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Clinical trial of a lyophilized inactivated hepatitis A candidate vaccine in healthy adult volunteers.

Author: FujiyamaS, HoriuchiK, IinoS, JyoK, KuwabaraY, KuzuharaS, MoritaM, OdohK, SaikaS, SatoS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A lyophilized inactivated hepatitis A vaccine was safe and immunogenic in healthy adult male volunteers. All subjects developed measurable antibody titers after the first injection.
Paper Details　
Original Abstract of the Article :
The safety and immunogenicity of a lyophilized inactivated hepatitis A vaccine was tested in healthy adult male volunteers. Thirty-six volunteers, all of whom were negative for antibody to HAV (anti-HAV), were divided into three dosage groups, 1.0, 0.5 and 0.25 micrograms of viral protein, respectiv...See full text at original site
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引用元：
https://doi.org/10.1016/0264-410x(92)90371-p

データ提供：米国国立医学図書館（NLM）

A Lyophilized Inactivated Hepatitis A Vaccine: A Oasis in the Desert of Viral Infections

Hepatitis A, a viral infection affecting the liver, is like a desert sandstorm, wreaking havoc on the body. This study, like a caravan of scientists searching for a protective shield against this formidable foe, investigates the safety and effectiveness of a new lyophilized inactivated hepatitis A vaccine.

A Promising Candidate Vaccine

The study found that the vaccine was both safe and effective in generating a strong immune response in healthy adult volunteers. This finding suggests that the vaccine could offer a valuable tool for preventing hepatitis A, like a sturdy camel caravan equipped with protective gear for navigating a dangerous desert.

Hope for Hepatitis A Prevention

This study provides hope for the prevention of hepatitis A. It highlights the potential of this new vaccine to protect individuals against this serious infection, like a desert oasis offering respite from the harsh realities of disease.

Dr. Camel's Conclusion

This study, like a desert oasis blooming with life amidst the arid landscape, showcases the promise of a new lyophilized inactivated hepatitis A vaccine. This vaccine, like a sturdy camel traversing the desert sands, has the potential to protect individuals from this debilitating infection and improve global health.
Date :
  1. Date Completed 1992-06-02
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

1315469

DOI: Digital Object Identifier

10.1016/0264-410x(92)90371-p

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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