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In-vitro bactericidal activity of four oral antibiotics against pathogens responsible for acute otitis media in children.

Author: BingenE, BourgeoisF, DoitC, Lambert-ZechovskyN, Mariani-KurkdjianP

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Amoxycillin-clavulanic acid showed rapid bactericidal activity against common otitis media pathogens in vitro. Erythromycin had bacteriostatic effects on some bacteria but not others. Cefaclor had no bactericidal activity.
Paper Details　
Original Abstract of the Article :
This study was designed to test the in-vitro activity of four oral antibiotics against the four microorganisms most frequently isolated in acute otitis media: beta-lactamase-positive Haemophilus influenzae (N = 10), beta-lactamase-positive Moraxella catarrhalis (N = 10), penicillin-sensitive Strepto...See full text at original site
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引用元：
https://doi.org/10.1016/s0195-6701(05)80011-8

データ提供：米国国立医学図書館（NLM）

Antibiotic Activity Against Otitis Media Pathogens

This study investigates the in-vitro bactericidal activity of four oral antibiotics against common pathogens responsible for acute otitis media in children. It's like a scientist in a desert laboratory, carefully testing different weapons against a group of invading microbes. The authors tested the effectiveness of amoxycillin-clavulanic acid, cefaclor, erythromycin, and erythromycin/sulfisoxazole against Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae, and Staphylococcus aureus.

Amoxycillin-Clavulanic Acid Emerges as a Strong Contender

The study found that amoxycillin-clavulanic acid exhibited rapid bactericidal activity against all tested organisms, while the other antibiotics demonstrated either bacteriostatic effects or no bactericidal activity. This finding highlights the importance of selecting the right antibiotic to effectively combat otitis media.

Guiding Antibiotic Choice for Otitis Media

This research provides valuable information to guide antibiotic selection for treating acute otitis media in children. The findings suggest that amoxycillin-clavulanic acid may be the most effective treatment option based on its rapid bactericidal activity against common otitis media pathogens.

Dr.Camel's Conclusion

This study explores the in-vitro bactericidal activity of different antibiotics against otitis media pathogens, providing insights into their effectiveness against various microorganisms. The research underscores the importance of appropriate antibiotic selection for optimal treatment outcomes and the need for continued research to optimize antimicrobial therapy for otitis media.

Date :
  1. Date Completed 1993-03-02
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

1362754

DOI: Digital Object Identifier

10.1016/s0195-6701(05)80011-8

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Article Analysis
・Effects of erythromycin and sulfisoxazole
SNS
PICO Info
in preparation
Languages

English

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