Effective treatment of head and neck cancer: A Synthesis of Findings from 89 Studies

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Original Abstract of the Article

Major Research Findings

Several key findings have emerged regarding nutritional support for head and neck cancer patients undergoing radiotherapy. 21 found that squamous cell carcinoma of the head and neck (HNSCC) is associated with weight loss before, during, and after radiotherapy (RT). 77 suggests that patients with head and neck cancer (HNC) often experience functional changes due to the malignancy itself or its treatment, which can affect structures involved in speech, breathing, chewing, swallowing, and saliva production. This can lead to limited food intake, contributing to weight loss, muscle mass loss, anorexia, malnutrition, fatigue, and anemia, ultimately resulting in cancer cachexia syndrome. 44 found that swallowing disorders, dysgeusia (altered taste), oral mucositis, and xerostomia (dry mouth) can impact nutritional status, oral intake, and weight loss in HNC patients. 15 confirmed low serum levels of leptin and high serum levels of proinflammatory cytokines in advanced stage cancer patients, suggesting a potential link to compromised nutritional status. 19 indicates that radiation therapy and concurrent chemotherapy (CRT) for head and neck cancer can impact functions like swallowing, mouth opening, nutrition, pain, and quality of life, highlighting the need for techniques or strategies to alleviate or rehabilitate functional losses associated with CRT.

Treatment Summary

Research highlights various treatments for head and neck cancer, including surgery, radiation therapy, chemotherapy, concurrent chemotherapy, interferon α2b, retinoic acid, hydroxyurea, mucositis prophylaxis, nutritional therapy, and speech therapy. 11 states that radiotherapy, alone or in combination with surgery, plays a crucial role in treating head and neck cancers. 56 mentions that alongside standard treatments like cytotoxic chemotherapy, monoclonal antibodies, and tyrosine kinase inhibitors, advancements in immunotherapy are being explored. 15 introduces a treatment regimen for advanced head and neck cancer that involves induction chemotherapy with cisplatin, fluorouracil (5-FU), l-leucovorin, and interferon α2b (PFL-IFN) followed by 7 cycles of 5-FU, hydroxyurea, and concurrent radiation (FHX). 48 suggests intraoperative radiation therapy (IORT) as a potential additional therapy for head and neck cancer. 19 emphasizes the need for techniques or strategies to mitigate or rehabilitate functional losses associated with radiation therapy and concurrent chemotherapy (CRT) for head and neck cancer. 82 evaluates recent advancements in telerehabilitation for managing patients with head and neck cancer during and after their treatment.

Benefits and Risks

Benefits Summary

Selecting the appropriate treatment for head and neck cancer can yield benefits like local tumor control, improved survival rates, preservation of organ function, and enhanced quality of life. 11 states that radiotherapy alone can cure many patients with localized tumors, allowing them to maintain full organ function. 56 notes the ongoing development of newer treatment modalities such as immunotherapy. 15 describes a treatment regimen for advanced head and neck cancer that shows potential for effectiveness. 19 highlights the necessity of strategies to address functional losses associated with radiation therapy and concurrent chemotherapy (CRT). 82 examines the advancement of telerehabilitation in managing patients with head and neck cancer during and after treatment.

Risks Summary

Treatment for head and neck cancer can involve risks such as weight loss, muscle mass loss, anorexia, malnutrition, fatigue, anemia, swallowing disorders, dysgeusia, oral mucositis, xerostomia, trismus (difficulty opening the mouth), and lymphopenia (low white blood cell count). 21 reports weight loss in HNSCC patients before, during, and after radiotherapy. 77 emphasizes that functional changes due to cancer or its treatment can lead to nutritional deficiencies and associated complications. 44 identifies swallowing disorders, dysgeusia, oral mucositis, and xerostomia as potential contributors to poor nutrition, oral intake, and weight loss in HNC patients. 15 observes low leptin and high proinflammatory cytokine levels in advanced-stage cancer patients, potentially linked to poor nutritional status. 19 warns that radiation therapy and concurrent chemotherapy (CRT) can negatively impact functions like swallowing, mouth opening, and overall quality of life. 35 mentions the possibility of radiation-induced trismus. 74 notes that radiotherapy can lead to lymphopenia.

Research Comparisons

Research Similarities

Many studies commonly utilize treatments like surgery, radiation therapy, chemotherapy, and concurrent chemotherapy for head and neck cancer. Similarly, they often identify side effects such as weight loss, swallowing difficulties, dysgeusia, oral mucositis, and xerostomia.

Research Differences

Studies vary in their focus on cancer stage, treatment methods, and how they assess side effects, leading to differing results. For example, 11 suggests that radiotherapy alone can effectively treat localized tumors. 15 presents a specific regimen for advanced-stage head and neck cancer, indicating potential effectiveness. 44 highlights the impact of swallowing disorders, dysgeusia, oral mucositis, and xerostomia on nutritional status. 19 emphasizes the need for strategies to manage functional losses associated with radiation therapy and concurrent chemotherapy (CRT).

Consistency and Contradictions in Findings

Inconsistent findings across studies on head and neck cancer treatment can arise due to variations in treatment methods and side effect assessment approaches. For instance, some studies report successful outcomes with radiotherapy alone, while others favor a combined approach with chemotherapy. Addressing these inconsistencies necessitates larger-scale studies and standardized evaluation methods.

Real-World Applications and Considerations

Head and neck cancer treatments are individualized, depending on the patient's condition, cancer type, and stage. It's crucial to consult with a doctor to determine the most suitable treatment option. It's also essential to manage treatment side effects carefully. If you experience weight loss, swallowing problems, or other symptoms, consult your doctor for appropriate management strategies.

Limitations of Current Research

Research on head and neck cancer treatment remains in progress and needs further expansion. Developing standardized assessment methods is also an ongoing challenge.

Future Research Directions

Future research in head and neck cancer treatment should focus on:

  • Developing new treatment options
  • Exploring ways to prevent and alleviate side effects
  • Standardizing assessment methods for improved consistency
  • Reducing the cost of treatment

Conclusion

Head and neck cancer can be effectively treated, improving survival rates. However, treatment involves potential side effects, so it's vital to consult your doctor to determine the best course of action for your specific situation.

