Comparison of the safety and efficacy of bisoprolol versus atenolol in stable exercise-induced angina pectoris: a Multicenter International Randomized Study of Angina Pectoris (MIRSA).

Author: Buchner-MoellD, LieK I, de MuinckE D, van de VenL L

Paper Details 
Original Abstract of the Article :
Bisoprolol 10 mg and atenolol 100 mg once daily were compared regarding efficacy and safety in stable effort angina in a 12-week, multicenter, double-blind, randomized, parallel-group study. Efficacy was evaluated with angina pectoris diaries and bicycle exercise tests. Spontaneously mentioned compl...See full text at original site
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引用元:
https://doi.org/10.1097/00005344-199206000-00005

データ提供:米国国立医学図書館(NLM)

Comparing the Effects of Beta-blockers: A Randomized Study on Bisoprolol and Atenolol

The field of cardiology is continuously seeking to improve treatment options for heart conditions. This research investigates the efficacy and safety of two beta-blockers, bisoprolol and atenolol, in patients with stable exercise-induced angina pectoris. The researchers employed a rigorous multicenter, double-blind, randomized, parallel-group study involving 147 patients. They meticulously compared the effects of bisoprolol 10 mg and atenolol 100 mg on angina frequency, exercise capacity, and adverse events over a 12-week period. Their findings provide valuable insights into the comparative benefits of these two commonly used beta-blockers.

A Balanced Approach: Bisoprolol and Atenolol in Angina Pectoris

The study demonstrates that both bisoprolol and atenolol effectively reduced anginal attack rates, improved exercise capacity, and lowered heart rate. However, the researchers found no statistically significant differences in efficacy or safety between the two drugs. Both regimens were well-tolerated, with similar incidence and nature of side effects. The study's findings provide reassurance regarding the effectiveness of both bisoprolol and atenolol in managing stable exercise-induced angina pectoris.

A Safe Oasis in the World of Beta-blockers

The research highlights the safety and efficacy of both bisoprolol and atenolol in managing angina pectoris. The study provides valuable insights for healthcare providers in choosing the appropriate beta-blocker for individual patients, considering potential side effects and patient preferences. The findings underscore the importance of evidence-based decision-making in cardiovascular care, ensuring optimal outcomes for patients.

Dr.Camel's Conclusion

This research offers a comprehensive comparison of two commonly used beta-blockers for angina pectoris. The findings are like a cool oasis in the desert, providing reassurance about the effectiveness and safety of both bisoprolol and atenolol. The study encourages a balanced approach, considering individual patient needs and preferences when selecting the appropriate medication.

Date :
  1. Date Completed 1992-07-21
  2. Date Revised 2019-07-24
Further Info :

Pubmed ID

1376806

DOI: Digital Object Identifier

10.1097/00005344-199206000-00005

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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