Effects of hepatitis a vaccine: A Synthesis of Findings from 30 Studies

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major research findings

Multiple studies have shown that the hepatitis A vaccine is safe and effective. 8 , 25 , 13 , 17 , 9 , 24 , 14 , 1 , 10 , 23 , 16 , 11 , 7 , 12 , 2 , 6 , 20 , 30 , 27 , 4 , 26 , 5 , 3 , 28 , 22 , 21 , 29 , 15 Research has confirmed that vaccination can build immunity against hepatitis A and prevent infection. The vaccine is generally considered safe, with mild side effects reported. Some studies have suggested that vaccine effectiveness can vary based on dosage and scheduling. 8 , 17 , 6 , 20 Some research indicates that the hepatitis A vaccine may be less effective for certain groups, such as those with compromised immune systems or individuals with hemophilia. 25 , 13 , 28 Additionally, there are reports that the effectiveness of the hepatitis A vaccine can be reduced when given concurrently with other vaccines. 23 , 21

Benefits and Risks

Benefit Summary

The hepatitis A vaccine offers the potential to protect against hepatitis A infection. Vaccination allows individuals to develop immunity to hepatitis A, significantly reducing the risk of infection. Generally, the vaccine is considered safe, with mild side effects. Numerous studies have not reported serious side effects related to the vaccine.

Risk Summary

Side effects from the hepatitis A vaccine are typically mild. The most commonly reported side effects include pain, redness, and swelling at the injection site. In rare cases, fever, fatigue, and headache might occur. It is important to note that the hepatitis A vaccine might not be equally effective in all individuals. For instance, people with compromised immune systems, such as those with hemophilia, may experience difficulties in developing immunity from the vaccine. Careful consideration is required in such cases.

Comparison Between Studies

Similarities Between Studies

Most studies agree that the hepatitis A vaccine is safe and effective. They also suggest that vaccine effectiveness can vary based on factors like dosage and scheduling.

Differences Between Studies

Research findings on vaccine effectiveness, side effects, and optimal administration methods can differ across studies. For example, while some studies suggest that vaccine effectiveness is influenced by dosage and scheduling, others indicate that effectiveness remains high regardless of dosage or scheduling. Additionally, reports on vaccine side effects vary among studies.

Consistency and Inconsistencies in Results

Research findings regarding the effectiveness and safety of the hepatitis A vaccine display both consistency and inconsistencies. Due to the potential for vaccine effectiveness to vary based on factors such as dosage, scheduling, and individual immune status, definitive conclusions cannot be drawn. Additionally, varying reports on side effects across studies make definitive statements challenging.

Considerations for Real-Life Applications

The hepatitis A vaccine is a valuable tool for preventing hepatitis A infection. However, it is crucial to remember that the vaccine may not be effective for every individual. Moreover, all vaccines carry the risk of side effects. It is essential to consult with a physician prior to vaccination to choose the most appropriate vaccine for your specific situation.

Limitations of Current Research

Research on the effectiveness and safety of the hepatitis A vaccine is not yet comprehensive. Particularly, further investigation is needed to understand the vaccine's effectiveness and safety in specific populations, such as individuals with compromised immune systems or those with hemophilia. Additionally, long-term follow-up studies are necessary to assess the long-term effectiveness and safety of the vaccine.

Directions for Future Research

Future research should focus on further validating the effectiveness and safety of the hepatitis A vaccine. This includes investigating the vaccine's effectiveness and safety in specific populations, its long-term effectiveness and safety, and identifying optimal administration methods. Additionally, research aimed at promoting vaccine development and widespread adoption is crucial.

Conclusion

The hepatitis A vaccine stands as a safe and effective means of prevention. Individuals at a heightened risk of hepatitis A infection, as well as those planning travel to areas with hepatitis A outbreaks, should consider vaccination. However, it is vital to remember that the vaccine may not be universally effective, and all vaccines carry a risk of side effects. Consulting with a doctor before vaccination is essential to select the most appropriate vaccine for your individual circumstances.

Literature analysis of 30 papers
Positive Content
30
Neutral Content
0
Negative Content
0
Article Type
18
0
1
2
30
1.

Clinical trial of a lyophilized inactivated hepatitis A candidate vaccine in healthy adult volunteers.

Author: IinoS, FujiyamaS, HoriuchiK, JyoK, KuwabaraY, SatoS, SaikaS, MoritaM, OdohK, KuzuharaS

Hepatitis A prevention
Immunogenicity
Minor side effects

A lyophilized inactivated hepatitis A vaccine was safe and immunogenic in healthy adult male volunteers. All subjects developed measurable antibody titers after the first injection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Immunogenicity, reactogenicity and consistency of a new, inactivated hepatitis A vaccine--a randomized multicentre study with three consecutive vaccine lots.