Treatment List

Surgery, Radiation Therapy, Chemotherapy, Concurrent Chemotherapy, Interferon α2b, Retinoic Acid, Hydroxyurea, Mucositis Prophylaxis, Nutritional Therapy, Speech Therapy

Keywords
Benefit Keywords
Increased response rate
Reduced toxicity
1
Prolonged disease-free survival
2
Improved tumor control
Reduced normal tissue damage
3
Improved local control
4
Second primary detection
5
Improved locoregional control
Improved survival
6
Improved understanding of head and neck cancer treatment
7
Improved local control
8
Response improvement
Survival improvement
9
Improved complete remission
Reduced local failure rates
10
Improved head and neck cancer treatment
11
Improved head and neck cancer treatment
12
Improved survival
13
Improved locoregional control
Improved tumor control
14
Organ preservation
Response rate
15
None reported
16
Head and neck cancer treatment
17
Improved head and neck squamous cell carcinoma treatment
18
Improved head and neck cancer treatment
19
Salivary flow improvement
20
Improved nutritional status
21
Head and neck cancer treatment
22
Improved local control
Improved survival
23
Oral cancer treatment
25
Improved locoregional control
Improved survival
26
Head and neck cancer treatment
27
Oral cancer treatment
28
Head and neck cancer treatment
29
Head and neck cancer treatment
33
Improved hyposalivation
Improved xerostomia
34
Preventive swallowing exercises
36
HNC treatment
37
Quality of life
Treatment decisions
38
Molecular agents
39
Head and neck cancer treatment
41
Guidelines for head and neck cancer survivorship
42
Cost-effective
Fewer operations
Similar survival
43
Head and neck cancer treatment
44
Head and neck cancer treatment
46
Head and neck cancer treatment
47
Improved survival
Local control of disease
48
Head and neck cancer treatment
49
Head and neck cancer treatment
50
Improved QOL
Reduced dry mouth
51
Mucositis Reduction
52
HNC treatment
Improved response rate
Improved survival
53
Improved HNC treatment
54
Improved survival
55
HNC treatment
56
Improved QoL
Improved functional capacity
Reduced fatigue
57
Head and neck lymphedema treatment
58
None reported
59
HaNC treatment
62
Head and neck cancer treatment
63
HNC treatment
64
Reduced mucositis pain
65
Hypofractionated RT for HNSCC
67
Tongue cancer treatment
68
3D printed TRDs for HNC RT
69
Improved mouth opening
Increased adherence
70
Swallowing therapy for HNC
71
HFRT for H&N malignancies
72
Improved local control
Improved overall survival
73
HNC treatment
RIL treatment
74
Head and neck cancer treatment
75
Trismus release
76
HNC treatment
77
HNC treatment
78
Head and neck cancer treatment
79
Weight loss mitigation
81
High patient satisfaction
Telerehabilitation efficacy
82
HNSCC survival
83
HNCaL rehabilitation
84
HNC treatment
Quality of life improvement
85
Improved HNC diagnosis
Improved survival
86
Head and neck cancer treatment
87
HNC treatment
88
HNC treatment
89
Risk Keywords
Radiotherapy effect
1
Late-appearing major complications
4
Late toxicity
8
Smoking during radiation
9
Increased acute mucositis
10
Increased staff demands
11
Mucositis
Neutropenia/thrombocytopenia
Significant toxicity
15
Increased morbidity
Weight loss
16
Head and neck squamous cell carcinomas
18
Head and neck cancer
19
None reported
21
Speech degeneration
Voice degeneration
24
Weight loss
30
Head and neck cancer
Trismus
35
Xerostomia
38
Locoregionally advanced head and neck cancer
39
Early death risk
40
Decreased survival
45
Second primary tumors
53
Heterogeneity in defining delay
55
Deglutition disorders
59
Oral dysfunction in HNC
60
Second primary tumors
61
ORN development
62
High morbidity
63
Trismus
70
Severe toxicities
73
HNC progression
Reduced survival
74
Smoking and other health factors in HNC patients
80
Literature analysis of 89 papers
Positive Content
75
Neutral Content
6
Negative Content
8
Article Type
31
17
51
30
86
1.

A kinetically based logical approach to the chemotherapy of head and neck cancer.

Author: PriceL A, HillB T

Increased response rate
Reduced toxicity
Radiotherapy effect

Chemotherapy with or without adriamycin was effective in treating advanced head and neck cancer, with a higher response rate in the group receiving adriamycin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Multimodality treatment in stage IV squamous cell carcinoma of the head and neck. A long-term follow-up.

Author: KlimaA, BergmannI, SzepesiS

Prolonged disease-free survival

In a study of 114 patients with advanced head and neck cancer, a combined treatment of chemotherapy and radiotherapy with or without a radiosensitizing agent was investigated. While only 4 patients survived (3 from the radiosensitizing group and 1 from the chemotherapy group) after 42-58 months, complete response after the radiosensitizing agent was associated with superior long-term disease-free survival compared to chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Optimized radiotherapy for head and neck cancer.

Author: RussellN S, BartelinkH

Improved tumor control
Reduced normal tissue damage

Optimizing radiation therapy for head and neck tumors requires combining radiation biology and physics to maximize tumor control while minimizing normal tissue damage. Techniques to predict treatment response based on tumor sensitivity and growth characteristics are gaining importance. Three-dimensional treatment planning allows for dose escalation and reduced normal tissue damage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

6.

The EORTC randomized trial on three fractions per day and misonidazole in advanced head and neck cancer: prognostic factors.

Author: Van den BogaertW, van der SchuerenE, HoriotJ C, De VilhenaM, SchraubS, SvobodaV, ArcangeliG, de PauwM, van GlabbekeM

Improved locoregional control
Improved survival

A study comparing multiple fractions per day (MFD) radiation therapy with or without misonidazole to conventional fractionation for advanced head and neck cancer did not find significant differences in treatment results. However, it identified key factors influencing prognosis, such as performance status, tumor site, stage, and volume.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppo di Studio sui Tumori della Testa e del Collo.

Author: PaccagnellaA, OrlandoA, MarchioriC, ZoratP L, CavanigliaG, SileniV C, JirilloA, TomioL, FilaG, FedeA

Improved understanding of head and neck cancer treatment

Current standard treatments for advanced head and neck cancer (surgery with radiation or radiation alone) have not had good results. Several studies investigating the use of chemotherapy before surgery (induction chemotherapy) have not shown improved survival.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Report of long-term follow-up in a randomized trial comparing radiation therapy and radiation therapy plus hyperthermia to metastatic lymph nodes in stage IV head and neck patients.

Author: ValdagniR, AmichettiM

Improved local control
Late toxicity

This study examines the long-term results of a previous randomized trial comparing conventional radiation therapy alone versus radiation therapy combined with hyperthermia for treating inoperable metastatic lymph nodes in head and neck cancer patients. The analysis focuses on the long-term control of the disease, its impact on survival, and the occurrence of late side effects from these treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer.

Author: BrowmanG P, WongG, HodsonI, SathyaJ, RussellR, McAlpineL, SkingleyP, LevineM N

Response improvement
Survival improvement
Smoking during radiation

Patients with head and neck cancer who continue to smoke during radiation therapy have lower rates of response and survival than patients who do not smoke during radiation therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Conventional vs accelerated fractionation in head and neck cancer.

