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A single-blind study of the efficacy and safety of intravenous granisetron compared with alizapride plus dexamethasone in the prophylaxis and control of emesis in patients receiving 5-day cytostatic therapy. The Granisetron Study Group.

Author: BremerK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Granisetron is more effective than alizapride and dexamethasone in preventing nausea and vomiting in cancer patients receiving chemotherapy. Granisetron is also easier to dose and has fewer side effects.
Paper Details　
Original Abstract of the Article :
200 cancer patients who were due to receive fractionated chemotherapy (cisplatin greater than or equal to 15, ifosfamide greater than or equal to 1.2 or etoposide greater than or equal to 120, all mg/m2 per day) for 5 days, entered a multicentre study. Patients were randomised single-blind to receiv...See full text at original site
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引用元：
https://doi.org/10.1016/0959-8049(92)90446-9

データ提供：米国国立医学図書館（NLM）

A single-blind study of the efficacy and safety of intravenous granisetron compared with alizapride plus dexamethasone in the prophylaxis and control of emesis in patients receiving 5-day cytostatic therapy. The Granisetron Study Group

The study compares the efficacy and safety of intravenous granisetron with alizapride plus dexamethasone in preventing and controlling emesis in patients receiving five-day cytostatic therapy. The researchers found that granisetron was superior to the combination in preventing nausea and vomiting, particularly in patients receiving cisplatin. Granisetron also demonstrated a simpler dosing regimen and fewer adverse events compared to the comparator group.

Granisetron: A potential oasis in the desert of chemotherapy-induced nausea and vomiting

The study highlights the potential benefits of granisetron in managing chemotherapy-induced nausea and vomiting. The findings suggest that granisetron may offer a more effective and safer treatment option compared to other antiemetic regimens.

Navigating the desert of chemotherapy side effects

As a wise camel, I know that navigating the desert of chemotherapy side effects can be challenging. This study offers valuable information about a potential treatment option for chemotherapy-induced nausea and vomiting. It is crucial to consult with your doctor to determine the most appropriate treatment plan, taking into account individual needs and potential risks and benefits.

Dr.Camel's Conclusion

The study demonstrates the efficacy and safety of intravenous granisetron in preventing and controlling emesis in patients receiving five-day cytostatic therapy. The findings suggest that granisetron may offer a more effective and simpler treatment option than other antiemetic regimens.

Date :
  1. Date Completed 1992-08-17
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

1320907

DOI: Digital Object Identifier

10.1016/0959-8049(92)90446-9

Related Literature

Article Analysis
・Effects of granisetron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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