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Psychoactivity and abuse potential of sumatriptan.

Author: BuschM, JasinskiD R, PrestonK L, SullivanJ T, TestaM P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sumatriptan is a migraine and cluster headache treatment that has low abuse potential. In a study, sumatriptan showed psychoactive effects but did not produce euphoria or act as a prototypic drug of abuse.
Paper Details　
Original Abstract of the Article :
Sumatriptan is a 5-HT1D agonist of therapeutic use in migraine and cluster headaches. To determine the profile of psychoactivity and abuse potential, a double-blind Latin-square crossover study was conducted in 12 male subjects with histories of substance abuse. The effects of subcutaneous placebo, ...See full text at original site
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引用元：
https://doi.org/10.1038/clpt.1992.202

データ提供：米国国立医学図書館（NLM）

Sumatriptan: Psychoactivity and Abuse Potential

This study investigates the psychoactivity and abuse potential of sumatriptan, a medication used to treat migraine and cluster headaches. The researchers conducted a double-blind study, evaluating the subjective, behavioral, and physiological effects of sumatriptan compared to placebo and morphine (a known drug of abuse). The findings suggest that sumatriptan, while psychoactive, has a low abuse potential.

A Balanced Approach to Medication Use

This study demonstrates the importance of carefully evaluating the potential for abuse with any medication. The researchers found that sumatriptan, while having some psychoactive effects, was not identified as a prototypic drug of abuse. This finding is reassuring for patients and healthcare providers who rely on sumatriptan to manage migraines and cluster headaches.

Understanding Medication Safety

It's important to use medications responsibly and follow your healthcare provider's instructions carefully. This study highlights the complexities of medication use and the need for ongoing research to ensure that medications are safe and effective. Open communication with your doctor is crucial for understanding your medications and managing potential risks.

Dr.Camel's Conclusion

Like a traveler navigating a desert oasis, we must approach medications with a balanced perspective. This study reminds us that while some medications may have potential for abuse, others are safe and effective when used appropriately. It's essential to work closely with your healthcare provider to ensure you receive the best possible care.
Date :
  1. Date Completed 1993-01-14
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

1333934

DOI: Digital Object Identifier

10.1038/clpt.1992.202

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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