Author: DobrowskyW, DobrowskyE, NaudéJ, MillesiW, PavelkaR, KautzkyM, GraslM, KöhlerW, WilsonG D, ReichelM

Improved complete remission
Reduced local failure rates
Increased acute mucositis

This study compared three different radiation therapy regimens for treating head and neck cancer: conventional fractionation (CF), continuous hyperfractionated accelerated radiation therapy (Vienna-CHART), and Vienna-CHART with the addition of mitomycin C (V-CHART + MMC). Vienna-CHART resulted in a higher complete remission rate compared to CF, but there was no significant difference in local failure rates between the three groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Chemotherapy alternated with radiotherapy in the treatment of advanced head and neck carcinoma: predictive factors of outcome.

Author: SanguinetiG, CorvòR, SormaniM P, BenassoM, NumicoG, BacigalupoA, RossoR, VitaleV

Improved head and neck cancer treatment

This study examined 115 patients with advanced head and neck cancer (stages III and IV) who received alternating chemoradiotherapy. The study focused on how factors before treatment and during treatment influenced local-regional control (cancer not spreading in the treated area) and overall survival. Patients included in the analysis had a good performance status (PS ≤ 1) and received radiotherapy doses within a 5% range of what was planned.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

A comparison of radiotherapy or radiochemotherapy with symptomatic treatment alone in patients with advanced head and neck carcinomas.

Author: CarvalhoA L, SalvajoliJ V, KowalskiL P

Improved survival

This study compared the survival rates of patients with advanced, inoperable head and neck cancer who received either chemotherapy, radiation therapy, or no treatment. The study found that survival was significantly better for patients who received any type of treatment, regardless of the specific treatment type or response to treatment. This suggests that treatment, even in advanced stages, can improve survival for patients with head and neck cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancers.

Author: DobrowskyW, NaudéJ

Improved locoregional control
Improved tumor control

Radiation therapy is a common treatment for advanced head and neck cancers that cannot be surgically removed. However, the success rate of controlling the cancer in the local area is low, leading to the development of new approaches, including different radiation schedules and combination with chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Induction chemotherapy followed by concomitant chemoradiation therapy in advanced head and neck cancer: a phase II study for organ-sparing purposes evaluating feasibility, effectiveness and toxicity.

Author: MantovaniGiovanni, ProtoErnesto, MassaElena, MulasCarlo, MadedduClelia, MuraLoredana, MuduM Caterina, AstaraGiorgio, MurgiaViviana, GramignanoGiulia, FerreliLuca, CamboniPaolo, LussoMaria Rita, MocciMiria, ToreGiorgio, MuraManfredi, AmichettiMaurizio, MaccioAntonio

Organ preservation
Response rate
Mucositis
Neutropenia/thrombocytopenia
Significant toxicity

A study of 26 patients with stage IV head and neck cancer found that a sequential induction chemotherapy and chemoradiotherapy program was moderately active but significantly toxic. The overall response rate was 52.6% for induction chemotherapy and 58.3% for chemoradiotherapy. The median overall survival time was 9 months. The treatment was associated with significant toxicity, mainly mucositis and neutropenia/thrombocytopenia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Early morbidity after radiotherapy with or without chemotherapy in advanced head and neck cancer. Experience from four nonrandomized studies.

Author: BieriSabine, BentzenSoeren M, HugueninPia, AllalAbdelkarim S, CozziLuca, LandmannChristine, MonneyMay, BernierJacques

None reported
Increased morbidity
Weight loss

Early treatment-related morbidity was significantly higher after combined radiotherapy and chemotherapy (RT + CT) compared to radiotherapy alone (RT) for head and neck squamous cell carcinoma. This included increased skin, mucosa, larynx, salivary gland, dysphagia, and weight loss complications. The prevalence of grade 2 morbidity was also higher after RT + CT.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer: a randomised comparison.

Author: SooK-C, TanE-H, WeeJ, LimD, TaiB-C, KhooM-L, GohC, LeongS-S, TanT, FongK-W, LuP, SeeA, MachinD

Head and neck cancer treatment

The study compared concurrent combination chemotherapy and radiotherapy with surgery and adjuvant radiotherapy in patients with stage III/IV nonmetastatic squamous cell head and neck cancer. Combination chemotherapy and concurrent irradiation with salvage surgery was not superior to conventional surgery and postoperative radiotherapy for resectable advanced squamous cell head and neck cancer, but this treatment schedule could be attempted for certain subsites.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

The role of salvage surgery in organ preservation strategies in advanced head and neck cancer.

Author: DequanterD, LothairePh

Improved head and neck squamous cell carcinoma treatment
Head and neck squamous cell carcinomas

Head and neck cancers represent a significant group of tumors where combining different treatments can improve survival rates. Surgery is still important for advanced cancers in order to preserve organs whenever possible.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Phase III randomized study: oral pilocarpine versus submandibular salivary gland transfer protocol for the management of radiation-induced xerostomia.

Author: JhaNaresh, SeikalyHadi, HarrisJeffrey, WilliamsDavid, SultanemKhalil, HierMichael, GhoshSunita, BlackMartin, ButlerJames, SutherlandDonna, KerrPaul, BarnabyPam

Salivary flow improvement

Submandibular salivary gland transfer was superior to pilocarpine in managing radiation-induced xerostomia in a phase III study, demonstrating increased salivary flow and improved quality of life.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review.

Author: GargShashank, YooJohn, WinquistEric

Improved nutritional status
None reported

Data from RCTs supporting the use of interventions to optimize nutrition in HNSCC patients receiving RT are limited. Potentially effective interventions have not been tested comparatively or in combination.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy.

Author: NugentBrenda, LewisSian, O'SullivanJoe M

Head and neck cancer treatment

This study examines the optimal method of enteral feeding for patients with head and neck cancer who require nutrition support during radiotherapy or chemoradiotherapy due to treatment-related toxicity or tumor obstruction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Radiotherapy alone or with concomitant daily low-dose carboplatin in locally advanced, unresectable head and neck cancer: definitive results of a phase III study with a follow-up period of up to ten years.

Author: Ruo ReddaMaria Grazia, RagonaRiccardo, RicardiUmberto, BeltramoGiancarlo, RampinoMonica, GabrielePietro, AllisSimona, La PortaMaria Rosa, MoroGregorio, MelanoAntonella, GabrieleAnna Maria, TessaMariella, FossatiPiero, OrecchiaRoberto

Improved local control
Improved survival

This prospective multicentric randomized trial evaluated the efficacy of a radiochemotherapy combination for the treatment of unresectable head and neck squamous cell carcinoma.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Voice and speech outcomes of chemoradiation for advanced head and neck cancer: a systematic review.

