

Conclusion

Haloperidol is an effective treatment for schizophrenia, but it's important to be aware of the potential for side effects. 25 Always follow your doctor's instructions when taking haloperidol and promptly report any side effects. 23 , 18 , 9

Literature analysis of 25 papers
Positive Content
20
Neutral Content
3
Negative Content
2
Article Type
19
3
5
4
25
1.

Parkinsonism by haloperidol and piribedil.

Author: CorsiniG U, Del ZompoM, SpissuA, MangoniA, GessaG L

Parkinsonism

Combining haloperidol and a low dose of piribedil (a dopamine agonist) resulted in marked rigidity and akinesia in schizophrenic patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Haloperidol and lorazepam combined: clinical effects and drug plasma levels in the treatment of acute schizophrenic psychosis.

Author: StevensA, StevensI, MahalA, GaertnerH J

Risk of lorazepam comedication

Lorazepam, combined with haloperidol, did not show any improvement in psychopathology or faster resolution of symptoms compared to haloperidol alone in acute schizophrenic patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Dosage of haloperidol for schizophrenia.

Author: RifkinA, DoddiS, KarajgiB, BorensteinM, WachspressM

Minimal side effects
Treat schizophrenia
No significant side effects

Dosages higher than 10 mg/d of haloperidol for most patients have no additional beneficial effect in the treatment of acute or exacerbated schizophrenia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Haloperidol blood levels and effects in schizophrenia and schizoaffective disorder: a progress report.

Author: VolavkaJ, CooperT B, MeisnerM, BitterI, CzoborP, JaegerJ

Side effects

There was no consistent relationship between plasma level of haloperidol and clinical improvement in acutely exacerbating schizophrenic or schizoaffective patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

Spontaneous motor activity in healthy volunteers after single doses of haloperidol.

Author: FreyS, BenteG, FuchsA, PreiswerkG, GlattA, ImhofP

Increased prolactin
Sedation

Haloperidol induced characteristic changes in motor activity, including a reduction in extremity motility and prolongation of movement and immobility phases of the head.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Flupenthixol in chronic schizophrenic inpatients: a controlled comparison with haloperidol.

Author: EhmannT S, DelvaN J, BeningerR J

Reduced psychopathology
Side effects

Haloperidol was more effective in reducing psychopathology than flupenthixol, but both drugs had similar levels of side effects. The study did not find evidence that flupenthixol is effective in activating chronic patients or alleviating affective symptoms.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Effects of high and low dosage of haloperidol on the brain in relation to schizophrenic thought disorder.

Author: WinterM, LehmannE, ScholzO B

Treats schizophrenia
None reported

Haloperidol, an antipsychotic drug, was studied in 40 acutely ill schizophrenic patients. There was a difference in psychopathological state between patients receiving a high dose (80 mg) and a low dose (16 mg).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

A randomized, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease.

Author: DevanandD P, MarderK, MichaelsK S, SackeimH A, BellK, SullivanM A, CooperT B, PeltonG H, MayeuxR

Agitation reduction
Psychosis reduction
Extrapyramidal signs
Narrow therapeutic window

Haloperidol in a dose of 2-3 mg/day was effective in treating psychosis and disruptive behaviors in patients with Alzheimer's disease, with a higher response rate than low-dose haloperidol or placebo. However, a subgroup of patients experienced moderate to severe extrapyramidal signs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

Haloperidol versus placebo for schizophrenia.

Author: JoyC B, AdamsC E, LawrieS M

Antipsychotic efficacy
Movement disorders

Haloperidol is a potent antipsychotic drug but with a high propensity to cause adverse effects. Given no choice of drug, use of haloperidol to counter the damaging and potentially dangerous consequences of untreated schizophrenia is justified. If a choice of drug is available, however, people with schizophrenia and clinicians may wish to start another antipsychotic with less likelihood of causing parkinsonism, akathisia and acute dystonias.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Effects of clozapine, olanzapine, risperidone, and haloperidol on hostility among patients with schizophrenia.

