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[A critical study of conditions for prescription and evaluation criteria of neuroleptic treatment in resistant schizophrenia].

Author: DollfusS, PetitM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A critical analysis of studies on clozapine for treatment-resistant schizophrenia highlighted the need for stringent criteria, including a longer duration of past neuroleptic treatment (more than 6 months), a longer placebo wash-out period (more than 6 weeks), and improvement with a second treatment after a first failed one. The study also pointed out that doses of neuroleptics used in comparison with clozapine are often too high, leading to side effects and reducing the benefits of clozapine.
Paper Details　
Original Abstract of the Article :
From the study of Kane et al. (1988), devoted to clozapine, a critical analysis of criteria of assessments about studies in treatment of resistant schizophrenic patients was drawn up. Therefore, among the inclusion criteria, the authors strengthen the necessity of a very long past neuroleptic treatm...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/1364078

データ提供：米国国立医学図書館（NLM）

Navigating the Complexities of Resistant Schizophrenia

This research delves into the challenging world of resistant schizophrenia, a condition that often proves difficult to treat with conventional antipsychotic medications. The study critically analyzes the criteria for diagnosing and treating resistant schizophrenia, examining the role of past treatment history, drug-free improvement, placebo wash-out periods, and medication dosages. The researchers advocate for a more nuanced and rigorous approach to the diagnosis and treatment of this complex condition.

Resistant Schizophrenia: A Labyrinth of Treatment Options

The study highlights the need for carefully defined criteria for diagnosing and treating resistant schizophrenia, a condition that can be challenging to manage. This approach, like a caravan navigating a complex desert labyrinth, requires a thorough understanding of the terrain and careful consideration of each step taken.

Effective Treatment for Resistant Schizophrenia: A Multi-faceted Approach

This research emphasizes the importance of a comprehensive and individualized approach to treating resistant schizophrenia, a condition that requires tailored treatment strategies and close monitoring. It underscores the need for ongoing research to develop more effective and individualized treatments for this challenging condition.

Dr.Camel's Conclusion

This research delves into the complexities of resistant schizophrenia, highlighting the need for a more refined approach to diagnosis and treatment. It reminds us that mental health conditions, like a vast desert, require careful exploration, a deep understanding of the landscape, and a personalized approach to ensure the best possible outcomes.

Date :
  1. Date Completed 1993-11-19
  2. Date Revised 2006-11-15
Further Info :

Pubmed ID

1364078

DOI: Digital Object Identifier

1364078

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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