Side Effects of bisoprolol: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Bisoprolol is a beta-blocker used to treat heart disease. Studies have shown that bisoprolol is effective in treating heart failure, particularly when used in combination with ACE inhibitors for systolic heart failure, reducing all-cause mortality by 34-5%. 5

Bisoprolol is also used to treat hypertension. In young/middle-aged hypertensive patients, bisoprolol has been shown to be effective in reversing left ventricular hypertrophy and is at least as good as ACE inhibitors. 8

In the treatment of hypertension in the elderly, bisoprolol, in combination with diuretics, can be an effective treatment option. 4

Reasons for Side Effects

Side effects of bisoprolol can be attributed to beta2 blockade and alpha blockade. 5

Common Side Effects

Metabolic Disturbances

Non-selective beta-blockers (e.g. propranolol) or modestly beta1-selective beta-blockers (e.g. metoprolol, atenolol) may cause metabolic disturbances. 5

Bronchospasm

Non-selective beta-blockers or modestly beta1-selective beta-blockers may cause bronchospasm. 5

Epinephrine/Hypertensive Interaction

Non-selective beta-blockers or modestly beta1-selective beta-blockers may cause epinephrine/hypertensive interactions when used in combination with cigarette smoking or insulin-induced hypoglycemia. 5

Dizziness

Beta-blockers with alpha-blocking activity (e.g. carvedilol) may cause dizziness. 5

Postural Hypotension

Beta-blockers with alpha-blocking activity (e.g. carvedilol) may cause postural hypotension. 5

Sexual Dysfunction

The presence of beta2 blockade, particularly when combined with alpha-blockade, may be associated with an increased occurrence of sexual dysfunction. 5

Insomnia

Lipophilic beta-blockers such as propranolol and metoprolol appear in high concentrations in human brain tissue and may be associated with side effects such as insomnia, dreams, and nightmares. 5

Countermeasures for Side Effects

Metabolic Disturbances

It is important to choose beta1-selective beta-blockers to prevent metabolic disturbances. 5

Bronchospasm

It is important to choose beta1-selective beta-blockers to prevent bronchospasm. 5

Epinephrine/Hypertensive Interaction

It is important to choose beta1-selective beta-blockers to prevent epinephrine/hypertensive interactions. 5

Dizziness

It is important to gradually increase the dosage or take precautions when standing up to reduce dizziness. 5

Postural Hypotension

It is important to gradually increase the dosage or take precautions when standing up to prevent postural hypotension. 5

Sexual Dysfunction

It is important to choose beta1-selective beta-blockers to prevent sexual dysfunction. 5

Insomnia

It is important to avoid taking bisoprolol before bedtime or adjust the time of administration to reduce insomnia. 5

Comparison Between Studies

Common Points

Multiple studies have shown that bisoprolol is effective in treating heart failure and hypertension.

Differences

The dosage of bisoprolol varies across studies. Similarly, the side effects of bisoprolol vary across studies.

Notes on Application to Real Life

Bisoprolol is an effective drug for treating heart failure and hypertension, but it can cause side effects. It is important to follow your doctor's instructions and be aware of side effects when taking bisoprolol.

Limitations of Current Research

Research on bisoprolol is still insufficient. In particular, research on the long-term effects of bisoprolol is lacking.

Future Research Directions

Further research is needed on the long-term effects of bisoprolol and its safety in different patient populations.

Conclusion

Bisoprolol is an effective drug for treating heart failure and hypertension, but it can cause side effects. It is important to follow your doctor's instructions and be aware of side effects when taking bisoprolol. Research on the long-term effects of bisoprolol is still insufficient. Further research is needed on the long-term effects of bisoprolol and its safety in different patient populations.

Literature analysis of 27 papers
Positive Content
25
Neutral Content
0
Negative Content
2
Article Type
8
0
0
5
27
1.

Drug-related bradycardia precipitating hospital admission in older adults: an ongoing problem.

Author: GriffithsCharlotte, IoannouAdam, DickinsonBenjamin, MetaxaSofia, AminFouad R, MandalAmit K J, MissourisConstantinos G

Bradycardia
Syncope

Drug-related bradycardia (DRB) was a significant cause of hospital admissions in older adults (4.32% of total admissions), particularly in patients with atrial fibrillation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Life-threatening QT prolongation in a boy with attention-deficit/hyperactivity disorder on atomoxetine.

Author: YamaguchiHiroshi, NagumoKiyoshi, NakashimaTaiji, KinugawaYoshikazu, KumakiSatoru

ADHD treatment
Cardiac effects

Atomoxetine, a noncentral nerve-stimulating agent that blocks noradrenalin reuptake, is used to treat attention-deficit/hyperactivity disorder (ADHD). While effective for ADHD, it can cause side effects like headache, abdominal pain, decreased appetite, and weight loss. This case report describes an 11-year-old Japanese boy with ADHD on atomoxetine who experienced a loss of consciousness. Electrocardiogram (ECG) showed significant QT prolongation, which worsened over time, along with bradycardia, inverted T waves, and premature ventricular contractions. Transthoracic echocardiography revealed Takotsubo cardiomyopathy. The boy recovered with bisoprolol and transcutaneous pacing. The case highlights the potential for serious cardiovascular side effects of atomoxetine in children and adolescents with ADHD. ECG screening and close monitoring are crucial to prevent life-threatening events.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Nitrendipine in the therapeutic management of elderly hypertensive patients: results of a multicenter trial. Andalousian Hypertension Group.

