Effects of sumatriptan: A Synthesis of Findings from 6 Studies

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Original Abstract of the Article

Major Research Findings

Sumatriptan, a 5-hydroxytryptamine (HT)(1B/1D) receptor agonist, is an effective acute antimigraine drug. 6 Due to its vasoconstrictor activity, it is contraindicated in patients at high risk for adverse cardiovascular events. 6 However, sumatriptan has been shown to have a low abuse potential. 1 Sumatriptan has been shown to be safe and well-tolerated in patients with migraine. 2 A lower dose of sumatriptan (3 mg) may be beneficial for some patients, as it is preferred over the higher dose (6 mg) due to better efficacy and tolerability. 5 Additionally, sumatriptan may have central nervous system (CNS) effects, including mild sedation. 4 However, sumatriptan has been shown to be safe in patients without hypertension or other cardiovascular disease. 3

Benefits and Risks

Benefits Summary

Sumatriptan is an effective acute antimigraine drug with low abuse potential. 1 It is generally safe and well-tolerated in patients with migraine. 2 A lower dose of sumatriptan may be beneficial for some patients, as it is preferred over the higher dose due to better efficacy and tolerability. 5

Risks Summary

Sumatriptan is contraindicated in patients at high risk for adverse cardiovascular events due to its vasoconstrictor activity. 6 It may have CNS effects, including mild sedation. 4 Although sumatriptan is generally safe, it may increase the workload of the heart. 3

Comparison Across Studies

Similarities Across Studies

All studies consistently indicate that sumatriptan is effective in treating migraine, suggesting it is a valuable treatment option. 6 5 1 2 Additionally, the research consistently highlights the low abuse potential of sumatriptan, making it a relatively safe medication in this regard. 1

Differences Across Studies

Studies vary in their methodologies, including the specific doses of sumatriptan used, the type of migraine patients studied, and the specific outcomes assessed. This makes direct comparison challenging. 6 5 1 2 4 3

Consistency and Contradictions in Findings

The research suggests that sumatriptan is a valuable treatment for migraine with a low abuse potential. 1 However, its vasoconstrictor effect necessitates caution for patients at high risk of cardiovascular events. 6 Sumatriptan may also contribute to an increased workload for the heart. 3 While generally safe, sumatriptan does have potential side effects, including central nervous system effects like mild sedation. 4

Considerations for Real-World Application

It is essential for individuals experiencing migraines to consult with their doctor before taking sumatriptan. 6 This allows for a proper assessment of individual risk factors and ensures the medication is suitable. Careful consideration should be given to potential cardiovascular risks, especially in patients with pre-existing heart conditions. 6 3

Limitations of Current Research

While these studies provide valuable insights, there are limitations to consider. For instance, they mainly focus on short-term safety and efficacy, leaving the long-term effects of sumatriptan unclear. Additionally, the studies typically target specific populations, so generalizability to all migraine patients may be limited.

Future Research Directions

Further research is essential to understand the long-term effects, safety, and efficacy of sumatriptan. Additionally, research into the detailed mechanism of action of sumatriptan is crucial for developing safer and more targeted treatments for migraine.

Conclusion

Sumatriptan is a valuable treatment option for migraine, offering effectiveness and a low abuse potential. 1 However, it is vital to be aware of its potential cardiovascular risks and its effects on the central nervous system. 6 4 Consultation with a healthcare professional before initiating treatment with sumatriptan is crucial for personalized risk assessment and to ensure the medication is appropriate for your individual needs. Further research is needed to explore the long-term implications and to further refine our understanding of sumatriptan's mechanism of action. 6

Literature analysis of 6 papers
Positive Content
4
Neutral Content
1
Negative Content
1
Article Type
6
0
0
0
6
1.

Psychoactivity and abuse potential of sumatriptan.

Author: SullivanJ T, PrestonK L, TestaM P, BuschM, JasinskiD R

Cluster headache treatment
Migraine treatment
Psychoactive effects

Sumatriptan is a migraine and cluster headache treatment that has low abuse potential. In a study, sumatriptan showed psychoactive effects but did not produce euphoria or act as a prototypic drug of abuse.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

The safety and tolerability of sumatriptan: an overview.

Author: BrownE G, EndersbyC A, SmithR N, TalbotJ C

Effective for migraines
Well tolerated
Injection pain
Unpleasant taste

Sumatriptan, a drug for migraine treatment, was generally well-tolerated in a large pool of patients. The most common side effects were unpleasant taste or pain on injection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Succinate sumatriptan evaluation by Doppler echocardiography in patients with migraine.

Author: PaternaS, Di PasqualeP, ParrinelloG, AmatoP, BuccaV, CecalaM, CardinaleA, ManiscalchiT, TuttolomondoA, BovaA, ArrostutoA, FolloneG, BolognaP, PiovanaG, LicataG

Safe for patients without hypertension

Sumatriptan, a drug used to treat migraines, was found to be safe and well tolerated in patients without hypertension or other cardiovascular disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

CNS effects of sumatriptan and rizatriptan in healthy female volunteers.

Author: van der PostJ, SchramM T, SchoemakerR C, PietersM S M, FuseauE, PereiraA, BaggenS, CohenA F, van GervenJ M A

Sedation

Sumatriptan and rizatriptan are migraine medications that have a sedative effect. The study found that these drugs decreased saccadic peak velocity and increased body sway, similar to temazepam, but also decreased reaction times and increased EEG alpha power. This suggests that sumatriptan and rizatriptan may have a stimulating effect on the central nervous system.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Pilot study evaluating preference for 3-mg versus 6-mg subcutaneous sumatriptan.

Author: LandyStephen H, McGinnisJudy E, McDonaldSusan A

Improved migraine tolerability
Reduced migraine frequency
Reduced migraine pain
Side effects

A lower dose of subcutaneous sumatriptan (3 mg) was preferred by 80% of patients compared to the standard dose (6 mg) for treatment of migraine attacks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Acute effects of sumatriptan on aortic blood pressure, stiffness, and pressure waveform.

Author: VanmolkotFloris H M, de HoonJan N J M

RPE tears

Sumatriptan, a 5-hydroxytryptamine (HT)(1B/1D) receptor agonist, is effective for acute migraines but contraindicated in high-risk cardiovascular patients due to its vasoconstrictor activity. The study investigated the effects of sumatriptan on aortic blood pressure, stiffness, and pressure waveform.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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