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Reactogenicity and immunogenicity of three different lots of a hepatitis A vaccine.

Author: BockH L, GmelinK, HofmannF, KallinowskiB, MaiwaldH, MoriabadiF K, ScheiermannN, SticklH, TheilmannL, WohlandB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Three lots of inactivated hepatitis A vaccine were found to be safe, well tolerated, and equally immunogenic in a study of 204 healthy individuals.
Paper Details　
Original Abstract of the Article :
To study the immunogenicity and reactogenicity of an inactivated hepatitis A vaccine, 204 healthy individuals were randomized into three equal groups, each to receive a different vaccine lot. Each subject received a total of three doses, each of 720 ELISA units of hepatitis A vaccine HM175, accordin...See full text at original site
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引用元：
https://doi.org/10.1016/0264-410x(92)90567-4

データ提供：米国国立医学図書館（NLM）

Hepatitis A Vaccination: A Safe and Effective Oasis in the Desert

The world of infectious diseases is a vast and challenging desert, where hepatitis A poses a significant threat. This study delves into the safety and efficacy of an inactivated hepatitis A vaccine, evaluating its reactogenicity and immunogenicity. The authors conducted a randomized study involving 204 healthy individuals, administering three doses of the vaccine according to a specific schedule. Their findings demonstrate that the vaccine is safe, well-tolerated, and highly effective in inducing protective antibodies against hepatitis A virus. This research is like a well-stocked caravan, providing a valuable tool for protecting individuals from the dangers of this infectious disease.

Hepatitis A Vaccination: A Safe and Effective Journey

The study's findings confirm the safety and effectiveness of the inactivated hepatitis A vaccine. The authors observed a high rate of seroconversion, indicating that the vaccine effectively induced protective immunity against the virus. This discovery is like finding a safe and reliable path through the desert of hepatitis A infection, leading to a future free from this debilitating disease.

From Desert to Oasis: Hepatitis A Vaccination's Impact

This research highlights the vital role of vaccination in protecting individuals from infectious diseases. The authors' findings demonstrate the effectiveness of the inactivated hepatitis A vaccine, offering a valuable tool for preventing this serious illness. This research is like a beacon of hope in the desert of infectious diseases, reminding us of the power of vaccination to protect our health.

Dr. Camel's Conclusion

This study is a testament to the power of vaccination in conquering infectious diseases. The findings demonstrate the safety and effectiveness of the inactivated hepatitis A vaccine, offering a valuable tool for protecting individuals from this serious illness. This research is like a refreshing spring in the desert of infectious diseases, reminding us of the importance of vaccination in maintaining our health.

Date :
  1. Date Completed 1993-02-01
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

1335644

DOI: Digital Object Identifier

10.1016/0264-410x(92)90567-4

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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