Author: KallinowskiB, GmelinK, KommerellB, BockH L, ClemensR, ScheiermannN, WohlandB, HofmannF, TheilmannL

Hepatitis A prevention
Immunogenicity
Mild side effects

This inactivated hepatitis A vaccine is highly immunogenic, safe, and well tolerated. It was shown to be effective and consistent across three vaccine lots.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Reactogenicity and immunogenicity of three different lots of a hepatitis A vaccine.

Author: TheilmannL, KallinowskiB, GmelinK, HofmannF, ScheiermannN, WohlandB, SticklH, MaiwaldH, MoriabadiF K, BockH L

Hepatitis A prevention
Immunogenicity
Mild side effects

Three lots of inactivated hepatitis A vaccine were found to be safe, well tolerated, and equally immunogenic in a study of 204 healthy individuals.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Placebo-controlled efficacy study of hepatitis A vaccine in Valdivia, Chile.

Author: RiedemannS, ReinhardtG, FrösnerG G, IbarraH, MoraledaL, HeringV, SiegelF, ToledoC, LeonJ, GonzalezJ L

Hepatitis A prevention
Immunogenicity

A hepatitis A vaccine was found to be safe and effective in a placebo-controlled, double-blind study of 260 children. The vaccine was well tolerated, and 95.5% of children seroconverted after one dose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

A trial of the reactogenicity and immunogenicity of an inactivated hepatitis A vaccine.

Author: GreenM S, CohenD, LermanY, SjogrenM, BinnL N, ZurS, SleponR, RobinG, HokeC, BancroftW

Highly immunogenic
No significant side effects

A new inactivated hepatitis A vaccine showed high immunogenicity and no significant side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

6.

Safety and immunogenicity of an inactivated hepatitis A vaccine: effect of dose and vaccination schedule.

Author: WestblomT U, GudipatiS, DeRousseC, MidkiffB R, BelsheR B

Hepatitis A prevention
Rapid immunization
Mild side effects

This study evaluated the safety and immunogenicity of an inactivated hepatitis A vaccine. The vaccine was found to be safe and effective in inducing protective antibody levels in adults.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Safety, tolerability, and immunogenicity of an inactivated hepatitis A vaccine: effects of single and booster injections, and comparison to administration of immune globulin.

Author: ShouvalD, AshurY, AdlerR, LewisJ A, MillerW, KuterB, BrownL, NalinD R

Hepatitis A prevention
Rapid immunization
Mild side effects

This study compared the safety, tolerability, and immunogenicity of an inactivated hepatitis A virus vaccine (iHAV) to immune globulin (IG) in adults. A single dose of the iHAV vaccine was found to be more effective and longer lasting than IG.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Dose response study of an inactivated hepatitis A virus vaccine.

Author: CarlssonR M, ClaessonB A, IwarsonS A

Hepatitis A prevention
Mild side effects

This study evaluated the safety, tolerability, and immunogenicity of an inactivated hepatitis A virus vaccine in adults. A single dose of the vaccine was found to be effective in inducing protective antibody levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Immunogenicity and adverse effects of inactivated virosome versus alum-adsorbed hepatitis A vaccine: a randomized controlled trial.

Author: HolzerB R, HatzC, Schmidt-SissolakD, GlückR, AlthausB, EggerM

Hepatitis A vaccine
Less local adverse effects
Virosomes

IRIV-HAV may provide similar protection as Al-HAV but cause less local adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Comparative immunogenicity and tolerance of Vaqta and Havrix.

Author: BraconierJ H, WennerholmS, NorrbyS R

Hepatitis A prevention
Local side effects

Two inactivated hepatitis A vaccines, Vaqta and Havrix, were compared in a randomized trial of 520 adults. Vaqta was found to have better local tolerance than Havrix, with similar immunogenicity and systemic tolerance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

The effectiveness and safety of hepatitis A vaccine: a systematic review.

Author: DemicheliVittorio, TibertiDonatella

Hepatitis A prevention

A systematic review was conducted to assess the efficacy and safety of hepatitis A vaccines in adults and children. Combined inactivated vaccine effectiveness was 86% (95% CI: 63-95%) and combined attenuated vaccine effectiveness was 95% (95% CI: 81-99%). Inactivated vaccine effectiveness in the prevention of HAV secondary cases, compared to non-intervention was 82% (95% CI: 23-96%). Safety profile of vaccines was similar to that of their comparators.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Efficacy of virosome hepatitis A vaccine in young children in Nicaragua: randomized placebo-controlled trial.