Author: CitromeL, VolavkaJ, CzoborP, SheitmanB, LindenmayerJ P, McEvoyJ, CooperT B, ChakosM, LiebermanJ A

Anti-hostility effect

Clozapine demonstrated a specific antiaggressive effect, showing significantly greater improvement than haloperidol or risperidone in patients with schizophrenia or schizoaffective disorder.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

The neurocognitive effects of low-dose haloperidol: a two-year comparison with risperidone.

Author: GreenMichael F, MarderStephen R, GlynnShirley M, McGurkSusan R, WirshingWilliam C, WirshingDonna A, LibermanRobert P, MintzJim

Improved neurocognitive function

This study aims to compare the neurocognitive effects of low-dose haloperidol and risperidone in patients with schizophrenia over a 2-year period. While newer antipsychotics have shown promise in managing neurocognitive deficits, most comparisons have been made with high doses of conventional medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

Comparative study of the effectiveness of zuclopenthixol acetate and haloperidol in acutely disturbed psychotic patients.

Author: TaymeeyapraditUnchulee, KuasirikulSurachai

Effective for psychosis

Zuclopenthixol acetate (ZPTA) and haloperidol (HAL) were both effective in treating acute psychosis with aggression, with ZPTA requiring less frequent administration. Both drugs had mild side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Actigraphic measurement of the effects of single-dose haloperidol and olanzapine on spontaneous motor activity in normal subjects.

Author: KiangMichael, DaskalakisZ Jeff, ChristensenBruce K, RemingtonGary, KapurShitij

Reduced motor activity

Olanzapine decreased total motor activity by increasing the amount of time subjects were immobile, while haloperidol did not have a significant effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Adverse effects of risperidone and haloperidol treatment in schizophrenia.

Author: YenYung-Chieh, LungFor-Wey, ChongMian-Yoon

Improved negative symptoms
Extrapyramidal side effects

Risperidone was more effective than haloperidol in improving negative symptoms in patients with schizophrenia. Risperidone was also better tolerated. Serum prolactin levels could predict the severity of parkinsonism and dyskinesia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidol.

Author: KeefeRichard S E, SeidmanLarry J, ChristensenBruce K, HamerRobert M, SharmaTonmoy, SitskoornMargriet M, LewineRichard R J, Yurgelun-ToddDeborah A, GurRuben C, TohenMauricio, TollefsonGary D, SangerTodd M, LiebermanJeffrey A

First-episode psychosis treatment

This study examines the neurocognitive effects of olanzapine and low doses of haloperidol in patients with first-episode psychosis. The research aims to address the controversy surrounding the effects of antipsychotic medication on neurocognitive function, particularly since previous research has focused on comparing novel antipsychotic medications to high doses of conventional medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Striatal dopaminergic D2 receptor occupancy and clinical efficacy in psychosis exacerbation: a 123I-IBZM study with ziprasidone and haloperidol.

Author: CorripioIluminada, CatafauAna M, PerezVíctor, PuigdemontDolors, MenaEsther, AguilarYolanda, CarrióIgnasi, AlvarezEnric

Lower D2 RO
Lower EPS
EPS

Ziprasidone, an atypical antipsychotic, induces lower striatal dopaminergic D2 receptor occupancy and fewer extrapyramidal side effects compared to haloperidol. High doses of ziprasidone may be more beneficial for patients with acute psychosis exacerbation, but caution should be taken regarding the potential for extrapyramidal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Impact of haloperidol, a dopamine D2 antagonist, on cognition and mood.

Author: SaeediHuma, RemingtonGary, ChristensenBruce K

Cognitive deficits
Mood changes

Haloperidol, an antipsychotic drug, blocks dopamine D(2) receptors. This study found that a single dose of haloperidol led to significant deficits in sustained attention, reaction time, and speed of information processing, as well as contentment, anger, and confusion in healthy participants. These cognitive and mood effects were most noticeable 4 hours after administration and were dose-dependent.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Haloperidol versus placebo for schizophrenia.

