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Multimodality treatment in stage IV squamous cell carcinoma of the head and neck. A long-term follow-up.

Author: BergmannI, KlimaA, SzepesiS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

In a study of 114 patients with advanced head and neck cancer, a combined treatment of chemotherapy and radiotherapy with or without a radiosensitizing agent was investigated. While only 4 patients survived (3 from the radiosensitizing group and 1 from the chemotherapy group) after 42-58 months, complete response after the radiosensitizing agent was associated with superior long-term disease-free survival compared to chemotherapy.
Paper Details　
Original Abstract of the Article :
We treated 114 patients with advanced inoperable head and neck cancer with a combined-modality protocol that included two cycles of chemotherapy followed by radiotherapy or three chemotherapy and in 18 patients with a radiosensitizing agent. At the beginning of the treatment all but one patient pres...See full text at original site
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引用元：
https://doi.org/10.1017/s0022215100119140

データ提供：米国国立医学図書館（NLM）

Multimodality Treatment in Stage IV Squamous Cell Carcinoma of the Head and Neck: A Long-Term Follow-Up

Squamous cell carcinoma of the head and neck (SCCHN), a type of cancer that affects the tissues lining the head and neck, can be particularly challenging to treat, especially in advanced stages. This research investigated the long-term outcomes of a multimodality treatment protocol for stage IV inoperable SCCHN. The study involved 114 patients who received a combination of chemotherapy and radiotherapy, with some patients also receiving a radiosensitizing agent. The study found that while the overall survival rate was low, with only four patients alive at a follow-up of 42-58 months, complete response after the radiosensitizing agent correlated with superior prolonged disease-free survival compared to complete responses after chemotherapy. The study highlights the potential benefits of multimodality treatment approaches for advanced SCCHN, while acknowledging the challenges posed by this aggressive disease.

Investigating Multimodality Treatment Strategies for Advanced SCCHN

This research provides valuable insights into the long-term outcomes of multimodality treatment for advanced SCCHN, highlighting the potential benefits of a combined approach. The study's findings contribute to the ongoing search for effective treatment strategies for this challenging disease, particularly in the context of advanced stages.

Facing the Challenges of Cancer Treatment: Hope and Resilience

Treating cancer is a difficult journey, often requiring multiple treatment modalities and a strong support system. This research highlights the importance of multimodality approaches, while acknowledging the limitations and challenges of treating advanced SCCHN. By continuing to explore new treatments and approaches, we can provide hope and support to those facing this challenging disease.

Dr.Camel's Conclusion

This study, like a caravan navigating a vast desert, highlights the importance of a multifaceted approach to overcoming significant challenges. By combining different treatment modalities, we can provide patients with the best possible chance of survival and improve their quality of life. This research underscores the ongoing search for effective treatments for advanced SCCHN, offering hope for improved outcomes and a brighter future for those affected by this disease.
Date :
  1. Date Completed 1992-05-19
  2. Date Revised 2019-07-24
Further Info :

Pubmed ID

1373429

DOI: Digital Object Identifier

10.1017/s0022215100119140

Related Literature

Article Analysis
・Effective treatment of head and neck cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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