Author: JacobiIrene, van der MolenLisette, HuiskensHermelinde, van RossumMaya A, HilgersFrans J M

Speech degeneration
Voice degeneration

This review examined the effects of chemotherapy and radiation therapy (CRT) on voice and speech in patients with advanced head and neck cancer. The review found that voice and speech deteriorated during treatment, improved slightly after treatment, and often exceeded pre-treatment levels after a year or more. However, these functions did not fully return to normal. Due to inconsistent measurements and a lack of pre-treatment data, further research with standardized assessments is needed to understand the impact of CRT on voice and speech.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.

Author: FurnessSusan, GlennyAnne-Marie, WorthingtonHelen V, PavittSue, OliverRichard, ClarksonJan E, MacluskeyMichaelina, ChanKelvin Kw, ConwayDavid I,

Oral cancer treatment

Cancers of the mouth and throat are often grouped together as oral cancers or head and neck cancers. Treatment for mouth cancer typically involves surgery followed by radiation therapy. Throat cancers are often more advanced at diagnosis and are treated with radiation or a combination of chemotherapy and radiation. Surgery for mouth cancer can cause disfigurement, and both surgery and radiation can lead to significant problems with eating, drinking, and speaking. New chemotherapy drugs, combinations of medications, and changes in the timing of surgery, radiation, and chemotherapy may potentially improve survival and quality of life for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Hyperfractionated or accelerated radiotherapy for head and neck cancer.

Author: BaujatBertrand, BourhisJean, BlanchardPierre, OvergaardJens, AngKian K, SaundersMichelle, Le MaîtreAurélie, BernierJacques, HoriotJean Claude, MaillardEmilie, PajakThomas F, PoulsenMichael G, BourredjemAbderrahmane, O'SullivanBrian, DobrowskyWerner, AndrzejHliniak, SkladowskiKrzystof, HayJohn H, PintoLuiz Hj, FuKaren K, FallaiCarlo, SylvesterRichard, PignonJean Pierre,

Improved locoregional control
Improved survival

Altered fractionation radiotherapy improved survival in patients with head and neck squamous cell carcinoma. In a meta-analysis of 15 trials involving 6515 patients, altered fractionation radiotherapy was associated with a 3.4% absolute benefit in five-year survival. Hyperfractionated radiotherapy was found to be the most beneficial, with an 8% improvement in five-year survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Hyperthermia with radiation in the treatment of locally advanced head and neck cancer: a report of randomized trial.

Author: HuilgolNagraj G, GuptaSapna, SridharC R

Head and neck cancer treatment

Head and neck cancer is a major cause of death for men in India. While surgery and radiation are common treatments, combined chemo-radiation is now the standard approach for many types of head and neck cancers. This approach helps preserve both function and structure but comes with increased short-term and long-term side effects. Radiation combined with hyperthermia offers a potential alternative that could achieve similar results with fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.

Author: FurnessSusan, GlennyAnne-Marie, WorthingtonHelen V, PavittSue, OliverRichard, ClarksonJan E, MacluskeyMichaelina, ChanKelvin Kw, ConwayDavid I

Oral cancer treatment

Cancers of the mouth and throat are often grouped together as oral or head and neck cancers. Treatment for mouth cancer usually involves surgery followed by radiation, while throat cancer, often diagnosed at a more advanced stage, is typically treated with radiation or combined chemotherapy and radiation. These treatments can be disfiguring and cause significant side effects, impacting speech, eating, and drinking. New chemotherapy drugs, combinations of treatments, and changes in the order of treatments could potentially lead to improved survival and quality of life for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Targeted therapy in head and neck cancer.

Author: BianchiniChiara, CiorbaAndrea, PelucchiStefano, PivaRoberta, PastoreAntonio

Head and neck cancer treatment

This review examines new understanding of how head and neck cancers develop and spread and discusses potential targeted treatments. Cancer cells often become resistant to current treatments and can return, posing a significant challenge for treating aggressive and metastatic cancers. While targeted treatments using antibodies are already used for certain blood cancers, these approaches are now being applied to solid tumors like head and neck cancers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Weight loss in patients with head and neck cancer during and after conventional and accelerated radiotherapy.

Author: OttossonSandra, ZackrissonBjörn, KjellénElisabeth, NilssonPer, LaurellGöran

Weight loss

There was no difference in weight loss between two radiotherapy (RT) fractionation schedules (conventional vs. accelerated) in patients with squamous cell carcinoma of the head and neck (SCCHN). Weight loss in these patients is multifactorial and the nadir of weight loss occurred at five months after the termination of treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy.

Author: NugentBrenda, LewisSian, O'SullivanJoe M

This review examines the optimal method of enteral feeding for patients with head and neck cancer undergoing radiotherapy or chemoradiotherapy. Due to treatment-related toxicity and obstruction, oral nutrition may not be sufficient.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Dental extractions prior to radiotherapy to the jaws for reducing post-radiotherapy dental complications.

Author: EliyasShiyana, Al-KhayattAhmed, PorterRichard W J, BriggsPeter

The review found no randomized controlled trials to assess the effect of extracting teeth prior to radiotherapy compared to leaving teeth in the mouth during radiotherapy to the jaws.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Psychosocial interventions for patients with head and neck cancer.

Author: SempleCherith, ParahooKader, NormanAlyson, McCaughanEilis, HumphrisGerry, MillsMoyra

Head and neck cancer treatment

Head and neck cancer can cause significant emotional and mental distress. The unique challenges of this cancer, affecting eating, speaking, and breathing, can make it particularly difficult to cope. However, there's a lack of clear evidence on the effectiveness of interventions designed to address the emotional and psychological distress experienced by patients with head and neck cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Management of radiotherapy-induced salivary hypofunction and consequent xerostomia in patients with oral or head and neck cancer: meta-analysis and literature review.

Author: LovelaceTiffany L, FoxNyssa F, SoodAmit J, NguyenShaun A, DayTerry A

Improved hyposalivation
Improved xerostomia

Cholinergic agonists, such as pilocarpine and cevimeline, are more effective in treating radiation-induced hyposalivation compared with salivary substitutes, hyperbaric oxygen, and acupuncture. However, salivary substitutes and hyperbaric oxygen were also found to subjectively improve patients' perception of xerostomia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

35.

Radiation-induced trismus in the ARTSCAN head and neck trial.

Author: LindblomUlrika, GärskogOla, KjellénElisabeth, LaurellGöran, Levring JäghagenEva, WahlbergPeter, ZackrissonBjörn, NilssonPer

Head and neck cancer
Trismus

Trismus, a common complication after head and neck cancer treatment, significantly impacts oral function and quality of life. This study investigates the long-term prevalence of trismus in patients treated with different radiation fractionation schedules. It also aims to model a dose-response relationship for trismus to better understand the link between radiation dose and trismus development.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Current assessment and treatment strategies of dysphagia in head and neck cancer patients: a systematic review of the 2012/13 literature.

