Effects of granisetron: A Synthesis of Findings from 15 Studies

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Original Abstract of the Article

Major Findings

Granisetron is an effective antiemetic agent that has been shown to be effective in preventing nausea and vomiting induced by chemotherapy and radiation therapy. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12 It is generally well-tolerated, with the most common side effect being headache. 8 , 6 , 7 , 1 , 3 , 9 , 4 , 2 Granisetron is effective in preventing nausea and vomiting when used in combination with other antiemetics. 11 , 6 , 2 Oral granisetron is an effective antiemetic and offers a convenient dosing regimen. 3 The efficacy of granisetron may be dose-dependent. 4 , 14 Granisetron may have an effect on the heart, but further research is needed to clarify its effects. 15 , 12 Granisetron may be more effective and safer than other antiemetics. 13 However, more research is needed to confirm its efficacy and safety.

Benefits and Risks

Benefit Summary

Granisetron is an effective antiemetic agent that has been shown to be effective in preventing nausea and vomiting induced by chemotherapy and radiation therapy. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12 It is generally well-tolerated. 8 , 6 , 7 , 1 , 3 , 9 , 4 , 2 Granisetron is effective in preventing nausea and vomiting when used in combination with other antiemetics. 11 , 6 , 2 Oral granisetron is an effective antiemetic and offers a convenient dosing regimen. 3

Risk Summary

The most common side effect of granisetron is headache. 8 , 6 , 7 , 1 , 3 , 9 , 4 , 2 Granisetron may cause constipation. 1 , 3 , 9 Granisetron may have an effect on the heart, but further research is needed to clarify its effects. 15 , 12

Comparison Between Studies

Similarities Between Studies

Many studies have shown that granisetron is effective in preventing nausea and vomiting induced by chemotherapy and radiation therapy. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12 Granisetron is generally well-tolerated. 8 , 6 , 7 , 1 , 3 , 9 , 4 , 2

Differences Between Studies

The administration route and dose of granisetron have varied between studies. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12 The methods used to assess efficacy and safety of granisetron have also differed. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12

Consistency and Contradictions in the Results

Many studies have shown that granisetron is effective in preventing nausea and vomiting induced by chemotherapy and radiation therapy. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12 However, the administration route and dose of granisetron have varied between studies. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12 These inconsistencies may be due to differences in study design, patient characteristics, and evaluation methods.

Considerations for Real-World Application

Granisetron may be used to reduce nausea and vomiting caused by chemotherapy or radiation therapy. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12 It is important to take granisetron as directed by your doctor. 1 , 3 , 9 If you have any questions about taking granisetron, talk to your doctor or pharmacist.

Limitations of Current Research

There are limitations to current research on the efficacy and safety of granisetron, such as the small number of patients, different study designs, and different evaluation methods. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12 Therefore, further research is needed to more clearly assess the efficacy and safety of granisetron.

Future Research Directions

Future research should involve more patients, stricter study designs, and more rigorous evaluation methods to more clearly assess the efficacy and safety of granisetron. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12 It is also important to compare the efficacy and safety of granisetron to other antiemetics. 1 , 9 , 5 , 13 The long-term effects of granisetron also need to be evaluated.

Conclusion

Granisetron may be a useful treatment for reducing nausea and vomiting caused by chemotherapy and radiation therapy. 10 , 11 , 8 , 6 , 7 , 1 , 3 , 5 , 9 , 4 , 2 , 15 , 14 , 13 , 12 However, it is important to take it as directed by your doctor. 1 , 3 , 9 If you have any questions about taking granisetron, talk to your doctor or pharmacist.

Literature analysis of 15 papers
Positive Content
15
Neutral Content
0
Negative Content
0
Article Type
15
0
0
0
15
1.

A single-blind study of the efficacy and safety of intravenous granisetron compared with alizapride plus dexamethasone in the prophylaxis and control of emesis in patients receiving 5-day cytostatic therapy. The Granisetron Study Group.

Author: BremerK

Nausea and vomiting prevention
Constipation
Extrapyramidal effects

Granisetron is more effective than alizapride and dexamethasone in preventing nausea and vomiting in cancer patients receiving chemotherapy. Granisetron is also easier to dose and has fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Fractionated chemotherapy--granisetron or conventional antiemetics? The Granisetron Study Group.

Author: DiehlV

Nausea and vomiting prevention
Constipation
Fever
Headache

Granisetron was superior to alizapride/dexamethasone and metoclopramide/dexamethasone in preventing nausea and vomiting in patients receiving chemotherapy. Granisetron was associated with fewer side effects, except for constipation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Oral granisetron--simple and effective: a preliminary report. The Granisetron Study Group.

Author: HackingA

Nausea and vomiting prevention
Abdominal pain
Constipation
Fever
Headache

Oral granisetron at 1.0 mg twice daily is an effective and safe antiemetic for patients receiving moderately emetogenic chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

High versus low dose granisetron, a selective 5HT3 antagonist, for the prevention of chemotherapy-induced nausea and vomiting.

Author: FalksonH C, FalksonC I, FalksonG

Effective antiemetic
Well tolerated
Mild headache

Granisetron, a 5HT3 receptor antagonist, effectively reduced nausea and vomiting in patients undergoing highly emetogenic chemotherapy. The higher dose of 160 micrograms/kg was more effective than 40 micrograms/kg.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Comparison of intravenous granisetron with metoclopramide in the treatment of chemotherapy-induced emesis.