Author: JoyC B, AdamsC E, LawrieS M

Improved schizophrenia
Akathisia
Dystonia
Movement disorders
Parkinsonism

This review of 21 randomized controlled trials comparing haloperidol with placebo for schizophrenia found that haloperidol was more effective at improving symptoms in the short term, but it also had a higher propensity to cause adverse effects, including movement disorders like dystonia, akathisia, and parkinsonism. The review concluded that haloperidol is a potent antipsychotic drug, but clinicians may wish to prescribe an alternative antipsychotic with less likelihood of adverse effects when a choice is available.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects.

Author: WoodwardNeil D, PurdonScot E, MeltzerHerbert Y, ZaldDavid H

Cognitive function improvement
Deleterious cognitive effects at high doses

This study found that haloperidol, a typical antipsychotic medication, may improve cognitive function in patients with schizophrenia. While high doses of haloperidol may have negative effects on cognition, lower doses do not appear to have the same effect.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

20.

Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: a placebo-controlled trial.

Author: ShimJoo-Cheol, ShinJae-Goo K, KellyDeanna L, JungDo-Un, SeoYoung-Soo, LiuKwang-Hyeon, ShonJi-Hong, ConleyRobert R

Hyperprolactinemia reversal
Menstrual restoration
No significant impact on extrapyramidal symptoms
No significant impact on psychopathology

Adjunctive aripiprazole treatment effectively reversed hyperprolactinemia in both men and women with schizophrenia, leading to the reinstatement of menstruation in female patients. This occurred without significant effects on psychopathology or extrapyramidal symptoms.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Parenteral haloperidol for rapid control of severe, disruptive symptoms of acute schizophrenia.

Author: ReschkeR W

Haloperidol efficacy
Psychotic treatment
Drowsiness
EPS

This study compared the efficacy and safety of intramuscular haloperidol (5 mg, 2 mg, and 1 mg), chlorpromazine (25 mg), and placebo in acute psychotic patients. Haloperidol at 5 mg and 2 mg was significantly more effective than lower doses and placebo. Side effects were minimal and easily managed with antiparkinson drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Quetiapine versus haloperidol in the treatment of delirium: a double-blind, randomized, controlled trial.

Author: ManeetonBenchalak, ManeetonNarong, SrisurapanontManit, ChittawatanaratKaweesak

Delirium symptom control
Hypersomnia

Low-dose quetiapine and haloperidol were equally effective and safe in controlling delirium symptoms in medically ill patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Haloperidol versus placebo for schizophrenia.

Author: AdamsClive E, BergmanHanna, IrvingClaire B, LawrieStephen

Antipsychotic effect
Alternatives preferred
Movement disorders

Haloperidol is a potent antipsychotic drug that can be used to treat schizophrenia and other serious mental illnesses. It has a high propensity to cause adverse effects such as parkinsonism, akathisia, and acute dystonias. It is most effective in the first 6 weeks of treatment, but many people do not complete the short trials. While haloperidol is justified when there is no other treatment option, other antipsychotics with less likelihood of adverse effects may be preferred when available.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Haloperidol discontinuation for people with schizophrenia.

Author: EssaliAdib, TurkmaniKhaled, AboudamaahShaimaa, AbouDamaahAlaa, Diaa AldeenMohammad Reyad, MarwaMohamad Essam, AlMounayerNawar

Improved schizophrenia treatment

Haloperidol is effective in treating schizophrenia, but can have side effects. This review investigates the effects of stopping haloperidol in people with schizophrenia who are stable on their prescription.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Intravenous haloperidol: A systematic review of side effects and recommendations for clinical use.

Author: BeachScott R, GrossAnne F, HartneyKimberly E, TaylorJohn B, RundellJames R

Delirium management
Catatonia
Extrapyramidal symptoms
QT prolongation
TdP

This review discusses the concerns regarding side effects of intravenous haloperidol (IVH), particularly its potential to cause QT prolongation, torsades de pointes (TdP), extrapyramidal symptoms, and catatonia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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