Author: KraaijengaS A C, van der MolenL, van den BrekelM W M, HilgersF J M

Preventive swallowing exercises

Functional swallowing assessment has become standard of care for patients with head and neck cancer (HNC). More research is needed on preventive swallowing exercises.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

The economic burden of head and neck cancer: a systematic literature review.

Author: WissingerErika, GriebschIngolf, LungershausenJuliane, FosterTalia, PashosChris L

HNC treatment

This study reviews research on the costs associated with diagnosing and treating head and neck cancer (HNC) in adults. HNC treatment is complex, involving various specialists and therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

The humanistic burden of head and neck cancer: a systematic literature review.

Author: WissingerErika, GriebschIngolf, LungershausenJuliane, ByrnesMichael, TraversKarin, PashosChris L

Quality of life
Treatment decisions
Xerostomia

Head and neck cancer (HNC) and its treatment profoundly affect patients' quality of life. PRO scores decrease significantly from diagnosis through the treatment period, but generally recover to baseline in the first year post-treatment. Baseline PRO scores can predict clinical endpoints such as overall and progression-free survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Molecular targeting in combination with platinum-based chemoradiotherapy in head and neck cancer treatment.

Author: MöckelmannNikolaus, KriegsMalte, LörinczBalazs B, BuschChia-Jung, KnechtRainald

Molecular agents
Locoregionally advanced head and neck cancer

While platinum-based chemotherapy and radiation (CRT) are the standard treatments for advanced head and neck cancer (HNSCC), 70% of patients die within five years due to cancer returning in the same area or spreading to other parts of the body. To improve outcomes, researchers are exploring combining CRT with medications that target specific molecules in cancer cells.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Early death among head and neck cancer patients.

Author: FarneboLovisa, MalilaNea, MäkitieAntti, LaurellGöran

Early death risk

Advanced head and neck cancer (HNC) has a high mortality rate and treatment is often burdensome for patients and costly for healthcare systems. This study investigates the occurrence of early death (within the first 6 months after treatment) in HNC patients, aiming to identify the reasons for this phenomenon and inform treatment decisions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Up-front neck dissection followed by definitive (chemo)-radiotherapy in head and neck squamous cell carcinoma: Rationale, complications, toxicity rates, and oncological outcomes - A systematic review.

Author: ElicinOlgun, NisaLluís, Dal PraAlan, BojaxhiuBeat, CaversaccioMarco, SchmückingMichael, AebersoldDaniel M, GigerRoland

Head and neck cancer treatment

Lymph node involvement in head and neck cancer is a major factor affecting a patient's outcome. This review focuses on the role of neck dissection (ND) done before radiation and chemotherapy (chemo-radiotherapy, (C)RT), called up-front neck dissection (UFND). While the timing of ND after (C)RT has been studied, the effectiveness of UFND remains unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

American Cancer Society Head and Neck Cancer Survivorship Care Guideline.

Author: CohenEzra E W, LaMonteSamuel J, ErbNicole L, BeckmanKerry L, SadeghiNader, HutchesonKatherine A, StubblefieldMichael D, AbbottDennis M, FisherPenelope S, SteinKevin D, LymanGary H, Pratt-ChapmanMandi L

Guidelines for head and neck cancer survivorship

This guideline from the American Cancer Society provides recommendations for the care of head and neck cancer survivors. The guideline covers monitoring for recurrence, screening for second primary cancers, managing long-term and late effects, health promotion, and care coordination.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer.

Author: MehannaHisham, WongWai-Lup, McConkeyChristopher C, RahmanJoy K, RobinsonMax, HartleyAndrew G J, NuttingChristopher, PowellNed, Al-BoozHoda, RobinsonMartin, JunorElizabeth, RizwanullahMohammed, von ZeidlerSandra V, WieshmannHulya, HulmeClaire, SmithAlison F, HallPeter, DunnJanet,

Cost-effective
Fewer operations
Similar survival

PET-CT-guided surveillance is noninferior to planned neck dissection in patients with squamous-cell carcinoma of the head and neck who have advanced nodal disease and have received chemoradiotherapy. It results in fewer neck dissections and is more cost-effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

44.

The effects of swallowing disorders, dysgeusia, oral mucositis and xerostomia on nutritional status, oral intake and weight loss in head and neck cancer patients: A systematic review.

Author: BressanValentina, StevaninSimone, BianchiMonica, AleoGiuseppe, BagnascoAnnamaria, SassoLoredana

Head and neck cancer treatment

Treating head and neck cancer often involves a combination of therapies to preserve function and appearance. While treatments have improved, they can still cause side effects. This review examines the impact of swallowing problems, changes in taste, mouth sores, and dry mouth on nutrition, eating habits, and weight loss in people with head and neck cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Haemoglobin and creatinine values as prognostic factors for outcome of concurrent radiochemotherapy in locally advanced head and neck cancers : Secondary results of two European randomized phase III trials (ARO 95-06, SAKK 10/94).

Author: GhadjarPirus, PöttgenChristoph, JoosDaniela, HayozStefanie, BaumannMichael, BodisStephan, BudachWilfried, StuderGabriela, StrombergerCarmen, ZimmermannFrank, KaulDavid, PlasswilmLudwig, OlzeHeidi, BernierJacques, WustPeter, AebersoldDaniel M, BudachVolker

Decreased survival

Lower baseline hemoglobin is associated with poorer treatment outcomes in patients with locally advanced head and neck cancer. Higher baseline creatinine is associated with improved overall survival in patients who receive chemoradiation, but not in those who receive radiotherapy alone.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

46.

Therapeutic exercises for affecting post-treatment swallowing in people treated for advanced-stage head and neck cancers.

Author: PerryAlison, LeeSiew Hwa, CottonSusan, KennedyCatriona

Head and neck cancer treatment

Head and neck cancer treatments have improved survival rates, but often cause difficulty swallowing (dysphagia) as a side effect. Dysphagia can be temporary or long-lasting. Treatment for dysphagia includes swallowing exercises, changes in diet (texture, size of food), or a combination of both.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Dysphagia, Speech, Voice, and Trismus following Radiotherapy and/or Chemotherapy in Patients with Head and Neck Carcinoma: Review of the Literature.

Author: HeijnenB J, SpeyerR, KertscherB, CordierR, KoetsenruijterK W J, SwanK, BogaardtH

Head and neck cancer treatment

This review examined the effects of radiation and chemotherapy on the upper airway and swallowing in head and neck cancer patients. While speech therapy can improve voice quality, treatment often leads to difficulties with swallowing, eating, and overall quality of life. However, the wide range of treatment protocols and patient characteristics makes it difficult to generalize these findings. More research is needed to understand the impact of cancer treatments on these areas.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Intraoperative radiation therapy (IORT) in head and neck cancer: A systematic review.