Author: ArandaP, LopezS, FernandezJ A, Lopez de NovalesE

Biochemical tolerance
Reduces blood pressure
Side effects

Nitrendipine was effective in controlling blood pressure in elderly patients with mild-to-moderate essential hypertension. Adding bisoprolol improved blood pressure control in some patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

4.

Clinical results with bisoprolol 2.5 mg/hydrochlorothiazide 6.25 mg combination in systolic hypertension in the elderly.

Author: BenetosAthanase, AdamopoulosChris, ArgyriadisPandelis, BeanKathy, ConsoliSilla, SafarMichel

Improve quality of life
Lower blood pressure
Side effects

This study compares the efficacy and safety of a low-dose combination of bisoprolol and hydrochlorothiazide versus amlodipine in elderly patients with isolated systolic hypertension. Both treatments show similar efficacy and tolerability, suggesting the combination therapy as a viable alternative.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Beta-blockers and heart failure.

Author: CruickshankJohn M

Heart failure treatment
Bronchospasm
Metabolic disturbance
Sexual dysfunction

This review discusses the use of beta-blockers (BB) in the treatment of heart failure (HF). BB are effective in treating systolic HF, reducing all-cause death by 34-5%. Bisoprolol, metoprolol, and carvedilol are considered the most effective BB for treating systolic HF. The choice of BB is important, as benefit is not a class-effect. Adverse effects are mainly associated with beta-2 blockade and alpha-blockade.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors.

Author: BakerJillian G

Bronchospasm

This study investigated the selectivity of beta-antagonists for different human beta-adrenoceptor subtypes. Most clinically used beta-blockers showed poor selectivity for beta1- over beta2-adrenoceptors, suggesting potential for developing more selective drugs to reduce side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Effects of bisoprolol on left ventricular hypertrophy in essential hypertension.

Author: de TeresaE, GonzálezM, Camacho-VázquezC, TabuencaM J

Heart function improvement
Ventricular hypertrophy reduction

Bisoprolol reduced left ventricular mass, preserved systolic function, and improved diastolic function of the left ventricle in hypertensive subjects with left ventricular hypertrophy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

A double-blind comparison of bisoprolol and captopril for treatment of essential hypertension in the elderly.

Author: BracchettiD, GradnikR, AlbertiA, BrunelliA, OrselliL, LeonardiG, PavesiP C, CantelliI

Lower blood pressure
Reduce heart rate
No significant side effects

Both bisoprolol and captopril showed significant antihypertensive effects in elderly patients with mild-to-moderate essential hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Hypertrophic cardiomyopathy in childhood and adolescence - strategies to prevent sudden death.

Author: Ostman-SmithIngegerd

Sudden death reduction
High morbidity
Inappropriate shocks

Hypertrophic cardiomyopathy is a common cause of sudden death in childhood, particularly in the 8- to 16-year age range. Beta-blocker therapy with lipophilic beta-blockers significantly reduces sudden death risk. Other treatments, like disopyramide and internal cardioverter defibrillator implantation, are also used.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Tolerability and Feasibility of Beta-Blocker Titration in HFpEF Versus HFrEF: Insights From the CIBIS-ELD Trial.

Author: EdelmannFrank, Musial-BrightLindy, GelbrichGoetz, TrippelTobias, RadenovicSara, WachterRolf, InkrotSimone, LoncarGoran, TahirovicElvis, CelicVera, VeskovicJovan, ZdravkovicMarija, LainscakMitja, ApostolovićSvetlana, NeskovicAleksandar N, PieskeBurkert, DüngenHans-Dirk,

Blood pressure reduction
Heart rate reduction
Diastolic function
HFpEF patients

This study evaluated the tolerability and feasibility of titrating two beta-blockers in elderly heart failure patients with preserved (HFpEF) and reduced (HFrEF) left ventricular ejection fraction. Tolerability was comparable between groups, with similar reductions in heart rate and blood pressure. However, only HFrEF patients experienced significant improvements in clinical parameters and left ventricular function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Present and future pharmacotherapy for heart failure.

Author: DoggrellSheila A, BrownLindsay

Heart failure treatment

Current heart failure treatment includes diuretics, ACE inhibitors, beta-blockers, and digitalis. This review discusses the potential benefits and drawbacks of these medications and suggests alternative or combination therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

[Use of bisoprolol in heart failure. The BISOCOR observational study].

Author: González-JuanateyJosé R, Alegría EzquerraEduardo, García SaavedraVicente, Pérez OjedaGermán, Ruiz RosJosé A, Espinosa CalianiJ Salvador, Anguita SánchezManuel,

Heart failure treatment

Beta-blockers are crucial for treating heart failure, but their effectiveness depends on dosage. This study analyzes the concordance between targeted and achieved bisoprolol doses in heart failure patients, highlighting the importance of accurate dosage for optimal outcomes.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Spanish

16.