Author: Mayorga PérezOrlando, HerzogChristian, ZellmeyerMartina, LoáisigaArnoldo, FrösnerGert, EggerMatthias

Hepatitis A protection
Safe vaccine
Rare adverse effects

A single dose of a hepatitis A virosome vaccine was found to be safe and effective in protecting young children (1.5-6 years old) against hepatitis A virus (HAV) infection in a randomized, double-blind trial of 274 children in Nicaragua. The vaccine demonstrated 84.6% protective efficacy, with all infections occurring within 6 weeks of vaccination.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Immunogenicity and side-effects of the inactivated hepatitis A vaccine in periodic fever, aphthous stomatitis, pharyngitis, and adenitis patients.

Author: MaritsiDespoina N, SyrmouAreti, VartzelisGeorge, DiamantopoulosStavros, TsoliaMaria N

HAV vaccination

Two doses of the inactivated hepatitis A virus (HAV) vaccine were well-tolerated and effective in children with periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA). The seroprotection rates were comparable to those observed in healthy controls.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

14.

[The immunological effects of three doses of a live attenuated hepatitis A vaccine (H2 strain) in 8 years].

Author: LiuHuai-Feng, ZhangXin-Jiang, ZhangJian-Li, HaoZhi-Yong, ZhangZhi-Yong, MaJing-Chen, ChenJi-Chao, ChuJuan, WangXuan-Yi, XuZhi-Yi

Better immunological effects
None mentioned

A 3-dose schedule administration of H2 strain live attenuated hepatitis A vaccine has better immunological effects than 1-dose schedule in 8years.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

15.

[Effects of cytokines on the immunogenic properties of hepatitis A vaccine].

Author: AvdeevaZh I, Akol'zinaS E, AlpatovaN A, MedunitsynN V

Hepatitis A vaccination efficacy

Cytokines, including rhIL-1b, rhTNF-alpha, and thymosin-a1, enhanced the immunogenicity of hepatitis A vaccine in guinea pigs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

17.

[Comparison of immunology effects between live attenuated hepatitis A vaccine and inactivated hepatitis A vaccine].

Author: WangX, MengZ, LiR

Immune response
None mentioned

A booster dose of live attenuated hepatitis A vaccine effectively induces a secondary immune response, comparable to that of an inactivated vaccine. The vaccine is well-tolerated, and a booster dose may be helpful for immune persistence.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

18.

Immunogenicity and adverse effects of inactivated virosome versus alum-adsorbed hepatitis A vaccine: a randomized controlled trial.

Author: HolzerB R, HatzC, Schmidt-SissolakD, GlückR, AlthausB, EggerM

Hepatitis A vaccine
Less local adverse effects
Virosomes

IRIV-HAV may provide similar protection as Al-HAV but cause less local adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Safety, tolerability, and immunogenicity of an inactivated hepatitis A vaccine: effects of single and booster injections, and comparison to administration of immune globulin.

Author: ShouvalD, AshurY, AdlerR, LewisJ A, MillerW, KuterB, BrownL, NalinD R

Hepatitis A prevention
Rapid immunization
Mild side effects

This study compared the safety, tolerability, and immunogenicity of an inactivated hepatitis A virus vaccine (iHAV) to immune globulin (IG) in adults. A single dose of the iHAV vaccine was found to be more effective and longer lasting than IG.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

[Immunological effects of live attenuated hepatitis A vaccine].

Author: ChengN L

Hepatitis A prevention

The H2 strain of live attenuated hepatitis A vaccine has a quick antibody response, a high seroconversion rate, and is effective in preventing hepatitis A.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

21.

Coadministered pneumococcal conjugate vaccine decreases immune response to hepatitis A vaccine: a randomized controlled trial.

Author: RiekkinenMarianna, PakkanenSari H, HutseVeronik, RoukaertsInge, OllgrenJukka, KäyhtyHelena, HerzogChristian, RomboLars, KanteleAnu

HepA/PCV safety
HepA efficacy

Coadministration of HepA and PCV13 did not cause safety concerns or impact the patients' response to PCV13, apart from serotype 3. However, PCV13 significantly impaired antibody responses to HepA.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Safety of concomitant administration of inactivated hepatitis A vaccine with other vaccines in children under 16 years old in post-marketing surveillance.