Author: KyrgiasGeorge, HajiioannouJiannis, ToliaMaria, KoulouliasVassilios, LachanasVasileios, SkoulakisCharalambos, SkarlatosIoannis, RapidisAlexandros, BizakisIoannis

Improved survival
Local control of disease

This review summarizes recent research on the use of intraoperative radiation therapy (IORT) as an adjuvant treatment for head and neck cancer. IORT offers a potential benefit by delivering a high dose of radiation directly to the tumor bed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Stereotactic body radiotherapy for recurrent head and neck cancer: A critical review.

Author: BaligaSujith, KabarritiRafi, OhriNitin, Haynes-LewisHilda, YaparpalviRavindra, KalnickiShalom, GargMadhur K

Head and neck cancer treatment

Treating head and neck cancer that returns after treatment is challenging. Re-irradiation has been used cautiously due to side effects, but a newer type of radiation therapy called Stereotactic Body Radiation Therapy (SBRT) offers more precise treatment and spares healthy tissue. While promising, SBRT is technically demanding. This review examines the role of re-irradiation in recurrent head and neck cancers, focusing on SBRT and its use with other treatments like cetuximab. The review also summarizes studies on SBRT, reporting response rates, survival, and side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Uniform FDG-PET guided GRAdient Dose prEscription to reduce late Radiation Toxicity (UPGRADE-RT): study protocol for a randomized clinical trial with dose reduction to the elective neck in head and neck squamous cell carcinoma.

Author: van den BoschSven, DijkemaTim, Kunze-BuschMartina C, TerhaardChris H J, RaaijmakersCornelis P J, DoornaertPatricia A H, HoebersFrank J P, VergeerMarije R, KreikeBas, WijersOda B, OyenWim J G, KaandersJohannes H A M

Head and neck cancer treatment

Radiation therapy for head and neck cancer often includes a dose to the neck region to prevent spread to lymph nodes even if they don't appear cancerous. However, with better imaging, we now know that hidden cancer cells are less common. This suggests that the current dose to the neck may be too high. Reducing the dose to the neck could help reduce side effects like swallowing problems, dry mouth, and thyroid issues, improving quality of life after treatment.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

51.

Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia: a randomized, open-label, active-controlled trial.

Author: HeydariradGhazaleh, RezaeizadehHossein, ChoopaniRasool, MosavatSeyed Hamdollah, AmeriAhmad

Improved QOL
Reduced dry mouth

Traditional Persian medicine preparation of hollyhocks and common mallow should be considered as a suitable treatment for xerostomia and improving QOL in HNC patients with radiation-induced xerostomia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

52.

A network meta-analysis in comparing prophylactic treatments of radiotherapy-induced oral mucositis for patients with head and neck cancers receiving radiotherapy.

Author: PengHao, ChenBin-Bin, ChenLei, ChenYu-Pei, LiuXu, TangLing-Long, MaoYan-Ping, LiWen-Fei, ZhangYuan, LinAi-Hua, SunYing, MaJun

Mucositis Reduction

Low-level laser therapy in addition to standard oral care may be the most effective prophylactic treatment for reducing severe radiotherapy-induced oral mucositis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

54.

Locally advanced squamous cell carcinoma of the head and neck: A systematic review and Bayesian network meta-analysis of the currently available treatment options.

Author: IoccaOreste, FarcomeniAlessio, Di RoccoArianna, Di MaioPasquale, GolusinskiPaweł, Pardiñas LópezSimón, SavoAlfredo, PelliniRaul, SprianoGiuseppe

Improved HNC treatment

There is no clear best treatment for locally advanced head and neck cancer (HNC). This review analyzes research on various chemotherapy drugs and radiation therapy schedules to compare different treatment options for this type of cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Association of Treatment Delays With Survival for Patients With Head and Neck Cancer: A Systematic Review.

Author: GraboyesEvan M, KompelliAnvesh R, NeskeyDavid M, BrennanEmily, NguyenShaun, SterbaKatherine R, WarrenGraham W, Hughes-HalbertChanita, NussenbaumBrian, DayTerry A

Improved survival
Heterogeneity in defining delay

A systematic review of 18 studies found that delays in the delivery of care for head and neck cancer are associated with worse survival outcomes. Delays in treatment initiation, postoperative radiotherapy, and treatment package time (TPT) were all linked to poorer survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

Emerging patient-specific treatment modalities in head and neck cancer - a systematic review.

Author: ElicinOlgun, CihoricNikola, Vlaskou BadraEugenia, OzsahinMahmut

HNC treatment

Head and neck cancer (HNC) is a type of cancer that weakens the immune system. Current treatments include radiation therapy, surgery, chemotherapy, monoclonal antibodies, and tyrosine kinase inhibitors. While other immunotherapies are being developed, immune checkpoint inhibitors are receiving a lot of attention for their potential benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Effectiveness of exercise-based rehabilitation on functional capacity and quality of life in head and neck cancer patients receiving chemo-radiotherapy.

Author: SamuelStephen Rajan, MaiyaArun G, FernandesDonald J, GuddattuVasudeva, SaxenaP U Prakash, KurianJestina Rachel, LinPo-Ju, MustianKaren M

Improved QoL
Improved functional capacity
Reduced fatigue

This study evaluates the effectiveness of exercise-based rehabilitation on functional capacity, quality of life, fatigue, hemoglobin, and platelet counts in patients with head and neck cancers (HNC) undergoing chemo-radiotherapy (CRT).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

58.

Treatment for lymphedema following head and neck cancer therapy: A systematic review.

Author: TykerAlbina, FrancoJoel, MassaSean T, DesaiShaun C, WalenScott G

Head and neck lymphedema treatment

This study aimed to provide a comprehensive review of treatments for head and neck lymphedema, a swelling that can occur after cancer treatment in this area. The researchers focused on specific challenges related to head and neck lymphedema that are different from lymphedema in the limbs. The goal is to create better guidelines for treating head and neck lymphedema and identify areas where more research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Deglutition disorders as a consequence of head and neck cancer therapies: a systematic review and meta-analysis.

Author: Porto de ToledoIsabela, PantojaLeticia Lopes Quirino, LuchesiKaren Fontes, AssadDaniele Xavier, De Luca CantoGraziela, GuerraEliete Neves Silva

None reported
Deglutition disorders

The frequency of deglutition disorders and its complications, such as aspiration, appear to be higher in the immediate to 6-month post-treatment period in patients with head and neck cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Oral Dysfunction in Patients With Head and Neck Cancer: A Systematic Review.

Author: ChenShu-Ching

Oral dysfunction in HNC

Head and neck cancers and their treatment can cause oral dysfunction, such as mucositis, dysphagia, and xerostomia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

The risk of second primary tumors in head and neck cancer: A systematic review.