Author: ChiouT J, WeiC H, HsiehR K, FanF S, LiuJ H, ChenP M

Reduces nausea and vomiting

This study evaluated the effect of granisetron, a 5HT3 receptor antagonist, on antiemesis in patients receiving cisplatin-based chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

[A comparative study of the effect of granisetron and a combination of granisetron plus steroids on cancer chemotherapy induced emesis].

Author: NukariyaN, NakaraiI, KobayashiH, KoizumiW, KomatsuH, UchiyamaT, YamaguchiT, TairaO, MinatoK, FutatsugiK

Anorexia relief
Antiemetic effect
Nausea relief
Diarrhea
Headache

This study investigated the effects of granisetron monotherapy and concurrent therapy with a steroid on acute and delayed emesis induced by cancer chemotherapy. Concurrent therapy with a steroid was found to be more effective in reducing emesis than granisetron monotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Japanese

7.

Efficacy and safety of granisetron, a selective 5-hydroxytryptamine-3 receptor antagonist, in the prevention of nausea and vomiting induced by high-dose cisplatin.

Author: NavariR M, KaplanH G, GrallaR J, GrunbergS M, PalmerR, FittsD

Granisetron antiemetic efficacy
Granisetron safety
Granisetron headache

Granisetron was effective in controlling vomiting in 57% to 60% of patients receiving cisplatin. The 10, 20, and 40 micrograms/kg doses were equally effective and well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

A dose-finding study of granisetron, a novel antiemetic, in patients receiving cytostatic chemotherapy. The Granisetron Study Group.

Author: SmithI E

Antiemetic
Well tolerated
Headache

Granisetron, an antiemetic medication used to prevent nausea and vomiting caused by chemotherapy, was studied at two different doses (40 mcg/kg and 160 mcg/kg) in patients receiving chemotherapy. The study found that both doses were effective in preventing nausea and vomiting, with complete response rates of 75% and 81%, respectively, in the first 24 hours. Granisetron was well-tolerated, with headache being the most common side effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

The antiemetic efficacy and safety of granisetron compared with metoclopramide plus dexamethasone in patients receiving fractionated chemotherapy over 5 days. The Granisetron Study Group.

Author:

Antiemetic efficacy
Safe
Constipation
Headache

Granisetron, a serotonin antagonist, was compared to metoclopramide plus dexamethasone for preventing nausea and vomiting in patients receiving chemotherapy. The study found that granisetron was equally effective as the combination therapy, with similar complete response rates (no vomiting, no worse than mild nausea) and fewer treatment failures. Importantly, granisetron was associated with fewer side effects, including a significantly lower incidence of extrapyramidal syndrome (20.6% for metoclopramide plus dexamethasone versus none for granisetron).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Influence of granisetron on thermoregulation during exercise in the heat.

Author: McLellanT M, DucharmeM B

Effective antiemetic
Minimal side effects

This study evaluated the effect of a single 2-mg oral dose of granisetron, a selective serotonin antagonist, on temperature regulation during exercise in a hot and relatively dry environment. The study did not show any significant effects of granisetron on temperature regulation during exercise, suggesting that granisetron is unlikely to interfere with thermoregulation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

[Granisetron versus granisetron plus methylprednisolone in the prevention of chemotherapy induced nausea and vomiting--in adjuvant chemotherapy, including CDDP against gastric cancer].

Author: KuritaA, TakashimaS, NakataM, KuboY, SaikiT, OhsumiS, YokoyamaN, TanadaM, TakiyamaW, SaekiH

Reduced nausea and vomiting
Mild adverse effects

Granisetron combined with methylprednisolone tender to be more effective than granisetron alone in preventing emesis after chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Japanese

12.

Cardiovascular effects of i.v. granisetron at two administration rates and of ondansetron in healthy adults.

Author: BoikeS C, IlsonB, ZariffaN, JorkaskyD K

Granisetron, given as a 30-second intravenous bolus dose, was found to be safe and well tolerated in healthy adults. The mean postdose QTc interval was significantly different among the four regimens tested, with ondansetron having a significantly greater mean post-dose QTc interval than the other regimens.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

[Preventive effects of ramosetron and granisetron in prevention of gastrointestinal reaction associated with chemotherapeutic agents: a comparative study].

Author: ZhangJing-dong, LiuYun-peng, TengYue-e, ShiJing

Antiemetic efficacy
Headache

Ramosetron is a safe and effective antiemetic for preventing gastrointestinal reactions induced by cisplatin or adramycin. It is more cost-effective than granisetron and resulted in significantly lower rates of anorexia and nausea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

14.

The efficacy of granisetron for cancer patients undergoing platinum-based chemotherapy: comparison of 1 miligram versus 3 miligram doses in preventing nausea and vomiting.

Author: KurniandaJohan, HisyamBarmawi, WahyuningsihEndang, HutajuluSusanna H

Prevent emesis
Prevent nausea

A study compared the efficacy of 1 mg and 3 mg intravenous granisetron in preventing chemotherapy-induced nausea and vomiting. Granisetron 3 mg was more effective than 1 mg in preventing both vomiting and nausea.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Pharmacokinetics and repolarization effects of intravenous and transdermal granisetron.

Author: MasonJay W, SelnessDaniel S, MoonThomas E, O'MahonyBridget, DonachiePeter, HowellJulian

Nausea treatment
Cardiac repolarization

This study evaluated the repolarization effects of granisetron, a 5-HT(3) receptor antagonist antiemetic, when administered intravenously and through a transdermal system (GTDS). The study highlights the need for clearer understanding of the effects of 5-HT(3) receptor antagonists on cardiac repolarization due to changes in product labeling across this therapeutic class.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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