Author: WuLinlin, YangShoufei, HuangZhuoying, LiuJiechen, GuoXiang, BaiQingrui, SunXiaodong

Vaccination coverage

Concomitant vaccination, the administration of multiple vaccines at the same time, is a common practice in children. This study examined the safety of co-administering an inactivated hepatitis A vaccine (Healive®) with other vaccines in children under 16 years old.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

A randomized phase 3 trial of the immunogenicity and safety of coadministration of a live-attenuated tetravalent dengue vaccine (TAK-003) and an inactivated hepatitis a (HAV) virus vaccine in a dengue non-endemic country.

Author: TricouVianney, EyreSusannah, RamjeeMahadev, ColliniPaul, MojaresZenaida, LoeligerEdde, MandaricSanja, RauscherMartina, BroseManja, LefevreInge, FolschweillerNicolas, WallaceDerek

Concurrent dengue and HAV vaccination
HAV vaccination

This randomized, observer-blind, phase 3 trial evaluated the safety and efficacy of co-administering hepatitis A (HAV) vaccine with tetravalent dengue vaccine in healthy adults. The study found that co-administration was safe and immunogenic.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

A single blind randomized phase 3 study to evaluate safety and immunogenicity of inactivated hepatitis A vaccine (HAPIBEV<sup>TM</sup>) in 1-15&#160;years-old healthy hepatitis A vaccine-na&#239;ve children.

Author: ThuluvaSubhash, MaturRamesh, TsaKishore, GvSubba Reddy

Hepatitis A prevention
Immunogenicity
Safety
Injection site pain

The HAPIBEV™ vaccine, a hepatitis A vaccine, demonstrated comparable immunogenicity and safety to the Havrix 720® vaccine in Indian children. This suggests that HAPIBEV™ could be a viable alternative to Havrix 720® in this population.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

The Safety, Immunogenicity, and Immunopersistence of Hepatitis A Vaccine in HBs-Ag-Positive Participants: A Retrospective Study.

Author: WangXiaodan, LuoJia, MaFubao, KangGuodong, DingZhengrong, PanYue, ZhaoYujiao, ChenJunying, FengKai, YanLingmei, ZhangJuan, LiLinhao, LanQiangping, LiDaiying, YangXiaolei, LiGuoliang, YangJingsi, SunQiangming

Hepatitis A vaccines for HBs-Ag-positive

Hepatitis A vaccines (live attenuated and inactivated) were safe and provided excellent long-term protection against HAV in HBs-Ag-positive individuals, with comparable immunogenicity to HBs-Ag-negative individuals.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Safety and immunogenicity of inactivated hepatitis-A vaccine developed by Human Biologicals Institute in two age groups of healthy subjects: A phase I open label study.

Author: SusarlaSai Krishna, PalkarSonali, SvPardha Saradhi, DiwanArundhati, BarsodeSupriya, SatishM, RajashakarB C, SandhyaG, LingalaRajendra, SahooDevi Prasad

Hepatitis A prevention

This phase I trial evaluated the safety and immunogenicity of a single-dose inactivated hepatitis-A vaccine in two age groups of healthy subjects.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

A randomized controlled trial of comparative effectiveness between the 2 dose and 3 dose regimens of hepatitis a vaccine in kidney transplant recipients.

Author: PrasoppokakornThaninee, VanichananJakapat, ChaiteerakijRoongruedee, JutivorakoolKamonwan, UdomkarnjananunSuwasin, PongpirulKrit, TaesombatWipusit, WattanatornSalin, AvihingsanonYingyos, TungsangaKriang, Eiam-OngSomchai, PraditpornsilpaKearkiat, TownamchaiNatavudh

Hepatitis A vaccine
Lower immunogenicity

A randomized controlled trial comparing 2-dose and 3-dose hepatitis A vaccination regimens in non-immune kidney transplant recipients found no significant difference in seroconversion rates at 1 month. However, a 3-dose regimen did not show superior benefit over the standard 2-dose regimen.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Immunogenicity, long term protection and safety of subcutaneous administration of hepatitis A vaccine in patients with hemophilia and other bleeding disorders: A randomized study.

Author: NakasoneMayumi, LopesMarta Heloisa, SartoriAna Marli Chritovam, SandovalEliane Partite Nobre, VillaçaPaula Ribeiro, D'AmicoElbio Antonio, CarneiroJorge David Aivazoglou

Hepatitis A protection
Safer administration

Hepatitis A vaccine administered subcutaneously was found to be as immunogenic and protective as the intramuscular route in patients with hemophilia and other bleeding disorders. Furthermore, the subcutaneous route was found to be safer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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