Author: Coca-PelazAndrés, RodrigoJuan P, SuárezCarlos, NixonIain J, MäkitieAntti, SanabriaAlvaro, QuerMiquel, StrojanPrimož, BradfordCarol R, KowalskiLuiz P, ShahaAshok R, de BreeRemco, HartlDana M, RinaldoAlessandra, TakesRobert P, FerlitoAlfio

Second primary tumors

The incidence of second primary tumors (SPTs) in head and neck cancer (HNC) patients is high, with a mean incidence of 13.2%, highlighting the need for early diagnosis strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

Denture use and osteoradionecrosis following radiotherapy for head and neck cancer: A systematic review.

Author: AbedHassan, BurkeMary, ScamblerSasha, ScottSuzanne E

HaNC treatment
ORN development

People with head and neck cancer (HNC) are often recommended to have teeth removed before radiation therapy to prevent problems after radiation. However, this can leave people with few teeth, which can affect their mental health and quality of life. While some doctors advise against dentures after radiation, due to concerns about bone damage, more research is needed to determine if dentures are safe and beneficial for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

[Head and neck cancer in the elderly-current aspects].

Author: HöingB, LangS, StuschkeM, HansenS

Head and neck cancer treatment
High morbidity

Head and neck cancer is usually treated with surgery and radiation therapy, which can have significant side effects. The study highlights the difficulty in deciding on the best treatment for older patients with head and neck cancer, as there's a lack of clear guidelines and evidence to guide treatment decisions for this specific population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : German

64.

Impact of Time to Diagnosis and Treatment in Head and Neck Cancer: A Systematic Review.

Author: SchutteHenrieke W, HeutinkFloris, WellensteinDavid J, van den BroekGuido B, van den HoogenFrank J A, MarresHenri A M, van HerpenCarla M L, KaandersJohannes H A M, MerkxThijs M A W, TakesRobert P

HNC treatment

This review examines the impact of the time between the first symptoms of head and neck cancer (HNC) and the start of treatment on the outcomes of treatment, including cancer control and function. The study focuses on cancers of the mouth, throat, and larynx.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Obstructive Sleep Apnoea in Patients Treated for Head and Neck Cancer: A Systematic Review of the Literature.

Author: RalliMassimo, CampoFlaminia, AngelettiDiletta, AllegraEugenia, MinniAntonio, PolimeniAntonella, GrecoAntonio, de VincentiisMarco

This systematic review evaluated the prevalence of obstructive sleep apnoea (OSA) in patients treated for head and neck cancer, highlighting the need for clinicians to consider sleep history and management strategies for this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

67.

Resource-sparing curative-intent hypofractionated-accelerated radiotherapy in head and neck cancer: More relevant than ever before in the COVID era.

Author: GuptaTejpal, Ghosh-LaskarSarbani, AgarwalJai Prakash

Hypofractionated RT for HNSCC

This study discusses the radiobiological basis and evidence for hypofractionated-accelerated radiotherapy (HYPNO) for head and neck squamous cell carcinoma (HNSCC), highlighting its potential for resource-constrained settings, particularly in the context of the COVID-19 pandemic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

Quality of life in tongue cancer treated patients before and after speech therapy: a randomized clinical trial.

Author: BalbinotJordana, RealCaroline Santana, MeloCecília Corte de, DornellesSílvia, CostaSady Selaimen da

Tongue cancer treatment

Tongue cancer treatments can cause significant physical and emotional challenges, including difficulty swallowing (dysphagia), which impacts quality of life. This study highlights the importance of rehabilitation in helping patients adjust to changes after treatment and regain function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

69.

3D-printed individualized tooth-borne tissue retraction devices compared to conventional dental splints for head and neck cancer radiotherapy: a randomized controlled trial.

Author: HeldThomas, HerpelChristopher, SchwindlingFranz Sebastian, ChristLeo, LangKristin, RegnerySebastian, EichkornTanja, HommertgenAdriane, JaekelCornelia, KrisamJohannes, MoratinJulius, MrosekJan, MetzgerKarl, ZaouiKarim, MoutsisTracy, HarrabiSemi, HerfarthKlaus, FreudlspergerChristian, RammelsbergPeter, DebusJürgen, AdebergSebastian

3D printed TRDs for HNC RT

This study investigated the use of 3D printed, tooth-borne tissue retraction devices (TRDs) compared to conventional dental splints for head and neck radiotherapy (RT). The goal is to reduce radiation-related toxicity by minimizing exposure to healthy tissues during RT for head and neck cancer.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

70.

Interventions for Trismus in Head and Neck Cancer Patients: A Systematic Review of Randomized Controlled Trials.

Author: CheeShuzhen, ByrnesYasmeen M, ChorathKevin T, RajasekaranKarthik, DengJie

Improved mouth opening
Increased adherence
Trismus

This systematic review found that there is no clear consensus on the optimal intervention for trismus in head and neck cancer patients. A variety of exercise regimens and jaw rehabilitation devices appear to have comparable effectiveness. Efforts focused on increasing adherence to a particular intervention protocol may improve outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

The PRO-ACTIVE trial protocol: a randomized study comparing the effectiveness of PROphylACTic swallow InterVEntion for patients receiving radiotherapy for head and neck cancer.

Author: MartinoR, FitchM I, FullerC D, HopeA, KrisciunasG, LangmoreS E, LazarusC, MacdonaldC L, McCullochT, MillsG, PalmaD A, PytyniaK, RingashJ, SultanemK, TheurerJ, ThorpeK E, HutchesonK

Swallowing therapy for HNC

This trial compares the effectiveness of prophylactic versus reactive swallowing therapy in patients with head and neck cancer (HNC) undergoing radiotherapy (RT). Swallowing therapy is commonly used to manage dysphagia, a common side effect of RT for HNC.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

73.

Stereotactic radiotherapy as planned boost after definitive radiotherapy for head and neck cancers: Systematic review.

Author: KimMichael S, MalikNauman H, ChenHanbo, PoonIan, HusainZain, EskanderAntoine, BoldtGabriel, LouieAlexander V, KaramIrene

Improved local control
Improved overall survival
Severe toxicities

Stereotactic radiotherapy (SBRT) used as a boost treatment following conventional radiotherapy for locoregionally advanced head and neck cancers (HNCs) has been investigated to improve local control (LC) and overall survival (OS). While median LC was 92% and median OS was 80% at 3 years, severe treatment-related late toxicities were reported. Therefore, SBRT boost should be used only in investigational settings until more data is available.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

The impact of radiation induced lymphopenia in the prognosis of head and neck cancer: A systematic review and meta-analysis.

Author: DaiDongjun, TianQiaoying, ShuiYongjie, LiJinfan, WeiQichun

HNC treatment
RIL treatment
HNC progression
Reduced survival

This meta-analysis of eight studies found that severe radiation-induced lymphopenia (RIL) is associated with decreased overall survival and an increased risk of disease progression in patients with head and neck cancer (HNC).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

75.