Treatment of the hyperventilation syndrome with bisoprolol: a placebo-controlled clinical trial.

Author: Van De VenL L, MouthaanB J, HoesM J

Improved hyperventilation symptoms
Reduced hyperventilation attacks

Bisoprolol was effective in reducing the number and severity of hyperventilation attacks in patients with hyperventilation syndrome. No serious side effects were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

[Ocular hypotensive effect of systemic beta-blockers in patients with primary glaucoma and arterial hypertension].

Author: OnishchenkoA L, KolbaskoA V, ZakharovaA V, OnishchenkoE G, ZhilinaN M

Reduced IOP

Oral selective beta-blockers significantly reduced intraocular pressure (IOP) in patients with primary open-angle glaucoma (POAG) and arterial hypertension (AH). IOP was reduced by 18.5% to 26% of baseline values after one year.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

18.

Temporary cognitive impairment related to administration of newly developed anticholinergic medicines for overactive bladder: two case reports.

Author: ShiotaTakako, TorimotoKazumasa, MomoseHitoshi, NakamuroTakuya, MochizukiHiroshi, KumamotoHiromi, HirayamaAkihide, FujimotoKiyohide

Cognitive impairment

This report describes two elderly Japanese patients who experienced temporary cognitive impairment caused by anticholinergic medications for overactive bladder. The report highlights the potential for cognitive side effects with anticholinergic medications and emphasizes the need for careful monitoring in vulnerable populations.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Comparison of the safety and efficacy of bisoprolol versus atenolol in stable exercise-induced angina pectoris: a Multicenter International Randomized Study of Angina Pectoris (MIRSA).

Author: de MuinckE D, Buchner-MoellD, van de VenL L, LieK I

Increases exercise capacity
Reduces RPP
Reduces anginal attack rate

Bisoprolol 10mg and atenolol 100mg were found to be equally effective in treating stable effort angina. Both had comparable side effect profiles.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

How should subgroup analyses affect clinical practice? Insights from the Metoprolol Succinate Controlled-Release/Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF).

Author: WikstrandJohn, WedelHans, GhaliJalal, DeedwaniaPrakash, FagerbergBjörn, GoldsteinSidney, GottliebStephen, HjalmarsonAke, KjekshusJohn, WaagsteinFinn

Heart failure treatment

This study examines the consistency of results from three large trials of beta-blockers in patients with heart failure. All three trials showed significant positive effects on total mortality and hospitalization rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Imidapril in heart failure.

Author: DolezalTomas

Acute MI treatment
Diabetic nephropathy treatment
Heart failure treatment
Hypertension treatment

Imidapril is a long-acting ACE inhibitor used to treat hypertension, chronic heart failure, acute MI, and diabetic nephropathy. It improves exercise time, physical working capacity, and left ventricular ejection fraction while reducing blood pressure. Imidapril is well tolerated and has a lower incidence of cough compared to other ACE inhibitors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Cardiovascular Drug Therapy during Interstage After Hybrid Approach: A Single-Center Experience in 51 Newborns with Hypoplastic Left Heart.

Author: MienertTino, EsmaeiliAnoosh, SteinbrennerBlanka, KhalilMarkus, MüllerMatthias, AkintuerkHakan, KerstGunter, SchranzDietmar

HLH treatment

Newborns with hypoplastic left heart (HLH) often undergo the Norwood procedure or a hybrid stage I procedure. The hybrid approach is preferred. This study emphasizes the importance of drug therapy for managing the high-risk interstage between stage I and comprehensive stage II or advanced biventricular repair.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

24.

Bisoprolol and hypertension: effects on sexual functioning in men.

Author: BroekmanC P, HaenselS M, Van de VenL L, SlobA K

Improved sexuality

Bisoprolol is an effective antihypertensive drug with no detrimental effects on sexuality in newly diagnosed men with hypertension. In men already on antihypertensive medication, bisoprolol improved certain aspects of sexuality.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

[The effects of bisoprolol and atenolol on glucose metabolism in hypertensive patients with non-insulin-dependent diabetes mellitus].

Author: VulpisV, AntonacciA, PrandiP, BokorD, PirrelliA

Blood pressure reduction
No effect on glucose metabolism
None mentioned

The study compared the effects of bisoprolol and atenolol, two beta-blockers, on glucose metabolism in hypertensive patients with type 2 diabetes. Both drugs effectively lowered blood pressure without significantly affecting glucose metabolism.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

27.

Dose-effect relationship and long-term effects of bisoprolol in mild to moderate hypertension.

Author: WeinerL, FrithzG

Blood pressure reduction
Heart rate reduction
Cold extremities

Bisoprolol, a new beta 1-selective beta-blocking agent, was effective in reducing blood pressure and heart rate in 48 hypertensive patients. The 20 mg dose was more effective than the 5 or 10 mg doses. The effects were sustained over 10 months of treatment. Side effects were common but mild.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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