Treatment prioritization and risk stratification of head and neck cancer during COVID-19 pandemic: A systematic review.

Author: AdhamM, AnamK, ReksodiputroL

Head and neck cancer treatment

This study examines the challenges of treating head and neck cancer patients during the COVID-19 pandemic. The study aims to review existing research on how to prioritize treatment and assess risk factors for these patients during the pandemic, ensuring safe and appropriate care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

76.

The Effectiveness of Surgical Methods for Trismus Release at Least 6 Months After Head and Neck Cancer Treatment: Systematic Review.

Author: SmeetsMaximiliaan, CroonenborghsTomas-Marijn, Van DesselJeroen, PolitisConstantinus, JacobsReinhilde, BilaMichel

Trismus release

Coronoidectomy appears to be a more effective surgical treatment for severe trismus following head and neck squamous cell cancer treatment compared to free flap reconstruction or myotomy. More research is needed to confirm this.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Managing Cachexia in Head and Neck Cancer: a Systematic Scoping Review.

Author: MäkitieAntti A, AlabiRasheed Omobolaji, OrellHelena, YoussefOmar, AlmangushAlhadi, HommaAkihiro, TakesRobert P, LópezFernando, de BreeRemco, RodrigoJuan P, FerlitoAlfio

HNC treatment

Head and neck cancer (HNC) can cause problems with speaking, breathing, chewing, swallowing, and saliva production, leading to eating difficulties. This can result in weight loss, muscle loss, loss of appetite, fatigue, and anemia, collectively known as cancer cachexia syndrome. This study will examine how to treat cancer cachexia in people with HNC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

Topical Prevention of Radiation Dermatitis in Head and Neck Cancer Patients: A Network Meta-analysis.

Author: KaoYung-Shuo, MaKevin Sheng-Kai, WuMin-You, WuYao-Cheng, TuYu-Kang, HungCheng-Hsien

Head and neck cancer treatment

Head and neck cancer is a common type of cancer, and radiation therapy is a primary treatment. One common side effect of radiation is skin irritation (radiation dermatitis). This study aims to identify the most effective creams and lotions to prevent radiation dermatitis in people with head and neck cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

80.

Smoking and other health factors in patients with head and neck cancer.

Author: McCarterKristen, BakerAmanda L, WolfendenLuke, WrattenChris, BauerJudith, BeckAlison K, ForbesErin, CarterGregory, LeighLucy, OldmeadowChristopher, BrittonBen

Smoking and other health factors in HNC patients

This study explores patterns of smoking and other health factors in patients with head and neck cancer (HNC) throughout treatment, follow-up, and survivorship. Understanding these factors is essential for providing comprehensive care to HNC patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

81.

Pilot randomized, controlled, preoperative intervention for nutrition trial in head and neck cancer.

Author: SykesKevin J, GibbsHeather, FarrokhianNathan, ArthurAnna, FlynnJohn, ShnayderYelizaveta, KakaralaKiran, NallaniRohit, SmithJoshua B, PennJoseph, FassasScott, CummingsEmily, ArambulaZack, KaradaghyOmar, BurAndrés M

Weight loss mitigation

A multimodal nutrition intervention for patients undergoing primary surgery with free flap reconstruction for head and neck cancer (HNC) showed potential to reduce weight loss. While the intervention did not significantly change nutrition risk scores, it mitigated weight loss in patients with dysphagia.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

82.

Feasibility and efficacy of telerehabilitation in the management of patients with head and neck cancer during and after oncological treatment: A systematic review.

Author: Martínez-GuijarroCelia, López-FernándezMaría Dolores, Lopez-GarzonMaria, Lozano-LozanoMario, Arroyo-MoralesManuel, Galiano-CastilloNoelia

High patient satisfaction
Telerehabilitation efficacy

This systematic review of 14 studies suggests that telerehabilitation is a feasible and effective intervention for patients with head and neck cancer (HNC) during and after oncological treatment. Further research is needed to support caregivers and to investigate long-term outcomes.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

83.

Programmed Cell Death Ligand 1 Expression on Immune Cells and Survival in Patients With Nonmetastatic Head and Neck Cancer: A Systematic Review and Meta-analysis.

Author: BlažekTomáš, PetrášMarek, KnybelLukáš, CvekJakub, SoumarováRenata

HNSCC survival

High PD-L1 expression on immune cells is associated with favorable overall survival (OS) in patients with head and neck squamous cell carcinoma (HNSCC). A meta-analysis of 17 cohort studies revealed a pooled adjusted hazard ratio (aHR) of 0.39 for OS in patients with high PD-L1 expression on immune cells. This finding suggests that PD-L1 expression on immune cells may serve as a prognostic biomarker in HNSCC.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

84.

Rehabilitation Interventions for Head and Neck Cancer-Associated Lymphedema: A Systematic Review.

Author: ChengJessica T, LeiteVictor F, TennisonJegy M, GutierrezCarolina, Kline-QuirozCristina, CapozziLauren C, YuShui, KrauseKate J, LangelierDavid, ParkeSara C

HNCaL rehabilitation

Lymphedema, swelling caused by fluid buildup, affects as many as 90% of people who have had head and neck cancer. This condition can significantly impair quality of life. While lymphedema after head and neck cancer (HNCaL) is common and can cause problems, there is limited research on effective rehabilitation treatments.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

85.

Telehealth Interventions in Head and Neck Cancer Patients: A Systematic Review.

Author: CaputoMathew P, RodriguezCarmen S, PadhyaTapan A, MifsudMatthew J

HNC treatment
Quality of life improvement

This study explores the potential of telehealth interventions to improve access to rehabilitative services and post-treatment quality of life for patients with head and neck cancer (HNC). HNC treatments often have adverse effects that impact quality of life.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

88.

App-Controlled Treatment Monitoring and Support for Patients With Head and Neck Cancer Undergoing Radiotherapy: Results From a Prospective Randomized Controlled Trial.

Author: SpraveTanja, PfaffenlehnerMichelle, StoianRaluca, ChristofiEleni, RühleAlexander, ZöllerDaniela, FabianAlexander, FahrnerHarald, BinderHarald, SchäferHenning, GkikaEleni, GrosuAnca-Ligia, HeinemannFelix, NicolayNils Henrik

HNC treatment

Head and neck cancers (HNCs) are common, and treatment often involves radiation and chemotherapy. These treatments can cause many side effects that impact patients' quality of life. Using telehealth to monitor symptoms and well-being during treatment could help identify people who need additional support.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

89.

A Systematic Review of the Economic Burden of Proton Therapy in Head and Neck Cancer.

Author: Bharathi RPoovizhi, MsAthiyamaan, KamathAshwin

HNC treatment

This systematic review explores the costs and cost-effectiveness of proton beam therapy (PBT) compared to other first-line treatments for head and neck cancer (HNC). PBT is a newer treatment option for HNC.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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